ID CP4F3_HUMAN Reviewed; 520 AA. AC Q08477; O60634; Q5U740; DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot. DT 21-DEC-2004, sequence version 2. DT 07-JUL-2009, entry version 93. DE RecName: Full=Leukotriene-B(4) omega-hydroxylase 2; DE EC=1.14.13.30; DE AltName: Full=Cytochrome P450 4F3; DE AltName: Full=CYPIVF3; DE AltName: Full=Leukotriene-B(4) 20-monooxygenase 2; DE AltName: Full=Cytochrome P450-LTB-omega; GN Name=CYP4F3; Synonyms=LTB4H; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASP-269. RC TISSUE=Leukocyte; RX MEDLINE=93252801; PubMed=8486631; RA Kikuta Y., Kusunose E., Endo K., Yamamoto S., Sogawa K., RA Fujii-Kuriyama Y., Kusunose M.; RT "A novel form of cytochrome P-450 family 4 in human polymorphonuclear RT leukocytes. cDNA cloning and expression of leukotriene B4 omega- RT hydroxylase."; RL J. Biol. Chem. 268:9376-9380(1993). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANT ASP-269. RX MEDLINE=98198504; PubMed=9539102; DOI=10.1089/dna.1998.17.221; RA Kikuta Y., Kato M., Yamashita Y., Miyauchi Y., Tanaka K., Kamada N., RA Kusunose M.; RT "Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular RT cloning and chromosomal localization."; RL DNA Cell Biol. 17:221-230(1998). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Fetal liver; RA Peng X., Morgan K., Morgan T.R.; RT "A novel form of cytochrome P-450 family 4 in human fetal liver."; RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ASP-269; ILE-270 AND RP THR-271. RG SeattleSNPs variation discovery resource; RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate CC monooxygenases. This enzyme requires molecular oxygen and NADPH CC for the omega-hydroxylation of LTB4, a potent chemoattractant for CC polymorphonuclear leukocytes. CC -!- CATALYTIC ACTIVITY: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa- CC 6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)- CC 5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O. CC -!- COFACTOR: Heme group (By similarity). CC -!- ENZYME REGULATION: Inhibited by carbon monoxide (CO). CC -!- PATHWAY: Lipid metabolism; leukotriene B4 degradation. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass CC membrane protein (By similarity). Microsome membrane; Single-pass CC membrane protein (By similarity). CC -!- TISSUE SPECIFICITY: Expressed in the polymorphonuclear leukocytes CC as well as leukocytes. CC -!- SIMILARITY: Belongs to the cytochrome P450 family. CC -!- SEQUENCE CAUTION: CC Sequence=AAC08589.1; Type=Frameshift; Positions=67, 114; CC -!- WEB RESOURCE: Name=SeattleSNPs; CC URL="http://pga.gs.washington.edu/data/cyp4f3/"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; D12620; BAA02144.1; -; mRNA. DR EMBL; D12621; BAA02145.1; -; mRNA. DR EMBL; AB002454; BAA25990.1; -; mRNA. DR EMBL; AB002461; BAA25991.1; -; Genomic_DNA. DR EMBL; AF054821; AAC08589.1; ALT_FRAME; mRNA. DR EMBL; AY792513; AAV40834.1; -; Genomic_DNA. DR IPI; IPI00002370; -. DR PIR; A46661; A46661. DR RefSeq; NP_000887.2; -. DR UniGene; Hs.106242; -. DR HSSP; P14779; 1JME. DR PRIDE; Q08477; -. DR Ensembl; ENSG00000186529; Homo sapiens. DR GeneID; 4051; -. DR KEGG; hsa:4051; -. DR NMPDR; fig|9606.3.peg.15898; -. DR UCSC; uc002nbj.1; human. DR GeneCards; GC19P015612; -. DR H-InvDB; HIX0058774; -. DR HGNC; HGNC:2646; CYP4F3. DR MIM; 601270; gene. DR PharmGKB; PA234; -. DR HOGENOM; Q08477; -. DR HOVERGEN; Q08477; -. DR OMA; Q08477; QHHGERR. DR BRENDA; 1.14.13.30; 247. DR Reactome; REACT_13433; Biological oxidations. DR NextBio; 15870; -. DR ArrayExpress; Q08477; -. DR Bgee; Q08477; -. DR CleanEx; HS_CYP4F3; -. DR GermOnline; ENSG00000186529; Homo sapiens. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005792; C:microsome; IEA:UniProtKB-SubCell. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0050051; F:leukotriene-B4 20-monooxygenase activity; IEA:EC. DR GO; GO:0006691; P:leukotriene metabolic process; TAS:ProtInc. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR InterPro; IPR001128; Cyt_P450. DR InterPro; IPR017973; Cyt_P450_C. DR InterPro; IPR017972; Cyt_P450_CS. DR InterPro; IPR002401; Cyt_P450_E_grp-I. DR Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1. DR PANTHER; PTHR19383; Cyt_P450; 1. DR Pfam; PF00067; p450; 1. DR PRINTS; PR00463; EP450I. DR PRINTS; PR00385; P450. DR PROSITE; PS00086; CYTOCHROME_P450; 1. PE 2: Evidence at transcript level; KW Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; KW Metal-binding; Microsome; Monooxygenase; NADP; Oxidoreductase; KW Polymorphism; Transmembrane. FT CHAIN 1 520 Leukotriene-B(4) omega-hydroxylase 2. FT /FTId=PRO_0000051851. FT TRANSMEM 11 31 Potential. FT METAL 468 468 Iron (heme axial ligand) (By similarity). FT BINDING 328 328 Heme (covalent; via 1 link) (By FT similarity). FT VARIANT 96 96 H -> Q (in dbSNP:rs34923393). FT /FTId=VAR_048457. FT VARIANT 106 106 Y -> C (in dbSNP:rs35888783). FT /FTId=VAR_048458. FT VARIANT 269 269 A -> D (in dbSNP:rs1805040). FT /FTId=VAR_001258. FT VARIANT 270 270 V -> I. FT /FTId=VAR_020664. FT VARIANT 271 271 I -> T. FT /FTId=VAR_020665. FT CONFLICT 184 186 EGS -> KGY (in Ref. 3; AAC08589). FT CONFLICT 488 488 R -> A (in Ref. 1 and 2). FT CONFLICT 512 512 L -> I (in Ref. 3; AAC08589). SQ SEQUENCE 520 AA; 59847 MW; 2519D875280CF9DC CRC64; MPQLSLSSLG LWPMAASPWL LLLLVGASWL LARILAWTYT FYDNCCRLRC FPQPPKRNWF LGHLGLIHSS EEGLLYTQSL ACTFGDMCCW WVGPWHAIVR IFHPTYIKPV LFAPAAIVPK DKVFYSFLKP WLGDGLLLSA GEKWSRHRRM LTPAFHFNIL KPYMKIFNES VNIMHAKWQL LASEGSARLD MFEHISLMTL DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVTKRHQQIL LYIDFLYYLT PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QERCRQEVQE LLKDREPKEI EWDDLAQLPF LTMCIKESLR LHPPVPAVSR CCTQDIVLPD GRVIPKGIIC LISVFGTHHN PAVWPDPEVY DPFRFDPKNI KERSPLAFIP FSAGPRNCIG QAFAMAEMKV VLGLTLLRFR VLPDHTEPRR KPELVLRAEG GLWLRVEPLS //