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Protein

GTPase-activating protein GYP1

Gene

GYP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates specifically the GTPase activity of YPT1. Functions on the Golgi as a negative regulator of YPT1.1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: SGD
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

BioCyciYEAST:G3O-33609-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase-activating protein GYP1
Alternative name(s):
GAP for YPT1
Gene namesi
Name:GYP1
Ordered Locus Names:YOR070C
ORF Names:YOR29-21
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR070C.
SGDiS000005596. GYP1.

Subcellular locationi

GO - Cellular componenti

  • Golgi apparatus Source: SGD
  • Golgi stack Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002080101 – 637GTPase-activating protein GYP1Add BLAST637

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69PhosphoserineCombined sources1
Modified residuei250PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08484.
PRIDEiQ08484.

PTM databases

iPTMnetiQ08484.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34469. 318 interactors.
DIPiDIP-1258N.
IntActiQ08484. 6 interactors.
MINTiMINT-409462.

Structurei

Secondary structure

1637
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi251 – 262Combined sources12
Helixi270 – 277Combined sources8
Helixi283 – 285Combined sources3
Helixi286 – 293Combined sources8
Helixi301 – 303Combined sources3
Helixi304 – 321Combined sources18
Beta strandi323 – 326Combined sources4
Helixi330 – 340Combined sources11
Helixi341 – 343Combined sources3
Helixi349 – 352Combined sources4
Helixi354 – 370Combined sources17
Turni372 – 374Combined sources3
Helixi380 – 392Combined sources13
Helixi393 – 395Combined sources3
Helixi398 – 403Combined sources6
Turni404 – 406Combined sources3
Helixi409 – 411Combined sources3
Helixi415 – 433Combined sources19
Helixi434 – 439Combined sources6
Helixi445 – 461Combined sources17
Helixi463 – 471Combined sources9
Helixi477 – 485Combined sources9
Turni486 – 488Combined sources3
Helixi489 – 491Combined sources3
Helixi494 – 508Combined sources15
Helixi571 – 585Combined sources15
Helixi587 – 590Combined sources4
Helixi595 – 602Combined sources8
Helixi612 – 629Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FKMX-ray1.90A249-637[»]
2G77X-ray2.26A244-637[»]
ProteinModelPortaliQ08484.
SMRiQ08484.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08484.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini280 – 508Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST229

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi117 – 129His-richAdd BLAST13

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00860000133753.
HOGENOMiHOG000162526.
InParanoidiQ08484.
KOiK20360.
OMAiDLDEDWS.
OrthoDBiEOG092C1ZRG.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 3 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVRSAAKEM HERDHNSDSS SLVTSLMKSW RISSASSSKK PSLYKMNTTE
60 70 80 90 100
STSLPSGYAS SADRDRRTSD GNFEAMAKQQ ASTRRTSNSY SPLRYVNPTL
110 120 130 140 150
STASNESPRP ALLLRQHHQR HHHHQQPRHS SSGSVGNNCS NSTEPNKKGD
160 170 180 190 200
RYFKDLDEDW SAVIDDYNMP IPILTNGGFG TPVAPTRTLS RKSTSSSINS
210 220 230 240 250
ISNMGTSAVR NSSSSFTYPQ LPQLQKEKTN DSKKTQLEIE NERDVQELNS
260 270 280 290 300
IIQRISKFDN ILKDKTIINQ QDLRQISWNG IPKIHRPVVW KLLIGYLPVN
310 320 330 340 350
TKRQEGFLQR KRKEYRDSLK HTFSDQHSRD IPTWHQIEID IPRTNPHIPL
360 370 380 390 400
YQFKSVQNSL QRILYLWAIR HPASGYVQGI NDLVTPFFET FLTEYLPPSQ
410 420 430 440 450
IDDVEIKDPS TYMVDEQITD LEADTFWCLT KLLEQITDNY IHGQPGILRQ
460 470 480 490 500
VKNLSQLVKR IDADLYNHFQ NEHVEFIQFA FRWMNCLLMR EFQMGTVIRM
510 520 530 540 550
WDTYLSETSQ EVTSSYSMSS NDIKPPVTPT EPRVASFVTP TKDFQSPTTA
560 570 580 590 600
LSNMTPNNAV EDSGKMRQSS LNEFHVFVCA AFLIKWSDQL MEMDFQETIT
610 620 630
FLQNPPTKDW TETDIEMLLS EAFIWQSLYK DATSHWL
Length:637
Mass (Da):73,289
Last modified:November 1, 1996 - v1
Checksum:i08C1A26B6ED37E13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70678 Genomic DNA. Translation: CAA94555.1.
Z74978 Genomic DNA. Translation: CAA99263.1.
BK006948 Genomic DNA. Translation: DAA10849.1.
PIRiS66953.
RefSeqiNP_014713.1. NM_001183489.1.

Genome annotation databases

EnsemblFungiiYOR070C; YOR070C; YOR070C.
GeneIDi854236.
KEGGisce:YOR070C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70678 Genomic DNA. Translation: CAA94555.1.
Z74978 Genomic DNA. Translation: CAA99263.1.
BK006948 Genomic DNA. Translation: DAA10849.1.
PIRiS66953.
RefSeqiNP_014713.1. NM_001183489.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FKMX-ray1.90A249-637[»]
2G77X-ray2.26A244-637[»]
ProteinModelPortaliQ08484.
SMRiQ08484.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34469. 318 interactors.
DIPiDIP-1258N.
IntActiQ08484. 6 interactors.
MINTiMINT-409462.

PTM databases

iPTMnetiQ08484.

Proteomic databases

MaxQBiQ08484.
PRIDEiQ08484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR070C; YOR070C; YOR070C.
GeneIDi854236.
KEGGisce:YOR070C.

Organism-specific databases

EuPathDBiFungiDB:YOR070C.
SGDiS000005596. GYP1.

Phylogenomic databases

GeneTreeiENSGT00860000133753.
HOGENOMiHOG000162526.
InParanoidiQ08484.
KOiK20360.
OMAiDLDEDWS.
OrthoDBiEOG092C1ZRG.

Enzyme and pathway databases

BioCyciYEAST:G3O-33609-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ08484.
PROiQ08484.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 3 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGYP1_YEAST
AccessioniPrimary (citable) accession number: Q08484
Secondary accession number(s): D6W2D3, O00028
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 206 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.