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Q08477

- CP4F3_HUMAN

UniProt

Q08477 - CP4F3_HUMAN

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Protein

Leukotriene-B(4) omega-hydroxylase 2

Gene

CYP4F3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH. Isoform CYP4F3A catalyzes the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.1 Publication
Isoform CYP4F3B: Has a 30-fold higher Km for LTB4 compared with CYP4F3A, but it utilizes arachidonic acid as a substrate for omega-hydroxylation and generates 20-HETE, an activator of kinases PKC and CK2.1 Publication

Catalytic activityi

(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O.

Cofactori

Heme group.By similarity

Enzyme regulationi

Inhibited by carbon monoxide (CO).

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei328 – 3281Heme (covalent; via 1 link)By similarity
Metal bindingi468 – 4681Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. alpha-tocopherol omega-hydroxylase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. leukotriene-B4 20-monooxygenase activity Source: UniProtKB-EC
  5. monooxygenase activity Source: ProtInc

GO - Biological processi

  1. arachidonic acid metabolic process Source: Reactome
  2. icosanoid metabolic process Source: Reactome
  3. leukotriene metabolic process Source: Reactome
  4. small molecule metabolic process Source: Reactome
  5. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiREACT_13425. Miscellaneous substrates.
REACT_13645. Eicosanoids.
REACT_13814. Fatty acids.
REACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).
SABIO-RKQ08477.
UniPathwayiUPA00883.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene-B(4) omega-hydroxylase 2 (EC:1.14.13.30)
Alternative name(s):
CYPIVF3
Cytochrome P450 4F3
Cytochrome P450-LTB-omega
Leukotriene-B(4) 20-monooxygenase 2
Gene namesi
Name:CYP4F3
Synonyms:LTB4H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:2646. CYP4F3.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA234.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Leukotriene-B(4) omega-hydroxylase 2PRO_0000051851Add
BLAST

Proteomic databases

PaxDbiQ08477.
PRIDEiQ08477.

PTM databases

PhosphoSiteiQ08477.

Expressioni

Tissue specificityi

Isoform CYP4F3A is expressed in the polymorphonuclear leukocytes as well as leukocytes and bone marrow. Isoform CYP4F3B is selectively expressed in liver and kidney and is also the predominant CYP4F isoform in trachea and tissues of the gastrointestinal tract.1 Publication

Gene expression databases

BgeeiQ08477.
CleanExiHS_CYP4F3.
ExpressionAtlasiQ08477. baseline and differential.
GenevestigatoriQ08477.

Interactioni

Protein-protein interaction databases

BioGridi110229. 1 interaction.
IntActiQ08477. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ08477.
SMRiQ08477. Positions 98-510.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiQ08477.
KOiK17726.
OMAiPVIRFCH.
OrthoDBiEOG7CNZFK.
PhylomeDBiQ08477.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform CYP4F3A (identifier: Q08477-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQLSLSSLG LWPMAASPWL LLLLVGASWL LARILAWTYT FYDNCCRLRC
60 70 80 90 100
FPQPPKRNWF LGHLGLIHSS EEGLLYTQSL ACTFGDMCCW WVGPWHAIVR
110 120 130 140 150
IFHPTYIKPV LFAPAAIVPK DKVFYSFLKP WLGDGLLLSA GEKWSRHRRM
160 170 180 190 200
LTPAFHFNIL KPYMKIFNES VNIMHAKWQL LASEGSARLD MFEHISLMTL
210 220 230 240 250
DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVTKRHQQIL LYIDFLYYLT
260 270 280 290 300
PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID
310 320 330 340 350
VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY
360 370 380 390 400
QERCRQEVQE LLKDREPKEI EWDDLAQLPF LTMCIKESLR LHPPVPAVSR
410 420 430 440 450
CCTQDIVLPD GRVIPKGIIC LISVFGTHHN PAVWPDPEVY DPFRFDPKNI
460 470 480 490 500
KERSPLAFIP FSAGPRNCIG QAFAMAEMKV VLGLTLLRFR VLPDHTEPRR
510 520
KPELVLRAEG GLWLRVEPLS
Length:520
Mass (Da):59,847
Last modified:December 21, 2004 - v2
Checksum:i2519D875280CF9DC
GO
Isoform CYP4F3B (identifier: Q08477-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-114: IHSSEEGLLY...TYIKPVLFAP → VTPTEQGMRV...NIIRSVINAS

Show »
Length:520
Mass (Da):59,739
Checksum:iEA737D889AD662C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1863EGS → KGY in AAC08589. 1 PublicationCurated
Sequence conflicti488 – 4881R → A in BAA02144. (PubMed:8486631)Curated
Sequence conflicti488 – 4881R → A in BAA25990. (PubMed:9539102)Curated
Sequence conflicti488 – 4881R → A in BAA25991. (PubMed:9539102)Curated
Sequence conflicti512 – 5121L → I in AAC08589. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961H → Q.
Corresponds to variant rs34923393 [ dbSNP | Ensembl ].
VAR_048457
Natural varianti106 – 1061Y → C.
Corresponds to variant rs35888783 [ dbSNP | Ensembl ].
VAR_048458
Natural varianti269 – 2691A → D.3 Publications
Corresponds to variant rs1805040 [ dbSNP | Ensembl ].
VAR_001258
Natural varianti270 – 2701V → I.1 Publication
Corresponds to variant rs28371536 [ dbSNP | Ensembl ].
VAR_020664
Natural varianti271 – 2711I → T.1 Publication
Corresponds to variant rs28371479 [ dbSNP | Ensembl ].
VAR_020665

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei67 – 11448IHSSE…VLFAP → VTPTEQGMRVLTQLVATYPQ GFKVWMGPIFPVIRFCHPNI IRSVINAS in isoform CYP4F3B. 3 PublicationsVSP_047193Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D12620 mRNA. Translation: BAA02144.1.
D12621 mRNA. Translation: BAA02145.1.
AB002454 mRNA. Translation: BAA25990.1.
AB002461 Genomic DNA. Translation: BAA25991.1.
AF054821 mRNA. Translation: AAC08589.1.
AK304200 mRNA. Translation: BAH14129.1.
AK316136 mRNA. Translation: BAH14507.1.
AY792513 Genomic DNA. Translation: AAV40834.1.
AD000685 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84489.1.
BC136299 mRNA. Translation: AAI36300.1.
CCDSiCCDS12332.1. [Q08477-1]
CCDS59362.1. [Q08477-2]
PIRiA46661.
RefSeqiNP_000887.2. NM_000896.2. [Q08477-1]
NP_001186137.1. NM_001199208.1. [Q08477-2]
NP_001186138.1. NM_001199209.1. [Q08477-2]
UniGeneiHs.106242.

Genome annotation databases

EnsembliENST00000221307; ENSP00000221307; ENSG00000186529. [Q08477-1]
ENST00000585846; ENSP00000468105; ENSG00000186529. [Q08477-2]
ENST00000586182; ENSP00000466395; ENSG00000186529. [Q08477-2]
ENST00000591058; ENSP00000466988; ENSG00000186529. [Q08477-2]
GeneIDi4051.
KEGGihsa:4051.
UCSCiuc002nbj.3. human. [Q08477-1]
uc002nbk.3. human.

Polymorphism databases

DMDMi56757430.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D12620 mRNA. Translation: BAA02144.1 .
D12621 mRNA. Translation: BAA02145.1 .
AB002454 mRNA. Translation: BAA25990.1 .
AB002461 Genomic DNA. Translation: BAA25991.1 .
AF054821 mRNA. Translation: AAC08589.1 .
AK304200 mRNA. Translation: BAH14129.1 .
AK316136 mRNA. Translation: BAH14507.1 .
AY792513 Genomic DNA. Translation: AAV40834.1 .
AD000685 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84489.1 .
BC136299 mRNA. Translation: AAI36300.1 .
CCDSi CCDS12332.1. [Q08477-1 ]
CCDS59362.1. [Q08477-2 ]
PIRi A46661.
RefSeqi NP_000887.2. NM_000896.2. [Q08477-1 ]
NP_001186137.1. NM_001199208.1. [Q08477-2 ]
NP_001186138.1. NM_001199209.1. [Q08477-2 ]
UniGenei Hs.106242.

3D structure databases

ProteinModelPortali Q08477.
SMRi Q08477. Positions 98-510.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110229. 1 interaction.
IntActi Q08477. 2 interactions.

PTM databases

PhosphoSitei Q08477.

Polymorphism databases

DMDMi 56757430.

Proteomic databases

PaxDbi Q08477.
PRIDEi Q08477.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221307 ; ENSP00000221307 ; ENSG00000186529 . [Q08477-1 ]
ENST00000585846 ; ENSP00000468105 ; ENSG00000186529 . [Q08477-2 ]
ENST00000586182 ; ENSP00000466395 ; ENSG00000186529 . [Q08477-2 ]
ENST00000591058 ; ENSP00000466988 ; ENSG00000186529 . [Q08477-2 ]
GeneIDi 4051.
KEGGi hsa:4051.
UCSCi uc002nbj.3. human. [Q08477-1 ]
uc002nbk.3. human.

Organism-specific databases

CTDi 4051.
GeneCardsi GC19P015751.
H-InvDB HIX0039919.
HIX0169080.
HIX0169326.
HGNCi HGNC:2646. CYP4F3.
MIMi 601270. gene.
neXtProti NX_Q08477.
PharmGKBi PA234.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118816.
HOGENOMi HOG000233833.
HOVERGENi HBG000182.
InParanoidi Q08477.
KOi K17726.
OMAi PVIRFCH.
OrthoDBi EOG7CNZFK.
PhylomeDBi Q08477.
TreeFami TF105088.

Enzyme and pathway databases

UniPathwayi UPA00883 .
Reactomei REACT_13425. Miscellaneous substrates.
REACT_13645. Eicosanoids.
REACT_13814. Fatty acids.
REACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).
SABIO-RK Q08477.

Miscellaneous databases

GeneWikii CYP4F3.
GenomeRNAii 4051.
NextBioi 15870.
PROi Q08477.
SOURCEi Search...

Gene expression databases

Bgeei Q08477.
CleanExi HS_CYP4F3.
ExpressionAtlasi Q08477. baseline and differential.
Genevestigatori Q08477.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase."
    Kikuta Y., Kusunose E., Endo K., Yamamoto S., Sogawa K., Fujii-Kuriyama Y., Kusunose M.
    J. Biol. Chem. 268:9376-9380(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CYP4F3A), VARIANT ASP-269.
    Tissue: Leukocyte.
  2. "Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization."
    Kikuta Y., Kato M., Yamashita Y., Miyauchi Y., Tanaka K., Kamada N., Kusunose M.
    DNA Cell Biol. 17:221-230(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM CYP4F3A), VARIANT ASP-269.
  3. "A novel form of cytochrome P-450 family 4 in human fetal liver."
    Peng X., Morgan K., Morgan T.R.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CYP4F3B).
    Tissue: Fetal liver.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CYP4F3B).
    Tissue: Tongue and Trachea.
  5. SeattleSNPs variation discovery resource
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASP-269; ILE-270 AND THR-271.
  6. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CYP4F3B).
  9. "Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase."
    Christmas P., Ursino S.R., Fox J.W., Soberman R.J.
    J. Biol. Chem. 274:21191-21199(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, ALTERNATIVE PROMOTER USAGE.
  10. "Alternative splicing determines the function of CYP4F3 by switching substrate specificity."
    Christmas P., Jones J.P., Patten C.J., Rock D.A., Zheng Y., Cheng S.M., Weber B.M., Carlesso N., Scadden D.T., Rettie A.E., Soberman R.J.
    J. Biol. Chem. 276:38166-38172(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, FUNCTION, SUBSTRATE SPECIFICITY, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCP4F3_HUMAN
AccessioniPrimary (citable) accession number: Q08477
Secondary accession number(s): B7Z8Z3, O60634, Q5U740
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3