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Q08478 (PIT1_ONCMY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pituitary-specific positive transcription factor 1

Short name=PIT-1
Alternative name(s):
Growth hormone factor 1
Short name=GHF-1
Gene names
Name:pou1f1
Synonyms:pit1
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifier8022 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the POU transcription factor family. Class-1 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Pituitary-specific positive transcription factor 1
PRO_0000100706

Regions

Domain192 – 26675POU-specific
DNA binding282 – 34160Homeobox

Sequences

Sequence LengthMass (Da)Tools
Q08478 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: DD7696FC6A6B1967

FASTA35839,376
        10         20         30         40         50         60 
MSCQAFSADS FTTLAGDSLP LLMHHASAAD CLPSSASTHT HNMVSAVPSG LSLLQSSKRS 

        70         80         90        100        110        120 
HMHLSTSTLG NALSNGPPGL HYPVTPCHYS NQQTTYGMMA AQEMLSASIS QTRILQTCSV 

       130        140        150        160        170        180 
PHPNMVNGAN TLQGSLAPCL YKFPEHGLGG GSCSLSHSFP PLPPAVLSEE PPLGGTKDLR 

       190        200        210        220        230        240 
LRSRPPDDPP DMDSPQIREL EKFANDFKLR RIKLGYTQTN VGEALAAVHG SEFSQTTICR 

       250        260        270        280        290        300 
FENLQLSFKN ACTLKAILAK WLDEAEQAGA LFNEKMGMNE RKRKRRTTIS LGAKEALERS 

       310        320        330        340        350 
FGEKIKPSSQ EIVRMAEGLH LEKEVVRVWF CNRRQREKRV KTSLHHSSYL TKDSPTYR 

« Hide

References

[1]"Molecular cloning of fish Pit-1 cDNA and its functional binding to promoter of gene expressed in the pituitary."
Yamada S., Hata J., Yamashita S.
J. Biol. Chem. 268:24361-24366(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16513 mRNA. Translation: BAA03964.1.
PIRA49511.
RefSeqNP_001118118.1. NM_001124646.1.
UniGeneOmy.8148.

3D structure databases

ProteinModelPortalQ08478.
SMRQ08478. Positions 197-341.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100136675.

Organism-specific databases

CTD5449.

Phylogenomic databases

HOVERGENHBG053120.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR015586. Pit_1.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PANTHERPTHR11636:SF17. PTHR11636:SF17. 1 hit.
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePIT1_ONCMY
AccessionPrimary (citable) accession number: Q08478
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families