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Protein

Trefoil factor 1

Gene

Tff1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: MGI
  • digestion Source: GO_Central
  • maintenance of gastrointestinal epithelium Source: Ensembl
  • negative regulation of cell proliferation Source: MGI
  • response to immobilization stress Source: Ensembl
  • response to iron ion Source: Ensembl
  • response to peptide hormone Source: Ensembl
  • response to wounding Source: MGI
  • wound healing Source: GO_Central

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 1
Alternative name(s):
Protein pS2
Gene namesi
Name:Tff1
Synonyms:Bcei, Ps2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:88135. Tff1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Or 23Sequence analysisAdd BLAST21
ChainiPRO_000002345722 – 87Trefoil factor 1Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22Pyrrolidone carboxylic acidSequence analysis1
Disulfide bondi34 ↔ 60PROSITE-ProRule annotation
Disulfide bondi44 ↔ 59PROSITE-ProRule annotation
Disulfide bondi54 ↔ 71PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ08423.
PeptideAtlasiQ08423.
PRIDEiQ08423.

Expressioni

Tissue specificityi

Strong expression found in normal gastric mucosa. Not detected in the small or large intestine nor in normal mammary gland.

Gene expression databases

BgeeiENSMUSG00000024032.
CleanExiMM_TFF1.
ExpressionAtlasiQ08423. baseline and differential.
GenevisibleiQ08423. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024831.

Structurei

3D structure databases

ProteinModelPortaliQ08423.
SMRiQ08423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 75P-typePROSITE-ProRule annotationAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi82 – 84Glu-rich (acidic)3

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J868. Eukaryota.
ENOG410Z7FU. LUCA.
GeneTreeiENSGT00840000129881.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiQ08423.
OMAiPEEECEF.
OrthoDBiEOG091G0XBT.
PhylomeDBiQ08423.
TreeFamiTF336092.

Family and domain databases

CDDicd00111. Trefoil. 1 hit.
InterProiView protein in InterPro
IPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
IPR028824. TFF1.
PANTHERiPTHR13826:SF18. PTHR13826:SF18. 1 hit.
PfamiView protein in Pfam
PF00088. Trefoil. 1 hit.
PRINTSiPR00680. PTREFOIL.
SMARTiView protein in SMART
SM00018. PD. 1 hit.
PROSITEiView protein in PROSITE
PS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKVICVLA VVLMLAFGSL AQAQAQAQAQ EETCIMAPRE RINCGFPGVT
60 70 80
AQQCTERGCC FDDSVRGFPW CFHPMAIENT QEEECPF
Length:87
Mass (Da):9,670
Last modified:October 1, 1994 - v1
Checksum:i193B9ED3D72E71DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21858 mRNA. Translation: CAA79913.1.
AJ271002 Genomic DNA. Translation: CAB65750.1.
AK008625 mRNA. Translation: BAB25787.1.
AK008809 mRNA. Translation: BAB25907.1.
AK008873 mRNA. Translation: BAB25943.1.
AK010179 mRNA. Translation: BAB26751.1.
AK131896 mRNA. Translation: BAE20857.1.
AK160174 mRNA. Translation: BAE35673.1.
CCDSiCCDS37546.1.
PIRiA40700.
RefSeqiNP_033388.1. NM_009362.2.
UniGeneiMm.2854.

Genome annotation databases

EnsembliENSMUST00000024831; ENSMUSP00000024831; ENSMUSG00000024032.
GeneIDi21784.
KEGGimmu:21784.
UCSCiuc008buo.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiTFF1_MOUSE
AccessioniPrimary (citable) accession number: Q08423
Secondary accession number(s): Q3TVE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 25, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot