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Q08477

- CP4F3_HUMAN

UniProt

Q08477 - CP4F3_HUMAN

Protein

Leukotriene-B(4) omega-hydroxylase 2

Gene

CYP4F3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 2 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH. Isoform CYP4F3A catalyzes the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.1 Publication
    Isoform CYP4F3B: Has a 30-fold higher Km for LTB4 compared with CYP4F3A, but it utilizes arachidonic acid as a substrate for omega-hydroxylation and generates 20-HETE, an activator of kinases PKC and CK2.1 Publication

    Catalytic activityi

    (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O.

    Cofactori

    Heme group.By similarity

    Enzyme regulationi

    Inhibited by carbon monoxide (CO).

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei328 – 3281Heme (covalent; via 1 link)By similarity
    Metal bindingi468 – 4681Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. alpha-tocopherol omega-hydroxylase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. leukotriene-B4 20-monooxygenase activity Source: UniProtKB-EC
    5. monooxygenase activity Source: ProtInc

    GO - Biological processi

    1. arachidonic acid metabolic process Source: Reactome
    2. icosanoid metabolic process Source: Reactome
    3. leukotriene metabolic process Source: Reactome
    4. small molecule metabolic process Source: Reactome
    5. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    ReactomeiREACT_13425. Miscellaneous substrates.
    REACT_13645. Eicosanoids.
    REACT_13814. Fatty acids.
    REACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).
    SABIO-RKQ08477.
    UniPathwayiUPA00883.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukotriene-B(4) omega-hydroxylase 2 (EC:1.14.13.30)
    Alternative name(s):
    CYPIVF3
    Cytochrome P450 4F3
    Cytochrome P450-LTB-omega
    Leukotriene-B(4) 20-monooxygenase 2
    Gene namesi
    Name:CYP4F3
    Synonyms:LTB4H
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:2646. CYP4F3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA234.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Leukotriene-B(4) omega-hydroxylase 2PRO_0000051851Add
    BLAST

    Proteomic databases

    PaxDbiQ08477.
    PRIDEiQ08477.

    PTM databases

    PhosphoSiteiQ08477.

    Expressioni

    Tissue specificityi

    Isoform CYP4F3A is expressed in the polymorphonuclear leukocytes as well as leukocytes and bone marrow. Isoform CYP4F3B is selectively expressed in liver and kidney and is also the predominant CYP4F isoform in trachea and tissues of the gastrointestinal tract.1 Publication

    Gene expression databases

    ArrayExpressiQ08477.
    BgeeiQ08477.
    CleanExiHS_CYP4F3.
    GenevestigatoriQ08477.

    Interactioni

    Protein-protein interaction databases

    BioGridi110229. 1 interaction.
    IntActiQ08477. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08477.
    SMRiQ08477. Positions 98-510.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000233833.
    HOVERGENiHBG000182.
    InParanoidiQ08477.
    KOiK17726.
    OMAiPVIRFCH.
    OrthoDBiEOG7CNZFK.
    PhylomeDBiQ08477.
    TreeFamiTF105088.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform CYP4F3A (identifier: Q08477-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPQLSLSSLG LWPMAASPWL LLLLVGASWL LARILAWTYT FYDNCCRLRC    50
    FPQPPKRNWF LGHLGLIHSS EEGLLYTQSL ACTFGDMCCW WVGPWHAIVR 100
    IFHPTYIKPV LFAPAAIVPK DKVFYSFLKP WLGDGLLLSA GEKWSRHRRM 150
    LTPAFHFNIL KPYMKIFNES VNIMHAKWQL LASEGSARLD MFEHISLMTL 200
    DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVTKRHQQIL LYIDFLYYLT 250
    PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID 300
    VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY 350
    QERCRQEVQE LLKDREPKEI EWDDLAQLPF LTMCIKESLR LHPPVPAVSR 400
    CCTQDIVLPD GRVIPKGIIC LISVFGTHHN PAVWPDPEVY DPFRFDPKNI 450
    KERSPLAFIP FSAGPRNCIG QAFAMAEMKV VLGLTLLRFR VLPDHTEPRR 500
    KPELVLRAEG GLWLRVEPLS 520
    Length:520
    Mass (Da):59,847
    Last modified:December 21, 2004 - v2
    Checksum:i2519D875280CF9DC
    GO
    Isoform CYP4F3B (identifier: Q08477-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         67-114: IHSSEEGLLY...TYIKPVLFAP → VTPTEQGMRV...NIIRSVINAS

    Show »
    Length:520
    Mass (Da):59,739
    Checksum:iEA737D889AD662C2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti184 – 1863EGS → KGY in AAC08589. 1 PublicationCurated
    Sequence conflicti488 – 4881R → A in BAA02144. (PubMed:8486631)Curated
    Sequence conflicti488 – 4881R → A in BAA25990. (PubMed:9539102)Curated
    Sequence conflicti488 – 4881R → A in BAA25991. (PubMed:9539102)Curated
    Sequence conflicti512 – 5121L → I in AAC08589. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti96 – 961H → Q.
    Corresponds to variant rs34923393 [ dbSNP | Ensembl ].
    VAR_048457
    Natural varianti106 – 1061Y → C.
    Corresponds to variant rs35888783 [ dbSNP | Ensembl ].
    VAR_048458
    Natural varianti269 – 2691A → D.3 Publications
    Corresponds to variant rs1805040 [ dbSNP | Ensembl ].
    VAR_001258
    Natural varianti270 – 2701V → I.1 Publication
    Corresponds to variant rs28371536 [ dbSNP | Ensembl ].
    VAR_020664
    Natural varianti271 – 2711I → T.1 Publication
    Corresponds to variant rs28371479 [ dbSNP | Ensembl ].
    VAR_020665

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei67 – 11448IHSSE…VLFAP → VTPTEQGMRVLTQLVATYPQ GFKVWMGPIFPVIRFCHPNI IRSVINAS in isoform CYP4F3B. 3 PublicationsVSP_047193Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12620 mRNA. Translation: BAA02144.1.
    D12621 mRNA. Translation: BAA02145.1.
    AB002454 mRNA. Translation: BAA25990.1.
    AB002461 Genomic DNA. Translation: BAA25991.1.
    AF054821 mRNA. Translation: AAC08589.1.
    AK304200 mRNA. Translation: BAH14129.1.
    AK316136 mRNA. Translation: BAH14507.1.
    AY792513 Genomic DNA. Translation: AAV40834.1.
    AD000685 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84489.1.
    BC136299 mRNA. Translation: AAI36300.1.
    CCDSiCCDS12332.1. [Q08477-1]
    CCDS59362.1. [Q08477-2]
    PIRiA46661.
    RefSeqiNP_000887.2. NM_000896.2. [Q08477-1]
    NP_001186137.1. NM_001199208.1. [Q08477-2]
    NP_001186138.1. NM_001199209.1. [Q08477-2]
    UniGeneiHs.106242.

    Genome annotation databases

    EnsembliENST00000221307; ENSP00000221307; ENSG00000186529. [Q08477-1]
    ENST00000585846; ENSP00000468105; ENSG00000186529. [Q08477-2]
    ENST00000586182; ENSP00000466395; ENSG00000186529. [Q08477-2]
    ENST00000591058; ENSP00000466988; ENSG00000186529. [Q08477-2]
    GeneIDi4051.
    KEGGihsa:4051.
    UCSCiuc002nbj.3. human. [Q08477-1]
    uc002nbk.3. human.

    Polymorphism databases

    DMDMi56757430.

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12620 mRNA. Translation: BAA02144.1 .
    D12621 mRNA. Translation: BAA02145.1 .
    AB002454 mRNA. Translation: BAA25990.1 .
    AB002461 Genomic DNA. Translation: BAA25991.1 .
    AF054821 mRNA. Translation: AAC08589.1 .
    AK304200 mRNA. Translation: BAH14129.1 .
    AK316136 mRNA. Translation: BAH14507.1 .
    AY792513 Genomic DNA. Translation: AAV40834.1 .
    AD000685 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84489.1 .
    BC136299 mRNA. Translation: AAI36300.1 .
    CCDSi CCDS12332.1. [Q08477-1 ]
    CCDS59362.1. [Q08477-2 ]
    PIRi A46661.
    RefSeqi NP_000887.2. NM_000896.2. [Q08477-1 ]
    NP_001186137.1. NM_001199208.1. [Q08477-2 ]
    NP_001186138.1. NM_001199209.1. [Q08477-2 ]
    UniGenei Hs.106242.

    3D structure databases

    ProteinModelPortali Q08477.
    SMRi Q08477. Positions 98-510.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110229. 1 interaction.
    IntActi Q08477. 2 interactions.

    PTM databases

    PhosphoSitei Q08477.

    Polymorphism databases

    DMDMi 56757430.

    Proteomic databases

    PaxDbi Q08477.
    PRIDEi Q08477.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221307 ; ENSP00000221307 ; ENSG00000186529 . [Q08477-1 ]
    ENST00000585846 ; ENSP00000468105 ; ENSG00000186529 . [Q08477-2 ]
    ENST00000586182 ; ENSP00000466395 ; ENSG00000186529 . [Q08477-2 ]
    ENST00000591058 ; ENSP00000466988 ; ENSG00000186529 . [Q08477-2 ]
    GeneIDi 4051.
    KEGGi hsa:4051.
    UCSCi uc002nbj.3. human. [Q08477-1 ]
    uc002nbk.3. human.

    Organism-specific databases

    CTDi 4051.
    GeneCardsi GC19P015751.
    H-InvDB HIX0039919.
    HIX0169080.
    HIX0169326.
    HGNCi HGNC:2646. CYP4F3.
    MIMi 601270. gene.
    neXtProti NX_Q08477.
    PharmGKBi PA234.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000233833.
    HOVERGENi HBG000182.
    InParanoidi Q08477.
    KOi K17726.
    OMAi PVIRFCH.
    OrthoDBi EOG7CNZFK.
    PhylomeDBi Q08477.
    TreeFami TF105088.

    Enzyme and pathway databases

    UniPathwayi UPA00883 .
    Reactomei REACT_13425. Miscellaneous substrates.
    REACT_13645. Eicosanoids.
    REACT_13814. Fatty acids.
    REACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).
    SABIO-RK Q08477.

    Miscellaneous databases

    GeneWikii CYP4F3.
    GenomeRNAii 4051.
    NextBioi 15870.
    PROi Q08477.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q08477.
    Bgeei Q08477.
    CleanExi HS_CYP4F3.
    Genevestigatori Q08477.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase."
      Kikuta Y., Kusunose E., Endo K., Yamamoto S., Sogawa K., Fujii-Kuriyama Y., Kusunose M.
      J. Biol. Chem. 268:9376-9380(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CYP4F3A), VARIANT ASP-269.
      Tissue: Leukocyte.
    2. "Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization."
      Kikuta Y., Kato M., Yamashita Y., Miyauchi Y., Tanaka K., Kamada N., Kusunose M.
      DNA Cell Biol. 17:221-230(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM CYP4F3A), VARIANT ASP-269.
    3. "A novel form of cytochrome P-450 family 4 in human fetal liver."
      Peng X., Morgan K., Morgan T.R.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CYP4F3B).
      Tissue: Fetal liver.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CYP4F3B).
      Tissue: Tongue and Trachea.
    5. SeattleSNPs variation discovery resource
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASP-269; ILE-270 AND THR-271.
    6. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CYP4F3B).
    9. "Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase."
      Christmas P., Ursino S.R., Fox J.W., Soberman R.J.
      J. Biol. Chem. 274:21191-21199(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, ALTERNATIVE PROMOTER USAGE.
    10. "Alternative splicing determines the function of CYP4F3 by switching substrate specificity."
      Christmas P., Jones J.P., Patten C.J., Rock D.A., Zheng Y., Cheng S.M., Weber B.M., Carlesso N., Scadden D.T., Rettie A.E., Soberman R.J.
      J. Biol. Chem. 276:38166-38172(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, FUNCTION, SUBSTRATE SPECIFICITY, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCP4F3_HUMAN
    AccessioniPrimary (citable) accession number: Q08477
    Secondary accession number(s): B7Z8Z3, O60634, Q5U740
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 146 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3