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Q08478

- PIT1_ONCMY

UniProt

Q08478 - PIT1_ONCMY

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Protein

Pituitary-specific positive transcription factor 1

Gene
pou1f1, pit1
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi282 – 34160HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary-specific positive transcription factor 1
Short name:
PIT-1
Alternative name(s):
Growth hormone factor 1
Short name:
GHF-1
Gene namesi
Name:pou1f1
Synonyms:pit1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Pituitary-specific positive transcription factor 1PRO_0000100706Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ08478.
SMRiQ08478. Positions 197-341.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini192 – 26675POU-specificAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG053120.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR015586. Pit_1.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PANTHERiPTHR11636:SF82. PTHR11636:SF82. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08478-1 [UniParc]FASTAAdd to Basket

« Hide

MSCQAFSADS FTTLAGDSLP LLMHHASAAD CLPSSASTHT HNMVSAVPSG    50
LSLLQSSKRS HMHLSTSTLG NALSNGPPGL HYPVTPCHYS NQQTTYGMMA 100
AQEMLSASIS QTRILQTCSV PHPNMVNGAN TLQGSLAPCL YKFPEHGLGG 150
GSCSLSHSFP PLPPAVLSEE PPLGGTKDLR LRSRPPDDPP DMDSPQIREL 200
EKFANDFKLR RIKLGYTQTN VGEALAAVHG SEFSQTTICR FENLQLSFKN 250
ACTLKAILAK WLDEAEQAGA LFNEKMGMNE RKRKRRTTIS LGAKEALERS 300
FGEKIKPSSQ EIVRMAEGLH LEKEVVRVWF CNRRQREKRV KTSLHHSSYL 350
TKDSPTYR 358
Length:358
Mass (Da):39,376
Last modified:February 1, 1995 - v1
Checksum:iDD7696FC6A6B1967
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16513 mRNA. Translation: BAA03964.1.
PIRiA49511.
RefSeqiNP_001118118.1. NM_001124646.1.
UniGeneiOmy.8148.

Genome annotation databases

GeneIDi100136675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16513 mRNA. Translation: BAA03964.1 .
PIRi A49511.
RefSeqi NP_001118118.1. NM_001124646.1.
UniGenei Omy.8148.

3D structure databases

ProteinModelPortali Q08478.
SMRi Q08478. Positions 197-341.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100136675.

Organism-specific databases

CTDi 5449.

Phylogenomic databases

HOVERGENi HBG053120.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR015586. Pit_1.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
PANTHERi PTHR11636:SF82. PTHR11636:SF82. 1 hit.
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of fish Pit-1 cDNA and its functional binding to promoter of gene expressed in the pituitary."
    Yamada S., Hata J., Yamashita S.
    J. Biol. Chem. 268:24361-24366(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiPIT1_ONCMY
AccessioniPrimary (citable) accession number: Q08478
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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