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Protein

Sensor protein RprX

Gene

rprX

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system RprX/RprY. May activate RprY by phosphorylation.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • phosphorelay sensor kinase activity Source: UniProtKB

GO - Biological processi

  • phosphorelay signal transduction system Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 755.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein RprX (EC:2.7.13.3)
Gene namesi
Name:rprX
Ordered Locus Names:BF3865
OrganismiBacteroides fragilis (strain YCH46)
Taxonomic identifieri295405 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000002197 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • intracellular Source: GOC
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Sensor protein RprXPRO_0000074864Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei299 – 2991Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ08408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini296 – 517222Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 histidine kinase domain.PROSITE-ProRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK07636.
OMAiNNETHAQ.
OrthoDBiPOG091H02OU.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKSTIWILG IIMGLSFLSL LYLQVSYIEE MVKMRKEQFN TSVRNALFQV
60 70 80 90 100
SKDVEYDETQ RWLLEDITEA ERRALAQSSS TTEQKNGLIQ QSERYRFKSP
110 120 130 140 150
DGTLYSEFEL KMITTEPSKV PKAMISERHG RNTIPQTSRS LTDAIKNRYM
160 170 180 190 200
YQRFLLDDVA LRMIYKASDK SIGERVNFKK LDNYLKSNFI NNGVELLYHF
210 220 230 240 250
SVIDKDGREV YRCSDYEDGG SEDSYTQPLF QNDPPAKMSI VKVHFPGKKD
260 270 280 290 300
YIFDSVSFMI PSMIFTIVLL ITFIFTIYIV FRQKKLTEMK NDFINNMTHE
310 320 330 340 350
FKTPISTISL AAQMLKDPAV GKSPQMFQHI SGVINDETKR LRFQVEKVLQ
360 370 380 390 400
MSMFDRQKAT LKMKELDANE LITGVINTFA LKVERYNGKI TSNLEATNPV
410 420 430 440 450
IFADEMHITN VIFNLMDNAV KYKKPEEDLV LNVRTWNEPG KLMISIQDNG
460 470 480 490 500
IGIKKENLKK VFDKFYRVHT GNLHDVKGFG LGLAYVKKII QDHKGTIRAE
510
SELNVGTKFI IALPLLKND
Length:519
Mass (Da):59,977
Last modified:November 23, 2004 - v2
Checksum:i88937AC6695218C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201L → W in AAB26173 (PubMed:8469117).Curated
Sequence conflicti33 – 331K → R in AAB26173 (PubMed:8469117).Curated
Sequence conflicti156 – 1561L → S in AAB26173 (PubMed:8469117).Curated
Sequence conflicti194 – 1941V → I in AAB26173 (PubMed:8469117).Curated
Sequence conflicti218 – 2181D → E in AAB26173 (PubMed:8469117).Curated
Sequence conflicti248 – 2481K → N in AAB26173 (PubMed:8469117).Curated
Sequence conflicti267 – 2671I → F in AAB26173 (PubMed:8469117).Curated
Sequence conflicti320 – 3201V → F in AAB26173 (PubMed:8469117).Curated
Sequence conflicti373 – 3731T → S in AAB26173 (PubMed:8469117).Curated
Sequence conflicti408 – 4081I → M in AAB26173 (PubMed:8469117).Curated
Sequence conflicti432 – 4321N → D in AAB26173 (PubMed:8469117).Curated
Sequence conflicti468 – 4681V → C in AAB26173 (PubMed:8469117).Curated
Sequence conflicti504 – 5041N → I in AAB26173 (PubMed:8469117).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S59000 Genomic DNA. Translation: AAB26173.2.
AP006841 Genomic DNA. Translation: BAD50607.1.
PIRiS33661.
RefSeqiWP_005790953.1. NC_006347.1.
YP_101141.1. NC_006347.1.

Genome annotation databases

EnsemblBacteriaiBAD50607; BAD50607; BF3865.
GeneIDi3084946.
KEGGibfr:BF3865.
PATRICi21053266. VBIBacFra17906_3710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S59000 Genomic DNA. Translation: AAB26173.2.
AP006841 Genomic DNA. Translation: BAD50607.1.
PIRiS33661.
RefSeqiWP_005790953.1. NC_006347.1.
YP_101141.1. NC_006347.1.

3D structure databases

ProteinModelPortaliQ08408.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD50607; BAD50607; BF3865.
GeneIDi3084946.
KEGGibfr:BF3865.
PATRICi21053266. VBIBacFra17906_3710.

Phylogenomic databases

KOiK07636.
OMAiNNETHAQ.
OrthoDBiPOG091H02OU.

Enzyme and pathway databases

BRENDAi2.7.13.3. 755.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPRX_BACFR
AccessioniPrimary (citable) accession number: Q08408
Secondary accession number(s): Q64PH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.