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Protein

Sodium-dependent neutral amino acid transporter B(0)AT2

Gene

Slc6a15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for methionine and for the branched-chain amino acids, particularly leucine, valine and isoleucine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.
R-RNO-442660. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent neutral amino acid transporter B(0)AT2
Alternative name(s):
Solute carrier family 6 member 15
Transporter v7-3
sodium- and chloride-dependent neurotransmitter transporter NTT73
Gene namesi
Name:Slc6a15
Synonyms:Ntt73
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi628664. Slc6a15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 69CytoplasmicSequence analysisAdd BLAST69
Transmembranei70 – 90Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei98 – 117Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei142 – 162Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini163 – 225ExtracellularSequence analysisAdd BLAST63
Transmembranei226 – 244Helical; Name=4Sequence analysisAdd BLAST19
Transmembranei253 – 270Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei306 – 323Helical; Name=6Sequence analysisAdd BLAST18
Transmembranei335 – 356Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini357 – 452ExtracellularSequence analysisAdd BLAST96
Transmembranei453 – 472Helical; Name=8Sequence analysisAdd BLAST20
Transmembranei496 – 514Helical; Name=9Sequence analysisAdd BLAST19
Transmembranei530 – 550Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei571 – 592Helical; Name=11Sequence analysisAdd BLAST22
Transmembranei620 – 642Helical; Name=12Sequence analysisAdd BLAST23
Topological domaini643 – 729CytoplasmicSequence analysisAdd BLAST87

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002148001 – 729Sodium-dependent neutral amino acid transporter B(0)AT2Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei55PhosphoserineBy similarity1
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Glycosylationi383N-linked (GlcNAc...)Sequence analysis1
Glycosylationi394N-linked (GlcNAc...)Sequence analysis1
Modified residuei687PhosphoserineBy similarity1
Modified residuei699PhosphoserineCombined sources1
Modified residuei701PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ08469.
PRIDEiQ08469.

PTM databases

iPTMnetiQ08469.
PhosphoSitePlusiQ08469.

Expressioni

Tissue specificityi

Widely distributed in the central nervous system, including the olfactory bulb, the hypothalamus, the cerebral cortex, the hippocampus, and the cerebellum. In addition, intense expression is found in the motor nuclei including the oculomotor nucleus, abducens nucleus, trigeminal motor nucleus, facial nucleus, hypoglossal nucleus and ventral horn of spinal cord. Intense hybridization signals are also observed in the nuclei containing monoaminergic neurons, such as locus coeruleus, the substantia nigra pars compacta, the ventral tegmental area, the dorsal raphe nucleus and the median raphe nucleus.1 Publication

Gene expression databases

BgeeiENSRNOG00000027468.
GenevisibleiQ08469. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032996.

Structurei

3D structure databases

ProteinModelPortaliQ08469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ08469.
KOiK05048.
OMAiAWVVVCL.
PhylomeDBiQ08469.
TreeFamiTF352709.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNSKVVKR DLDDDVIESV KDLLSNEDSV EDVSKKSELI VDVQEEKDTD
60 70 80 90 100
AEDGSEVDDE RPAWNSKLQY ILAQVGFSVG LGNVWRFPYL CQKNGGGAYL
110 120 130 140 150
LPYLILLLVI GIPLFFLELS VGQRIRRGSI GVWNYISPKL GGIGFASCVV
160 170 180 190 200
CYFVALYYNV IIGWTLFYFS QSFQQPLPWD QCPLVKNASH TYIEPECEKS
210 220 230 240 250
SATTYYWYRE ALAISSSISE SGGLNWKMTG CLLAAWVMVC LAMIKGIQSS
260 270 280 290 300
GKIMYFSSLF PYVVLICFLI RSLLLNGSID GIRHMFTPKL EMMLEPKVWR
310 320 330 340 350
EAATQVFFAL GLGFGGVIAF SSYNKRDNNC HFDAVLVSFI NFFTSVLATL
360 370 380 390 400
VVFAVLGFKA NIVNEKCISQ NSEMILKLLK TGNVSWDVIP RHINLSAVTA
410 420 430 440 450
EDYHVVYDII QKVKEEEFAV LHLKACQIED ELNKAVQGTG LAFIAFTEAM
460 470 480 490 500
THFPASPFWS VMFFLMLINL GLGSMFGTIE GIITPVVDTF KVRKEILTVI
510 520 530 540 550
CCLLAFCIGL MFVQRSGNYF VTMFDDYSAT LPLLIVVILE NIAVSFVYGI
560 570 580 590 600
DKFLEDLTDM LGFAPSKYYY YMWKYISPLM LVTLLIASIV NMGLSPPGYN
610 620 630 640 650
AWIKEKASEE FLSYPMWGMV VCFSLMVLAI LPVPVVFVIR RCNLIDDSSG
660 670 680 690 700
NLASVTYKRG RVLKEPVNLD GDDASLIHGK IPSEMSSPNF GKNIYRKQSG
710 720
SPTLDTAPNG RYGIGYLMAD MPDMPESDL
Length:729
Mass (Da):81,596
Last modified:February 1, 1995 - v1
Checksum:iECDDC6403741B53E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 3MPK → IP in AAB25532 (PubMed:1363329).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22022 mRNA. Translation: AAA41729.1.
S56968 mRNA. Translation: AAB25532.1.
PIRiI65413.
RefSeqiNP_758824.1. NM_172321.1.
UniGeneiRn.9716.

Genome annotation databases

EnsembliENSRNOT00000029208; ENSRNOP00000032996; ENSRNOG00000027468.
ENSRNOT00000090641; ENSRNOP00000073005; ENSRNOG00000027468.
GeneIDi282712.
KEGGirno:282712.
UCSCiRGD:628664. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22022 mRNA. Translation: AAA41729.1.
S56968 mRNA. Translation: AAB25532.1.
PIRiI65413.
RefSeqiNP_758824.1. NM_172321.1.
UniGeneiRn.9716.

3D structure databases

ProteinModelPortaliQ08469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032996.

PTM databases

iPTMnetiQ08469.
PhosphoSitePlusiQ08469.

Proteomic databases

PaxDbiQ08469.
PRIDEiQ08469.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000029208; ENSRNOP00000032996; ENSRNOG00000027468.
ENSRNOT00000090641; ENSRNOP00000073005; ENSRNOG00000027468.
GeneIDi282712.
KEGGirno:282712.
UCSCiRGD:628664. rat.

Organism-specific databases

CTDi55117.
RGDi628664. Slc6a15.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ08469.
KOiK05048.
OMAiAWVVVCL.
PhylomeDBiQ08469.
TreeFamiTF352709.

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.
R-RNO-442660. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

PROiQ08469.

Gene expression databases

BgeeiENSRNOG00000027468.
GenevisibleiQ08469. RN.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS6A15_RAT
AccessioniPrimary (citable) accession number: Q08469
Secondary accession number(s): Q63838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.