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Q083S7 (CDD_SHEFN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytidine deaminase
EC=3.5.4.5
Alternative name(s):
Cytidine aminohydrolase
Short name=CDA
Gene names
Name:cdd
Ordered Locus Names:Sfri_1637
OrganismShewanella frigidimarina (strain NCIMB 400) [Complete proteome] [HAMAP]
Taxonomic identifier318167 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP MF_01558

Catalytic activity

Cytidine + H2O = uridine + NH3. HAMAP MF_01558

Cofactor

Binds 1 zinc ion By similarity. HAMAP MF_01558

Subunit structure

Homodimer By similarity. HAMAP MF_01558

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncytidine deaminase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298Cytidine deaminase HAMAP MF_01558
PRO_1000068962

Regions

Region88 – 903Substrate binding By similarity

Sites

Active site1031Proton donor By similarity
Metal binding1011Zinc; catalytic By similarity
Metal binding1281Zinc; catalytic By similarity
Metal binding1311Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q083S7 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: 01CA4F986ED81484

FASTA29832,381
        10         20         30         40         50         60 
MQNRFLESIT QLDKPLANAL VPLLHDQFCG HIDASQFAGL VKASGKTEQQ VLMDLLPIAA 

        70         80         90        100        110        120 
ALANPPISEF YVGAIAKGSS GDLYMGANLE LPGEALFHSV HAEQSAISHA WLSGETEIVD 

       130        140        150        160        170        180 
IIVNFSPCGH CRQFMNELVN GSKINIHLPN QETQTLAHYL PYAFGPSDLD VTVPLLCKRE 

       190        200        210        220        230        240 
QEFNCDSDDP MIIEAIDQMG LSYAPYTNNN AAVVLETNDG ATFCGRYAES AAFNPSMQPM 

       250        260        270        280        290 
QMALSNLIRN NRQYSEIKRA VLVESSVGKI TLVGAAMDAL HAIAPIELQH MVVEPLLG

« Hide

References

[1]"Complete sequence of Shewanella frigidimarina NCIMB 400."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Fredrickson J.K., Kolker E., McCuel L.A., DiChristina T., Nealson K.H., Newman D., Tiedje J.M. expand/collapse author list , Zhou J., Romine M.F., Culley D.E., Serres M., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCIMB 400.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000447 Genomic DNA. Translation: ABI71488.1.
RefSeqYP_750326.1. NC_008345.1.

3D structure databases

ProteinModelPortalQ083S7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ083S7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4277296.
GenomeReviewsGene locus Sfri_1637 in contig CP000447_GR.
KEGGsfr:Sfri_1637.
NMPDRfig|318167.10.peg.1579.
PATRIC23497219. VBISheFri14343_1697.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0295.
HOGENOMHBG591160.
OMANRSHAPY.
PhylomeDBQ083S7.
ProtClustDBPRK09027.

Family and domain databases

HAMAPMF_01558. Cyt_deam.
[Tree]
InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR013171. Cyd/dCyd_deaminase_Zn-bd.
IPR006263. Cyt_deam_dimer.
IPR016193. Cytidine_deaminase-like.
IPR020797. Cytidine_deaminase_bacteria.
[Graphical view]
KOK01489.
PANTHERPTHR11644:SF12. PTHR11644:SF12. 1 hit.
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
PF08211. dCMP_cyt_deam_2. 1 hit.
[Graphical view]
PIRSFPIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAMSSF53927. Cytidine_deaminase-like. 2 hits.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDD_SHEFN
AccessionPrimary (citable) accession number: Q083S7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 31, 2006
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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