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Q08431

- MFGM_HUMAN

UniProt

Q08431 - MFGM_HUMAN

Protein

Lactadherin

Gene

MFGE8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization By similarity. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.By similarity1 Publication
    Medin is the main constituent of aortic medial amyloid.1 Publication

    GO - Molecular functioni

    1. phosphatidylethanolamine binding Source: Ensembl
    2. phosphatidylserine binding Source: Ensembl

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. cell adhesion Source: UniProtKB-KW
    3. phagocytosis, engulfment Source: Ensembl
    4. phagocytosis, recognition Source: Ensembl
    5. positive regulation of apoptotic cell clearance Source: Ensembl
    6. single fertilization Source: UniProtKB-KW
    7. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Angiogenesis, Cell adhesion, Fertilization, Host-virus interaction

    Enzyme and pathway databases

    ReactomeiREACT_75925. Amyloids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lactadherin
    Alternative name(s):
    Breast epithelial antigen BA46
    HMFG
    MFGM
    Milk fat globule-EGF factor 8
    Short name:
    MFG-E8
    SED1
    Cleaved into the following 2 chains:
    Gene namesi
    Name:MFGE8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:7036. MFGE8.

    Subcellular locationi

    Membrane 1 Publication; Peripheral membrane protein 1 Publication. Secreted 1 Publication

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular region Source: Reactome
    3. extracellular space Source: UniProt
    4. extracellular vesicular exosome Source: UniProtKB
    5. extrinsic component of plasma membrane Source: Ensembl
    6. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Amyloid, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30772.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Add
    BLAST
    Chaini24 – 387364LactadherinPRO_0000007650Add
    BLAST
    Chaini202 – 387186Lactadherin short formPRO_0000007651Add
    BLAST
    Chaini268 – 31750MedinPRO_0000007652Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 38By similarity
    Disulfide bondi32 ↔ 55By similarity
    Disulfide bondi57 ↔ 66By similarity
    Disulfide bondi70 ↔ 225By similarity
    Disulfide bondi212 ↔ 216By similarity
    Glycosylationi228 – 2281N-linked (GlcNAc...); atypical1 Publication
    Disulfide bondi230 ↔ 387By similarity
    Glycosylationi238 – 2381N-linked (GlcNAc...)1 Publication
    Glycosylationi325 – 3251N-linked (GlcNAc...)1 Publication
    Glycosylationi329 – 3291N-linked (GlcNAc...)1 Publication
    Glycosylationi350 – 3501N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ08431.
    PaxDbiQ08431.
    PRIDEiQ08431.

    PTM databases

    PhosphoSiteiQ08431.

    Expressioni

    Tissue specificityi

    Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.

    Gene expression databases

    ArrayExpressiQ08431.
    BgeeiQ08431.
    CleanExiHS_MFGE8.
    GenevestigatoriQ08431.

    Organism-specific databases

    HPAiCAB002753.
    HPA002807.

    Interactioni

    Protein-protein interaction databases

    BioGridi110398. 2 interactions.
    IntActiQ08431. 1 interaction.
    MINTiMINT-5004478.
    STRINGi9606.ENSP00000268150.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08431.
    SMRiQ08431. Positions 27-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 6744EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini70 – 225156F5/8 type C 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini230 – 387158F5/8 type C 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 483Cell attachment site

    Domaini

    The F5/8 type C 2 domain mediates high-affinity binding to phosphatidylserine-containing membranes.By similarity

    Sequence similaritiesi

    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 2 F5/8 type C domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG151024.
    HOGENOMiHOG000236278.
    HOVERGENiHBG002385.
    InParanoidiQ08431.
    KOiK17253.
    PhylomeDBiQ08431.
    TreeFamiTF330156.

    Family and domain databases

    Gene3Di2.60.120.260. 2 hits.
    InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR008979. Galactose-bd-like.
    IPR027060. Lactadherin.
    [Graphical view]
    PANTHERiPTHR10127:SF303. PTHR10127:SF303. 1 hit.
    PfamiPF00008. EGF. 1 hit.
    PF00754. F5_F8_type_C. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 1 hit.
    SM00231. FA58C. 2 hits.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 2 hits.
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS01285. FA58C_1. 2 hits.
    PS01286. FA58C_2. 2 hits.
    PS50022. FA58C_3. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q08431-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPRPRLLAAL CGALLCAPSL LVALDICSKN PCHNGGLCEE ISQEVRGDVF    50
    PSYTCTCLKG YAGNHCETKC VEPLGMENGN IANSQIAASS VRVTFLGLQH 100
    WVPELARLNR AGMVNAWTPS SNDDNPWIQV NLLRRMWVTG VVTQGASRLA 150
    SHEYLKAFKV AYSLNGHEFD FIHDVNKKHK EFVGNWNKNA VHVNLFETPV 200
    EAQYVRLYPT SCHTACTLRF ELLGCELNGC ANPLGLKNNS IPDKQITASS 250
    SYKTWGLHLF SWNPSYARLD KQGNFNAWVA GSYGNDQWLQ VDLGSSKEVT 300
    GIITQGARNF GSVQFVASYK VAYSNDSANW TEYQDPRTGS SKIFPGNWDN 350
    HSHKKNLFET PILARYVRIL PVAWHNRIAL RLELLGC 387
    Length:387
    Mass (Da):43,123
    Last modified:November 1, 1997 - v2
    Checksum:i2EE6571DEC83782D
    GO
    Isoform 2 (identifier: Q08431-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-75: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:312
    Mass (Da):35,189
    Checksum:i9E3857A7E7096C8B
    GO
    Isoform 3 (identifier: Q08431-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         291-342: Missing.

    Show »
    Length:335
    Mass (Da):37,523
    Checksum:i20E84E5DB78E8E25
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti268 – 2681R → W in CAD97938. 1 PublicationCurated
    Sequence conflicti352 – 3521S → T in CAD97938. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31R → S.
    Corresponds to variant rs4945 [ dbSNP | Ensembl ].
    VAR_029794
    Natural varianti76 – 761M → L.3 Publications
    Corresponds to variant rs1878326 [ dbSNP | Ensembl ].
    VAR_024263

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7575Missing in isoform 2. 1 PublicationVSP_039108Add
    BLAST
    Alternative sequencei291 – 34252Missing in isoform 3. 2 PublicationsVSP_039953Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58516 mRNA. Translation: AAC50549.1.
    AY141974 mRNA. Translation: AAN08508.1.
    BT006948 mRNA. Translation: AAP35594.1.
    AK312640 mRNA. Translation: BAG35524.1.
    AK223182 mRNA. Translation: BAD96902.1.
    AK222735 mRNA. Translation: BAD96455.1.
    BX537974 mRNA. Translation: CAD97938.1.
    AC067805 Genomic DNA. No translation available.
    CH471101 Genomic DNA. Translation: EAX02026.1.
    BC003610 mRNA. Translation: AAH03610.1.
    S56151 mRNA. Translation: AAB19771.1.
    CCDSiCCDS10347.1. [Q08431-1]
    CCDS45345.1. [Q08431-3]
    PIRiA47285.
    RefSeqiNP_001108086.1. NM_001114614.1.
    NP_005919.2. NM_005928.2.
    UniGeneiHs.3745.

    Genome annotation databases

    EnsembliENST00000268150; ENSP00000268150; ENSG00000140545.
    ENST00000566497; ENSP00000456281; ENSG00000140545.
    GeneIDi4240.
    KEGGihsa:4240.
    UCSCiuc002bnf.4. human. [Q08431-1]
    uc002bnh.4. human. [Q08431-3]

    Polymorphism databases

    DMDMi2506380.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58516 mRNA. Translation: AAC50549.1 .
    AY141974 mRNA. Translation: AAN08508.1 .
    BT006948 mRNA. Translation: AAP35594.1 .
    AK312640 mRNA. Translation: BAG35524.1 .
    AK223182 mRNA. Translation: BAD96902.1 .
    AK222735 mRNA. Translation: BAD96455.1 .
    BX537974 mRNA. Translation: CAD97938.1 .
    AC067805 Genomic DNA. No translation available.
    CH471101 Genomic DNA. Translation: EAX02026.1 .
    BC003610 mRNA. Translation: AAH03610.1 .
    S56151 mRNA. Translation: AAB19771.1 .
    CCDSi CCDS10347.1. [Q08431-1 ]
    CCDS45345.1. [Q08431-3 ]
    PIRi A47285.
    RefSeqi NP_001108086.1. NM_001114614.1.
    NP_005919.2. NM_005928.2.
    UniGenei Hs.3745.

    3D structure databases

    ProteinModelPortali Q08431.
    SMRi Q08431. Positions 27-387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110398. 2 interactions.
    IntActi Q08431. 1 interaction.
    MINTi MINT-5004478.
    STRINGi 9606.ENSP00000268150.

    PTM databases

    PhosphoSitei Q08431.

    Polymorphism databases

    DMDMi 2506380.

    Proteomic databases

    MaxQBi Q08431.
    PaxDbi Q08431.
    PRIDEi Q08431.

    Protocols and materials databases

    DNASUi 4240.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000268150 ; ENSP00000268150 ; ENSG00000140545 .
    ENST00000566497 ; ENSP00000456281 ; ENSG00000140545 .
    GeneIDi 4240.
    KEGGi hsa:4240.
    UCSCi uc002bnf.4. human. [Q08431-1 ]
    uc002bnh.4. human. [Q08431-3 ]

    Organism-specific databases

    CTDi 4240.
    GeneCardsi GC15M089441.
    H-InvDB HIX0012558.
    HGNCi HGNC:7036. MFGE8.
    HPAi CAB002753.
    HPA002807.
    MIMi 602281. gene.
    neXtProti NX_Q08431.
    PharmGKBi PA30772.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG151024.
    HOGENOMi HOG000236278.
    HOVERGENi HBG002385.
    InParanoidi Q08431.
    KOi K17253.
    PhylomeDBi Q08431.
    TreeFami TF330156.

    Enzyme and pathway databases

    Reactomei REACT_75925. Amyloids.

    Miscellaneous databases

    ChiTaRSi MFGE8. human.
    GeneWikii MFGE8.
    GenomeRNAii 4240.
    NextBioi 16719.
    PROi Q08431.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q08431.
    Bgeei Q08431.
    CleanExi HS_MFGE8.
    Genevestigatori Q08431.

    Family and domain databases

    Gene3Di 2.60.120.260. 2 hits.
    InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR008979. Galactose-bd-like.
    IPR027060. Lactadherin.
    [Graphical view ]
    PANTHERi PTHR10127:SF303. PTHR10127:SF303. 1 hit.
    Pfami PF00008. EGF. 1 hit.
    PF00754. F5_F8_type_C. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 1 hit.
    SM00231. FA58C. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 2 hits.
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS01285. FA58C_1. 2 hits.
    PS01286. FA58C_2. 2 hits.
    PS50022. FA58C_3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented on an epidermal growth factor-like domain."
      Couto J.R., Taylor M.R., Godwin S.G., Ceriani R.L., Peterson J.A.
      DNA Cell Biol. 15:281-286(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Mammary carcinoma and Mammary gland.
    2. "Characterization of human epididymal protein."
      Sivashanmugam P., Richardson R.T., Hamil K.G., Hall S.H., French F.S., O'Rand M.G.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-76.
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-76.
      Tissue: Dermoid cancer and Pancreas.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Retina.
    7. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-76.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Skin.
    10. "A Mr 46,000 human milk fat globule protein that is highly expressed in human breast tumors contains factor VIII-like domains."
      Larocca D., Peterson J.A., Urrea R., Kuniyoshi J., Bistrain A.M., Ceriani R.L.
      Cancer Res. 51:4994-4998(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 170-387.
      Tissue: Mammary gland.
    11. "Isolation and characterization of full and truncated forms of human breast carcinoma protein BA46 from human milk fat globule membranes."
      Giuffrida M.G., Cavaletto M., Giunta C., Conti A., Godovac-Zimmermann J.
      J. Protein Chem. 17:143-148(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
      Tissue: Milk.
    12. "Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid."
      Haeggqvist B., Naeslund J., Sletten K., Westermark G.T., Mucchiano G., Tjernberg L.O., Nordstedt C., Engstroem U., Westermark P.
      Proc. Natl. Acad. Sci. U.S.A. 96:8669-8674(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 268-317, IDENTIFICATION OF MEDIN.
    13. "Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion."
      Taylor M.R., Couto J.R., Scallan C.D., Ceriani R.L., Peterson J.A.
      DNA Cell Biol. 16:861-869(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    14. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
      Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
      Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-228; ASN-238; ASN-325; ASN-329 AND ASN-350.
      Tissue: Milk.
    15. "SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions."
      Raymond A., Ensslin M.A., Shur B.D.
      J. Cell. Biochem. 106:957-966(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiMFGM_HUMAN
    AccessioniPrimary (citable) accession number: Q08431
    Secondary accession number(s): B2R6M7
    , Q53FU9, Q7Z3D2, Q9BTL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 134 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3