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Protein

Prolactin receptor

Gene

Prlr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a receptor for the anterior pituitary hormone prolactin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi206ZincBy similarity1
Metal bindingi207ZincBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • peptide hormone binding Source: MGI
  • prolactin receptor activity Source: MGI

GO - Biological processi

  • activation of transmembrane receptor protein tyrosine kinase activity Source: MGI
  • JAK-STAT cascade Source: MGI
  • lactation Source: MGI
  • mammary gland alveolus development Source: MGI
  • mammary gland epithelial cell differentiation Source: MGI
  • mammary gland epithelium development Source: MGI
  • prostate gland growth Source: MGI
  • regulation of cell adhesion Source: MGI
  • regulation of epithelial cell differentiation Source: MGI

Keywordsi

Molecular functionReceptor
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1170546 Prolactin receptor signaling
R-MMU-982772 Growth hormone receptor signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin receptor
Short name:
PRL-R
Gene namesi
Name:Prlr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:97763 Prlr

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 229ExtracellularBy similarityAdd BLAST210
Transmembranei230 – 253HelicalBy similarityAdd BLAST24
Topological domaini254 – 608CytoplasmicBy similarityAdd BLAST355

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi1721

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001097820 – 608Prolactin receptorAdd BLAST589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 41By similarity
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi70 ↔ 81By similarity
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ08501
PaxDbiQ08501
PRIDEiQ08501

PTM databases

iPTMnetiQ08501
PhosphoSitePlusiQ08501

Expressioni

Gene expression databases

BgeeiENSMUSG00000005268
CleanExiMM_PRLR
ExpressionAtlasiQ08501 baseline and differential
GenevisibleiQ08501 MM

Interactioni

Subunit structurei

Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AGAP2Q99490-22EBI-7737664,EBI-7737644From a different organism.

Protein-protein interaction databases

BioGridi202385, 4 interactors
IntActiQ08501, 3 interactors
MINTiQ08501
STRINGi10090.ENSMUSP00000122219

Structurei

3D structure databases

ProteinModelPortaliQ08501
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 122Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST101
Domaini124 – 224Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi210 – 214WSXWS motif5
Motifi262 – 270Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUSW Eukaryota
ENOG410XRJS LUCA
GeneTreeiENSGT00530000063112
HOGENOMiHOG000059569
HOVERGENiHBG007314
InParanoidiQ08501
KOiK05081
OMAiEDQQLMP
OrthoDBiEOG091G07CK
PhylomeDBiQ08501
TreeFamiTF330851

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR013783 Ig-like_fold
IPR003528 Long_hematopoietin_rcpt_CS
IPR033230 PRLR
PANTHERiPTHR23036:SF86 PTHR23036:SF86, 1 hit
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01352 HEMATOPO_REC_L_F1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform PRL-R3 (identifier: Q08501-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSALAYMLL VLSISLLNGQ SPPGKPEIHK CRSPDKETFT CWWNPGSDGG
60 70 80 90 100
LPTNYSLTYS KEGEKNTYEC PDYKTSGPNS CFFSKQYTSI WKIYIITVNA
110 120 130 140 150
TNEMGSSTSD PLYVDVTYIV EPEPPRNLTL EVKQLKDKKT YLWVKWLPPT
160 170 180 190 200
ITDVKTGWFT MEYEIRLKSE EADEWEIHFT GHQTQFKVFD LYPGQKYLVQ
210 220 230 240 250
TRCKPDHGYW SRWGQEKSIE IPNDFTLKDT TVWIIVAVLS AVICLIMVWA
260 270 280 290 300
VALKGYSMMT CIFPPVPGPK IKGFDTHLLE KGKSEELLSA LGCQDFPPTS
310 320 330 340 350
DCEDLLVEFL EVDDNEDERL MPSHSKEYPG QGVKPTHLDP DSDSGHGSYD
360 370 380 390 400
SHSLLSEKCE EPQAYPPAFH IPEITEKPEN PEANIPPTPN PQNNTPNCHT
410 420 430 440 450
DTSKSTTWPL PPGQHTRRSP YHSIADVCKL AGSPGDTLDS FLDKAEENVL
460 470 480 490 500
KLSEDAGEEE VAVQEGAKSF PSDKQNTSWP PLQEKGPIVY AKPPDYVEIH
510 520 530 540 550
KVNKDGVLSL LPKQRENHQT ENPGVPETSK EYAKVSGVTD NNILVLVPDS
560 570 580 590 600
RAQNTALLEE SAKKVPPSLE QNQSEKDLAS FTATSSNCRL QLGRLDYLDP

TCFMHSFH
Length:608
Mass (Da):68,241
Last modified:February 1, 1995 - v1
Checksum:iB8CE202B2EFC9FC6
GO
Isoform PRL-R1 (identifier: Q08501-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-303: KGKSEELLSALGCQDFPPTSDCE → LWCSILQLTSLVKIPTTEFLCDL
     304-608: Missing.

Show »
Length:303
Mass (Da):34,734
Checksum:iE22B50EFDB77B755
GO
Isoform PRL-R2 (identifier: Q08501-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-292: KGKSEELLSALG → VHNKEQLENYVY
     293-608: Missing.

Show »
Length:292
Mass (Da):33,633
Checksum:iF02BA23FE6AC74F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti558L → F in CAA51789 (PubMed:8319571).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001723281 – 303KGKSE…TSDCE → LWCSILQLTSLVKIPTTEFL CDL in isoform PRL-R1. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_001721281 – 292KGKSE…LSALG → VHNKEQLENYVY in isoform PRL-R2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_001722293 – 608Missing in isoform PRL-R2. 1 PublicationAdd BLAST316
Alternative sequenceiVSP_001724304 – 608Missing in isoform PRL-R1. 1 PublicationAdd BLAST305

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13593 mRNA Translation: AAC37641.1
L14811 mRNA Translation: AAA02686.1
D10214 mRNA Translation: BAA01066.1
X73372 mRNA Translation: CAA51789.1
M22959 mRNA Translation: AAA39977.1
M22958 mRNA Translation: AAA39976.1
CCDSiCCDS27377.1 [Q08501-1]
CCDS56975.1 [Q08501-2]
PIRiI53269
I77524
I77525
RefSeqiNP_001240711.1, NM_001253782.2 [Q08501-2]
NP_035299.4, NM_011169.5 [Q08501-1]
XP_006520097.1, XM_006520034.3 [Q08501-1]
XP_006520098.1, XM_006520035.1 [Q08501-1]
XP_006520099.1, XM_006520036.1 [Q08501-1]
XP_006520100.1, XM_006520037.2 [Q08501-1]
XP_006520101.1, XM_006520038.1 [Q08501-2]
UniGeneiMm.10516
Mm.442446

Genome annotation databases

EnsembliENSMUST00000124470; ENSMUSP00000122219; ENSMUSG00000005268 [Q08501-1]
ENSMUST00000128450; ENSMUSP00000122209; ENSMUSG00000005268 [Q08501-3]
ENSMUST00000137867; ENSMUSP00000121935; ENSMUSG00000005268 [Q08501-3]
ENSMUST00000148257; ENSMUSP00000118355; ENSMUSG00000005268 [Q08501-2]
GeneIDi19116
KEGGimmu:19116
UCSCiuc007vfw.2 mouse [Q08501-3]
uc007vfy.2 mouse [Q08501-1]
uc029snt.1 mouse [Q08501-2]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiPRLR_MOUSE
AccessioniPrimary (citable) accession number: Q08501
Secondary accession number(s): P15212, P15213, Q62099
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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