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Protein

ATP-dependent permease AUS1

Gene

AUS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Transporter involved in the uptake of sterol.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi782 – 789ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • sterol-transporting ATPase activity Source: SGD
  • xenobiotic-transporting ATPase activity Source: GO_Central

GO - Biological processi

  • cellular response to drug Source: GO_Central
  • sterol import Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33561-MONOMER.

Protein family/group databases

TCDBi3.A.1.205.15. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent permease AUS1
Gene namesi
Name:AUS1
Ordered Locus Names:YOR011W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR011W.
SGDiS000005537. AUS1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 420CytoplasmicSequence analysisAdd BLAST419
Transmembranei421 – 443HelicalSequence analysisAdd BLAST23
Transmembranei468 – 490HelicalSequence analysisAdd BLAST23
Transmembranei497 – 519HelicalSequence analysisAdd BLAST23
Transmembranei529 – 551HelicalSequence analysisAdd BLAST23
Transmembranei558 – 575HelicalSequence analysisAdd BLAST18
Transmembranei636 – 658HelicalSequence analysisAdd BLAST23
Topological domaini659 – 1080CytoplasmicSequence analysisAdd BLAST422
Transmembranei1081 – 1103HelicalSequence analysisAdd BLAST23
Transmembranei1107 – 1129HelicalSequence analysisAdd BLAST23
Transmembranei1156 – 1178HelicalSequence analysisAdd BLAST23
Transmembranei1193 – 1215HelicalSequence analysisAdd BLAST23
Transmembranei1224 – 1246HelicalSequence analysisAdd BLAST23
Transmembranei1346 – 1368HelicalSequence analysisAdd BLAST23
Topological domaini1369 – 1394CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000934342 – 1394ATP-dependent permease AUS1Add BLAST1393

Proteomic databases

PRIDEiQ08409.

Interactioni

Protein-protein interaction databases

BioGridi34416. 63 interactors.
DIPiDIP-994N.
IntActiQ08409. 20 interactors.
MINTiMINT-4084107.

Structurei

3D structure databases

ProteinModelPortaliQ08409.
SMRiQ08409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 273ABC transporter 1PROSITE-ProRule annotationAdd BLAST241
Domaini751 – 978ABC transporter 2PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075308.
HOGENOMiHOG000162078.
InParanoidiQ08409.
OMAiSALWESS.
OrthoDBiEOG092C1HKF.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISKYFTPV ADGSLTFNGA NIQFGADAQG ESKKSYDAED SMPNPANQLN
60 70 80 90 100
DITFQAEAGE MVLVLGYPTS TLFKTLFHGK TSLSYSPPGS IKFKNNEFKS
110 120 130 140 150
FSEKCPHQII YNNEQDVHFP FLTVEQTIDF ALSCKFDIPK GERDQIRNEL
160 170 180 190 200
LREFGLSHVL KTIVGNDFFR GVSGGERKRI SIIETFIANG SVYLWDNSTK
210 220 230 240 250
GLDSATALDF LEILRKMAKA TRSVNLVRIS QASDKIVDKF DKILMLSDSY
260 270 280 290 300
QLFYGTVDEC LTYFRDTLGI EKDPNDCIIE YLTSILNFQF KNKNLGNLSN
310 320 330 340 350
SSSASVLKTA TGEVTKYTYN SDFDLYDQWK HSSYYRNIKQ QIQGSSIDDS
360 370 380 390 400
IKEVDPSDVS PIFNIPLKKQ LLFCTKRAFQ RSLGDKAYMT AQFISVVIQS
410 420 430 440 450
LVIGSLFYEI PLTTIGSYSR GSLTFFSILF FTFLSLADMP IAFQRQPVVK
460 470 480 490 500
KQSQLHFYTN WVETLSTTVF DYCFKLCLVI VFSIILYFLA HLQYKAARFF
510 520 530 540 550
IFLLFLSFYN FCMVSLFALT TLVAPTISVA NLFAGILLLA IAMYASYVIY
560 570 580 590 600
LKNMHPWFVW IAYLNPAMYA MEAILSNELY NLKLDCSETI VPRGPTYNDV
610 620 630 640 650
PFSHKACAWQ GATLGNDYVR GRDYLKQGLS YTYHHVWRNF GIIIGFLVFF
660 670 680 690 700
IACTLFASQY IKPYFNKDEI ERNNSRLTRW LPFLNKKRGT RSSARNDSKY
710 720 730 740 750
VGIPKSHSVS SSSSSLSAVP YQISPSNKEM ALNDYNEQPI TETVETQKHI
760 770 780 790 800
ISWKNINYTV GTKKLINNAS GFISSGLTAL MGESGAGKTT LLNVLSQRVE
810 820 830 840 850
TGVVSGEILI DGHPLTDEDA FKRSIGFVQQ QDLHLDLLSV KESLEISCLL
860 870 880 890 900
RGDGDRAYLD TVSNLLKLPS DILVADLNPT QRKLLSIGVE LVTKPSLLLF
910 920 930 940 950
LDEPTSGLDA EAALTIVKFL KQLSLQGQAI FCTIHQPSKS VISHFDNIFL
960 970 980 990 1000
LKRGGECVFF GPMDDACGYF MSHDNTLVYD KEHDNPADFV IDAVGNSNSS
1010 1020 1030 1040 1050
AGKDTAEEAL TLNKEAIDWS ALWESSVEKK LVKKETARLE DDARASGVDY
1060 1070 1080 1090 1100
TTSLWKQPSY LQQLALITRR QYICTKRDMT YVMAKYCLNG GAGLFIGFSF
1110 1120 1130 1140 1150
WHIKHNIIGL QDSIFFCFMA LCVSSPLINQ IQDKALKTKE VYVAREARSN
1160 1170 1180 1190 1200
TYHWTVLLLS QSIIELPLAL TSSTLFFVCA FFSCGFNNAG WSAGVFFLNY
1210 1220 1230 1240 1250
MLFAAYYSTL GLWLIYTAPN LQTAAVFVAF IYSFTASFCG VMQPYSLFPT
1260 1270 1280 1290 1300
FWKFMYRVSP YTYFVETFVS ILLHNWEIKC DMSEMVPGQP LTGQSCGQFM
1310 1320 1330 1340 1350
EAFIEEYGGY LHNKNTFTVC AYCTYTVGDD FLKNENMSYD HVWRNFGIEW
1360 1370 1380 1390
AFVGFNFFAM FAGYYLTYVA RIWPKVFKII TKVIPHRGKK PVQN
Length:1,394
Mass (Da):157,751
Last modified:November 1, 1996 - v1
Checksum:i357A35A0FCF0C93B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74919 Genomic DNA. Translation: CAA99199.1.
Z74920 Genomic DNA. Translation: CAA99202.1.
BK006948 Genomic DNA. Translation: DAA10794.1.
PIRiS66876.
RefSeqiNP_014654.1. NM_001183430.1.

Genome annotation databases

EnsemblFungiiYOR011W; YOR011W; YOR011W.
GeneIDi854175.
KEGGisce:YOR011W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74919 Genomic DNA. Translation: CAA99199.1.
Z74920 Genomic DNA. Translation: CAA99202.1.
BK006948 Genomic DNA. Translation: DAA10794.1.
PIRiS66876.
RefSeqiNP_014654.1. NM_001183430.1.

3D structure databases

ProteinModelPortaliQ08409.
SMRiQ08409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34416. 63 interactors.
DIPiDIP-994N.
IntActiQ08409. 20 interactors.
MINTiMINT-4084107.

Protein family/group databases

TCDBi3.A.1.205.15. the atp-binding cassette (abc) superfamily.

Proteomic databases

PRIDEiQ08409.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR011W; YOR011W; YOR011W.
GeneIDi854175.
KEGGisce:YOR011W.

Organism-specific databases

EuPathDBiFungiDB:YOR011W.
SGDiS000005537. AUS1.

Phylogenomic databases

GeneTreeiENSGT00550000075308.
HOGENOMiHOG000162078.
InParanoidiQ08409.
OMAiSALWESS.
OrthoDBiEOG092C1HKF.

Enzyme and pathway databases

BioCyciYEAST:G3O-33561-MONOMER.

Miscellaneous databases

PROiQ08409.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAUS1_YEAST
AccessioniPrimary (citable) accession number: Q08409
Secondary accession number(s): D6W278, O94147
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.