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Reviewed, UniProtKB/Swiss-Prot Q08409 (AUS1_YEAST)

Last modified June 16, 2009. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ATP-dependent permease AUS1
Gene names
Name: AUS1
Ordered Locus Names: YOR011W
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length1394 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Transporter involved in the uptake of sterol. Ref.2

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the ABC transporter family. PDR subfamily.

Contains 2 ABC transporter domains.

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Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainRepeat
Transmembrane
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processsterol transport Ref.2

Inferred from mutant phenotype. Source: SGD

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrion

Inferred from direct assay. Source: SGD

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity, coupled to transmembrane movement of substances

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13941394ATP-dependent permease AUS1
PRO_0000093434

Regions

Topological domain1 – 388388Cytoplasmic Potential
Transmembrane389 – 40820 Potential
Transmembrane421 – 44323 Potential
Transmembrane468 – 49023 Potential
Transmembrane497 – 51923 Potential
Transmembrane529 – 55123 Potential
Transmembrane558 – 57518 Potential
Transmembrane636 – 65823 Potential
Topological domain659 – 1080422Cytoplasmic Potential
Transmembrane1081 – 110323 Potential
Transmembrane1107 – 112923 Potential
Transmembrane1156 – 117823 Potential
Transmembrane1193 – 121523 Potential
Transmembrane1224 – 124623 Potential
Transmembrane1346 – 136823 Potential
Topological domain1369 – 139426Cytoplasmic Potential
Domain33 – 273241ABC transporter 1
Domain751 – 978228ABC transporter 2
Nucleotide binding782 – 7898ATP Potential

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Sequences

Sequence LengthMass (Da)Tools
Q08409-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 357A35A0FCF0C93B

FASTA1,394157,751
        10         20         30         40         50         60 
MSISKYFTPV ADGSLTFNGA NIQFGADAQG ESKKSYDAED SMPNPANQLN DITFQAEAGE 

        70         80         90        100        110        120 
MVLVLGYPTS TLFKTLFHGK TSLSYSPPGS IKFKNNEFKS FSEKCPHQII YNNEQDVHFP 

       130        140        150        160        170        180 
FLTVEQTIDF ALSCKFDIPK GERDQIRNEL LREFGLSHVL KTIVGNDFFR GVSGGERKRI 

       190        200        210        220        230        240 
SIIETFIANG SVYLWDNSTK GLDSATALDF LEILRKMAKA TRSVNLVRIS QASDKIVDKF 

       250        260        270        280        290        300 
DKILMLSDSY QLFYGTVDEC LTYFRDTLGI EKDPNDCIIE YLTSILNFQF KNKNLGNLSN 

       310        320        330        340        350        360 
SSSASVLKTA TGEVTKYTYN SDFDLYDQWK HSSYYRNIKQ QIQGSSIDDS IKEVDPSDVS 

       370        380        390        400        410        420 
PIFNIPLKKQ LLFCTKRAFQ RSLGDKAYMT AQFISVVIQS LVIGSLFYEI PLTTIGSYSR 

       430        440        450        460        470        480 
GSLTFFSILF FTFLSLADMP IAFQRQPVVK KQSQLHFYTN WVETLSTTVF DYCFKLCLVI 

       490        500        510        520        530        540 
VFSIILYFLA HLQYKAARFF IFLLFLSFYN FCMVSLFALT TLVAPTISVA NLFAGILLLA 

       550        560        570        580        590        600 
IAMYASYVIY LKNMHPWFVW IAYLNPAMYA MEAILSNELY NLKLDCSETI VPRGPTYNDV 

       610        620        630        640        650        660 
PFSHKACAWQ GATLGNDYVR GRDYLKQGLS YTYHHVWRNF GIIIGFLVFF IACTLFASQY 

       670        680        690        700        710        720 
IKPYFNKDEI ERNNSRLTRW LPFLNKKRGT RSSARNDSKY VGIPKSHSVS SSSSSLSAVP 

       730        740        750        760        770        780 
YQISPSNKEM ALNDYNEQPI TETVETQKHI ISWKNINYTV GTKKLINNAS GFISSGLTAL 

       790        800        810        820        830        840 
MGESGAGKTT LLNVLSQRVE TGVVSGEILI DGHPLTDEDA FKRSIGFVQQ QDLHLDLLSV 

       850        860        870        880        890        900 
KESLEISCLL RGDGDRAYLD TVSNLLKLPS DILVADLNPT QRKLLSIGVE LVTKPSLLLF 

       910        920        930        940        950        960 
LDEPTSGLDA EAALTIVKFL KQLSLQGQAI FCTIHQPSKS VISHFDNIFL LKRGGECVFF 

       970        980        990       1000       1010       1020 
GPMDDACGYF MSHDNTLVYD KEHDNPADFV IDAVGNSNSS AGKDTAEEAL TLNKEAIDWS 

      1030       1040       1050       1060       1070       1080 
ALWESSVEKK LVKKETARLE DDARASGVDY TTSLWKQPSY LQQLALITRR QYICTKRDMT 

      1090       1100       1110       1120       1130       1140 
YVMAKYCLNG GAGLFIGFSF WHIKHNIIGL QDSIFFCFMA LCVSSPLINQ IQDKALKTKE 

      1150       1160       1170       1180       1190       1200 
VYVAREARSN TYHWTVLLLS QSIIELPLAL TSSTLFFVCA FFSCGFNNAG WSAGVFFLNY 

      1210       1220       1230       1240       1250       1260 
MLFAAYYSTL GLWLIYTAPN LQTAAVFVAF IYSFTASFCG VMQPYSLFPT FWKFMYRVSP 

      1270       1280       1290       1300       1310       1320 
YTYFVETFVS ILLHNWEIKC DMSEMVPGQP LTGQSCGQFM EAFIEEYGGY LHNKNTFTVC 

      1330       1340       1350       1360       1370       1380 
AYCTYTVGDD FLKNENMSYD HVWRNFGIEW AFVGFNFFAM FAGYYLTYVA RIWPKVFKII 

      1390 
TKVIPHRGKK PVQN

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References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed: 9169874] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast."
Wilcox L.J., Balderes D.A., Wharton B., Tinkelenberg A.H., Rao G., Sturley S.L.
J. Biol. Chem. 277:32466-32472(2002) [PubMed: 12077145] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z74919 Genomic DNA. Translation: CAA99199.1.
Z74920 Genomic DNA. Translation: CAA99202.1.
PIRS66876.
RefSeqNP_014654.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:994N.
IntActQ08409. 21 interactions.

Genome annotation databases

EnsemblYOR011W. Saccharomyces cerevisiae. [Contig view]
GeneID854175.
GenomeReviewsGene locus YOR011W in contig Y13140_GR.
KEGGsce:YOR011W.
NMPDRfig|4932.3.peg.5750.

Organism-specific databases

CYGDYOR011w.
SGDS000005537. AUS1.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMQ08409.
OMAQ08409. VRISQAS.

Gene expression databases

ArrayExpressQ08409.
GermOnlineYOR011W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR003593. ATPase_AAA+_core.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF06422. PDR_CDR. 2 hits.
[Graphical view]
ProDomPD000006. ABC_transporter. 2 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
PROSITEPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio975973.

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Entry information

Entry nameAUS1_YEAST
AccessionPrimary (citable) accession number: Q08409
Secondary accession number(s): O94147
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents