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Protein

Glutathione S-transferase

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1
Binding sitei45GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase (EC:2.5.1.18)
Alternative name(s):
Class-alpha
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858021 – 222Glutathione S-transferaseAdd BLAST222

Proteomic databases

PaxDbiQ08393

Expressioni

Gene expression databases

BgeeiENSGALG00000016328

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026289

Structurei

3D structure databases

ProteinModelPortaliQ08393
SMRiQ08393
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83GST N-terminalAdd BLAST81
Domaini85 – 208GST C-terminalAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115734
HOVERGENiHBG053749
InParanoidiQ08393
KOiK00799
OMAiEQAWIDM
OrthoDBiEOG091G0O3D
PhylomeDBiQ08393
TreeFamiTF105321

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR003080 GST_alpha
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01266 GSTRNSFRASEA
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q08393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKPKLHYT RGRGKMESIR WLLAAAGVEF EEEFIEKKED LEKLRNDGSL
60 70 80 90 100
LFQQVPMVEI DGMKMVQSRA ILCYIAGKYN LYGKDLKERA WIDMYVEGTT
110 120 130 140 150
DLMGMIMALP FQAADVKEKN IALITERATT RYFPVYEKAL KDHGQDYLVG
160 170 180 190 200
NKLSWADIHL LEAILMTEEL KSDILSAFPL LQAFKGRMSN VPTIKKFLQP
210 220
GSQRKPPLDE KSIANVRKIF SF
Length:222
Mass (Da):25,414
Last modified:May 30, 2000 - v2
Checksum:i7B25B823051C9B8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15387 mRNA Translation: AAA16573.2
PIRiS43432
RefSeqiNP_001001776.1, NM_001001776.1
XP_015140310.1, XM_015284824.1
XP_015140311.1, XM_015284825.1
UniGeneiGga.39241

Genome annotation databases

EnsembliENSGALT00000026339; ENSGALP00000026289; ENSGALG00000016328
ENSGALT00000065509; ENSGALP00000053994; ENSGALG00000016328
GeneIDi414895
KEGGigga:414895

Similar proteinsi

Entry informationi

Entry nameiGSTA2_CHICK
AccessioniPrimary (citable) accession number: Q08393
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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