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Protein

Ciliary neurotrophic factor receptor subunit alpha

Gene

Cntfr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to CNTF. The alpha subunit provides the receptor specificity.

GO - Molecular functioni

  • ciliary neurotrophic factor receptor activity Source: RGD

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor receptor subunit alpha
Short name:
CNTF receptor subunit alpha
Short name:
CNTFR-alpha
Gene namesi
Name:Cntfr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303100 Cntfr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001099523 – 342Ciliary neurotrophic factor receptor subunit alphaAdd BLAST320
PropeptideiPRO_0000010996343 – 372Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 89PROSITE-ProRule annotation
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi342GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ08406
PRIDEiQ08406

PTM databases

SwissPalmiQ08406

Expressioni

Tissue specificityi

Nervous system.

Interactioni

Subunit structurei

Heterotrimer of the alpha subunit, LIFR and IL6ST.

Protein-protein interaction databases

BioGridi260344, 2 interactors
IntActiQ08406, 2 interactors
STRINGi10116.ENSRNOP00000066185

Structurei

3D structure databases

ProteinModelPortaliQ08406
SMRiQ08406
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 104Ig-like C2-typeAdd BLAST78
Domaini108 – 205Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini206 – 306Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi290 – 294WSXWS motif5

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IH2U Eukaryota
ENOG4110HUW LUCA
HOVERGENiHBG051048
InParanoidiQ08406
KOiK05059
PhylomeDBiQ08406

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003530 Hematopoietin_rcpt_L_F3_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01354 HEMATOPO_REC_L_F3, 1 hit
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASVPWACC AVLAAAAAAV YTQKHSPQEA PHVQYERLGT DVTLPCGTAS
60 70 80 90 100
WDAAVTWRVN GTDLAPDLLN GSQLILRSLE LGHSGLYACF HRDSWHLRHQ
110 120 130 140 150
VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LSAPTYIPNT FNVTVLHGSK
160 170 180 190 200
MMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN TTAITFDEFT
210 220 230 240 250
IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI
260 270 280 290 300
LDQWQHVELS NGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT
310 320 330 340 350
PWTEEPRHLT TEAQAPETTT STTSSLAPPP TTKICDPGEL SSGGGPSIPF
360 370
LTSVPVTLVL AAAAATANNL LI
Length:372
Mass (Da):40,822
Last modified:November 1, 1995 - v2
Checksum:i3B87EE63923FB149
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261N → D in AAB25918 (PubMed:8460125).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54212 mRNA Translation: AAB25290.1
S57711 mRNA Translation: AAB25918.1
PIRiI58141
RefSeqiNP_001003929.1, NM_001003929.1
UniGeneiRn.55036

Genome annotation databases

GeneIDi313173
KEGGirno:313173

Similar proteinsi

Entry informationi

Entry nameiCNTFR_RAT
AccessioniPrimary (citable) accession number: Q08406
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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