ID EPS8_MOUSE Reviewed; 821 AA. AC Q08509; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 16-JUN-2009, entry version 83. DE RecName: Full=Epidermal growth factor receptor kinase substrate 8; GN Name=Eps8; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=94008987; PubMed=8404850; RA Fazioli F., Minichiello L., Matoska V., Castagnino P., Miki T., RA Wong W.T., di Fiore P.P.; RT "Eps8, a substrate for the epidermal growth factor receptor kinase, RT enhances EGF-dependent mitogenic signals."; RL EMBO J. 12:3799-3808(1993). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Kidney; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP INTERACTION WITH SHB. RX PubMed=7537362; RA Karlsson T., Songyang Z., Landgren E., Lavergne C., Di Fiore P.P., RA Anafi M., Pawson T., Cantley L.C., Claesson-Welsh L., Welsh M.; RT "Molecular interactions of the Src homology 2 domain protein Shb with RT phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 RT domain proteins."; RL Oncogene 10:1475-1483(1995). RN [4] RP X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 532-591, AND RP HOMODIMERIZATION. RX MEDLINE=97448677; PubMed=9303002; DOI=10.1038/nsb0997-739; RA Kishan K.V.R., Scita G., Wong W.T., di Fiore P.P., Newcomer M.E.; RT "The SH3 domain of Eps8 exists as a novel intertwined dimer."; RL Nat. Struct. Biol. 4:739-743(1997). CC -!- FUNCTION: Upon binding to EGF receptor enhances EGF-dependent CC mitogenic signals. Can bind multiple cellular targets. CC -!- SUBUNIT: Homodimer. Interacts with BAIAP2 (By similarity). CC Interacts with SHB. CC -!- INTERACTION: CC Q8IZP0:ABI1 (xeno); NbExp=2; IntAct=EBI-375596, EBI-375446; CC Q8CBW3:Abi1; NbExp=1; IntAct=EBI-375596, EBI-375511; CC Q9UQB8:BAIAP2 (xeno); NbExp=6; IntAct=EBI-375596, EBI-525456; CC -!- DOMAIN: The SH3 domain mediates interaction with SHB (By CC similarity). CC -!- PTM: Phosphorylated by several receptor tyrosine kinases. CC -!- SIMILARITY: Belongs to the EPS8 family. CC -!- SIMILARITY: Contains 1 PH domain. CC -!- SIMILARITY: Contains 1 SH3 domain. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; L21671; AAA16358.1; -; mRNA. DR EMBL; BC016890; AAH16890.1; -; mRNA. DR IPI; IPI00622390; -. DR PIR; S39983; S39983. DR UniGene; Mm.235346; -. DR UniGene; Mm.412332; -. DR PDB; 1AOJ; X-ray; 2.50 A; A/B=532-591. DR PDB; 1I07; X-ray; 1.80 A; A/B=532-591. DR PDB; 1I0C; X-ray; 2.00 A; A/B=532-591. DR PDBsum; 1AOJ; -. DR PDBsum; 1I07; -. DR PDBsum; 1I0C; -. DR IntAct; Q08509; 3. DR PhosphoSite; Q08509; -. DR Ensembl; ENSMUSG00000015766; Mus musculus. DR MGI; MGI:104684; Eps8. DR HOVERGEN; Q08509; -. DR ArrayExpress; Q08509; -. DR Bgee; Q08509; -. DR GermOnline; ENSMUSG00000015766; Mus musculus. DR GO; GO:0017146; C:N-methyl-D-aspartate selective glutamate re...; IDA:MGI. DR GO; GO:0014069; C:postsynaptic density; IDA:MGI. DR GO; GO:0019717; C:synaptosome; IDA:MGI. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0031532; P:actin cytoskeleton reorganization; IMP:MGI. DR GO; GO:0008344; P:adult locomotory behavior; IMP:MGI. DR GO; GO:0048149; P:behavioral response to ethanol; IMP:MGI. DR InterPro; IPR013625; PTB. DR InterPro; IPR006020; PTB_PID. DR InterPro; IPR001452; SH3_domain. DR Pfam; PF08416; PTB; 1. DR Pfam; PF00018; SH3_1; 1. DR ProDom; PD000066; SH3; 1. DR SMART; SM00462; PTB; 1. DR SMART; SM00326; SH3; 1. DR PROSITE; PS50003; PH_DOMAIN; FALSE_NEG. DR PROSITE; PS50002; SH3; 1. PE 1: Evidence at protein level; KW 3D-structure; Phosphoprotein; SH3 domain. FT CHAIN 1 821 Epidermal growth factor receptor kinase FT substrate 8. FT /FTId=PRO_0000086995. FT DOMAIN 69 129 PH; first part. FT DOMAIN 381 414 PH; second part. FT DOMAIN 532 591 SH3. FT COMPBIAS 210 213 Poly-Pro. FT COMPBIAS 322 325 Poly-Pro. FT COMPBIAS 421 440 Pro-rich. FT COMPBIAS 620 650 Pro-rich. FT COMPBIAS 658 663 Poly-Ser. FT MOD_RES 524 524 Phosphotyrosine (By similarity). FT MOD_RES 810 810 Phosphoserine (By similarity). FT MOD_RES 814 814 Phosphoserine (By similarity). FT STRAND 534 539 FT STRAND 556 559 FT HELIX 561 563 FT STRAND 566 570 FT STRAND 576 580 FT HELIX 581 583 FT STRAND 584 587 SQ SEQUENCE 821 AA; 91738 MW; 6B9EB95DD22D910C CRC64; MNGHMSNRSS GYGVYPSQLN GYGSSPPYSQ MDREHSSRTS AKALYEQRKN YARDSVSSVS DVSQYRVEHL TTFVLDRKDA MITVEDGIRK LKLLDAKGKV WTQDMILQVD DRAVSLIDLE SKNELENFPL NTISHCQAVV HACSYDSILA LVCKEPTQSK PDLHLFQCDE VKANLISEDI ESAISDSKGG KQKRRPEALR MIAKADPGIP PPPRAPAPVP PGTVTQVDVR SRVAAWSAWA ADQGDFEKPR QYHEQEETPE MMAARIDRDV QILNHILDDI EFFITKLQKA AEAFSELSKR KKSKKSKRKG PGEGVLTLRA KPPPPDEFVD CFQKFKHGFN LLAKLKSHIQ NPSASDLVHF LFTPLNMVVQ ATGGPELASS VLSPLLTKDT VDFLNYTATA EERKLWMSLG DSWVKVRAEW PKEQFIPPYV PRFRNGWEPP MLNFMGAPTE QDMYQLAESV ANAEHQRKQD SKRLSTEHSN VSDYPPADGY AYSSSMYHRG PHADHGEAAM PFKSTPNHQV DRNYDAVKTQ PKKYAKSKYD FVARNSSELS VMKDDVLEIL DDRRQWWKVR NASGDSGFVP NNILDIMRTP ESGVGRADPP YTHTIQKQRT EYGLRSADTP SAPSPPPTPA PVPVPLPPSV PAPVSVPKVP ADVTRQNSSS SDSGGSIVRD SQRYKQLPVD RRKSQMEEVQ DELFQRLTIG RSAAQRKFHV PRQNVPVINI TYDSSPEEVK TWLQSKGFNP VTVNSLGVLN GAQLFSLNKD ELRSVCPEGA RVFNQITVQK AALEDSNGSS ELQEIMRRRQ EKISAAASDS GVESFDEGSS H //