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Protein

Adenylate cyclase type 2

Gene

ADCY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).By similarity1 Publication

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.1 Publication

Cofactori

Mg2+1 Publication, Mn2+1 PublicationNote: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).By similarity

Enzyme regulationi

Activated by forskolin (PubMed:15385642). Is not activated by calmodulin. Inhibited by calcium ions, already at micromolar concentration. Activated by the G protein alpha subunit GNAS. Activated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation (PubMed:15385642). Phosphorylation by PKC activates the enzyme (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi295 – 2951Magnesium 1; catalyticPROSITE-ProRule annotation
Metal bindingi295 – 2951Magnesium 2; catalyticPROSITE-ProRule annotation
Metal bindingi296 – 2961Magnesium 2; via carbonyl oxygen; catalyticPROSITE-ProRule annotation
Metal bindingi339 – 3391Magnesium 1; catalyticPROSITE-ProRule annotation
Metal bindingi339 – 3391Magnesium 2; catalyticPROSITE-ProRule annotation
Binding sitei383 – 3831ATPBy similarity
Binding sitei939 – 9391ATPBy similarity
Binding sitei1066 – 10661ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi295 – 3006ATPBy similarity
Nucleotide bindingi337 – 3393ATPBy similarity
Nucleotide bindingi1019 – 10213ATPBy similarity
Nucleotide bindingi1026 – 10305ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi4.6.1.1. 2681.
ReactomeiR-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-163615. PKA activation.
R-HSA-164378. PKA activation in glucagon signalling.
R-HSA-170660. Adenylate cyclase activating pathway.
R-HSA-170670. Adenylate cyclase inhibitory pathway.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-5610787. Hedgehog 'off' state.
SIGNORiQ08462.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 2 (EC:4.6.1.11 Publication)
Alternative name(s):
ATP pyrophosphate-lyase 2
Adenylate cyclase type II
Adenylyl cyclase 2
Gene namesi
Name:ADCY2
Synonyms:KIAA1060
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:233. ADCY2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545CytoplasmicSequence analysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence analysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence analysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence analysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST
Topological domaini208 – 601394CytoplasmicSequence analysisAdd
BLAST
Transmembranei602 – 62221HelicalSequence analysisAdd
BLAST
Transmembranei628 – 65225HelicalSequence analysisAdd
BLAST
Transmembranei680 – 70122HelicalSequence analysisAdd
BLAST
Transmembranei734 – 75522HelicalSequence analysisAdd
BLAST
Transmembranei763 – 78018HelicalSequence analysisAdd
BLAST
Transmembranei801 – 82121HelicalSequence analysisAdd
BLAST
Topological domaini822 – 1091270CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • dendrite Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • intracellular Source: BHF-UCL
  • membrane Source: UniProtKB
  • membrane raft Source: BHF-UCL
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24561.

Chemistry

ChEMBLiCHEMBL2097167.

Polymorphism and mutation databases

BioMutaiADCY2.
DMDMi118572617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10911091Adenylate cyclase type 2PRO_0000195684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei491 – 4911Phosphoserine; by PKCBy similarity
Modified residuei544 – 5441Phosphoserine; by PKCBy similarity
Glycosylationi713 – 7131N-linked (GlcNAc...)Sequence analysis
Glycosylationi716 – 7161N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Phosphorylated by RAF1.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ08462.
PRIDEiQ08462.

PTM databases

iPTMnetiQ08462.
PhosphoSiteiQ08462.

Expressioni

Tissue specificityi

Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus.2 Publications

Gene expression databases

BgeeiQ08462.
CleanExiHS_ADCY2.
ExpressionAtlasiQ08462. baseline and differential.
GenevisibleiQ08462. HS.

Organism-specific databases

HPAiCAB031482.
HPA038015.
HPA038483.

Interactioni

Subunit structurei

Interacts with RAF1 (PubMed:15385642). Interacts with GNAS. Interacts with the G protein beta and gamma subunit complex (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106622. 2 interactions.
DIPiDIP-422N.
IntActiQ08462. 1 interaction.
STRINGi9606.ENSP00000342952.

Structurei

3D structure databases

ProteinModelPortaliQ08462.
SMRiQ08462. Positions 278-464, 879-1078.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni905 – 92218Interaction with GNASBy similarityAdd
BLAST
Regioni990 – 9934Interaction with GNASBy similarity

Domaini

The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.By similarity

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiQ08462.
KOiK08042.
OMAiQEHSQEP.
OrthoDBiEOG76X5ZC.
PhylomeDBiQ08462.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR032628. AC_N.
IPR030672. Adcy.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF16214. AC_N. 1 hit.
PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF039050. Ade_cyc. 1 hit.
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q08462-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWQEAMRRRR YLRDRSEEAA GGGDGLPRSR DWLYESYYCM SQQHPLIVFL
60 70 80 90 100
LLIVMGSCLA LLAVFFALGL EVEDHVAFLI TVPTALAIFF AIFILVCIES
110 120 130 140 150
VFKKLLRLFS LVIWICLVAM GYLFMCFGGT VSPWDQVSFF LFIIFVVYTM
160 170 180 190 200
LPFNMRDAII ASVLTSSSHT IVLSVCLSAT PGGKEHLVWQ ILANVIIFIC
210 220 230 240 250
GNLAGAYHKH LMELALQQTY QDTCNCIKSR IKLEFEKRQQ ERLLLSLLPA
260 270 280 290 300
HIAMEMKAEI IQRLQGPKAG QMENTNNFHN LYVKRHTNVS ILYADIVGFT
310 320 330 340 350
RLASDCSPGE LVHMLNELFG KFDQIAKENE CMRIKILGDC YYCVSGLPIS
360 370 380 390 400
LPNHAKNCVK MGLDMCEAIK KVRDATGVDI NMRVGVHSGN VLCGVIGLQK
410 420 430 440 450
WQYDVWSHDV TLANHMEAGG VPGRVHISSV TLEHLNGAYK VEEGDGDIRD
460 470 480 490 500
PYLKQHLVKT YFVINPKGER RSPQHLFRPR HTLDGAKMRA SVRMTRYLES
510 520 530 540 550
WGAAKPFAHL HHRDSMTTEN GKISTTDVPM GQHNFQNRTL RTKSQKKRFE
560 570 580 590 600
EELNERMIQA IDGINAQKQW LKSEDIQRIS LLFYNKVLEK EYRATALPAF
610 620 630 640 650
KYYVTCACLI FFCIFIVQIL VLPKTSVLGI SFGAAFLLLA FILFVCFAGQ
660 670 680 690 700
LLQCSKKASP LLMWLLKSSG IIANRPWPRI SLTIITTAII LMMAVFNMFF
710 720 730 740 750
LSDSEETIPP TANTTNTSFS ASNNQVAILR AQNLFFLPYF IYSCILGLIS
760 770 780 790 800
CSVFLRVNYE LKMLIMMVAL VGYNTILLHT HAHVLGDYSQ VLFERPGIWK
810 820 830 840 850
DLKTMGSVSL SIFFITLLVL GRQNEYYCRL DFLWKNKFKK EREEIETMEN
860 870 880 890 900
LNRVLLENVL PAHVAEHFLA RSLKNEELYH QSYDCVCVMF ASIPDFKEFY
910 920 930 940 950
TESDVNKEGL ECLRLLNEII ADFDDLLSKP KFSGVEKIKT IGSTYMAATG
960 970 980 990 1000
LSAVPSQEHS QEPERQYMHI GTMVEFAFAL VGKLDAINKH SFNDFKLRVG
1010 1020 1030 1040 1050
INHGPVIAGV IGAQKPQYDI WGNTVNVASR MDSTGVLDKI QVTEETSLVL
1060 1070 1080 1090
QTLGYTCTCR GIINVKGKGD LKTYFVNTEM SRSLSQSNVA S
Length:1,091
Mass (Da):123,603
Last modified:November 28, 2006 - v5
Checksum:i41FD8BC607C075D1
GO
Isoform 2 (identifier: Q08462-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: MWQEAMRRRR...LLLIVMGSCL → MDLRWARDLH...KRWRIQREES
     60-239: Missing.

Note: No experimental confirmation available.
Show »
Length:911
Mass (Da):103,158
Checksum:i658C0FA201D0E85E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 20720VWQIL…LAGAY → GLADPGQCDHFHLWEPGXTN in AAP97285 (Ref. 1) CuratedAdd
BLAST
Sequence conflicti675 – 6751R → Q in CAA52282 (PubMed:1427768).Curated
Sequence conflicti675 – 6751R → Q in AAA64923 (PubMed:1427768).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti147 – 1471V → L.1 Publication
Corresponds to variant rs13166360 [ dbSNP | Ensembl ].
VAR_029012
Natural varianti163 – 1631V → I.
Corresponds to variant rs34043481 [ dbSNP | Ensembl ].
VAR_048247

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5959MWQEA…MGSCL → MDLRWARDLHLREASRSVAF TTLRLGAVTTGLLTFREPGD KEKSGKGLGKRWRIQREES in isoform 2. 1 PublicationVSP_055811Add
BLAST
Alternative sequencei60 – 239180Missing in isoform 2. 1 PublicationVSP_055812Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410885 mRNA. Translation: AAP97285.1.
AK294555 mRNA. Translation: BAH11807.1.
AC010346 Genomic DNA. No translation available.
AC010437 Genomic DNA. No translation available.
AC024577 Genomic DNA. No translation available.
AC093305 Genomic DNA. No translation available.
AC113366 Genomic DNA. No translation available.
BC111743 mRNA. Translation: AAI11744.1.
AB028983 mRNA. Translation: BAA83012.1.
X74210 mRNA. Translation: CAA52282.1.
L21993 mRNA. Translation: AAA64923.1.
CCDSiCCDS3872.2. [Q08462-1]
PIRiI37136.
RefSeqiNP_065433.2. NM_020546.2. [Q08462-1]
UniGeneiHs.481545.

Genome annotation databases

EnsembliENST00000338316; ENSP00000342952; ENSG00000078295. [Q08462-1]
GeneIDi108.
KEGGihsa:108.
UCSCiuc003jdz.2. human. [Q08462-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410885 mRNA. Translation: AAP97285.1.
AK294555 mRNA. Translation: BAH11807.1.
AC010346 Genomic DNA. No translation available.
AC010437 Genomic DNA. No translation available.
AC024577 Genomic DNA. No translation available.
AC093305 Genomic DNA. No translation available.
AC113366 Genomic DNA. No translation available.
BC111743 mRNA. Translation: AAI11744.1.
AB028983 mRNA. Translation: BAA83012.1.
X74210 mRNA. Translation: CAA52282.1.
L21993 mRNA. Translation: AAA64923.1.
CCDSiCCDS3872.2. [Q08462-1]
PIRiI37136.
RefSeqiNP_065433.2. NM_020546.2. [Q08462-1]
UniGeneiHs.481545.

3D structure databases

ProteinModelPortaliQ08462.
SMRiQ08462. Positions 278-464, 879-1078.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106622. 2 interactions.
DIPiDIP-422N.
IntActiQ08462. 1 interaction.
STRINGi9606.ENSP00000342952.

Chemistry

ChEMBLiCHEMBL2097167.

PTM databases

iPTMnetiQ08462.
PhosphoSiteiQ08462.

Polymorphism and mutation databases

BioMutaiADCY2.
DMDMi118572617.

Proteomic databases

PaxDbiQ08462.
PRIDEiQ08462.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338316; ENSP00000342952; ENSG00000078295. [Q08462-1]
GeneIDi108.
KEGGihsa:108.
UCSCiuc003jdz.2. human. [Q08462-1]

Organism-specific databases

CTDi108.
GeneCardsiADCY2.
HGNCiHGNC:233. ADCY2.
HPAiCAB031482.
HPA038015.
HPA038483.
MIMi103071. gene.
neXtProtiNX_Q08462.
PharmGKBiPA24561.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiQ08462.
KOiK08042.
OMAiQEHSQEP.
OrthoDBiEOG76X5ZC.
PhylomeDBiQ08462.
TreeFamiTF313845.

Enzyme and pathway databases

BRENDAi4.6.1.1. 2681.
ReactomeiR-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-163615. PKA activation.
R-HSA-164378. PKA activation in glucagon signalling.
R-HSA-170660. Adenylate cyclase activating pathway.
R-HSA-170670. Adenylate cyclase inhibitory pathway.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-5610787. Hedgehog 'off' state.
SIGNORiQ08462.

Miscellaneous databases

ChiTaRSiADCY2. human.
GeneWikiiADCY2.
GenomeRNAii108.
PROiQ08462.
SOURCEiSearch...

Gene expression databases

BgeeiQ08462.
CleanExiHS_ADCY2.
ExpressionAtlasiQ08462. baseline and differential.
GenevisibleiQ08462. HS.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR032628. AC_N.
IPR030672. Adcy.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF16214. AC_N. 1 hit.
PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF039050. Ade_cyc. 1 hit.
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human adenylyl cyclase gene."
    Guo J.H., Yu L.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Amygdala.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-147.
  5. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-1091 (ISOFORM 1).
    Tissue: Brain.
  6. "Different chromosomal localization of two adenylyl cyclase genes expressed in human brain."
    Stengel D., Parma J., Gannage M.-H., Roeckel N., Mattei M.-G., Barouki R., Hanoune J.
    Hum. Genet. 90:126-130(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 616-1091 (ISOFORM 1).
    Tissue: Brain.
  7. "A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line."
    Hellevuo K., Yoshimura M., Kao M., Hoffman P.L., Cooper D.M.F., Tabakoff B.
    Biochem. Biophys. Res. Commun. 192:311-318(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 948-1017 (ISOFORM 1), TISSUE SPECIFICITY.
  8. "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland."
    Cote M., Guillon G., Payet M.D., Gallo-Payet N.
    J. Clin. Endocrinol. Metab. 86:4495-4503(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  9. "Raf kinase activation of adenylyl cyclases: isoform-selective regulation."
    Ding Q., Gros R., Gray I.D., Taussig R., Ferguson S.S., Feldman R.D.
    Mol. Pharmacol. 66:921-928(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, COFACTOR, ENZYME REGULATION, PHOSPHORYLATION BY RAF1, SUBCELLULAR LOCATION, INTERACTION WITH RAF1.
  10. "Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains."
    Bogard A.S., Xu C., Ostrom R.S.
    J. Pharmacol. Exp. Ther. 337:209-217(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiADCY2_HUMAN
AccessioniPrimary (citable) accession number: Q08462
Secondary accession number(s): B7Z2C1
, Q2NKL8, Q9UDB2, Q9UPU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 28, 2006
Last modified: June 8, 2016
This is version 158 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.