ID   CDD_SHEFN               Reviewed;         298 AA.
AC   Q083S7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Cytidine deaminase;
DE            EC=3.5.4.5;
DE   AltName: Full=Cytidine aminohydrolase;
DE            Short=CDA;
GN   Name=cdd; OrderedLocusNames=Sfri_1637;
OS   Shewanella frigidimarina (strain NCIMB 400).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=318167;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Fredrickson J.K., Kolker E., McCuel L.A., DiChristina T.,
RA   Nealson K.H., Newman D., Tiedje J.M., Zhou J., Romine M.F.,
RA   Culley D.E., Serres M., Chertkov O., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Richardson P.;
RT   "Complete sequence of Shewanella frigidimarina NCIMB 400.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This enzyme scavenge exogenous and endogenous cytidine
CC       and 2'-deoxycytidine for UMP synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family.
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DR   EMBL; CP000447; ABI71488.1; -; Genomic_DNA.
DR   RefSeq; YP_750326.1; -.
DR   GeneID; 4277296; -.
DR   GenomeReviews; CP000447_GR; Sfri_1637.
DR   KEGG; sfr:Sfri_1637; -.
DR   NMPDR; fig|318167.10.peg.1579; -.
DR   HOGENOM; Q083S7; -.
DR   OMA; Q083S7; FSPCGHC.
DR   GO; GO:0004126; F:cytidine deaminase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   HAMAP; MF_01558; -; 1.
DR   InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR   InterPro; IPR002125; CMP_dCMP_Zn_bd.
DR   InterPro; IPR013171; dC_C_deam_Zn_bd.
DR   Pfam; PF00383; dCMP_cyt_deam_1; 1.
DR   Pfam; PF08211; dCMP_cyt_deam_2; 1.
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Metal-binding; Zinc.
FT   CHAIN         1    298       Cytidine deaminase.
FT                                /FTId=PRO_1000068962.
FT   REGION       88     90       Substrate binding (By similarity).
FT   ACT_SITE    103    103       Proton donor (By similarity).
FT   METAL       101    101       Zinc; catalytic (By similarity).
FT   METAL       128    128       Zinc; catalytic (By similarity).
FT   METAL       131    131       Zinc; catalytic (By similarity).
SQ   SEQUENCE   298 AA;  32381 MW;  01CA4F986ED81484 CRC64;
     MQNRFLESIT QLDKPLANAL VPLLHDQFCG HIDASQFAGL VKASGKTEQQ VLMDLLPIAA
     ALANPPISEF YVGAIAKGSS GDLYMGANLE LPGEALFHSV HAEQSAISHA WLSGETEIVD
     IIVNFSPCGH CRQFMNELVN GSKINIHLPN QETQTLAHYL PYAFGPSDLD VTVPLLCKRE
     QEFNCDSDDP MIIEAIDQMG LSYAPYTNNN AAVVLETNDG ATFCGRYAES AAFNPSMQPM
     QMALSNLIRN NRQYSEIKRA VLVESSVGKI TLVGAAMDAL HAIAPIELQH MVVEPLLG
//