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Q08493

- PDE4C_HUMAN

UniProt

Q08493 - PDE4C_HUMAN

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Protein

cAMP-specific 3',5'-cyclic phosphodiesterase 4C

Gene

PDE4C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.1 Publication

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

Cofactori

a divalent metal cation1 PublicationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.1 Publication

Enzyme regulationi

Inhibited by rolipram.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei388 – 3881Proton donorBy similarity
Metal bindingi392 – 3921Divalent metal cation 1
Metal bindingi428 – 4281Divalent metal cation 1
Metal bindingi429 – 4291Divalent metal cation 1
Metal bindingi429 – 4291Divalent metal cation 2
Binding sitei429 – 4291cAMPBy similarity
Metal bindingi546 – 5461Divalent metal cation 1
Binding sitei546 – 5461cAMPBy similarity
Sitei549 – 5491Binds AMP, but not cAMPBy similarity
Binding sitei597 – 5971cAMPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi388 – 3925cAMPBy similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: ProtInc
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cAMP catabolic process Source: UniProtKB-UniPathway
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_15334. DARPP-32 events.
REACT_19327. G alpha (s) signalling events.
UniPathwayiUPA00762; UER00747.

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC:3.1.4.53)
Alternative name(s):
DPDE1
PDE21
Gene namesi
Name:PDE4C
Synonyms:DPDE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:8782. PDE4C.

Subcellular locationi

Cell projectioncilium By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. extracellular space Source: UniProt
  3. primary cilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA264.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 712712cAMP-specific 3',5'-cyclic phosphodiesterase 4CPRO_0000198811Add
BLAST

Proteomic databases

PaxDbiQ08493.
PRIDEiQ08493.

PTM databases

PhosphoSiteiQ08493.

Expressioni

Tissue specificityi

Expressed in various tissues but not in cells of the immune system.

Gene expression databases

BgeeiQ08493.
CleanExiHS_PDE4C.
ExpressionAtlasiQ08493. baseline and differential.
GenevestigatoriQ08493.

Organism-specific databases

HPAiHPA048975.

Interactioni

Subunit structurei

Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.By similarity

Protein-protein interaction databases

BioGridi111169. 1 interaction.
STRINGi9606.ENSP00000347689.

Structurei

Secondary structure

1
712
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi317 – 3237Combined sources
Helixi324 – 3263Combined sources
Helixi334 – 3407Combined sources
Helixi345 – 35612Combined sources
Helixi359 – 3624Combined sources
Helixi367 – 37913Combined sources
Beta strandi385 – 3895Combined sources
Helixi390 – 40415Combined sources
Helixi407 – 4093Combined sources
Turni410 – 4123Combined sources
Helixi415 – 42713Combined sources
Turni428 – 4314Combined sources
Helixi435 – 4373Combined sources
Helixi456 – 46712Combined sources
Helixi468 – 4703Combined sources
Turni476 – 4794Combined sources
Helixi482 – 49716Combined sources
Helixi501 – 5033Combined sources
Helixi504 – 51613Combined sources
Helixi531 – 54616Combined sources
Helixi549 – 5513Combined sources
Helixi554 – 56916Combined sources
Helixi600 – 6034Combined sources
Helixi605 – 61612Combined sources
Turni617 – 6204Combined sources
Helixi621 – 63010Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LXUmodel-A306-649[»]
2QYMX-ray1.90A306-663[»]
ProteinModelPortaliQ08493.
SMRiQ08493. Positions 234-640.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08493.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG122287.
GeneTreeiENSGT00760000118889.
HOVERGENiHBG108239.
KOiK13293.
OMAiGENCDIF.
OrthoDBiEOG7HQNBC.
PhylomeDBiQ08493.
TreeFamiTF314638.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform PDE4C1 (identifier: Q08493-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENLGVGEGA EACSRLSRSR GRHSMTRAPK HLWRQPRRPI RIQQRFYSDP
60 70 80 90 100
DKSAGCRERD LSPRPELRKS RLSWPVSSCR RFDLENGLSC GRRALDPQSS
110 120 130 140 150
PGLGRIMQAP VPHSQRRESF LYRSDSDYEL SPKAMSRNSS VASDLHGEDM
160 170 180 190 200
IVTPFAQVLA SLRTVRSNVA ALARQQCLGA AKQGPVGNPS SSNQLPPAED
210 220 230 240 250
TGQKLALETL DELDWCLDQL ETLQTRHSVG EMASNKFKRI LNRELTHLSE
260 270 280 290 300
TSRSGNQVSE YISRTFLDQQ TEVELPKVTA EEAPQPMSRI SGLHGLCHSA
310 320 330 340 350
SLSSATVPRF GVQTDQEEQL AKELEDTNKW GLDVFKVAEL SGNRPLTAII
360 370 380 390 400
FSIFQERDLL KTFQIPADTL ATYLLMLEGH YHANVAYHNS LHAADVAQST
410 420 430 440 450
HVLLATPALE AVFTDLEILA ALFASAIHDV DHPGVSNQFL INTNSELALM
460 470 480 490 500
YNDASVLENH HLAVGFKLLQ AENCDIFQNL SAKQRLSLRR MVIDMVLATD
510 520 530 540 550
MSKHMNLLAD LKTMVETKKV TSLGVLLLDN YSDRIQVLQN LVHCADLSNP
560 570 580 590 600
TKPLPLYRQW TDRIMAEFFQ QGDRERESGL DISPMCDKHT ASVEKSQVGF
610 620 630 640 650
IDYIAHPLWE TWADLVHPDA QDLLDTLEDN REWYQSKIPR SPSDLTNPER
660 670 680 690 700
DGPDRFQFEL TLEEAEEEDE EEEEEGEETA LAKEALELPD TELLSPEAGP
710
DPGDLPLDNQ RT
Length:712
Mass (Da):79,902
Last modified:March 27, 2002 - v2
Checksum:i1932116C9CE0322C
GO
Isoform PDE4C2 (identifier: Q08493-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:606
Mass (Da):67,791
Checksum:i3C42FC9F237333E1
GO
Isoform PDE4C3 (identifier: Q08493-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MENLGVGEGA...LSWPVSSCRR → MQGPPAPAPV...RRFTVAHPLC

Show »
Length:680
Mass (Da):75,614
Checksum:iE555883F32D17B64
GO
Isoform PDE4C4 (identifier: Q08493-4)

Sequence is not available
Length:
Mass (Da):
Isoform PDE4C5 (identifier: Q08493-5)

Sequence is not available
Length:
Mass (Da):
Isoform PDE4C6 (identifier: Q08493-6)

Sequence is not available
Length:
Mass (Da):
Isoform PDE4C7 (identifier: Q08493-7)

Sequence is not available
Length:
Mass (Da):

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041K → N in AAD47053. (PubMed:10574328)Curated
Sequence conflicti204 – 2041K → N in AAD47054. (PubMed:10574328)Curated
Sequence conflicti211 – 2111D → Y in AAD47053. (PubMed:10574328)Curated
Sequence conflicti211 – 2111D → Y in AAD47054. (PubMed:10574328)Curated
Sequence conflicti339 – 3402EL → DV in CAA86601. (PubMed:7843419)Curated
Sequence conflicti444 – 4463NSE → K in AAC83047. (PubMed:15057824)Curated
Sequence conflicti446 – 4472EL → DV in CAA86601. (PubMed:7843419)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti131 – 1311S → L.
Corresponds to variant rs10413646 [ dbSNP | Ensembl ].
VAR_050473
Natural varianti289 – 2891R → Q.
Corresponds to variant rs34503849 [ dbSNP | Ensembl ].
VAR_050474
Natural varianti344 – 3441R → Q.
Corresponds to variant rs2229228 [ dbSNP | Ensembl ].
VAR_034374
Natural varianti344 – 3441R → W.
Corresponds to variant rs11879710 [ dbSNP | Ensembl ].
VAR_061497

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 106106Missing in isoform PDE4C2. CuratedVSP_004575Add
BLAST
Alternative sequencei1 – 8181MENLG…SSCRR → MQGPPAPAPVPGPGSPRGSP RGSPGLFRKLLVNQSIRLQR RFTVAHPLC in isoform PDE4C3. CuratedVSP_004574Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46632 mRNA. Translation: CAA86601.1.
AF157816
, AF157811, AF157814, AF157815 Genomic DNA. Translation: AAD47053.1.
AF157816
, AF157812, AF157814, AF157815 Genomic DNA. Translation: AAD47054.1.
AF157816, AF157814, AF157815 Genomic DNA. Translation: AAD47055.1.
AK095384 mRNA. Translation: BAG53036.1.
AC005759 Genomic DNA. Translation: AAC83047.1.
CH471106 Genomic DNA. Translation: EAW84677.1.
L20968 mRNA. Translation: AAA03591.1.
CCDSiCCDS12373.1. [Q08493-1]
CCDS42523.1. [Q08493-3]
CCDS46016.1. [Q08493-2]
PIRiS71626.
RefSeqiNP_000914.2. NM_000923.4. [Q08493-1]
NP_001092288.1. NM_001098818.2. [Q08493-3]
NP_001092289.1. NM_001098819.2. [Q08493-2]
UniGeneiHs.132584.

Genome annotation databases

EnsembliENST00000262805; ENSP00000262805; ENSG00000105650. [Q08493-3]
ENST00000355502; ENSP00000347689; ENSG00000105650. [Q08493-1]
ENST00000447275; ENSP00000402091; ENSG00000105650. [Q08493-2]
ENST00000594465; ENSP00000470210; ENSG00000105650. [Q08493-1]
ENST00000594617; ENSP00000469696; ENSG00000105650. [Q08493-1]
GeneIDi5143.
KEGGihsa:5143.
UCSCiuc002nif.4. human. [Q08493-1]
uc002nii.4. human. [Q08493-3]

Polymorphism databases

DMDMi20141263.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46632 mRNA. Translation: CAA86601.1 .
AF157816
, AF157811 , AF157814 , AF157815 Genomic DNA. Translation: AAD47053.1 .
AF157816
, AF157812 , AF157814 , AF157815 Genomic DNA. Translation: AAD47054.1 .
AF157816 , AF157814 , AF157815 Genomic DNA. Translation: AAD47055.1 .
AK095384 mRNA. Translation: BAG53036.1 .
AC005759 Genomic DNA. Translation: AAC83047.1 .
CH471106 Genomic DNA. Translation: EAW84677.1 .
L20968 mRNA. Translation: AAA03591.1 .
CCDSi CCDS12373.1. [Q08493-1 ]
CCDS42523.1. [Q08493-3 ]
CCDS46016.1. [Q08493-2 ]
PIRi S71626.
RefSeqi NP_000914.2. NM_000923.4. [Q08493-1 ]
NP_001092288.1. NM_001098818.2. [Q08493-3 ]
NP_001092289.1. NM_001098819.2. [Q08493-2 ]
UniGenei Hs.132584.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LXU model - A 306-649 [» ]
2QYM X-ray 1.90 A 306-663 [» ]
ProteinModelPortali Q08493.
SMRi Q08493. Positions 234-640.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111169. 1 interaction.
STRINGi 9606.ENSP00000347689.

Chemistry

BindingDBi Q08493.
ChEMBLi CHEMBL291.
DrugBanki DB00201. Caffeine.
DB00651. Dyphylline.
DB05266. Ibudilast.
DB01088. Iloprost.
DB00920. Ketotifen.
DB01656. Roflumilast.
GuidetoPHARMACOLOGYi 1302.

PTM databases

PhosphoSitei Q08493.

Polymorphism databases

DMDMi 20141263.

Proteomic databases

PaxDbi Q08493.
PRIDEi Q08493.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262805 ; ENSP00000262805 ; ENSG00000105650 . [Q08493-3 ]
ENST00000355502 ; ENSP00000347689 ; ENSG00000105650 . [Q08493-1 ]
ENST00000447275 ; ENSP00000402091 ; ENSG00000105650 . [Q08493-2 ]
ENST00000594465 ; ENSP00000470210 ; ENSG00000105650 . [Q08493-1 ]
ENST00000594617 ; ENSP00000469696 ; ENSG00000105650 . [Q08493-1 ]
GeneIDi 5143.
KEGGi hsa:5143.
UCSCi uc002nif.4. human. [Q08493-1 ]
uc002nii.4. human. [Q08493-3 ]

Organism-specific databases

CTDi 5143.
GeneCardsi GC19M018318.
HGNCi HGNC:8782. PDE4C.
HPAi HPA048975.
MIMi 600128. gene.
neXtProti NX_Q08493.
PharmGKBi PA264.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG122287.
GeneTreei ENSGT00760000118889.
HOVERGENi HBG108239.
KOi K13293.
OMAi GENCDIF.
OrthoDBi EOG7HQNBC.
PhylomeDBi Q08493.
TreeFami TF314638.

Enzyme and pathway databases

UniPathwayi UPA00762 ; UER00747 .
Reactomei REACT_15334. DARPP-32 events.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

EvolutionaryTracei Q08493.
GeneWikii PDE4C.
GenomeRNAii 5143.
NextBioi 19838.
PROi Q08493.
SOURCEi Search...

Gene expression databases

Bgeei Q08493.
CleanExi HS_PDE4C.
ExpressionAtlasi Q08493. baseline and differential.
Genevestigatori Q08493.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
InterProi IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C)."
    Engels P., Sullivan M., Mueller T., Luebbert H.
    FEBS Lett. 358:305-310(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE4C1).
    Tissue: Substantia nigra.
  2. "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND."
    Sullivan M., Olsen A.S., Houslay M.D.
    Cell. Signal. 11:735-742(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS PDE4C1; PDE4C2 AND PDE4C3).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PDE4C1).
    Tissue: Tongue.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs."
    Bolger G., Michaeli T., Martins T., St John T., Steiner B., Rodgers L., Riggs M., Wigler M., Ferguson K.
    Mol. Cell. Biol. 13:6558-6571(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 462-712.
  7. "Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors."
    Wang H., Peng M.-S., Chen Y., Geng J., Robinson H., Houslay M.D., Cai J., Ke H.
    Biochem. J. 408:193-201(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 306-663 IN COMPLEX WITH METAL IONS, FUNCTION, COFACTOR.

Entry informationi

Entry nameiPDE4C_HUMAN
AccessioniPrimary (citable) accession number: Q08493
Secondary accession number(s): B3KTC4
, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 27, 2002
Last modified: November 26, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3