Reviewed,
UniProtKB/Swiss-Prot Q08462 (ADCY2_HUMAN)
Last modified
November 25, 2008.
Version 84.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Adenylate cyclase type 2 EC=4.6.1.1 Alternative name(s): Adenylate cyclase type II ATP pyrophosphate-lyase 2 Adenylyl cyclase 2 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1091 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. |
| Catalytic activity | ATP = 3',5'-cyclic AMP + diphosphate. |
| Cofactor | Binds 2 magnesium ions per subunit By similarity. |
| Enzyme regulation | Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex By similarity. |
| Subcellular location | |
| Tissue specificity | Expressed in brain. |
| Sequence similarities | Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains. |
Ontologies
Keywords | |
|---|---|
| Biological process | cAMP biosynthesis |
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat Transmembrane |
| Ligand | Magnesium Metal-binding |
| Molecular function | Lyase |
| PTM | Glycoprotein |
Gene Ontology (GO) | |
| Biological process | cAMP biosynthetic process Non-traceable author statement. Source: UniProtKB intracellular signaling cascadeInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Non-traceable author statement. Source: UniProtKB |
| Molecular function | adenylate cyclase activity Ref.4 Non-traceable author statement. Source: UniProtKB magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1091 | 1091 | Adenylate cyclase type 2 | PRO_0000195684 | |||||
Regions | |||||||||
| Topological domain | 1 – 45 | 45 | Cytoplasmic Potential | ||||||
| Transmembrane | 46 – 66 | 21 | Potential | ||||||
| Transmembrane | 76 – 96 | 21 | Potential | ||||||
| Transmembrane | 108 – 128 | 21 | Potential | ||||||
| Transmembrane | 133 – 153 | 21 | Potential | ||||||
| Transmembrane | 159 – 179 | 21 | Potential | ||||||
| Transmembrane | 187 – 207 | 21 | Potential | ||||||
| Topological domain | 208 – 601 | 394 | Cytoplasmic Potential | ||||||
| Transmembrane | 602 – 622 | 21 | Potential | ||||||
| Transmembrane | 628 – 652 | 25 | Potential | ||||||
| Transmembrane | 680 – 701 | 22 | Potential | ||||||
| Transmembrane | 734 – 755 | 22 | Potential | ||||||
| Transmembrane | 763 – 780 | 18 | Potential | ||||||
| Transmembrane | 801 – 821 | 21 | Potential | ||||||
| Topological domain | 822 – 1091 | 270 | Cytoplasmic Potential | ||||||
Sites | |||||||||
| Metal binding | 295 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 295 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 296 | 1 | Magnesium 2; via carbonyl oxygen By similarity | ||||||
| Metal binding | 339 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 339 | 1 | Magnesium 2 By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 713 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 716 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 147 | 1 | V → L: dbSNP rs13166360. | VAR_029012 | |||||
Experimental info | |||||||||
| Sequence conflict | 188 – 207 | 20 | VWQIL…LAGAY → GLADPGQCDHFHLWEPGXTN in AAP97285. Ref.1 | ||||||
| Sequence conflict | 675 | 1 | R → Q in CAA52282 and AAA64923. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning of human adenylyl cyclase gene." Guo J.H., Yu L. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-147. |
| [3] | "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed: 10470851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-1091. Tissue: Brain. |
| [4] | "Different chromosomal localization of two adenylyl cyclase genes expressed in human brain." Stengel D., Parma J., Gannage M.-H., Roeckel N., Mattei M.-G., Barouki R., Hanoune J. Hum. Genet. 90:126-130(1992) [PubMed: 1427768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 616-1091. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF410885 mRNA. Translation: AAP97285.1. BC111743 mRNA. Translation: AAI11744.1. AB028983 mRNA. Translation: BAA83012.1. X74210 mRNA. Translation: CAA52282.1. L21993 mRNA. Translation: AAA64923.1. | |
| PIR | I37136. |
| RefSeq | NP_065433.2. |
| UniGene | Hs.481545 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AB8 based on UniProtKB P26769. |
| SMR | Q08462. Positions 879-1078. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:422N. |
PTM databases | |
| PhosphoSite | Q08462. |
Genome annotation databases | |
| Ensembl | ENSG00000078295. Homo sapiens. [Contig view] |
| GeneID | 108. |
| KEGG | hsa:108. |
Organism-specific databases | |
| HGNC | HGNC:233. ADCY2. |
| MIM | 103071. gene. |
| PharmGKB | PA24561. |
| HUGE | Search... |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | Q08462. |
Gene expression databases | |
| ArrayExpress | Q08462. |
| CleanEx | HS_ADCY2. |
| GermOnline | ENSG00000078295. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001054. A/G_cyclase. IPR009398. Aden_cycl_like. [Graphical view] |
| Gene3D | G3DSA:3.30.70.1230. A/G_cyclase. 2 hits. |
| Pfam | PF06327. DUF1053. 1 hit. PF00211. Guanylate_cyc. 2 hits. [Graphical view] |
| SMART | SM00044. CYCc. 2 hits. [Graphical view] |
| PROSITE | PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 419. |
| SOURCE | Search... |
Entry information
| Entry name | ADCY2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q08462 Secondary accession number(s): Q2NKL8, Q9UPU2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


