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Protein

Putative lipase YOR059C

Gene

YOR059C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  • lysophospholipase activity Source: SGD

GO - Biological processi

  • lipid catabolic process Source: UniProtKB-KW
  • lipid homeostasis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciYEAST:G3O-33599-MONOMER.

Protein family/group databases

ESTHERiyeast-yo059. Duf_676.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative lipase YOR059C (EC:3.1.-.-)
Gene namesi
Ordered Locus Names:YOR059C
ORF Names:YOR29-10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR059C.
SGDiS000005585. YOR059C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei269 – 28921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • lipid particle Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Putative lipase YOR059CPRO_0000237649Add
BLAST

Proteomic databases

MaxQBiQ08448.

Interactioni

Protein-protein interaction databases

BioGridi34458. 19 interactions.
DIPiDIP-4169N.
IntActiQ08448. 8 interactions.
MINTiMINT-484035.

Structurei

3D structure databases

ProteinModelPortaliQ08448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the putative lipase ROG1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000013022.
HOGENOMiHOG000141742.
InParanoidiQ08448.
OMAiTAFITDC.
OrthoDBiEOG7MSMZJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR007751. DUF676_lipase-like.
[Graphical view]
PfamiPF05057. DUF676. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSDKHLFVL IHGLWGNYTH MESMRTILST TLKKEDVNDD MIYFLPKQNA
60 70 80 90 100
MFKTFDGIEI IGYRTLIEVC EFIRDYKDGK ITKLSVMGYS QGGLVARFMI
110 120 130 140 150
GKMLTEFKEL FEDIEPQLFI TMATPHLGVE FYNPTGIAYK SALYSALRTL
160 170 180 190 200
GSTILGKSGR EMFIANSSNN ILVKLSQGEY LEALSLFKWR IAFANVKNDR
210 220 230 240 250
TVAFYTAFIT DCDPFIDFDN KLKYTFEEKI PGSGYKGILP KIVDLNALNV
260 270 280 290 300
NSHAPTKPTK TYKKWGRTIL IILVATFLIL PIALVMNGLG TAYSYIVTCK
310 320 330 340 350
YRKMLSNGIL HNEVRGKLGL TEQLKGYVTD AYGSIINSAL DMDANYEASN
360 370 380 390 400
SNLVNEEELP WKEFIQKYTT INDGVWKSKF KKLPFDENRK VILRNLNKLK
410 420 430 440 450
WIRVPIYIKA VNAHGVIVAR RGMDENTAAT GIACIEFTAQ LLAYLMHKSN
Length:450
Mass (Da):51,106
Last modified:November 1, 1996 - v1
Checksum:iE04CCDA6FCE96AAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70678 Genomic DNA. Translation: CAA94544.1.
Z74967 Genomic DNA. Translation: CAA99252.1.
BK006948 Genomic DNA. Translation: DAA10838.1.
PIRiS66942.
RefSeqiNP_014702.1. NM_001183478.1.

Genome annotation databases

EnsemblFungiiYOR059C; YOR059C; YOR059C.
GeneIDi854225.
KEGGisce:YOR059C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70678 Genomic DNA. Translation: CAA94544.1.
Z74967 Genomic DNA. Translation: CAA99252.1.
BK006948 Genomic DNA. Translation: DAA10838.1.
PIRiS66942.
RefSeqiNP_014702.1. NM_001183478.1.

3D structure databases

ProteinModelPortaliQ08448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34458. 19 interactions.
DIPiDIP-4169N.
IntActiQ08448. 8 interactions.
MINTiMINT-484035.

Protein family/group databases

ESTHERiyeast-yo059. Duf_676.

Proteomic databases

MaxQBiQ08448.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR059C; YOR059C; YOR059C.
GeneIDi854225.
KEGGisce:YOR059C.

Organism-specific databases

EuPathDBiFungiDB:YOR059C.
SGDiS000005585. YOR059C.

Phylogenomic databases

GeneTreeiENSGT00390000013022.
HOGENOMiHOG000141742.
InParanoidiQ08448.
OMAiTAFITDC.
OrthoDBiEOG7MSMZJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-33599-MONOMER.

Miscellaneous databases

NextBioi976097.
PROiQ08448.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR007751. DUF676_lipase-like.
[Graphical view]
PfamiPF05057. DUF676. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of a 54.7 kb fragment of yeast chromosome XV reveals the presence of two tRNAs and 24 new open reading frames."
    Valens M., Bohn C., Daignan-Fornier B., Dang V.-D., Bolotin-Fukuhara M.
    Yeast 13:379-390(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae."
    Athenstaedt K., Zweytick D., Jandrositz A., Kohlwein S.D., Daum G.
    J. Bacteriol. 181:6441-6448(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYO059_YEAST
AccessioniPrimary (citable) accession number: Q08448
Secondary accession number(s): D6W2C2, O00022
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1210 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.