Reviewed, UniProtKB/Swiss-Prot Q083S7 (CDD_SHEFN)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
      Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	Sfri_1637

Organism

Shewanella frigidimarina (strain NCIMB 400) [Complete proteome] [HAMAP]

Taxonomic identifier

318167 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	Cytidine deaminase HAMAP MF_01558		PRO_1000068962
Regions
	Region	88 – 90	3	Substrate binding By similarity
Sites
	Active site	103	1	Proton donor By similarity
	Metal binding	101	1	Zinc; catalytic By similarity
	Metal binding	128	1	Zinc; catalytic By similarity
	Metal binding	131	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q083S7-1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: 01CA4F986ED81484	FASTA	298	32,381
	10 20 30 40 50 60 MQNRFLESIT QLDKPLANAL VPLLHDQFCG HIDASQFAGL VKASGKTEQQ VLMDLLPIAA 70 80 90 100 110 120 ALANPPISEF YVGAIAKGSS GDLYMGANLE LPGEALFHSV HAEQSAISHA WLSGETEIVD 130 140 150 160 170 180 IIVNFSPCGH CRQFMNELVN GSKINIHLPN QETQTLAHYL PYAFGPSDLD VTVPLLCKRE 190 200 210 220 230 240 QEFNCDSDDP MIIEAIDQMG LSYAPYTNNN AAVVLETNDG ATFCGRYAES AAFNPSMQPM 250 260 270 280 290 QMALSNLIRN NRQYSEIKRA VLVESSVGKI TLVGAAMDAL HAIAPIELQH MVVEPLLG

References

[1]

"Complete sequence of Shewanella frigidimarina NCIMB 400." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Fredrickson J.K., Kolker E., McCuel L.A., DiChristina T., Nealson K.H., Newman D., Tiedje J.M. , Zhou J., Romine M.F., Culley D.E., Serres M., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000447 Genomic DNA. Translation: ABI71488.1.
RefSeq	YP_750326.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4277296.
GenomeReviews	Gene locus Sfri_1637 in contig CP000447_GR.
KEGG	sfr:Sfri_1637.
NMPDR	fig|318167.10.peg.1579.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q083S7.
OMA	Q083S7. FSPCGHC.
Family and domain databases
HAMAP	MF_01558. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR013171. dC_C_deam_Zn_bd. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_SHEFN

Accession

Primary (citable) accession number: Q083S7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 31, 2006
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)