SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q08481

- PECA1_MOUSE

UniProt

Q08481 - PECA1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Platelet endothelial cell adhesion molecule
Gene
Pecam1, Pecam, Pecam-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Modulates BDKRB2 activation By similarity. Induces susceptibility to atherosclerosis.1 Publication

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. Rho protein signal transduction Source: MGI
  2. cell adhesion Source: UniProtKB-KW
  3. cellular component movement Source: Ensembl
  4. negative regulation of Rho GTPase activity Source: Ensembl
  5. negative regulation of actin filament polymerization Source: Ensembl
  6. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  7. positive regulation of leukocyte migration Source: Ensembl
  8. positive regulation of tyrosine phosphorylation of Stat5 protein Source: MGI
  9. regulation of cell migration Source: MGI
  10. response to cytokine Source: Ensembl
  11. wound healing Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet endothelial cell adhesion molecule
Short name:
PECAM-1
Alternative name(s):
CD_antigen: CD31
Gene namesi
Name:Pecam1
Synonyms:Pecam, Pecam-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:97537. Pecam1.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein By similarity. Cell membrane; Lipid-anchor By similarity. Cell junction
Note: Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 590573Extracellular Reviewed prediction
Add
BLAST
Transmembranei591 – 60919Helical; Reviewed prediction
Add
BLAST
Topological domaini610 – 727118Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-SubCell
  2. cell periphery Source: MGI
  3. external side of plasma membrane Source: BHF-UCL
  4. integral component of membrane Source: UniProtKB-KW
  5. membrane Source: MGI
  6. membrane raft Source: MGI
  7. plasma membrane Source: MGI
  8. smooth muscle contractile fiber Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show reduced atherosclerotic lesions. There is down-regulation of ICAM-1 in endothelial cells at the lesion periphery, and reduced disruption of Cx43 junctional staining at arterial branch points and in the descending aorta.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi679 – 6791Y → F: Reduces tyrosine phosphorylation by FER by about 60%. 1 Publication
Mutagenesisi702 – 7021Y → F: Reduces tyrosine phosphorylation by FER by about 60%. 1 Publication
Mutagenesisi717 – 7171Y → F: No significant effect on phosphorylation by FER. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 Publication
Add
BLAST
Chaini18 – 727710Platelet endothelial cell adhesion molecule
PRO_0000014896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 99 Reviewed prediction
Glycosylationi74 – 741N-linked (GlcNAc...)1 Publication
Glycosylationi141 – 1411N-linked (GlcNAc...)1 Publication
Disulfide bondi142 ↔ 195 Reviewed prediction
Disulfide bondi245 ↔ 293 Reviewed prediction
Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi336 ↔ 375 Reviewed prediction
Glycosylationi345 – 3451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi360 – 3601N-linked (GlcNAc...)1 Publication
Disulfide bondi420 ↔ 465 Reviewed prediction
Glycosylationi424 – 4241N-linked (GlcNAc...)1 Publication
Disulfide bondi512 ↔ 561 Reviewed prediction
Glycosylationi540 – 5401N-linked (GlcNAc...)1 Publication
Lipidationi611 – 6111S-palmitoyl cysteine By similarity
Modified residuei679 – 6791Phosphotyrosine; by FER Inferred
Modified residuei702 – 7021Phosphotyrosine; by FER2 Publications

Post-translational modificationi

Phosphorylated on Ser and Tyr residues after cellular activation. In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation By similarity. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation.1 Publication
Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ08481.
PaxDbiQ08481.
PRIDEiQ08481.

PTM databases

PhosphoSiteiQ08481.

Expressioni

Tissue specificityi

Isoform 1 and isoform 3 are expressed in lung and platelets.1 Publication

Gene expression databases

ArrayExpressiQ08481.
BgeeiQ08481.
CleanExiMM_PECAM1.
GenevestigatoriQ08481.

Interactioni

Subunit structurei

Interacts with PTPN11; Tyr-702 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ By similarity.

Protein-protein interaction databases

IntActiQ08481. 5 interactions.
MINTiMINT-4106994.
STRINGi10090.ENSMUSP00000067111.

Structurei

3D structure databases

ProteinModelPortaliQ08481.
SMRiQ08481. Positions 193-393, 693-727.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 12687Ig-like C2-type 1
Add
BLAST
Domaini135 – 21379Ig-like C2-type 2
Add
BLAST
Domaini225 – 30985Ig-like C2-type 3
Add
BLAST
Domaini315 – 39177Ig-like C2-type 4
Add
BLAST
Domaini413 – 47260Ig-like C2-type 5
Add
BLAST
Domaini488 – 57891Ig-like C2-type 6
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni710 – 72718May play a role in cytoprotective signaling By similarity
Add
BLAST

Domaini

The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity By similarity.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG78738.
GeneTreeiENSGT00440000034155.
HOGENOMiHOG000049132.
HOVERGENiHBG059434.
KOiK06471.
OrthoDBiEOG7Z95KP.
TreeFamiTF338229.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q08481-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLLALGLTLV LYASLQAEEN SFTINSIHME SLPSWEVMNG QQLTLECLVD    50
ISTTSKSRSQ HRVLFYKDDA MVYNVTSREH TESYVIPQAR VFHSGKYKCT 100
VMLNNKEKTT IEYEVKVHGV SKPKVTLDKK EVTEGGVVTV NCSLQEEKPP 150
IFFKIEKLEV GTKFVKRRID KTSNENFVLM EFPIEAQDHV LVFRCQAGIL 200
SGFKLQESEP IRSEYVTVQE SFSTPKFEIK PPGMIIEGDQ LHIRCIVQVT 250
HLVQEFTEII IQKDKAIVAT SKQSSEAVYS VMAMVEYSGH YTCKVESNRI 300
SKASSIMVNI TELFPKPKLE FSSSRLDQGE LLDLSCSVSG TPVANFTIQK 350
EETVLSQYQN FSKIAEESDS GEYSCTAGIG KVVKRSGLVP IQVCEMLSKP 400
SIFHDAKSEI IKGHAIGISC QSENGTAPIT YHLMKAKSDF QTLEVTSNDP 450
ATFTDKPTRD MEYQCRADNC HSHPAVFSEI LRVRVIAPVD EVVISILSSN 500
EVQSGSEMVL RCSVKEGTSP ITFQFYKEKE DRPFHQAVVN DTQAFWHNKQ 550
ASKKQEGQYY CTASNRASSM RTSPRSSTLA VRVFLAPWKK GLIAVVVIGV 600
VIATLIVAAK CYFLRKAKAK QKPVEMSRPA APLLNSNSEK ISEPSVEANS 650
HYGYDDVSGN DAVKPINQNK DPQNMDVEYT EVEVSSLEPH QALGTRATET 700
VYSEIRKVDP NLMENRYSRT EGSLNGT 727
Length:727
Mass (Da):81,263
Last modified:October 1, 1994 - v1
Checksum:i34C04752D199BAA5
GO
Isoform 2 (identifier: Q08481-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     692-727: ALGTRATETVYSEIRKVDPNLMENRYSRTEGSLNGT → ENGRLP

Show »
Length:697
Mass (Da):77,917
Checksum:iEF8538025C1AB55F
GO
Isoform 3 (identifier: Q08481-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     711-727: NLMENRYSRTEGSLNGT → KNGRLP

Show »
Length:716
Mass (Da):80,004
Checksum:iE4D281B5523017B6
GO
Isoform 4 (identifier: Q08481-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-219: Missing.

Show »
Length:626
Mass (Da):69,823
Checksum:i0CF4D64C49CE468B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei119 – 219101Missing in isoform 4.
VSP_038723Add
BLAST
Alternative sequencei692 – 72736ALGTR…SLNGT → ENGRLP in isoform 2.
VSP_038724Add
BLAST
Alternative sequencei711 – 72717NLMEN…SLNGT → KNGRLP in isoform 3.
VSP_038725Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181E → T AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L06039 mRNA. Translation: AAA16230.1.
AK169431 mRNA. Translation: BAE41172.1.
AL603664 Genomic DNA. Translation: CAM18558.1.
AL603664 Genomic DNA. Translation: CAM18559.1.
AL603664 Genomic DNA. Translation: CAM18560.1.
CH466558 Genomic DNA. Translation: EDL34303.1.
CH466558 Genomic DNA. Translation: EDL34304.1.
CH466558 Genomic DNA. Translation: EDL34305.1.
BC008519 mRNA. Translation: AAH08519.1.
BC085502 mRNA. Translation: AAH85502.1.
CCDSiCCDS25558.1. [Q08481-2]
CCDS25559.1. [Q08481-3]
RefSeqiNP_001027550.1. NM_001032378.1. [Q08481-2]
NP_032842.2. NM_008816.2. [Q08481-3]
XP_006532533.1. XM_006532470.1. [Q08481-1]
XP_006532539.1. XM_006532476.1. [Q08481-4]
UniGeneiMm.343951.

Genome annotation databases

EnsembliENSMUST00000080853; ENSMUSP00000079664; ENSMUSG00000020717. [Q08481-3]
ENSMUST00000103069; ENSMUSP00000099358; ENSMUSG00000020717. [Q08481-2]
ENSMUST00000106796; ENSMUSP00000102408; ENSMUSG00000020717. [Q08481-1]
ENSMUST00000183610; ENSMUSP00000138959; ENSMUSG00000020717. [Q08481-4]
GeneIDi18613.
KEGGimmu:18613.
UCSCiuc007lze.1. mouse. [Q08481-1]
uc007lzf.1. mouse. [Q08481-3]
uc007lzg.1. mouse. [Q08481-2]
uc007lzh.1. mouse. [Q08481-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

PECAM-1

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L06039 mRNA. Translation: AAA16230.1 .
AK169431 mRNA. Translation: BAE41172.1 .
AL603664 Genomic DNA. Translation: CAM18558.1 .
AL603664 Genomic DNA. Translation: CAM18559.1 .
AL603664 Genomic DNA. Translation: CAM18560.1 .
CH466558 Genomic DNA. Translation: EDL34303.1 .
CH466558 Genomic DNA. Translation: EDL34304.1 .
CH466558 Genomic DNA. Translation: EDL34305.1 .
BC008519 mRNA. Translation: AAH08519.1 .
BC085502 mRNA. Translation: AAH85502.1 .
CCDSi CCDS25558.1. [Q08481-2 ]
CCDS25559.1. [Q08481-3 ]
RefSeqi NP_001027550.1. NM_001032378.1. [Q08481-2 ]
NP_032842.2. NM_008816.2. [Q08481-3 ]
XP_006532533.1. XM_006532470.1. [Q08481-1 ]
XP_006532539.1. XM_006532476.1. [Q08481-4 ]
UniGenei Mm.343951.

3D structure databases

ProteinModelPortali Q08481.
SMRi Q08481. Positions 193-393, 693-727.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q08481. 5 interactions.
MINTi MINT-4106994.
STRINGi 10090.ENSMUSP00000067111.

PTM databases

PhosphoSitei Q08481.

Proteomic databases

MaxQBi Q08481.
PaxDbi Q08481.
PRIDEi Q08481.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000080853 ; ENSMUSP00000079664 ; ENSMUSG00000020717 . [Q08481-3 ]
ENSMUST00000103069 ; ENSMUSP00000099358 ; ENSMUSG00000020717 . [Q08481-2 ]
ENSMUST00000106796 ; ENSMUSP00000102408 ; ENSMUSG00000020717 . [Q08481-1 ]
ENSMUST00000183610 ; ENSMUSP00000138959 ; ENSMUSG00000020717 . [Q08481-4 ]
GeneIDi 18613.
KEGGi mmu:18613.
UCSCi uc007lze.1. mouse. [Q08481-1 ]
uc007lzf.1. mouse. [Q08481-3 ]
uc007lzg.1. mouse. [Q08481-2 ]
uc007lzh.1. mouse. [Q08481-4 ]

Organism-specific databases

CTDi 5175.
MGIi MGI:97537. Pecam1.

Phylogenomic databases

eggNOGi NOG78738.
GeneTreei ENSGT00440000034155.
HOGENOMi HOG000049132.
HOVERGENi HBG059434.
KOi K06471.
OrthoDBi EOG7Z95KP.
TreeFami TF338229.

Miscellaneous databases

NextBioi 294550.
PROi Q08481.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q08481.
Bgeei Q08481.
CleanExi MM_PECAM1.
Genevestigatori Q08481.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1."
    Xie Y., Muller W.A.
    Proc. Natl. Acad. Sci. U.S.A. 90:5569-5573(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
    Tissue: Lung.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Strain: C57BL/6J.
    Tissue: Stomach.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6 and FVB/N.
    Tissue: Mammary tumor.
  6. "Association of murine CD31 with transmigrating lymphocytes following antigenic stimulation."
    Bogen S.A., Baldwin H.S., Watkins S.C., Albelda S.M., Abbas A.K.
    Am. J. Pathol. 141:843-854(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-26.
    Tissue: Heart.
  7. "Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation."
    Udell C.M., Samayawardhena L.A., Kawakami Y., Kawakami T., Craig A.W.
    J. Biol. Chem. 281:20949-20957(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-679 AND TYR-702 BY FES AND FER, MUTAGENESIS OF TYR-679; TYR-702 AND TYR-717.
  8. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-702, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  9. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  10. "An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling."
    Bergom C., Paddock C., Gao C., Holyst T., Newman D.K., Newman P.J.
    J. Cell Sci. 121:1235-1242(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 2 AND 3), TISSUE SPECIFICITY.
  11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-74; ASN-141; ASN-360; ASN-424 AND ASN-540.

Entry informationi

Entry nameiPECA1_MOUSE
AccessioniPrimary (citable) accession number: Q08481
Secondary accession number(s): B1ARB1
, B1ARB2, Q3TES6, Q922E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 9, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi