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Protein

Trefoil factor 1

Gene

Tff1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: MGI
  • digestion Source: GO_Central
  • maintenance of gastrointestinal epithelium Source: InterPro
  • negative regulation of cell proliferation Source: MGI
  • response to wounding Source: MGI
  • wound healing Source: GO_Central

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 1
Alternative name(s):
Protein pS2
Gene namesi
Name:Tff1
Synonyms:Bcei, Ps2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:88135 Tff1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Or 23Sequence analysisAdd BLAST21
ChainiPRO_000002345722 – 87Trefoil factor 1Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22Pyrrolidone carboxylic acidSequence analysis1
Disulfide bondi34 ↔ 60PROSITE-ProRule annotation
Disulfide bondi44 ↔ 59PROSITE-ProRule annotation
Disulfide bondi54 ↔ 71PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ08423
PeptideAtlasiQ08423
PRIDEiQ08423

Expressioni

Tissue specificityi

Strong expression found in normal gastric mucosa. Not detected in the small or large intestine nor in normal mammary gland.

Gene expression databases

BgeeiENSMUSG00000024032
CleanExiMM_TFF1
ExpressionAtlasiQ08423 baseline and differential
GenevisibleiQ08423 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024831

Structurei

3D structure databases

ProteinModelPortaliQ08423
SMRiQ08423
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 75P-typePROSITE-ProRule annotationAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi82 – 84Glu-rich (acidic)3

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J868 Eukaryota
ENOG410Z7FU LUCA
GeneTreeiENSGT00840000129881
HOGENOMiHOG000121778
HOVERGENiHBG004364
InParanoidiQ08423
KOiK22456
OMAiPEEECEF
OrthoDBiEOG091G0XBT
PhylomeDBiQ08423
TreeFamiTF336092

Family and domain databases

CDDicd00111 Trefoil, 1 hit
InterProiView protein in InterPro
IPR017994 P_trefoil_chordata
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
IPR028824 TFF1
PANTHERiPTHR13826:SF18 PTHR13826:SF18, 1 hit
PfamiView protein in Pfam
PF00088 Trefoil, 1 hit
PRINTSiPR00680 PTREFOIL
SMARTiView protein in SMART
SM00018 PD, 1 hit
PROSITEiView protein in PROSITE
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKVICVLA VVLMLAFGSL AQAQAQAQAQ EETCIMAPRE RINCGFPGVT
60 70 80
AQQCTERGCC FDDSVRGFPW CFHPMAIENT QEEECPF
Length:87
Mass (Da):9,670
Last modified:October 1, 1994 - v1
Checksum:i193B9ED3D72E71DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21858 mRNA Translation: CAA79913.1
AJ271002 Genomic DNA Translation: CAB65750.1
AK008625 mRNA Translation: BAB25787.1
AK008809 mRNA Translation: BAB25907.1
AK008873 mRNA Translation: BAB25943.1
AK010179 mRNA Translation: BAB26751.1
AK131896 mRNA Translation: BAE20857.1
AK160174 mRNA Translation: BAE35673.1
CCDSiCCDS37546.1
PIRiA40700
RefSeqiNP_033388.1, NM_009362.2
UniGeneiMm.2854

Genome annotation databases

EnsembliENSMUST00000024831; ENSMUSP00000024831; ENSMUSG00000024032
GeneIDi21784
KEGGimmu:21784
UCSCiuc008buo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTFF1_MOUSE
AccessioniPrimary (citable) accession number: Q08423
Secondary accession number(s): Q3TVE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 25, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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