Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G1-specific transcription factors activator MSA1

Gene

MSA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activator of G1-specific transcription factors, MBF and SBF. Promotes both the timing of G1-specific gene transcription and cell cycle initiation. Associates with SBF- and MBF-regulated target promoters and this binding is maximal during the G1 phase, prior to maximum budding. Affects cell cycle initiation by advancing the timing of transcription of G1-specific genes. Overexpression advances the timing of SBF-dependent transcription and budding. Depletion delays both indicators of cell cycle initiation.2 Publications

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: SGD
  • regulation of cell size Source: SGD
  • regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33606-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
G1-specific transcription factors activator MSA1
Alternative name(s):
MBF and SBF-associated protein 1
Gene namesi
Name:MSA1
Ordered Locus Names:YOR066W
ORF Names:YOR29-17
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR066W
SGDiS000005592 MSA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002376511 – 629G1-specific transcription factors activator MSA1Add BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei268PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CDC28.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08471
PaxDbiQ08471
PRIDEiQ08471

PTM databases

iPTMnetiQ08471

Expressioni

Developmental stagei

Expressed periodically during the cell cycle with peak mRNA levels occurring at the late M/early G1 phase, prior to budding, and levels decrease rapidly as cells enter into the S phase. In early G1 peak occurs (at protein level).1 Publication

Interactioni

Subunit structurei

Interacts with transcription complexes SCB-binding factor (SBF) and MCB-binding factor (MBF) at their target promoters. Interacts with MBP1 and SWI6.1 Publication

Protein-protein interaction databases

BioGridi34465, 85 interactors
DIPiDIP-2714N
IntActiQ08471, 6 interactors
MINTiQ08471
STRINGi4932.YOR066W

Structurei

3D structure databases

ProteinModelPortaliQ08471
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi317 – 333Asn-richAdd BLAST17
Compositional biasi446 – 475Gln-richAdd BLAST30

Phylogenomic databases

HOGENOMiHOG000113659
InParanoidiQ08471
KOiK21628
OMAiIECTPLI
OrthoDBiEOG092C32CG

Sequencei

Sequence statusi: Complete.

Q08471-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKSMIKKRG RPPITKDYPN PLQSPMAHSS MQVQKQGPHS FAKPLMKVGQ
60 70 80 90 100
SSPSPNKRRL SIDHHHNLAA TTRKGRYRGV LLSTPTKKSS TNGSTPISTP
110 120 130 140 150
SSNDSYNNTV FSETRKTFLQ SSPPIMTSSP AFQKKNDYMF PSQEQFKLSL
160 170 180 190 200
TITESGKAVI AGSLPFSPSS KSSHLMNNNN KKIMQNEKIH KGSKKNAPKF
210 220 230 240 250
EKRRILSLLK QMKNEKYCDT DTLPEAPPAK PSRSDIIDTE LPTIIETSAS
260 270 280 290 300
PIGSARNNNI LLSQPPQSPP SSAQLKPPST PKSSLQFRMG FTPNVALNSV
310 320 330 340 350
SLSDTISKST NAVGASNNNN QNGNSISNIA DANTLLTLTN SPGVFLSPRN
360 370 380 390 400
KMLPKSTTAS NEQQQEFVFK FSSGDPLLLT DDADGNWPEM LFNVSNTPRR
410 420 430 440 450
QKCFNTPPSW INFGSPGLFS PPRSSNVMVN GTTVATASDS GNVHRQLQAQ
460 470 480 490 500
LEAQVQVQSQ SNSPTQRQQQ QRQFQIPPPH INMNSSPPQI NIASPPHQSM
510 520 530 540 550
SRVSSIYFNK EKTTTGVANM LGNTKSENLQ PPANLFTAAH GPSTPRNQEF
560 570 580 590 600
QLPTLIECTP LIQQTMNGSL GTKYIPGTSI SNSATPNLHG FPVGTGKAPS
610 620
SFDDSLKQNP YSNKQDDART ALKRLIDDQ
Length:629
Mass (Da):68,691
Last modified:November 1, 1996 - v1
Checksum:i302204DCC8ECFD0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70678 Genomic DNA Translation: CAA94551.1
Z74974 Genomic DNA Translation: CAA99259.1
AY692621 Genomic DNA Translation: AAT92640.1
BK006948 Genomic DNA Translation: DAA10845.1
PIRiS66949
RefSeqiNP_014709.1, NM_001183485.1

Genome annotation databases

EnsemblFungiiYOR066W; YOR066W; YOR066W
GeneIDi854232
KEGGisce:YOR066W

Similar proteinsi

Entry informationi

Entry nameiMSA1_YEAST
AccessioniPrimary (citable) accession number: Q08471
Secondary accession number(s): D6W2C9, O00026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health