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Protein

Pituitary-specific positive transcription factor 1

Gene

pou1f1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi282 – 341HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary-specific positive transcription factor 1
Short name:
PIT-1
Alternative name(s):
Growth hormone factor 1
Short name:
GHF-1
Gene namesi
Name:pou1f1
Synonyms:pit1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007061 – 358Pituitary-specific positive transcription factor 1Add BLAST358

Structurei

3D structure databases

ProteinModelPortaliQ08478
SMRiQ08478
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 266POU-specificPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG053120

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR015586 Pit_1
IPR013847 POU
IPR000327 POU_dom
PANTHERiPTHR11636:SF84 PTHR11636:SF84, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q08478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQAFSADS FTTLAGDSLP LLMHHASAAD CLPSSASTHT HNMVSAVPSG
60 70 80 90 100
LSLLQSSKRS HMHLSTSTLG NALSNGPPGL HYPVTPCHYS NQQTTYGMMA
110 120 130 140 150
AQEMLSASIS QTRILQTCSV PHPNMVNGAN TLQGSLAPCL YKFPEHGLGG
160 170 180 190 200
GSCSLSHSFP PLPPAVLSEE PPLGGTKDLR LRSRPPDDPP DMDSPQIREL
210 220 230 240 250
EKFANDFKLR RIKLGYTQTN VGEALAAVHG SEFSQTTICR FENLQLSFKN
260 270 280 290 300
ACTLKAILAK WLDEAEQAGA LFNEKMGMNE RKRKRRTTIS LGAKEALERS
310 320 330 340 350
FGEKIKPSSQ EIVRMAEGLH LEKEVVRVWF CNRRQREKRV KTSLHHSSYL

TKDSPTYR
Length:358
Mass (Da):39,376
Last modified:February 1, 1995 - v1
Checksum:iDD7696FC6A6B1967
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16513 mRNA Translation: BAA03964.1
PIRiA49511
RefSeqiNP_001118118.1, NM_001124646.1
UniGeneiOmy.8148

Genome annotation databases

GeneIDi100136675

Similar proteinsi

Entry informationi

Entry nameiPIT1_ONCMY
AccessioniPrimary (citable) accession number: Q08478
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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