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Q08462

- ADCY2_HUMAN

UniProt

Q08462 - ADCY2_HUMAN

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Protein

Adenylate cyclase type 2

Gene

ADCY2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 2 magnesium ions per subunit.By similarity

Enzyme regulationi

Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi295 – 2951Magnesium 1PROSITE-ProRule annotation
Metal bindingi295 – 2951Magnesium 2PROSITE-ProRule annotation
Metal bindingi296 – 2961Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi339 – 3391Magnesium 1PROSITE-ProRule annotation
Metal bindingi339 – 3391Magnesium 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. adenylate cyclase activity Source: UniProtKB
  2. adenylate cyclase binding Source: BHF-UCL
  3. ATP binding Source: UniProtKB-KW
  4. calcium- and calmodulin-responsive adenylate cyclase activity Source: Ensembl
  5. metal ion binding Source: UniProtKB-KW
  6. protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

  1. activation of phospholipase C activity Source: Reactome
  2. activation of protein kinase A activity Source: Reactome
  3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Reactome
  4. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Reactome
  5. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: BHF-UCL
  6. cAMP biosynthetic process Source: BHF-UCL
  7. cellular response to glucagon stimulus Source: Reactome
  8. energy reserve metabolic process Source: Reactome
  9. epidermal growth factor receptor signaling pathway Source: Reactome
  10. fibroblast growth factor receptor signaling pathway Source: Reactome
  11. innate immune response Source: Reactome
  12. intracellular signal transduction Source: InterPro
  13. neurotrophin TRK receptor signaling pathway Source: Reactome
  14. signal transduction Source: Reactome
  15. small molecule metabolic process Source: Reactome
  16. synaptic transmission Source: Reactome
  17. transmembrane transport Source: Reactome
  18. water transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi4.6.1.1. 2681.
ReactomeiREACT_15312. Adenylate cyclase activating pathway.
REACT_15333. Adenylate cyclase inhibitory pathway.
REACT_15530. PKA activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_1946. PKA activation in glucagon signalling.
REACT_24023. Regulation of water balance by renal Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 2 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 2
Adenylate cyclase type II
Adenylyl cyclase 2
Gene namesi
Name:ADCY2
Synonyms:KIAA1060
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:233. ADCY2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. dendrite Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. intracellular Source: BHF-UCL
  5. membrane Source: UniProtKB
  6. membrane raft Source: BHF-UCL
  7. plasma membrane Source: UniProtKB
  8. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24561.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10911091Adenylate cyclase type 2PRO_0000195684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi713 – 7131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi716 – 7161N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated by RAF1.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ08462.
PRIDEiQ08462.

PTM databases

PhosphoSiteiQ08462.

Expressioni

Tissue specificityi

Expressed in brain.

Gene expression databases

BgeeiQ08462.
CleanExiHS_ADCY2.
ExpressionAtlasiQ08462. baseline and differential.
GenevestigatoriQ08462.

Organism-specific databases

HPAiCAB031482.
HPA038015.
HPA038483.

Interactioni

Subunit structurei

Interacts with RAF1.1 Publication

Protein-protein interaction databases

BioGridi106622. 2 interactions.
DIPiDIP-422N.
IntActiQ08462. 1 interaction.
STRINGi9606.ENSP00000342952.

Structurei

3D structure databases

ProteinModelPortaliQ08462.
SMRiQ08462. Positions 278-464, 879-1078.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini208 – 601394CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini822 – 1091270CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei46 – 6621HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Transmembranei602 – 62221HelicalSequence AnalysisAdd
BLAST
Transmembranei628 – 65225HelicalSequence AnalysisAdd
BLAST
Transmembranei680 – 70122HelicalSequence AnalysisAdd
BLAST
Transmembranei734 – 75522HelicalSequence AnalysisAdd
BLAST
Transmembranei763 – 78018HelicalSequence AnalysisAdd
BLAST
Transmembranei801 – 82121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiQ08462.
KOiK08042.
OMAiFLPYFIY.
OrthoDBiEOG76X5ZC.
PhylomeDBiQ08462.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q08462-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWQEAMRRRR YLRDRSEEAA GGGDGLPRSR DWLYESYYCM SQQHPLIVFL
60 70 80 90 100
LLIVMGSCLA LLAVFFALGL EVEDHVAFLI TVPTALAIFF AIFILVCIES
110 120 130 140 150
VFKKLLRLFS LVIWICLVAM GYLFMCFGGT VSPWDQVSFF LFIIFVVYTM
160 170 180 190 200
LPFNMRDAII ASVLTSSSHT IVLSVCLSAT PGGKEHLVWQ ILANVIIFIC
210 220 230 240 250
GNLAGAYHKH LMELALQQTY QDTCNCIKSR IKLEFEKRQQ ERLLLSLLPA
260 270 280 290 300
HIAMEMKAEI IQRLQGPKAG QMENTNNFHN LYVKRHTNVS ILYADIVGFT
310 320 330 340 350
RLASDCSPGE LVHMLNELFG KFDQIAKENE CMRIKILGDC YYCVSGLPIS
360 370 380 390 400
LPNHAKNCVK MGLDMCEAIK KVRDATGVDI NMRVGVHSGN VLCGVIGLQK
410 420 430 440 450
WQYDVWSHDV TLANHMEAGG VPGRVHISSV TLEHLNGAYK VEEGDGDIRD
460 470 480 490 500
PYLKQHLVKT YFVINPKGER RSPQHLFRPR HTLDGAKMRA SVRMTRYLES
510 520 530 540 550
WGAAKPFAHL HHRDSMTTEN GKISTTDVPM GQHNFQNRTL RTKSQKKRFE
560 570 580 590 600
EELNERMIQA IDGINAQKQW LKSEDIQRIS LLFYNKVLEK EYRATALPAF
610 620 630 640 650
KYYVTCACLI FFCIFIVQIL VLPKTSVLGI SFGAAFLLLA FILFVCFAGQ
660 670 680 690 700
LLQCSKKASP LLMWLLKSSG IIANRPWPRI SLTIITTAII LMMAVFNMFF
710 720 730 740 750
LSDSEETIPP TANTTNTSFS ASNNQVAILR AQNLFFLPYF IYSCILGLIS
760 770 780 790 800
CSVFLRVNYE LKMLIMMVAL VGYNTILLHT HAHVLGDYSQ VLFERPGIWK
810 820 830 840 850
DLKTMGSVSL SIFFITLLVL GRQNEYYCRL DFLWKNKFKK EREEIETMEN
860 870 880 890 900
LNRVLLENVL PAHVAEHFLA RSLKNEELYH QSYDCVCVMF ASIPDFKEFY
910 920 930 940 950
TESDVNKEGL ECLRLLNEII ADFDDLLSKP KFSGVEKIKT IGSTYMAATG
960 970 980 990 1000
LSAVPSQEHS QEPERQYMHI GTMVEFAFAL VGKLDAINKH SFNDFKLRVG
1010 1020 1030 1040 1050
INHGPVIAGV IGAQKPQYDI WGNTVNVASR MDSTGVLDKI QVTEETSLVL
1060 1070 1080 1090
QTLGYTCTCR GIINVKGKGD LKTYFVNTEM SRSLSQSNVA S
Length:1,091
Mass (Da):123,603
Last modified:November 28, 2006 - v5
Checksum:i41FD8BC607C075D1
GO
Isoform 2 (identifier: Q08462-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: MWQEAMRRRR...LLLIVMGSCL → MDLRWARDLH...KRWRIQREES
     60-239: Missing.

Note: No experimental confirmation available.

Show »
Length:911
Mass (Da):103,158
Checksum:i658C0FA201D0E85E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 20720VWQIL…LAGAY → GLADPGQCDHFHLWEPGXTN in AAP97285. 1 PublicationCuratedAdd
BLAST
Sequence conflicti675 – 6751R → Q in CAA52282. (PubMed:1427768)Curated
Sequence conflicti675 – 6751R → Q in AAA64923. (PubMed:1427768)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti147 – 1471V → L.1 Publication
Corresponds to variant rs13166360 [ dbSNP | Ensembl ].
VAR_029012
Natural varianti163 – 1631V → I.
Corresponds to variant rs34043481 [ dbSNP | Ensembl ].
VAR_048247

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5959MWQEA…MGSCL → MDLRWARDLHLREASRSVAF TTLRLGAVTTGLLTFREPGD KEKSGKGLGKRWRIQREES in isoform 2. 1 PublicationVSP_055811Add
BLAST
Alternative sequencei60 – 239180Missing in isoform 2. 1 PublicationVSP_055812Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF410885 mRNA. Translation: AAP97285.1.
AK294555 mRNA. Translation: BAH11807.1.
AC010346 Genomic DNA. No translation available.
AC010437 Genomic DNA. No translation available.
AC024577 Genomic DNA. No translation available.
AC093305 Genomic DNA. No translation available.
AC113366 Genomic DNA. No translation available.
BC111743 mRNA. Translation: AAI11744.1.
AB028983 mRNA. Translation: BAA83012.1.
X74210 mRNA. Translation: CAA52282.1.
L21993 mRNA. Translation: AAA64923.1.
CCDSiCCDS3872.2. [Q08462-1]
PIRiI37136.
RefSeqiNP_065433.2. NM_020546.2. [Q08462-1]
UniGeneiHs.481545.

Genome annotation databases

EnsembliENST00000338316; ENSP00000342952; ENSG00000078295. [Q08462-1]
GeneIDi108.
KEGGihsa:108.
UCSCiuc003jdz.1. human. [Q08462-1]

Polymorphism databases

DMDMi118572617.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF410885 mRNA. Translation: AAP97285.1 .
AK294555 mRNA. Translation: BAH11807.1 .
AC010346 Genomic DNA. No translation available.
AC010437 Genomic DNA. No translation available.
AC024577 Genomic DNA. No translation available.
AC093305 Genomic DNA. No translation available.
AC113366 Genomic DNA. No translation available.
BC111743 mRNA. Translation: AAI11744.1 .
AB028983 mRNA. Translation: BAA83012.1 .
X74210 mRNA. Translation: CAA52282.1 .
L21993 mRNA. Translation: AAA64923.1 .
CCDSi CCDS3872.2. [Q08462-1 ]
PIRi I37136.
RefSeqi NP_065433.2. NM_020546.2. [Q08462-1 ]
UniGenei Hs.481545.

3D structure databases

ProteinModelPortali Q08462.
SMRi Q08462. Positions 278-464, 879-1078.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106622. 2 interactions.
DIPi DIP-422N.
IntActi Q08462. 1 interaction.
STRINGi 9606.ENSP00000342952.

Chemistry

BindingDBi Q08462.
ChEMBLi CHEMBL2097167.

PTM databases

PhosphoSitei Q08462.

Polymorphism databases

DMDMi 118572617.

Proteomic databases

PaxDbi Q08462.
PRIDEi Q08462.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338316 ; ENSP00000342952 ; ENSG00000078295 . [Q08462-1 ]
GeneIDi 108.
KEGGi hsa:108.
UCSCi uc003jdz.1. human. [Q08462-1 ]

Organism-specific databases

CTDi 108.
GeneCardsi GC05P007449.
HGNCi HGNC:233. ADCY2.
HPAi CAB031482.
HPA038015.
HPA038483.
MIMi 103071. gene.
neXtProti NX_Q08462.
PharmGKBi PA24561.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2114.
GeneTreei ENSGT00760000119042.
HOGENOMi HOG000006941.
HOVERGENi HBG050458.
InParanoidi Q08462.
KOi K08042.
OMAi FLPYFIY.
OrthoDBi EOG76X5ZC.
PhylomeDBi Q08462.
TreeFami TF313845.

Enzyme and pathway databases

BRENDAi 4.6.1.1. 2681.
Reactomei REACT_15312. Adenylate cyclase activating pathway.
REACT_15333. Adenylate cyclase inhibitory pathway.
REACT_15530. PKA activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_1946. PKA activation in glucagon signalling.
REACT_24023. Regulation of water balance by renal Aquaporins.

Miscellaneous databases

ChiTaRSi ADCY2. human.
GeneWikii ADCY2.
GenomeRNAii 108.
NextBioi 35478960.
PROi Q08462.
SOURCEi Search...

Gene expression databases

Bgeei Q08462.
CleanExi HS_ADCY2.
ExpressionAtlasi Q08462. baseline and differential.
Genevestigatori Q08462.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
IPR029787. Nucleotide_cyclase.
[Graphical view ]
Pfami PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human adenylyl cyclase gene."
    Guo J.H., Yu L.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Amygdala.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-147.
  5. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-1091 (ISOFORM 1).
    Tissue: Brain.
  6. "Different chromosomal localization of two adenylyl cyclase genes expressed in human brain."
    Stengel D., Parma J., Gannage M.-H., Roeckel N., Mattei M.-G., Barouki R., Hanoune J.
    Hum. Genet. 90:126-130(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 616-1091 (ISOFORM 1).
    Tissue: Brain.
  7. "A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line."
    Hellevuo K., Yoshimura M., Kao M., Hoffman P.L., Cooper D.M.F., Tabakoff B.
    Biochem. Biophys. Res. Commun. 192:311-318(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 948-1017 (ISOFORM 1).
  8. "Raf kinase activation of adenylyl cyclases: isoform-selective regulation."
    Ding Q., Gros R., Gray I.D., Taussig R., Ferguson S.S., Feldman R.D.
    Mol. Pharmacol. 66:921-928(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY RAF1, INTERACTION WITH RAF1, ENZYME REGULATION.

Entry informationi

Entry nameiADCY2_HUMAN
AccessioniPrimary (citable) accession number: Q08462
Secondary accession number(s): B7Z2C1
, Q2NKL8, Q9UDB2, Q9UPU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 28, 2006
Last modified: October 29, 2014
This is version 143 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3