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Protein

Protein YNG1

Gene

YNG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Histone-binding component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation. YNG1 is required for the HAT activity of NuA3 but not for its integrity. Mediates the interaction of SAS3 with nucleosomes.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei157 – 1571Histone H3K4me3By similarity
Metal bindingi158 – 1581Zinc 1By similarity
Metal bindingi160 – 1601Zinc 1By similarity
Binding sitei168 – 1681Histone H3K4me3By similarity
Metal bindingi171 – 1711Zinc 2By similarity
Binding sitei172 – 1721Histone H3K4me3By similarity
Metal bindingi176 – 1761Zinc 2By similarity
Binding sitei180 – 1801Histone H3K4me3By similarity
Metal bindingi182 – 1821Zinc 1; via pros nitrogenBy similarity
Metal bindingi185 – 1851Zinc 1By similarity
Metal bindingi198 – 1981Zinc 2By similarity
Metal bindingi202 – 2021Zinc 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 20450PHD-type; degenerateAdd
BLAST

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • chromatin modification Source: SGD
  • histone acetylation Source: SGD
  • positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33604-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YNG1
Alternative name(s):
ING1 homolog 1
Gene namesi
Name:YNG1
Ordered Locus Names:YOR064C
ORF Names:YOR29-15
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR064C.
SGDiS000005590. YNG1.

Subcellular locationi

GO - Cellular componenti

  • NuA3a histone acetyltransferase complex Source: SGD
  • NuA3 histone acetyltransferase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Protein YNG1PRO_0000240248Add
BLAST

Proteomic databases

MaxQBiQ08465.
PRIDEiQ08465.

Interactioni

Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA3 complex, composed of at least NTO1, SAS3, TAF14, YNG1 and EAF6. Interacts with histone H3-K4 trimethylated.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HHT2P618305EBI-31890,EBI-8098
SAS3P342185EBI-31890,EBI-16484
TAF14P351893EBI-31890,EBI-18920

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi34463. 53 interactions.
DIPiDIP-3833N.
IntActiQ08465. 6 interactions.
MINTiMINT-510020.

Structurei

Secondary structure

1
219
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni159 – 1613Combined sources
Beta strandi165 – 1695Combined sources
Beta strandi173 – 1753Combined sources
Turni183 – 1853Combined sources
Helixi200 – 2089Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JMINMR-A141-219[»]
2JMJNMR-A141-219[»]
ProteinModelPortaliQ08465.
SMRiQ08465. Positions 153-212.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08465.

Family & Domainsi

Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.1 Publication

Sequence similaritiesi

Belongs to the ING family.Curated
Contains 1 PHD-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 20450PHD-type; degenerateAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00830000129158.
HOGENOMiHOG000239724.
InParanoidiQ08465.
KOiK11379.
OMAiPMVACDN.
OrthoDBiEOG092C2K1R.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028651. ING_fam.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10333. PTHR10333. 1 hit.
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08465-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHLANENSD SDIRYSFLST LDHLPCELIR SLRLMQTIDL FKNEEDEPGM
60 70 80 90 100
ERACRDLLLV ATYINDLVDD QIHFLKQHKK ELEIQKSVTK NFNSSLENIK
110 120 130 140 150
SKLTLEEPGA YKEPKLLLKI NLKKAKSRER KESITSPTIG INQGDVTEGN
160 170 180 190 200
NNQEEVYCFC RNVSYGPMVA CDNPACPFEW FHYGCVGLKQ APKGKWYCSK
210
DCKEIANQRS KSKRQKRRK
Length:219
Mass (Da):25,350
Last modified:November 1, 1996 - v1
Checksum:i5232A71839E2FDA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70678 Genomic DNA. Translation: CAA94549.1.
Z74972 Genomic DNA. Translation: CAA99257.1.
AY557753 Genomic DNA. Translation: AAS56079.1.
BK006948 Genomic DNA. Translation: DAA10843.1.
PIRiS66947.
RefSeqiNP_014707.1. NM_001183483.1.

Genome annotation databases

EnsemblFungiiYOR064C; YOR064C; YOR064C.
GeneIDi854230.
KEGGisce:YOR064C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70678 Genomic DNA. Translation: CAA94549.1.
Z74972 Genomic DNA. Translation: CAA99257.1.
AY557753 Genomic DNA. Translation: AAS56079.1.
BK006948 Genomic DNA. Translation: DAA10843.1.
PIRiS66947.
RefSeqiNP_014707.1. NM_001183483.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JMINMR-A141-219[»]
2JMJNMR-A141-219[»]
ProteinModelPortaliQ08465.
SMRiQ08465. Positions 153-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34463. 53 interactions.
DIPiDIP-3833N.
IntActiQ08465. 6 interactions.
MINTiMINT-510020.

Proteomic databases

MaxQBiQ08465.
PRIDEiQ08465.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR064C; YOR064C; YOR064C.
GeneIDi854230.
KEGGisce:YOR064C.

Organism-specific databases

EuPathDBiFungiDB:YOR064C.
SGDiS000005590. YNG1.

Phylogenomic databases

GeneTreeiENSGT00830000129158.
HOGENOMiHOG000239724.
InParanoidiQ08465.
KOiK11379.
OMAiPMVACDN.
OrthoDBiEOG092C2K1R.

Enzyme and pathway databases

BioCyciYEAST:G3O-33604-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ08465.
PROiQ08465.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028651. ING_fam.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10333. PTHR10333. 1 hit.
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYNG1_YEAST
AccessioniPrimary (citable) accession number: Q08465
Secondary accession number(s): D6W2C7, O00025
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 861 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.