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Protein

Trefoil factor 1

Gene

Tff1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.

GO - Biological processi

  • cell differentiation Source: MGI
  • maintenance of gastrointestinal epithelium Source: Ensembl
  • negative regulation of cell proliferation Source: MGI
  • response to immobilization stress Source: Ensembl
  • response to iron ion Source: Ensembl
  • response to peptide hormone Source: Ensembl
  • response to wounding Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 1
Alternative name(s):
Protein pS2
Gene namesi
Name:Tff1
Synonyms:Bcei, Ps2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:88135. Tff1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Or 23Sequence analysisAdd
BLAST
Chaini22 – 8766Trefoil factor 1PRO_0000023457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Pyrrolidone carboxylic acidSequence analysis
Disulfide bondi34 ↔ 60PROSITE-ProRule annotation
Disulfide bondi44 ↔ 59PROSITE-ProRule annotation
Disulfide bondi54 ↔ 71PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ08423.
PRIDEiQ08423.

Expressioni

Tissue specificityi

Strong expression found in normal gastric mucosa. Not detected in the small or large intestine nor in normal mammary gland.

Gene expression databases

BgeeiQ08423.
CleanExiMM_TFF1.
ExpressionAtlasiQ08423. baseline and differential.
GenevisibleiQ08423. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024831.

Structurei

3D structure databases

ProteinModelPortaliQ08423.
SMRiQ08423. Positions 28-87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 7544P-typePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi82 – 843Glu-rich (acidic)

Sequence similaritiesi

Contains 1 P-type (trefoil) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J868. Eukaryota.
ENOG410Z7FU. LUCA.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiQ08423.
OMAiPEEECEF.
OrthoDBiEOG70W3GT.
PhylomeDBiQ08423.
TreeFamiTF336092.

Family and domain databases

Gene3Di4.10.110.10. 1 hit.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 1 hit.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 1 hit.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 1 hit.
PROSITEiPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKVICVLA VVLMLAFGSL AQAQAQAQAQ EETCIMAPRE RINCGFPGVT
60 70 80
AQQCTERGCC FDDSVRGFPW CFHPMAIENT QEEECPF
Length:87
Mass (Da):9,670
Last modified:October 1, 1994 - v1
Checksum:i193B9ED3D72E71DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21858 mRNA. Translation: CAA79913.1.
AJ271002 Genomic DNA. Translation: CAB65750.1.
AK008625 mRNA. Translation: BAB25787.1.
AK008809 mRNA. Translation: BAB25907.1.
AK008873 mRNA. Translation: BAB25943.1.
AK010179 mRNA. Translation: BAB26751.1.
AK131896 mRNA. Translation: BAE20857.1.
AK160174 mRNA. Translation: BAE35673.1.
CCDSiCCDS37546.1.
PIRiA40700.
RefSeqiNP_033388.1. NM_009362.2.
UniGeneiMm.2854.

Genome annotation databases

EnsembliENSMUST00000024831; ENSMUSP00000024831; ENSMUSG00000024032.
GeneIDi21784.
KEGGimmu:21784.
UCSCiuc008buo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21858 mRNA. Translation: CAA79913.1.
AJ271002 Genomic DNA. Translation: CAB65750.1.
AK008625 mRNA. Translation: BAB25787.1.
AK008809 mRNA. Translation: BAB25907.1.
AK008873 mRNA. Translation: BAB25943.1.
AK010179 mRNA. Translation: BAB26751.1.
AK131896 mRNA. Translation: BAE20857.1.
AK160174 mRNA. Translation: BAE35673.1.
CCDSiCCDS37546.1.
PIRiA40700.
RefSeqiNP_033388.1. NM_009362.2.
UniGeneiMm.2854.

3D structure databases

ProteinModelPortaliQ08423.
SMRiQ08423. Positions 28-87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024831.

Proteomic databases

PaxDbiQ08423.
PRIDEiQ08423.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024831; ENSMUSP00000024831; ENSMUSG00000024032.
GeneIDi21784.
KEGGimmu:21784.
UCSCiuc008buo.1. mouse.

Organism-specific databases

CTDi7031.
MGIiMGI:88135. Tff1.

Phylogenomic databases

eggNOGiENOG410J868. Eukaryota.
ENOG410Z7FU. LUCA.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiQ08423.
OMAiPEEECEF.
OrthoDBiEOG70W3GT.
PhylomeDBiQ08423.
TreeFamiTF336092.

Miscellaneous databases

NextBioi301128.
PROiQ08423.
SOURCEiSearch...

Gene expression databases

BgeeiQ08423.
CleanExiMM_TFF1.
ExpressionAtlasiQ08423. baseline and differential.
GenevisibleiQ08423. MM.

Family and domain databases

Gene3Di4.10.110.10. 1 hit.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 1 hit.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 1 hit.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 1 hit.
PROSITEiPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression."
    Lefebvre O., Wolf C., Kedinger M., Chenard M.-P., Tomasetto C., Chambon P., Rio M.-C.
    J. Cell Biol. 122:191-198(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Mouse trefoil factor genes: genomic organization, sequences and methylation analyses."
    Ribieras S., Lefebvre O., Tomasetto C., Rio M.C.
    Gene 266:67-75(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Stomach and Tongue.

Entry informationi

Entry nameiTFF1_MOUSE
AccessioniPrimary (citable) accession number: Q08423
Secondary accession number(s): Q3TVE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: December 9, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.