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Protein

Major pollen allergen Cor a 1 isoforms 5, 6, 11 and 16

Gene
N/A
Organism
Corylus avellana (European hazel) (Corylus maxima)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major pollen allergen Cor a 1 isoforms 5, 6, 11 and 16
Alternative name(s):
Allergen Cor a I
Allergen: Cor a 1
OrganismiCorylus avellana (European hazel) (Corylus maxima)
Taxonomic identifieri13451 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeCorylus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. The Cor a 1 isoforms display different antigenic and allergenic properties.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei232. Cor a 1.
233. Cor a 1.0101.
234. Cor a 1.0102.
235. Cor a 1.0103.
236. Cor a 1.0104.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 160159Major pollen allergen Cor a 1 isoforms 5, 6, 11 and 16PRO_0000154187Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ08407.
SMRiQ08407. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVFNYEVET PSVIPAARLF KSYVLDGDKL IPKVAPQAIT SVENVEGNGG
60 70 80 90 100
PGTIKNITFG EGSRYKYVKE RVDEVDNTNF TYSYTVIEGD VLGDKLEKVC
110 120 130 140 150
HELKIVAAPG GGSILKISSK FHAKGDHEIN AEEMKGAKEM AEKLLRAVET
160
YLLAHSAEYN
Length:160
Mass (Da):17,512
Last modified:January 23, 2007 - v3
Checksum:i1FA022ABE8884E48
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81V → A in clone COR A 1/11.
Natural varianti11 – 111P → T in clone COR A 1/11.
Natural varianti15 – 151P → S in clone COR A 1/16.
Natural varianti46 – 461E → G in clone COR A 1/16.
Natural varianti81 – 811T → K in clone COR A 1/6 and 1/16.
Natural varianti101 – 1011H → S in clone COR A 1/6 and 1/16.
Natural varianti114 – 1141I → T in clone COR A 1/16.
Natural varianti134 – 1341M → I in clone COR A 1/11.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70999 mRNA. Translation: CAA50327.1.
X71000 mRNA. Translation: CAA50328.1.
X70997 mRNA. Translation: CAA50325.1.
X70998 mRNA. Translation: CAA50326.1.
PIRiS30053.
S30054.
S30055.
S30056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70999 mRNA. Translation: CAA50327.1.
X71000 mRNA. Translation: CAA50328.1.
X70997 mRNA. Translation: CAA50325.1.
X70998 mRNA. Translation: CAA50326.1.
PIRiS30053.
S30054.
S30055.
S30056.

3D structure databases

ProteinModelPortaliQ08407.
SMRiQ08407. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei232. Cor a 1.
233. Cor a 1.0101.
234. Cor a 1.0102.
235. Cor a 1.0103.
236. Cor a 1.0104.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPAC1_CORAV
AccessioniPrimary (citable) accession number: Q08407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The sequence shown is that of clone Cor a I/5.

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.