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Protein

Ciliary neurotrophic factor receptor subunit alpha

Gene

Cntfr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to CNTF. The alpha subunit provides the receptor specificity.

GO - Molecular functioni

  • ciliary neurotrophic factor receptor activity Source: RGD
  • cytokine binding Source: RGD

GO - Biological processi

  • ciliary neurotrophic factor-mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor receptor subunit alpha
Short name:
CNTF receptor subunit alpha
Short name:
CNTFR-alpha
Gene namesi
Name:Cntfr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303100. Cntfr.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 342320Ciliary neurotrophic factor receptor subunit alphaPRO_0000010995Add
BLAST
Propeptidei343 – 37230Removed in mature formSequence analysisPRO_0000010996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 89PROSITE-ProRule annotation
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence analysis
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence analysis
Lipidationi342 – 3421GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ08406.
PRIDEiQ08406.

PTM databases

SwissPalmiQ08406.

Expressioni

Tissue specificityi

Nervous system.

Interactioni

Subunit structurei

Heterotrimer of the alpha subunit, LIFR and IL6ST.

GO - Molecular functioni

  • cytokine binding Source: RGD

Protein-protein interaction databases

BioGridi260344. 2 interactions.
IntActiQ08406. 2 interactions.
STRINGi10116.ENSRNOP00000066185.

Structurei

3D structure databases

ProteinModelPortaliQ08406.
SMRiQ08406. Positions 202-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 10478Ig-like C2-typeAdd
BLAST
Domaini108 – 20598Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini206 – 306101Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi290 – 2945WSXWS motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IH2U. Eukaryota.
ENOG4110HUW. LUCA.
HOVERGENiHBG051048.
InParanoidiQ08406.
KOiK05059.
PhylomeDBiQ08406.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASVPWACC AVLAAAAAAV YTQKHSPQEA PHVQYERLGT DVTLPCGTAS
60 70 80 90 100
WDAAVTWRVN GTDLAPDLLN GSQLILRSLE LGHSGLYACF HRDSWHLRHQ
110 120 130 140 150
VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LSAPTYIPNT FNVTVLHGSK
160 170 180 190 200
MMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN TTAITFDEFT
210 220 230 240 250
IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI
260 270 280 290 300
LDQWQHVELS NGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT
310 320 330 340 350
PWTEEPRHLT TEAQAPETTT STTSSLAPPP TTKICDPGEL SSGGGPSIPF
360 370
LTSVPVTLVL AAAAATANNL LI
Length:372
Mass (Da):40,822
Last modified:November 1, 1995 - v2
Checksum:i3B87EE63923FB149
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti261 – 2611N → D in AAB25918 (PubMed:8460125).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54212 mRNA. Translation: AAB25290.1.
S57711 mRNA. Translation: AAB25918.1.
PIRiI58141.
RefSeqiNP_001003929.1. NM_001003929.1.
UniGeneiRn.55036.

Genome annotation databases

GeneIDi313173.
KEGGirno:313173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S54212 mRNA. Translation: AAB25290.1.
S57711 mRNA. Translation: AAB25918.1.
PIRiI58141.
RefSeqiNP_001003929.1. NM_001003929.1.
UniGeneiRn.55036.

3D structure databases

ProteinModelPortaliQ08406.
SMRiQ08406. Positions 202-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi260344. 2 interactions.
IntActiQ08406. 2 interactions.
STRINGi10116.ENSRNOP00000066185.

PTM databases

SwissPalmiQ08406.

Proteomic databases

PaxDbiQ08406.
PRIDEiQ08406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi313173.
KEGGirno:313173.

Organism-specific databases

CTDi1271.
RGDi1303100. Cntfr.

Phylogenomic databases

eggNOGiENOG410IH2U. Eukaryota.
ENOG4110HUW. LUCA.
HOVERGENiHBG051048.
InParanoidiQ08406.
KOiK05059.
PhylomeDBiQ08406.

Miscellaneous databases

PROiQ08406.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development."
    Ip N.Y., McClain J., Barrezueta N.X., Aldrich T.H., Pan L., Li Y., Wiegand S.J., Friedman B., Davis S., Yancopoulos G.D.
    Neuron 10:89-102(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system."
    Clatterbuck R.E., Price D.L., Koliatsos V.E.
    Proc. Natl. Acad. Sci. U.S.A. 90:2222-2226(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 185-277.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCNTFR_RAT
AccessioniPrimary (citable) accession number: Q08406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.