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Protein

Frizzled-1

Gene

Fzd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6 or WNT7A. Contradictory results have been reported for activation by WNT7B. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).By similarityCurated

Caution

Activation by specific Wnt family members may depend on the cells used for the experiment. Contradictory results have been reported for activation by WNT7B in human and mouse.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GO_Central
  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • Wnt-activated receptor activity Source: GO_Central
  • Wnt-protein binding Source: GO_Central

GO - Biological processi

  • canonical Wnt signaling pathway Source: BHF-UCL
  • cellular response to growth factor stimulus Source: RGD
  • cellular response to peptide hormone stimulus Source: RGD
  • cellular response to vitamin D Source: RGD
  • lung alveolus development Source: RGD
  • non-canonical Wnt signaling pathway Source: GO_Central
  • positive regulation of DNA binding transcription factor activity Source: BHF-UCL
  • positive regulation of neuron projection development Source: ParkinsonsUK-UCL
  • regulation of osteoblast differentiation Source: RGD
  • Wnt signaling pathway Source: RGD

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-1
Short name:
Fz-1
Short name:
rFz1
Gene namesi
Name:Fzd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61916 Fzd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini69 – 316ExtracellularSequence analysisAdd BLAST248
Transmembranei317 – 337Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini338 – 348CytoplasmicSequence analysisAdd BLAST11
Transmembranei349 – 369Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini370 – 396ExtracellularSequence analysisAdd BLAST27
Transmembranei397 – 417Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini418 – 439CytoplasmicSequence analysisAdd BLAST22
Transmembranei440 – 460Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini461 – 483ExtracellularSequence analysisAdd BLAST23
Transmembranei484 – 504Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini505 – 530CytoplasmicSequence analysisAdd BLAST26
Transmembranei531 – 551Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini552 – 595ExtracellularSequence analysisAdd BLAST44
Transmembranei596 – 616Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini617 – 641CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 68Sequence analysisAdd BLAST68
ChainiPRO_000001297569 – 641Frizzled-1Add BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi111 ↔ 172PROSITE-ProRule annotation
Disulfide bondi119 ↔ 165PROSITE-ProRule annotation
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 192PROSITE-ProRule annotation
Disulfide bondi182 ↔ 221PROSITE-ProRule annotation
Disulfide bondi186 ↔ 209PROSITE-ProRule annotation
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ08463
PRIDEiQ08463

PTM databases

PhosphoSitePlusiQ08463

Expressioni

Tissue specificityi

Widely expressed. Most abundant in kidney, liver, uterus, ovary and heart. Lower levels seen in brain and intestine. Extremely low in calvaria, mammary glands and testis.1 Publication

Developmental stagei

Expressed predominantly in neonatal tissues, at lower levels in adult.

Interactioni

Subunit structurei

Interacts with MYOC (By similarity). Interacts with WNT7B (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • Wnt-protein binding Source: GO_Central

Protein-protein interaction databases

IntActiQ08463, 1 interactor
STRINGi10116.ENSRNOP00000021979

Structurei

3D structure databases

ProteinModelPortaliQ08463
SMRiQ08463
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 224FZPROSITE-ProRule annotationAdd BLAST119

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi619 – 624Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi639 – 641PDZ-binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 90Poly-Pro6

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
HOGENOMiHOG000233236
HOVERGENiHBG006977
InParanoidiQ08463
PhylomeDBiQ08463

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR026548 FZD1
IPR017981 GPCR_2-like
PANTHERiPTHR11309 PTHR11309, 1 hit
PTHR11309:SF81 PTHR11309:SF81, 1 hit
PfamiView protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit
PRINTSiPR00489 FRIZZLED
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit
SUPFAMiSSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEAVPSES RAAGRPSLEL CAVALPGRRE EVGHQDTAGH RRPRAHSRCW
60 70 80 90 100
ARGLLLLLWL LEAPLLLGVR AQPAGQVSGP GQQRPPPPQP QQGGQQYNGE
110 120 130 140 150
RGISIPDHGY CQPISIPLCT DIAYNQTIMP NLLGHTNQED AGLEVHQFYP
160 170 180 190 200
LVKVQCSAEL KFFLCSMYAP VCTVLEQALP PCRSLCERAQ GCEALMNKFG
210 220 230 240 250
FQWPDTLKCE KFPVHGAGEL CVGQNTSDKG TPTPSLLPEF WTSNPQHGGG
260 270 280 290 300
GYRGGYPGGA GPVERGKFSC PRALRVPSYL NYHFLGEKDC GAPCEPTKVY
310 320 330 340 350
GLMYFGPEEL RFSRTWIGIW SVLCCASTLF TVLTYLVDMR RFSYPERPII
360 370 380 390 400
FLSGCYTAVA VAYIAGFLLE DRVVCNDKFA EDGARTVAQG TKKEGCTILF
410 420 430 440 450
MMLYFFSMAS SIWWVILSLT WFLAAGMKWG HEAIEANSQY FHLAAWAVPA
460 470 480 490 500
IKTITILALG QVDGDVLSGV CFVGLNNVDA LRGFVLAPLF VYLFIGTSFL
510 520 530 540 550
LAGFVSLFRI RTIMKHDGTK TEKLEKLMVR IGVFSVLYTV PATIVIACYF
560 570 580 590 600
YEQAFRDQWE RSWVAQSCKS YAIPCPHLQG GGGVPPHPPM SPDFTVFMIK
610 620 630 640
YLMTLIVGIT SGFWIWSGKT LNSWRKFYTR LTNSKQGETT V
Length:641
Mass (Da):71,027
Last modified:November 1, 1996 - v1
Checksum:iD82E2C113E81B8B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02529 mRNA Translation: AAA41173.1
PIRiA45054
UniGeneiRn.6575

Genome annotation databases

UCSCiRGD:61916 rat

Similar proteinsi

Entry informationi

Entry nameiFZD1_RAT
AccessioniPrimary (citable) accession number: Q08463
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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