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Q08462

- ADCY2_HUMAN

UniProt

Q08462 - ADCY2_HUMAN

Protein

Adenylate cyclase type 2

Gene

ADCY2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 5 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Enzyme regulationi

    Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex By similarity. Phosphorylation by RAF1 results in its activation.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi295 – 2951Magnesium 1PROSITE-ProRule annotation
    Metal bindingi295 – 2951Magnesium 2PROSITE-ProRule annotation
    Metal bindingi296 – 2961Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi339 – 3391Magnesium 1PROSITE-ProRule annotation
    Metal bindingi339 – 3391Magnesium 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. adenylate cyclase activity Source: UniProtKB
    2. adenylate cyclase binding Source: BHF-UCL
    3. ATP binding Source: UniProtKB-KW
    4. calcium- and calmodulin-responsive adenylate cyclase activity Source: Ensembl
    5. metal ion binding Source: UniProtKB-KW
    6. nucleotide binding Source: UniProtKB-KW
    7. protein heterodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. activation of phospholipase C activity Source: Reactome
    2. activation of protein kinase A activity Source: Reactome
    3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Reactome
    4. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Reactome
    5. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: BHF-UCL
    6. cAMP biosynthetic process Source: BHF-UCL
    7. cellular response to glucagon stimulus Source: Reactome
    8. energy reserve metabolic process Source: Reactome
    9. epidermal growth factor receptor signaling pathway Source: Reactome
    10. fibroblast growth factor receptor signaling pathway Source: Reactome
    11. innate immune response Source: Reactome
    12. intracellular signal transduction Source: InterPro
    13. neurotrophin TRK receptor signaling pathway Source: Reactome
    14. signal transduction Source: Reactome
    15. small molecule metabolic process Source: Reactome
    16. synaptic transmission Source: Reactome
    17. transmembrane transport Source: Reactome
    18. water transport Source: Reactome

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi4.6.1.1. 2681.
    ReactomeiREACT_15312. Adenylate cyclase activating pathway.
    REACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15530. PKA activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_1946. PKA activation in glucagon signalling.
    REACT_24023. Regulation of water balance by renal Aquaporins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 2 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 2
    Adenylate cyclase type II
    Adenylyl cyclase 2
    Gene namesi
    Name:ADCY2
    Synonyms:KIAA1060
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:233. ADCY2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. dendrite Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. intracellular Source: BHF-UCL
    5. membrane Source: UniProtKB
    6. membrane raft Source: BHF-UCL
    7. plasma membrane Source: UniProtKB
    8. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24561.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10911091Adenylate cyclase type 2PRO_0000195684Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi713 – 7131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi716 – 7161N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated by RAF1.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ08462.
    PRIDEiQ08462.

    PTM databases

    PhosphoSiteiQ08462.

    Expressioni

    Tissue specificityi

    Expressed in brain.

    Gene expression databases

    ArrayExpressiQ08462.
    BgeeiQ08462.
    CleanExiHS_ADCY2.
    GenevestigatoriQ08462.

    Organism-specific databases

    HPAiCAB031482.
    HPA038015.
    HPA038483.

    Interactioni

    Subunit structurei

    Interacts with RAF1.1 Publication

    Protein-protein interaction databases

    BioGridi106622. 2 interactions.
    DIPiDIP-422N.
    IntActiQ08462. 1 interaction.
    STRINGi9606.ENSP00000342952.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08462.
    SMRiQ08462. Positions 278-464, 879-1078.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini208 – 601394CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini822 – 1091270CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei602 – 62221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei628 – 65225HelicalSequence AnalysisAdd
    BLAST
    Transmembranei680 – 70122HelicalSequence AnalysisAdd
    BLAST
    Transmembranei734 – 75522HelicalSequence AnalysisAdd
    BLAST
    Transmembranei763 – 78018HelicalSequence AnalysisAdd
    BLAST
    Transmembranei801 – 82121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2114.
    HOGENOMiHOG000006941.
    HOVERGENiHBG050458.
    InParanoidiQ08462.
    KOiK08042.
    OMAiFLPYFIY.
    OrthoDBiEOG76X5ZC.
    PhylomeDBiQ08462.
    TreeFamiTF313845.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view]
    PfamiPF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q08462-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWQEAMRRRR YLRDRSEEAA GGGDGLPRSR DWLYESYYCM SQQHPLIVFL     50
    LLIVMGSCLA LLAVFFALGL EVEDHVAFLI TVPTALAIFF AIFILVCIES 100
    VFKKLLRLFS LVIWICLVAM GYLFMCFGGT VSPWDQVSFF LFIIFVVYTM 150
    LPFNMRDAII ASVLTSSSHT IVLSVCLSAT PGGKEHLVWQ ILANVIIFIC 200
    GNLAGAYHKH LMELALQQTY QDTCNCIKSR IKLEFEKRQQ ERLLLSLLPA 250
    HIAMEMKAEI IQRLQGPKAG QMENTNNFHN LYVKRHTNVS ILYADIVGFT 300
    RLASDCSPGE LVHMLNELFG KFDQIAKENE CMRIKILGDC YYCVSGLPIS 350
    LPNHAKNCVK MGLDMCEAIK KVRDATGVDI NMRVGVHSGN VLCGVIGLQK 400
    WQYDVWSHDV TLANHMEAGG VPGRVHISSV TLEHLNGAYK VEEGDGDIRD 450
    PYLKQHLVKT YFVINPKGER RSPQHLFRPR HTLDGAKMRA SVRMTRYLES 500
    WGAAKPFAHL HHRDSMTTEN GKISTTDVPM GQHNFQNRTL RTKSQKKRFE 550
    EELNERMIQA IDGINAQKQW LKSEDIQRIS LLFYNKVLEK EYRATALPAF 600
    KYYVTCACLI FFCIFIVQIL VLPKTSVLGI SFGAAFLLLA FILFVCFAGQ 650
    LLQCSKKASP LLMWLLKSSG IIANRPWPRI SLTIITTAII LMMAVFNMFF 700
    LSDSEETIPP TANTTNTSFS ASNNQVAILR AQNLFFLPYF IYSCILGLIS 750
    CSVFLRVNYE LKMLIMMVAL VGYNTILLHT HAHVLGDYSQ VLFERPGIWK 800
    DLKTMGSVSL SIFFITLLVL GRQNEYYCRL DFLWKNKFKK EREEIETMEN 850
    LNRVLLENVL PAHVAEHFLA RSLKNEELYH QSYDCVCVMF ASIPDFKEFY 900
    TESDVNKEGL ECLRLLNEII ADFDDLLSKP KFSGVEKIKT IGSTYMAATG 950
    LSAVPSQEHS QEPERQYMHI GTMVEFAFAL VGKLDAINKH SFNDFKLRVG 1000
    INHGPVIAGV IGAQKPQYDI WGNTVNVASR MDSTGVLDKI QVTEETSLVL 1050
    QTLGYTCTCR GIINVKGKGD LKTYFVNTEM SRSLSQSNVA S 1091
    Length:1,091
    Mass (Da):123,603
    Last modified:November 28, 2006 - v5
    Checksum:i41FD8BC607C075D1
    GO
    Isoform 2 (identifier: Q08462-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-59: MWQEAMRRRR...LLLIVMGSCL → MDLRWARDLH...KRWRIQREES
         60-239: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:911
    Mass (Da):103,158
    Checksum:i658C0FA201D0E85E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti188 – 20720VWQIL…LAGAY → GLADPGQCDHFHLWEPGXTN in AAP97285. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti675 – 6751R → Q in CAA52282. (PubMed:1427768)Curated
    Sequence conflicti675 – 6751R → Q in AAA64923. (PubMed:1427768)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti147 – 1471V → L.1 Publication
    Corresponds to variant rs13166360 [ dbSNP | Ensembl ].
    VAR_029012
    Natural varianti163 – 1631V → I.
    Corresponds to variant rs34043481 [ dbSNP | Ensembl ].
    VAR_048247

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5959MWQEA…MGSCL → MDLRWARDLHLREASRSVAF TTLRLGAVTTGLLTFREPGD KEKSGKGLGKRWRIQREES in isoform 2. 1 PublicationVSP_055811Add
    BLAST
    Alternative sequencei60 – 239180Missing in isoform 2. 1 PublicationVSP_055812Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF410885 mRNA. Translation: AAP97285.1.
    AK294555 mRNA. Translation: BAH11807.1.
    AC010346 Genomic DNA. No translation available.
    AC010437 Genomic DNA. No translation available.
    AC024577 Genomic DNA. No translation available.
    AC093305 Genomic DNA. No translation available.
    AC113366 Genomic DNA. No translation available.
    BC111743 mRNA. Translation: AAI11744.1.
    AB028983 mRNA. Translation: BAA83012.1.
    X74210 mRNA. Translation: CAA52282.1.
    L21993 mRNA. Translation: AAA64923.1.
    CCDSiCCDS3872.2.
    PIRiI37136.
    RefSeqiNP_065433.2. NM_020546.2.
    UniGeneiHs.481545.

    Genome annotation databases

    EnsembliENST00000338316; ENSP00000342952; ENSG00000078295. [Q08462-1]
    ENST00000537121; ENSP00000444803; ENSG00000078295. [Q08462-2]
    GeneIDi108.
    KEGGihsa:108.
    UCSCiuc003jdz.1. human.

    Polymorphism databases

    DMDMi118572617.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF410885 mRNA. Translation: AAP97285.1 .
    AK294555 mRNA. Translation: BAH11807.1 .
    AC010346 Genomic DNA. No translation available.
    AC010437 Genomic DNA. No translation available.
    AC024577 Genomic DNA. No translation available.
    AC093305 Genomic DNA. No translation available.
    AC113366 Genomic DNA. No translation available.
    BC111743 mRNA. Translation: AAI11744.1 .
    AB028983 mRNA. Translation: BAA83012.1 .
    X74210 mRNA. Translation: CAA52282.1 .
    L21993 mRNA. Translation: AAA64923.1 .
    CCDSi CCDS3872.2.
    PIRi I37136.
    RefSeqi NP_065433.2. NM_020546.2.
    UniGenei Hs.481545.

    3D structure databases

    ProteinModelPortali Q08462.
    SMRi Q08462. Positions 278-464, 879-1078.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106622. 2 interactions.
    DIPi DIP-422N.
    IntActi Q08462. 1 interaction.
    STRINGi 9606.ENSP00000342952.

    Chemistry

    BindingDBi Q08462.
    ChEMBLi CHEMBL3760.

    PTM databases

    PhosphoSitei Q08462.

    Polymorphism databases

    DMDMi 118572617.

    Proteomic databases

    PaxDbi Q08462.
    PRIDEi Q08462.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338316 ; ENSP00000342952 ; ENSG00000078295 . [Q08462-1 ]
    ENST00000537121 ; ENSP00000444803 ; ENSG00000078295 . [Q08462-2 ]
    GeneIDi 108.
    KEGGi hsa:108.
    UCSCi uc003jdz.1. human.

    Organism-specific databases

    CTDi 108.
    GeneCardsi GC05P007449.
    HGNCi HGNC:233. ADCY2.
    HPAi CAB031482.
    HPA038015.
    HPA038483.
    MIMi 103071. gene.
    neXtProti NX_Q08462.
    PharmGKBi PA24561.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2114.
    HOGENOMi HOG000006941.
    HOVERGENi HBG050458.
    InParanoidi Q08462.
    KOi K08042.
    OMAi FLPYFIY.
    OrthoDBi EOG76X5ZC.
    PhylomeDBi Q08462.
    TreeFami TF313845.

    Enzyme and pathway databases

    BRENDAi 4.6.1.1. 2681.
    Reactomei REACT_15312. Adenylate cyclase activating pathway.
    REACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15530. PKA activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_1946. PKA activation in glucagon signalling.
    REACT_24023. Regulation of water balance by renal Aquaporins.

    Miscellaneous databases

    ChiTaRSi ADCY2. human.
    GeneWikii ADCY2.
    GenomeRNAii 108.
    NextBioi 419.
    PROi Q08462.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q08462.
    Bgeei Q08462.
    CleanExi HS_ADCY2.
    Genevestigatori Q08462.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view ]
    Pfami PF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of human adenylyl cyclase gene."
      Guo J.H., Yu L.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Amygdala.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-147.
    5. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-1091 (ISOFORM 1).
      Tissue: Brain.
    6. "Different chromosomal localization of two adenylyl cyclase genes expressed in human brain."
      Stengel D., Parma J., Gannage M.-H., Roeckel N., Mattei M.-G., Barouki R., Hanoune J.
      Hum. Genet. 90:126-130(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 616-1091 (ISOFORM 1).
      Tissue: Brain.
    7. "A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line."
      Hellevuo K., Yoshimura M., Kao M., Hoffman P.L., Cooper D.M.F., Tabakoff B.
      Biochem. Biophys. Res. Commun. 192:311-318(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 948-1017 (ISOFORM 1).
    8. "Raf kinase activation of adenylyl cyclases: isoform-selective regulation."
      Ding Q., Gros R., Gray I.D., Taussig R., Ferguson S.S., Feldman R.D.
      Mol. Pharmacol. 66:921-928(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY RAF1, INTERACTION WITH RAF1, ENZYME REGULATION.

    Entry informationi

    Entry nameiADCY2_HUMAN
    AccessioniPrimary (citable) accession number: Q08462
    Secondary accession number(s): B7Z2C1
    , Q2NKL8, Q9UDB2, Q9UPU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 142 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3