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Protein

Dematin

Gene

DMTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.6 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • protein self-association Source: UniProtKB
  • receptor binding Source: UniProtKB
  • spectrin binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158856-MONOMER.
ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.

Names & Taxonomyi

Protein namesi
Recommended name:
Dematin
Alternative name(s):
Dematin actin-binding protein
Erythrocyte membrane protein band 4.9
Gene namesi
Name:DMTN
Synonyms:DMT, EPB49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:3382. DMTN.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: UniProtKB
  • actin filament Source: UniProtKB
  • cell projection membrane Source: UniProtKB
  • cortical cytoskeleton Source: Ensembl
  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB
  • cytosol Source: UniProtKB
  • endomembrane system Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • platelet dense tubular network membrane Source: UniProtKB
  • postsynaptic density Source: Ensembl
  • spectrin-associated cytoskeleton Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi124S → A: Reduces interaction with plasmodium berghei 14-3-3 protein. Inhibits phosphorylation and interaction with plasmodium berghei 14-3-3 protein; when associated with A-333 and A-403. 1 Publication1
Mutagenesisi333S → A: Reduces interaction with plasmodium berghei 14-3-3 protein. Inhibits phosphorylation and interaction with plasmodium berghei 14-3-3 protein; when associated with A-124 and A-403. 1 Publication1
Mutagenesisi403S → A: Inhibits phosphorylation and interaction with plasmodium berghei 14-3-3 protein; when associated with A-124 and A-333. 2 Publications1
Mutagenesisi403S → E: Reduces F-actin bundling but not F-actin binding activity. 2 Publications1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi2039.
OpenTargetsiENSG00000158856.
PharmGKBiPA27815.

Polymorphism and mutation databases

BioMutaiDMTN.
DMDMi22654240.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187551 – 405DematinAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei18PhosphoserineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei110PhosphoserineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei156PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei279PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei315PhosphoserineBy similarity1
Modified residuei333PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei403Phosphoserine; by PKA3 Publications1

Post-translational modificationi

Phosphorylated. Phosphorylation at Ser-403 by PKA causes the C-terminal headpiece domain to associate with the N-terminal core domain, and leads to the inhibition of its actin bundling activity.4 Publications
The N-terminus is blocked.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ08495.
PaxDbiQ08495.
PeptideAtlasiQ08495.
PRIDEiQ08495.

PTM databases

iPTMnetiQ08495.
PhosphoSitePlusiQ08495.

Expressioni

Tissue specificityi

Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney.1 Publication

Gene expression databases

BgeeiENSG00000158856.
CleanExiHS_EPB49.
ExpressionAtlasiQ08495. baseline and differential.
GenevisibleiQ08495. HS.

Organism-specific databases

HPAiHPA024290.

Interactioni

Subunit structurei

Monomeric (isoform 2); under reducing conditions. Self-associates. Exists under oxidizing condition as a trimer of two isoforms 2 and isoform 1 linked by disulfide bonds (Probable). Found in a complex with DMTN, F-actin and spectrin. Found in a complex with ADD2, DMTN and SLC2A1. Interacts with F-actin, ITPKB, RASGRF2 and spectrin. Isoform 2 interacts with SLC2A1 (via C-terminus cytoplasmic region). Isoform 1 and isoform 2 interact (phosphorylated form) with plasmodium berghei 14-3-3 protein; the interaction occurs in a PKA-dependent manner.Curated8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-715275,EBI-618309

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • protein self-association Source: UniProtKB
  • receptor binding Source: UniProtKB
  • spectrin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108353. 18 interactors.
IntActiQ08495. 10 interactors.
MINTiMINT-1390442.
STRINGi9606.ENSP00000265800.

Structurei

Secondary structure

1405
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni346 – 348Combined sources3
Helixi364 – 366Combined sources3
Helixi368 – 370Combined sources3
Helixi373 – 379Combined sources7
Beta strandi380 – 382Combined sources3
Helixi384 – 389Combined sources6
Helixi392 – 402Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QZPNMR-A342-405[»]
1ZV6NMR-A342-405[»]
ProteinModelPortaliQ08495.
SMRiQ08495.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08495.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini337 – 405HPPROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni224 – 308Interaction with RASGRF21 PublicationAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi216 – 222Poly-Glu7

Domaini

Both the N-terminal core domain and the C-terminal headpiece domain are sufficient for binding to F-actin and necessary for actin bundling activity.

Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated
Contains 1 HP (headpiece) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1044. Eukaryota.
ENOG410XRPY. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000285997.
HOVERGENiHBG031499.
InParanoidiQ08495.
OMAiWAESRTP.
OrthoDBiEOG091G06PE.
PhylomeDBiQ08495.
TreeFamiTF318042.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
InterProiIPR032402. AbLIM_anchor.
IPR003128. Villin_headpiece.
[Graphical view]
PfamiPF16182. AbLIM_anchor. 2 hits.
PF02209. VHP. 1 hit.
[Graphical view]
SMARTiSM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
PROSITEiPS51089. HP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q08495-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERLQKQPLT SPGSVSPSRD SSVPGSPSSI VAKMDNQVLG YKDLAAIPKD
60 70 80 90 100
KAILDIERPD LMIYEPHFTY SLLEHVELPR SRERSLSPKS TSPPPSPEVW
110 120 130 140 150
ADSRSPGIIS QASAPRTTGT PRTSLPHFHH PETSRPDSNI YKKPPIYKQR
160 170 180 190 200
ESVGGSPQTK HLIEDLIIES SKFPAAQPPD PNQPAKIETD YWPCPPSLAV
210 220 230 240 250
VETEWRKRKA SRRGAEEEEE EEDDDSGEEM KALRERQREE LSKVTSNLGK
260 270 280 290 300
MILKEEMEKS LPIRRKTRSL PDRTPFHTSL HQGTSKSSSL PAYGRTTLSR
310 320 330 340 350
LQSTEFSPSG SETGSPGLQN GEGQRGRMDR GNSLPCVLEQ KIYPYEMLVV
360 370 380 390 400
TNKGRTKLPP GVDRMRLERH LSAEDFSRVF AMSPEEFGKL ALWKRNELKK

KASLF
Length:405
Mass (Da):45,514
Last modified:August 30, 2002 - v3
Checksum:i77D6372E5B16EFF4
GO
Isoform 2 (identifier: Q08495-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     320-341: Missing.

Show »
Length:383
Mass (Da):43,088
Checksum:i3C46AB7704507B6E
GO
Isoform 3 (identifier: Q08495-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-31: Missing.
     320-341: Missing.

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):40,680
Checksum:i1F985F9D3643F995
GO
Isoform 4 (identifier: Q08495-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-31: Missing.
     83-97: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):41,558
Checksum:iBD11861605E9B618
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81S → Q in AAA58438 (PubMed:8341682).Curated1
Sequence conflicti81S → Q in AAC50223 (PubMed:7615546).Curated1
Sequence conflicti155G → A in BAG52385 (PubMed:14702039).Curated1
Sequence conflicti292A → R in AAA58438 (PubMed:8341682).Curated1
Sequence conflicti292A → R in AAC50223 (PubMed:7615546).Curated1
Sequence conflicti347M → V in AAA58438 (PubMed:8341682).Curated1
Sequence conflicti380F → S in AAA58438 (PubMed:8341682).Curated1
Sequence conflicti403S → P in BAG52385 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0448037 – 31Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_05742883 – 97Missing in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_004189320 – 341Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19713 mRNA. Translation: AAA58438.1.
U28389 mRNA. Translation: AAC50223.1.
AK055842 mRNA. Translation: BAG51582.1.
AK091581 mRNA. Translation: BAG52385.1.
AK289650 mRNA. Translation: BAF82339.1.
AK295452 mRNA. Translation: BAG58387.1.
BT007396 mRNA. Translation: AAP36060.1.
AC091171 Genomic DNA. No translation available.
BC006318 mRNA. Translation: AAH06318.1.
BC017445 mRNA. Translation: AAH17445.1.
BC052805 mRNA. Translation: AAH52805.1.
CCDSiCCDS47820.1. [Q08495-2]
CCDS47821.1. [Q08495-3]
CCDS6020.1. [Q08495-1]
CCDS78311.1. [Q08495-4]
PIRiA48222.
I39062.
RefSeqiNP_001107607.1. NM_001114135.4. [Q08495-1]
NP_001107608.1. NM_001114136.2. [Q08495-1]
NP_001107609.1. NM_001114137.3. [Q08495-2]
NP_001107610.1. NM_001114138.2. [Q08495-2]
NP_001107611.1. NM_001114139.3. [Q08495-3]
NP_001289745.1. NM_001302816.2. [Q08495-2]
NP_001289746.1. NM_001302817.2. [Q08495-4]
NP_001310307.1. NM_001323378.1. [Q08495-1]
NP_001310308.1. NM_001323379.1. [Q08495-1]
NP_001310309.1. NM_001323380.1. [Q08495-1]
NP_001310310.1. NM_001323381.1. [Q08495-1]
NP_001310311.1. NM_001323382.1. [Q08495-1]
NP_001310312.1. NM_001323383.1. [Q08495-2]
NP_001310313.1. NM_001323384.1. [Q08495-2]
NP_001310314.1. NM_001323385.1. [Q08495-2]
NP_001310316.1. NM_001323387.1. [Q08495-3]
NP_001310317.1. NM_001323388.1. [Q08495-4]
NP_001310318.1. NM_001323389.1.
NP_001310319.1. NM_001323390.1.
NP_001310320.1. NM_001323391.1.
NP_001310321.1. NM_001323392.1.
NP_001310322.1. NM_001323393.1.
NP_001310323.1. NM_001323394.1.
NP_001310324.1. NM_001323395.1.
NP_001310325.1. NM_001323396.1.
NP_001310326.1. NM_001323397.1.
NP_001310327.1. NM_001323398.1.
NP_001310328.1. NM_001323399.1.
NP_001310329.1. NM_001323400.1.
NP_001310330.1. NM_001323401.1.
NP_001969.2. NM_001978.4. [Q08495-1]
XP_005273489.1. XM_005273432.1. [Q08495-1]
XP_016868678.1. XM_017013189.1. [Q08495-2]
XP_016868682.1. XM_017013193.1. [Q08495-4]
XP_016868683.1. XM_017013194.1. [Q08495-4]
XP_016868684.1. XM_017013195.1. [Q08495-3]
XP_016868685.1. XM_017013196.1. [Q08495-3]
XP_016868686.1. XM_017013197.1. [Q08495-3]
XP_016868687.1. XM_017013198.1. [Q08495-3]
UniGeneiHs.106124.

Genome annotation databases

EnsembliENST00000265800; ENSP00000265800; ENSG00000158856. [Q08495-1]
ENST00000358242; ENSP00000350977; ENSG00000158856. [Q08495-1]
ENST00000381470; ENSP00000370879; ENSG00000158856. [Q08495-2]
ENST00000415253; ENSP00000401291; ENSG00000158856. [Q08495-2]
ENST00000432128; ENSP00000416111; ENSG00000158856. [Q08495-1]
ENST00000443491; ENSP00000397904; ENSG00000158856. [Q08495-3]
ENST00000517305; ENSP00000430609; ENSG00000158856. [Q08495-1]
ENST00000517600; ENSP00000430618; ENSG00000158856. [Q08495-4]
ENST00000519907; ENSP00000429377; ENSG00000158856. [Q08495-2]
ENST00000523266; ENSP00000427866; ENSG00000158856. [Q08495-1]
ENST00000523782; ENSP00000429234; ENSG00000158856. [Q08495-3]
GeneIDi2039.
KEGGihsa:2039.
UCSCiuc064kwf.1. human. [Q08495-1]
uc064kwj.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19713 mRNA. Translation: AAA58438.1.
U28389 mRNA. Translation: AAC50223.1.
AK055842 mRNA. Translation: BAG51582.1.
AK091581 mRNA. Translation: BAG52385.1.
AK289650 mRNA. Translation: BAF82339.1.
AK295452 mRNA. Translation: BAG58387.1.
BT007396 mRNA. Translation: AAP36060.1.
AC091171 Genomic DNA. No translation available.
BC006318 mRNA. Translation: AAH06318.1.
BC017445 mRNA. Translation: AAH17445.1.
BC052805 mRNA. Translation: AAH52805.1.
CCDSiCCDS47820.1. [Q08495-2]
CCDS47821.1. [Q08495-3]
CCDS6020.1. [Q08495-1]
CCDS78311.1. [Q08495-4]
PIRiA48222.
I39062.
RefSeqiNP_001107607.1. NM_001114135.4. [Q08495-1]
NP_001107608.1. NM_001114136.2. [Q08495-1]
NP_001107609.1. NM_001114137.3. [Q08495-2]
NP_001107610.1. NM_001114138.2. [Q08495-2]
NP_001107611.1. NM_001114139.3. [Q08495-3]
NP_001289745.1. NM_001302816.2. [Q08495-2]
NP_001289746.1. NM_001302817.2. [Q08495-4]
NP_001310307.1. NM_001323378.1. [Q08495-1]
NP_001310308.1. NM_001323379.1. [Q08495-1]
NP_001310309.1. NM_001323380.1. [Q08495-1]
NP_001310310.1. NM_001323381.1. [Q08495-1]
NP_001310311.1. NM_001323382.1. [Q08495-1]
NP_001310312.1. NM_001323383.1. [Q08495-2]
NP_001310313.1. NM_001323384.1. [Q08495-2]
NP_001310314.1. NM_001323385.1. [Q08495-2]
NP_001310316.1. NM_001323387.1. [Q08495-3]
NP_001310317.1. NM_001323388.1. [Q08495-4]
NP_001310318.1. NM_001323389.1.
NP_001310319.1. NM_001323390.1.
NP_001310320.1. NM_001323391.1.
NP_001310321.1. NM_001323392.1.
NP_001310322.1. NM_001323393.1.
NP_001310323.1. NM_001323394.1.
NP_001310324.1. NM_001323395.1.
NP_001310325.1. NM_001323396.1.
NP_001310326.1. NM_001323397.1.
NP_001310327.1. NM_001323398.1.
NP_001310328.1. NM_001323399.1.
NP_001310329.1. NM_001323400.1.
NP_001310330.1. NM_001323401.1.
NP_001969.2. NM_001978.4. [Q08495-1]
XP_005273489.1. XM_005273432.1. [Q08495-1]
XP_016868678.1. XM_017013189.1. [Q08495-2]
XP_016868682.1. XM_017013193.1. [Q08495-4]
XP_016868683.1. XM_017013194.1. [Q08495-4]
XP_016868684.1. XM_017013195.1. [Q08495-3]
XP_016868685.1. XM_017013196.1. [Q08495-3]
XP_016868686.1. XM_017013197.1. [Q08495-3]
XP_016868687.1. XM_017013198.1. [Q08495-3]
UniGeneiHs.106124.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QZPNMR-A342-405[»]
1ZV6NMR-A342-405[»]
ProteinModelPortaliQ08495.
SMRiQ08495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108353. 18 interactors.
IntActiQ08495. 10 interactors.
MINTiMINT-1390442.
STRINGi9606.ENSP00000265800.

PTM databases

iPTMnetiQ08495.
PhosphoSitePlusiQ08495.

Polymorphism and mutation databases

BioMutaiDMTN.
DMDMi22654240.

Proteomic databases

MaxQBiQ08495.
PaxDbiQ08495.
PeptideAtlasiQ08495.
PRIDEiQ08495.

Protocols and materials databases

DNASUi2039.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265800; ENSP00000265800; ENSG00000158856. [Q08495-1]
ENST00000358242; ENSP00000350977; ENSG00000158856. [Q08495-1]
ENST00000381470; ENSP00000370879; ENSG00000158856. [Q08495-2]
ENST00000415253; ENSP00000401291; ENSG00000158856. [Q08495-2]
ENST00000432128; ENSP00000416111; ENSG00000158856. [Q08495-1]
ENST00000443491; ENSP00000397904; ENSG00000158856. [Q08495-3]
ENST00000517305; ENSP00000430609; ENSG00000158856. [Q08495-1]
ENST00000517600; ENSP00000430618; ENSG00000158856. [Q08495-4]
ENST00000519907; ENSP00000429377; ENSG00000158856. [Q08495-2]
ENST00000523266; ENSP00000427866; ENSG00000158856. [Q08495-1]
ENST00000523782; ENSP00000429234; ENSG00000158856. [Q08495-3]
GeneIDi2039.
KEGGihsa:2039.
UCSCiuc064kwf.1. human. [Q08495-1]
uc064kwj.1. human.

Organism-specific databases

CTDi2039.
DisGeNETi2039.
GeneCardsiDMTN.
HGNCiHGNC:3382. DMTN.
HPAiHPA024290.
MIMi125305. gene.
neXtProtiNX_Q08495.
OpenTargetsiENSG00000158856.
PharmGKBiPA27815.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1044. Eukaryota.
ENOG410XRPY. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000285997.
HOVERGENiHBG031499.
InParanoidiQ08495.
OMAiWAESRTP.
OrthoDBiEOG091G06PE.
PhylomeDBiQ08495.
TreeFamiTF318042.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158856-MONOMER.
ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.

Miscellaneous databases

ChiTaRSiDMTN. human.
EvolutionaryTraceiQ08495.
GeneWikiiEPB49.
GenomeRNAii2039.
PROiQ08495.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158856.
CleanExiHS_EPB49.
ExpressionAtlasiQ08495. baseline and differential.
GenevisibleiQ08495. HS.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
InterProiIPR032402. AbLIM_anchor.
IPR003128. Villin_headpiece.
[Graphical view]
PfamiPF16182. AbLIM_anchor. 2 hits.
PF02209. VHP. 1 hit.
[Graphical view]
SMARTiSM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
PROSITEiPS51089. HP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEMA_HUMAN
AccessioniPrimary (citable) accession number: Q08495
Secondary accession number(s): A8K0T5
, B3KP70, B3KRH3, B4DI75, E9PEJ0, Q13215, Q9BRE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: August 30, 2002
Last modified: November 30, 2016
This is version 172 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.