Q08393 (GSTA2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Glutathione S-transferase EC=2.5.1.18 Alternative name(s): Class-alpha
Organism	Gallus gallus (Chicken) [Reference proteome]
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GST superfamily. Alpha family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutathione metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutathione transferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Glutathione S-transferase		PRO_0000185802
Regions
	Domain	3 – 83	81	GST N-terminal
	Domain	85 – 208	124	GST C-terminal
	Region	54 – 55	2	Glutathione binding By similarity
	Region	67 – 68	2	Glutathione binding By similarity
Sites
	Binding site	9	1	Glutathione By similarity
	Binding site	45	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q08393 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 7B25B823051C9B8A	FASTA	222	25,414
	10 20 30 40 50 60 MAGKPKLHYT RGRGKMESIR WLLAAAGVEF EEEFIEKKED LEKLRNDGSL LFQQVPMVEI 70 80 90 100 110 120 DGMKMVQSRA ILCYIAGKYN LYGKDLKERA WIDMYVEGTT DLMGMIMALP FQAADVKEKN 130 140 150 160 170 180 IALITERATT RYFPVYEKAL KDHGQDYLVG NKLSWADIHL LEAILMTEEL KSDILSAFPL 190 200 210 220 LQAFKGRMSN VPTIKKFLQP GSQRKPPLDE KSIANVRKIF SF

References

[1]	Tam M.F., Liu L.-F. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Nucleotide sequence of class-alpha glutathione S-transferases from chicken liver." Liu L.-F., Wu S.-H., Tam M.F. Biochim. Biophys. Acta 1216:332-334(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-222. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L15387 mRNA. Translation: AAA16573.2.
IPI	IPI00587274.
PIR	S43432.
RefSeq	NP_001001776.1. NM_001001776.1.
UniGene	Gga.39241.
3D structure databases
ProteinModelPortal	Q08393.
SMR	Q08393. Positions 2-220.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000036174.
Proteomic databases
PaxDb	Q08393.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000026339; ENSGALP00000026289; ENSGALG00000016328. ENSGALT00000036961; ENSGALP00000036174; ENSGALG00000016328.
GeneID	414895.
KEGG	gga:414895.
Organism-specific databases
CTD	111484.
Phylogenomic databases
eggNOG	NOG266414.
GeneTree	ENSGT00670000097856.
HOGENOM	HOG000115734.
HOVERGEN	HBG053749.
InParanoid	Q08393.
KO	K00799.
OMA	DLMGMIM.
OrthoDB	EOG45757Q.
Gene expression databases
ArrayExpress	Q08393.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR003080. GST_alpha. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
PANTHER	PTHR11571:SF4. PTHR11571:SF4. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01266. GSTRNSFRASEA.
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20818769.

Entry information

Entry name

GSTA2_CHICK

Accession

Primary (citable) accession number: Q08393

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	May 30, 2000
Last modified:	April 3, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program