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Q08463

- FZD1_RAT

UniProt

Q08463 - FZD1_RAT

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Protein
Frizzled-1
Gene
Fzd1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt8 induces expression of beta-catenin target genes.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. PDZ domain binding Source: RefGenome
  3. Wnt-activated receptor activity Source: RefGenome
  4. Wnt-protein binding Source: RefGenome
  5. identical protein binding Source: IntAct
  6. protein binding Source: IntAct
  7. protein heterodimerization activity Source: BHF-UCL
  8. protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  1. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
  2. Wnt signaling pathway Source: RGD
  3. Wnt signaling pathway, calcium modulating pathway Source: RefGenome
  4. axonogenesis Source: RefGenome
  5. brain development Source: RefGenome
  6. canonical Wnt signaling pathway Source: BHF-UCL
  7. cellular response to growth factor stimulus Source: RGD
  8. cellular response to peptide hormone stimulus Source: RGD
  9. cellular response to vitamin D Source: RGD
  10. epithelial cell differentiation Source: RefGenome
  11. gonad development Source: RefGenome
  12. lung alveolus development Source: RGD
  13. negative regulation of BMP signaling pathway Source: RefGenome
  14. negative regulation of canonical Wnt signaling pathway Source: RefGenome
  15. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  16. regulation of osteoblast differentiation Source: RGD
  17. vasculature development Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-1
Short name:
Fz-1
Short name:
rFz1
Gene namesi
Name:Fzd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi61916. Fzd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini69 – 316248Extracellular Reviewed prediction
Add
BLAST
Transmembranei317 – 33721Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini338 – 34811Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei349 – 36921Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini370 – 39627Extracellular Reviewed prediction
Add
BLAST
Transmembranei397 – 41721Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini418 – 43922Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei440 – 46021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini461 – 48323Extracellular Reviewed prediction
Add
BLAST
Transmembranei484 – 50421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini505 – 53026Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei531 – 55121Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini552 – 59544Extracellular Reviewed prediction
Add
BLAST
Transmembranei596 – 61621Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini617 – 64125Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical part of cell Source: RefGenome
  2. cytoplasm Source: RefGenome
  3. integral component of membrane Source: UniProtKB-KW
  4. neuron projection Source: RGD
  5. neuron projection membrane Source: RefGenome
  6. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 6868 Reviewed prediction
Add
BLAST
Chaini69 – 641573Frizzled-1
PRO_0000012975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi111 ↔ 172 By similarity
Disulfide bondi119 ↔ 165 By similarity
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi156 ↔ 192 By similarity
Disulfide bondi182 ↔ 221 By similarity
Disulfide bondi186 ↔ 209 By similarity
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ08463.
PRIDEiQ08463.

PTM databases

PhosphoSiteiQ08463.

Expressioni

Tissue specificityi

Widely expressed. Most abundant in kidney, liver, uterus, ovary and heart. Lower levels seen in brain and intestine. Extremely low in calvaria, mammary glands and testis.

Developmental stagei

Expressed predominantly in neonatal tissues, at lower levels in adult.

Gene expression databases

GenevestigatoriQ08463.

Interactioni

Subunit structurei

Interacts with MYOC By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-8766455,EBI-8766455
Fzd2Q084646EBI-8766455,EBI-7402050

Protein-protein interaction databases

IntActiQ08463. 1 interaction.
STRINGi10116.ENSRNOP00000021979.

Structurei

3D structure databases

ProteinModelPortaliQ08463.
SMRiQ08463. Positions 109-225.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 224119FZ
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi619 – 6246Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
Motifi639 – 6413PDZ-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi85 – 906Poly-Pro

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.
The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257258.
HOGENOMiHOG000233236.
HOVERGENiHBG006977.
InParanoidiQ08463.
PhylomeDBiQ08463.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026548. FZD1.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF81. PTHR11309:SF81. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08463-1 [UniParc]FASTAAdd to Basket

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MAEEAVPSES RAAGRPSLEL CAVALPGRRE EVGHQDTAGH RRPRAHSRCW    50
ARGLLLLLWL LEAPLLLGVR AQPAGQVSGP GQQRPPPPQP QQGGQQYNGE 100
RGISIPDHGY CQPISIPLCT DIAYNQTIMP NLLGHTNQED AGLEVHQFYP 150
LVKVQCSAEL KFFLCSMYAP VCTVLEQALP PCRSLCERAQ GCEALMNKFG 200
FQWPDTLKCE KFPVHGAGEL CVGQNTSDKG TPTPSLLPEF WTSNPQHGGG 250
GYRGGYPGGA GPVERGKFSC PRALRVPSYL NYHFLGEKDC GAPCEPTKVY 300
GLMYFGPEEL RFSRTWIGIW SVLCCASTLF TVLTYLVDMR RFSYPERPII 350
FLSGCYTAVA VAYIAGFLLE DRVVCNDKFA EDGARTVAQG TKKEGCTILF 400
MMLYFFSMAS SIWWVILSLT WFLAAGMKWG HEAIEANSQY FHLAAWAVPA 450
IKTITILALG QVDGDVLSGV CFVGLNNVDA LRGFVLAPLF VYLFIGTSFL 500
LAGFVSLFRI RTIMKHDGTK TEKLEKLMVR IGVFSVLYTV PATIVIACYF 550
YEQAFRDQWE RSWVAQSCKS YAIPCPHLQG GGGVPPHPPM SPDFTVFMIK 600
YLMTLIVGIT SGFWIWSGKT LNSWRKFYTR LTNSKQGETT V 641
Length:641
Mass (Da):71,027
Last modified:November 1, 1996 - v1
Checksum:iD82E2C113E81B8B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02529 mRNA. Translation: AAA41173.1.
PIRiA45054.
UniGeneiRn.6575.

Genome annotation databases

UCSCiRGD:61916. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02529 mRNA. Translation: AAA41173.1 .
PIRi A45054.
UniGenei Rn.6575.

3D structure databases

ProteinModelPortali Q08463.
SMRi Q08463. Positions 109-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q08463. 1 interaction.
STRINGi 10116.ENSRNOP00000021979.

Chemistry

GuidetoPHARMACOLOGYi 229.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q08463.

Proteomic databases

PaxDbi Q08463.
PRIDEi Q08463.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:61916. rat.

Organism-specific databases

RGDi 61916. Fzd1.

Phylogenomic databases

eggNOGi NOG257258.
HOGENOMi HOG000233236.
HOVERGENi HBG006977.
InParanoidi Q08463.
PhylomeDBi Q08463.

Miscellaneous databases

PROi Q08463.

Gene expression databases

Genevestigatori Q08463.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026548. FZD1.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF81. PTHR11309:SF81. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues."
    Chan S.D.H., Karpf D.B., Fowlkes M.E., Hooks M., Bradley M.S., Vuong V., Bambino T., Liu M.Y.C., Arnaud C.D., Strewler G.J., Nissenson R.A.
    J. Biol. Chem. 267:25202-25207(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Osteosarcoma.
  2. "Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner."
    Sheldahl L.C., Park M., Malbon C.C., Moon R.T.
    Curr. Biol. 9:695-698(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: COUPLING TO BETA-CATENIN PATHWAY.

Entry informationi

Entry nameiFZD1_RAT
AccessioniPrimary (citable) accession number: Q08463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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