Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q08469

- S6A15_RAT

UniProt

Q08469 - S6A15_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sodium-dependent neutral amino acid transporter B(0)AT2

Gene

Slc6a15

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for methionine and for the branched-chain amino acids, particularly leucine, valine and isoleucine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).By similarity

GO - Molecular functioni

  1. neurotransmitter:sodium symporter activity Source: InterPro
  2. proline:sodium symporter activity Source: UniProtKB

GO - Biological processi

  1. leucine transport Source: Ensembl
  2. neutral amino acid transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_243822. Amino acid transport across the plasma membrane.
REACT_244063. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent neutral amino acid transporter B(0)AT2
Alternative name(s):
Solute carrier family 6 member 15
Transporter v7-3
sodium- and chloride-dependent neurotransmitter transporter NTT73
Gene namesi
Name:Slc6a15
Synonyms:Ntt73
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi628664. Slc6a15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6969CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei98 – 11720Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini163 – 22563ExtracellularSequence AnalysisAdd
BLAST
Transmembranei226 – 24419Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei253 – 27018Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei306 – 32318Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei335 – 35622Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini357 – 45296ExtracellularSequence AnalysisAdd
BLAST
Transmembranei453 – 47220Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei496 – 51419Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei530 – 55021Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei571 – 59222Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei620 – 64223Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini643 – 72987CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Sodium-dependent neutral amino acid transporter B(0)AT2PRO_0000214800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551PhosphoserineBy similarity
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis
Modified residuei687 – 6871PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ08469.

Expressioni

Tissue specificityi

Widely distributed in the central nervous system, including the olfactory bulb, the hypothalamus, the cerebral cortex, the hippocampus, and the cerebellum. In addition, intense expression is found in the motor nuclei including the oculomotor nucleus, abducens nucleus, trigeminal motor nucleus, facial nucleus, hypoglossal nucleus and ventral horn of spinal cord. Intense hybridization signals are also observed in the nuclei containing monoaminergic neurons, such as locus coeruleus, the substantia nigra pars compacta, the ventral tegmental area, the dorsal raphe nucleus and the median raphe nucleus.1 Publication

Gene expression databases

GenevestigatoriQ08469.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032996.

Structurei

3D structure databases

ProteinModelPortaliQ08469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ08469.
KOiK05048.
OMAiTPKLEMM.
OrthoDBiEOG793B71.
PhylomeDBiQ08469.
TreeFamiTF352709.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08469-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKNSKVVKR DLDDDVIESV KDLLSNEDSV EDVSKKSELI VDVQEEKDTD
60 70 80 90 100
AEDGSEVDDE RPAWNSKLQY ILAQVGFSVG LGNVWRFPYL CQKNGGGAYL
110 120 130 140 150
LPYLILLLVI GIPLFFLELS VGQRIRRGSI GVWNYISPKL GGIGFASCVV
160 170 180 190 200
CYFVALYYNV IIGWTLFYFS QSFQQPLPWD QCPLVKNASH TYIEPECEKS
210 220 230 240 250
SATTYYWYRE ALAISSSISE SGGLNWKMTG CLLAAWVMVC LAMIKGIQSS
260 270 280 290 300
GKIMYFSSLF PYVVLICFLI RSLLLNGSID GIRHMFTPKL EMMLEPKVWR
310 320 330 340 350
EAATQVFFAL GLGFGGVIAF SSYNKRDNNC HFDAVLVSFI NFFTSVLATL
360 370 380 390 400
VVFAVLGFKA NIVNEKCISQ NSEMILKLLK TGNVSWDVIP RHINLSAVTA
410 420 430 440 450
EDYHVVYDII QKVKEEEFAV LHLKACQIED ELNKAVQGTG LAFIAFTEAM
460 470 480 490 500
THFPASPFWS VMFFLMLINL GLGSMFGTIE GIITPVVDTF KVRKEILTVI
510 520 530 540 550
CCLLAFCIGL MFVQRSGNYF VTMFDDYSAT LPLLIVVILE NIAVSFVYGI
560 570 580 590 600
DKFLEDLTDM LGFAPSKYYY YMWKYISPLM LVTLLIASIV NMGLSPPGYN
610 620 630 640 650
AWIKEKASEE FLSYPMWGMV VCFSLMVLAI LPVPVVFVIR RCNLIDDSSG
660 670 680 690 700
NLASVTYKRG RVLKEPVNLD GDDASLIHGK IPSEMSSPNF GKNIYRKQSG
710 720
SPTLDTAPNG RYGIGYLMAD MPDMPESDL
Length:729
Mass (Da):81,596
Last modified:February 1, 1995 - v1
Checksum:iECDDC6403741B53E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 33MPK → IP in AAB25532. (PubMed:1363329)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22022 mRNA. Translation: AAA41729.1.
S56968 mRNA. Translation: AAB25532.1.
PIRiI65413.
RefSeqiNP_758824.1. NM_172321.1.
UniGeneiRn.9716.

Genome annotation databases

EnsembliENSRNOT00000029208; ENSRNOP00000032996; ENSRNOG00000027468.
GeneIDi282712.
KEGGirno:282712.
UCSCiRGD:628664. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22022 mRNA. Translation: AAA41729.1 .
S56968 mRNA. Translation: AAB25532.1 .
PIRi I65413.
RefSeqi NP_758824.1. NM_172321.1.
UniGenei Rn.9716.

3D structure databases

ProteinModelPortali Q08469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000032996.

Proteomic databases

PRIDEi Q08469.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000029208 ; ENSRNOP00000032996 ; ENSRNOG00000027468 .
GeneIDi 282712.
KEGGi rno:282712.
UCSCi RGD:628664. rat.

Organism-specific databases

CTDi 55117.
RGDi 628664. Slc6a15.

Phylogenomic databases

eggNOGi COG0733.
GeneTreei ENSGT00760000119044.
HOGENOMi HOG000116406.
HOVERGENi HBG071421.
InParanoidi Q08469.
KOi K05048.
OMAi TPKLEMM.
OrthoDBi EOG793B71.
PhylomeDBi Q08469.
TreeFami TF352709.

Enzyme and pathway databases

Reactomei REACT_243822. Amino acid transport across the plasma membrane.
REACT_244063. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

NextBioi 624845.
PROi Q08469.

Gene expression databases

Genevestigatori Q08469.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Neurotransmitter transporter family cDNAs in a rat midbrain library: 'orphan transporters' suggest sizable structural variations."
    Uhl G.R., Kitayama S., Gregor P., Nanthakumar E., Persico A.M., Shimada S.
    Brain Res. Mol. Brain Res. 16:353-359(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Widespread brain distribution of mRNA encoding the orphan neurotransmitter transporter v7-3."
    Inoue K., Sato K., Tohyama M., Shimada S., Uhl G.R.
    Brain Res. Mol. Brain Res. 37:217-223(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiS6A15_RAT
AccessioniPrimary (citable) accession number: Q08469
Secondary accession number(s): Q63838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3