Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q08493

- PDE4C_HUMAN

UniProt

Q08493 - PDE4C_HUMAN

Protein

cAMP-specific 3',5'-cyclic phosphodiesterase 4C

Gene

PDE4C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (27 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.1 Publication

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.1 Publication

    Enzyme regulationi

    Inhibited by rolipram.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei388 – 3881Proton donorBy similarity
    Metal bindingi392 – 3921Divalent metal cation 1
    Metal bindingi428 – 4281Divalent metal cation 1
    Metal bindingi429 – 4291Divalent metal cation 1
    Metal bindingi429 – 4291Divalent metal cation 2
    Binding sitei429 – 4291cAMPBy similarity
    Metal bindingi546 – 5461Divalent metal cation 1
    Binding sitei546 – 5461cAMPBy similarity
    Sitei549 – 5491Binds AMP, but not cAMPBy similarity
    Binding sitei597 – 5971cAMPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi388 – 3925cAMPBy similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: ProtInc
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cAMP catabolic process Source: UniProtKB-UniPathway
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_15334. DARPP-32 events.
    REACT_19327. G alpha (s) signalling events.
    UniPathwayiUPA00762; UER00747.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC:3.1.4.53)
    Alternative name(s):
    DPDE1
    PDE21
    Gene namesi
    Name:PDE4C
    Synonyms:DPDE1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:8782. PDE4C.

    Subcellular locationi

    Cell projectioncilium By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular space Source: UniProt
    3. primary cilium Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cilium

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA264.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 712712cAMP-specific 3',5'-cyclic phosphodiesterase 4CPRO_0000198811Add
    BLAST

    Proteomic databases

    PaxDbiQ08493.
    PRIDEiQ08493.

    PTM databases

    PhosphoSiteiQ08493.

    Expressioni

    Tissue specificityi

    Expressed in various tissues but not in cells of the immune system.

    Gene expression databases

    ArrayExpressiQ08493.
    BgeeiQ08493.
    CleanExiHS_PDE4C.
    GenevestigatoriQ08493.

    Organism-specific databases

    HPAiHPA048975.

    Interactioni

    Subunit structurei

    Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.By similarity

    Protein-protein interaction databases

    BioGridi111169. 1 interaction.
    STRINGi9606.ENSP00000347689.

    Structurei

    Secondary structure

    1
    712
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi317 – 3237
    Helixi324 – 3263
    Helixi334 – 3407
    Helixi345 – 35612
    Helixi359 – 3624
    Helixi367 – 37913
    Beta strandi385 – 3895
    Helixi390 – 40415
    Helixi407 – 4093
    Turni410 – 4123
    Helixi415 – 42713
    Turni428 – 4314
    Helixi435 – 4373
    Helixi456 – 46712
    Helixi468 – 4703
    Turni476 – 4794
    Helixi482 – 49716
    Helixi501 – 5033
    Helixi504 – 51613
    Helixi531 – 54616
    Helixi549 – 5513
    Helixi554 – 56916
    Helixi600 – 6034
    Helixi605 – 61612
    Turni617 – 6204
    Helixi621 – 63010

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LXUmodel-A306-649[»]
    2QYMX-ray1.90A306-663[»]
    ProteinModelPortaliQ08493.
    SMRiQ08493. Positions 234-640.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ08493.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG122287.
    HOVERGENiHBG108239.
    InParanoidiQ08493.
    KOiK01120.
    OMAiGENCDIF.
    OrthoDBiEOG7HQNBC.
    PhylomeDBiQ08493.
    TreeFamiTF314638.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    InterProiIPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform PDE4C1 (identifier: Q08493-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MENLGVGEGA EACSRLSRSR GRHSMTRAPK HLWRQPRRPI RIQQRFYSDP    50
    DKSAGCRERD LSPRPELRKS RLSWPVSSCR RFDLENGLSC GRRALDPQSS 100
    PGLGRIMQAP VPHSQRRESF LYRSDSDYEL SPKAMSRNSS VASDLHGEDM 150
    IVTPFAQVLA SLRTVRSNVA ALARQQCLGA AKQGPVGNPS SSNQLPPAED 200
    TGQKLALETL DELDWCLDQL ETLQTRHSVG EMASNKFKRI LNRELTHLSE 250
    TSRSGNQVSE YISRTFLDQQ TEVELPKVTA EEAPQPMSRI SGLHGLCHSA 300
    SLSSATVPRF GVQTDQEEQL AKELEDTNKW GLDVFKVAEL SGNRPLTAII 350
    FSIFQERDLL KTFQIPADTL ATYLLMLEGH YHANVAYHNS LHAADVAQST 400
    HVLLATPALE AVFTDLEILA ALFASAIHDV DHPGVSNQFL INTNSELALM 450
    YNDASVLENH HLAVGFKLLQ AENCDIFQNL SAKQRLSLRR MVIDMVLATD 500
    MSKHMNLLAD LKTMVETKKV TSLGVLLLDN YSDRIQVLQN LVHCADLSNP 550
    TKPLPLYRQW TDRIMAEFFQ QGDRERESGL DISPMCDKHT ASVEKSQVGF 600
    IDYIAHPLWE TWADLVHPDA QDLLDTLEDN REWYQSKIPR SPSDLTNPER 650
    DGPDRFQFEL TLEEAEEEDE EEEEEGEETA LAKEALELPD TELLSPEAGP 700
    DPGDLPLDNQ RT 712
    Length:712
    Mass (Da):79,902
    Last modified:March 27, 2002 - v2
    Checksum:i1932116C9CE0322C
    GO
    Isoform PDE4C2 (identifier: Q08493-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-106: Missing.

    Show »
    Length:606
    Mass (Da):67,791
    Checksum:i3C42FC9F237333E1
    GO
    Isoform PDE4C3 (identifier: Q08493-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-81: MENLGVGEGA...LSWPVSSCRR → MQGPPAPAPV...RRFTVAHPLC

    Show »
    Length:680
    Mass (Da):75,614
    Checksum:iE555883F32D17B64
    GO
    Isoform PDE4C4 (identifier: Q08493-4)

    Sequence is not available
    Length:
    Mass (Da):
    Isoform PDE4C5 (identifier: Q08493-5)

    Sequence is not available
    Length:
    Mass (Da):
    Isoform PDE4C6 (identifier: Q08493-6)

    Sequence is not available
    Length:
    Mass (Da):
    Isoform PDE4C7 (identifier: Q08493-7)

    Sequence is not available
    Length:
    Mass (Da):

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti204 – 2041K → N in AAD47053. (PubMed:10574328)Curated
    Sequence conflicti204 – 2041K → N in AAD47054. (PubMed:10574328)Curated
    Sequence conflicti211 – 2111D → Y in AAD47053. (PubMed:10574328)Curated
    Sequence conflicti211 – 2111D → Y in AAD47054. (PubMed:10574328)Curated
    Sequence conflicti339 – 3402EL → DV in CAA86601. (PubMed:7843419)Curated
    Sequence conflicti444 – 4463NSE → K in AAC83047. (PubMed:15057824)Curated
    Sequence conflicti446 – 4472EL → DV in CAA86601. (PubMed:7843419)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti131 – 1311S → L.
    Corresponds to variant rs10413646 [ dbSNP | Ensembl ].
    VAR_050473
    Natural varianti289 – 2891R → Q.
    Corresponds to variant rs34503849 [ dbSNP | Ensembl ].
    VAR_050474
    Natural varianti344 – 3441R → Q.
    Corresponds to variant rs2229228 [ dbSNP | Ensembl ].
    VAR_034374
    Natural varianti344 – 3441R → W.
    Corresponds to variant rs11879710 [ dbSNP | Ensembl ].
    VAR_061497

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 106106Missing in isoform PDE4C2. CuratedVSP_004575Add
    BLAST
    Alternative sequencei1 – 8181MENLG…SSCRR → MQGPPAPAPVPGPGSPRGSP RGSPGLFRKLLVNQSIRLQR RFTVAHPLC in isoform PDE4C3. CuratedVSP_004574Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46632 mRNA. Translation: CAA86601.1.
    AF157816
    , AF157811, AF157814, AF157815 Genomic DNA. Translation: AAD47053.1.
    AF157816
    , AF157812, AF157814, AF157815 Genomic DNA. Translation: AAD47054.1.
    AF157816, AF157814, AF157815 Genomic DNA. Translation: AAD47055.1.
    AK095384 mRNA. Translation: BAG53036.1.
    AC005759 Genomic DNA. Translation: AAC83047.1.
    CH471106 Genomic DNA. Translation: EAW84677.1.
    L20968 mRNA. Translation: AAA03591.1.
    CCDSiCCDS12373.1. [Q08493-1]
    CCDS42523.1. [Q08493-3]
    CCDS46016.1. [Q08493-2]
    PIRiS71626.
    RefSeqiNP_000914.2. NM_000923.4. [Q08493-1]
    NP_001092288.1. NM_001098818.2. [Q08493-3]
    NP_001092289.1. NM_001098819.2. [Q08493-2]
    UniGeneiHs.132584.

    Genome annotation databases

    EnsembliENST00000262805; ENSP00000262805; ENSG00000105650. [Q08493-3]
    ENST00000355502; ENSP00000347689; ENSG00000105650. [Q08493-1]
    ENST00000447275; ENSP00000402091; ENSG00000105650. [Q08493-2]
    ENST00000594465; ENSP00000470210; ENSG00000105650. [Q08493-1]
    ENST00000594617; ENSP00000469696; ENSG00000105650. [Q08493-1]
    GeneIDi5143.
    KEGGihsa:5143.
    UCSCiuc002nif.4. human. [Q08493-1]
    uc002nii.4. human. [Q08493-3]

    Polymorphism databases

    DMDMi20141263.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46632 mRNA. Translation: CAA86601.1 .
    AF157816
    , AF157811 , AF157814 , AF157815 Genomic DNA. Translation: AAD47053.1 .
    AF157816
    , AF157812 , AF157814 , AF157815 Genomic DNA. Translation: AAD47054.1 .
    AF157816 , AF157814 , AF157815 Genomic DNA. Translation: AAD47055.1 .
    AK095384 mRNA. Translation: BAG53036.1 .
    AC005759 Genomic DNA. Translation: AAC83047.1 .
    CH471106 Genomic DNA. Translation: EAW84677.1 .
    L20968 mRNA. Translation: AAA03591.1 .
    CCDSi CCDS12373.1. [Q08493-1 ]
    CCDS42523.1. [Q08493-3 ]
    CCDS46016.1. [Q08493-2 ]
    PIRi S71626.
    RefSeqi NP_000914.2. NM_000923.4. [Q08493-1 ]
    NP_001092288.1. NM_001098818.2. [Q08493-3 ]
    NP_001092289.1. NM_001098819.2. [Q08493-2 ]
    UniGenei Hs.132584.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LXU model - A 306-649 [» ]
    2QYM X-ray 1.90 A 306-663 [» ]
    ProteinModelPortali Q08493.
    SMRi Q08493. Positions 234-640.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111169. 1 interaction.
    STRINGi 9606.ENSP00000347689.

    Chemistry

    BindingDBi Q08493.
    ChEMBLi CHEMBL2111340.
    DrugBanki DB00651. Dyphylline.
    GuidetoPHARMACOLOGYi 1302.

    PTM databases

    PhosphoSitei Q08493.

    Polymorphism databases

    DMDMi 20141263.

    Proteomic databases

    PaxDbi Q08493.
    PRIDEi Q08493.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262805 ; ENSP00000262805 ; ENSG00000105650 . [Q08493-3 ]
    ENST00000355502 ; ENSP00000347689 ; ENSG00000105650 . [Q08493-1 ]
    ENST00000447275 ; ENSP00000402091 ; ENSG00000105650 . [Q08493-2 ]
    ENST00000594465 ; ENSP00000470210 ; ENSG00000105650 . [Q08493-1 ]
    ENST00000594617 ; ENSP00000469696 ; ENSG00000105650 . [Q08493-1 ]
    GeneIDi 5143.
    KEGGi hsa:5143.
    UCSCi uc002nif.4. human. [Q08493-1 ]
    uc002nii.4. human. [Q08493-3 ]

    Organism-specific databases

    CTDi 5143.
    GeneCardsi GC19M018318.
    HGNCi HGNC:8782. PDE4C.
    HPAi HPA048975.
    MIMi 600128. gene.
    neXtProti NX_Q08493.
    PharmGKBi PA264.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG122287.
    HOVERGENi HBG108239.
    InParanoidi Q08493.
    KOi K01120.
    OMAi GENCDIF.
    OrthoDBi EOG7HQNBC.
    PhylomeDBi Q08493.
    TreeFami TF314638.

    Enzyme and pathway databases

    UniPathwayi UPA00762 ; UER00747 .
    Reactomei REACT_15334. DARPP-32 events.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    EvolutionaryTracei Q08493.
    GeneWikii PDE4C.
    GenomeRNAii 5143.
    NextBioi 19838.
    PROi Q08493.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q08493.
    Bgeei Q08493.
    CleanExi HS_PDE4C.
    Genevestigatori Q08493.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    InterProi IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C)."
      Engels P., Sullivan M., Mueller T., Luebbert H.
      FEBS Lett. 358:305-310(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE4C1).
      Tissue: Substantia nigra.
    2. "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND."
      Sullivan M., Olsen A.S., Houslay M.D.
      Cell. Signal. 11:735-742(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS PDE4C1; PDE4C2 AND PDE4C3).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PDE4C1).
      Tissue: Tongue.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs."
      Bolger G., Michaeli T., Martins T., St John T., Steiner B., Rodgers L., Riggs M., Wigler M., Ferguson K.
      Mol. Cell. Biol. 13:6558-6571(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 462-712.
    7. "Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors."
      Wang H., Peng M.-S., Chen Y., Geng J., Robinson H., Houslay M.D., Cai J., Ke H.
      Biochem. J. 408:193-201(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 306-663 IN COMPLEX WITH METAL IONS, FUNCTION, COFACTOR.

    Entry informationi

    Entry nameiPDE4C_HUMAN
    AccessioniPrimary (citable) accession number: Q08493
    Secondary accession number(s): B3KTC4
    , Q9UN44, Q9UN45, Q9UN46, Q9UPJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3