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Q08393

- GSTA2_CHICK

UniProt

Q08393 - GSTA2_CHICK

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Protein
Glutathione S-transferase
Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Glutathione By similarity
Binding sitei45 – 451Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_222911. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase (EC:2.5.1.18)
Alternative name(s):
Class-alpha
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 3

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Glutathione S-transferase
PRO_0000185802Add
BLAST

Proteomic databases

PaxDbiQ08393.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036174.

Structurei

3D structure databases

ProteinModelPortaliQ08393.
SMRiQ08393. Positions 2-220.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8381GST N-terminal
Add
BLAST
Domaini85 – 208124GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 552Glutathione binding By similarity
Regioni67 – 682Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.

Phylogenomic databases

eggNOGiNOG266414.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiQ08393.
KOiK00799.
OMAiRYESYTE.
OrthoDBiEOG79CZ0K.
PhylomeDBiQ08393.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08393-1 [UniParc]FASTAAdd to Basket

« Hide

MAGKPKLHYT RGRGKMESIR WLLAAAGVEF EEEFIEKKED LEKLRNDGSL    50
LFQQVPMVEI DGMKMVQSRA ILCYIAGKYN LYGKDLKERA WIDMYVEGTT 100
DLMGMIMALP FQAADVKEKN IALITERATT RYFPVYEKAL KDHGQDYLVG 150
NKLSWADIHL LEAILMTEEL KSDILSAFPL LQAFKGRMSN VPTIKKFLQP 200
GSQRKPPLDE KSIANVRKIF SF 222
Length:222
Mass (Da):25,414
Last modified:May 30, 2000 - v2
Checksum:i7B25B823051C9B8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15387 mRNA. Translation: AAA16573.2.
PIRiS43432.
RefSeqiNP_001001776.1. NM_001001776.1.
UniGeneiGga.39241.

Genome annotation databases

EnsembliENSGALT00000026339; ENSGALP00000026289; ENSGALG00000016328.
GeneIDi414895.
KEGGigga:414895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15387 mRNA. Translation: AAA16573.2 .
PIRi S43432.
RefSeqi NP_001001776.1. NM_001001776.1.
UniGenei Gga.39241.

3D structure databases

ProteinModelPortali Q08393.
SMRi Q08393. Positions 2-220.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000036174.

Proteomic databases

PaxDbi Q08393.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000026339 ; ENSGALP00000026289 ; ENSGALG00000016328 .
GeneIDi 414895.
KEGGi gga:414895.

Organism-specific databases

CTDi 111484.

Phylogenomic databases

eggNOGi NOG266414.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115734.
HOVERGENi HBG053749.
InParanoidi Q08393.
KOi K00799.
OMAi RYESYTE.
OrthoDBi EOG79CZ0K.
PhylomeDBi Q08393.
TreeFami TF105321.

Enzyme and pathway databases

Reactomei REACT_222911. Glutathione conjugation.

Miscellaneous databases

NextBioi 20818769.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01266. GSTRNSFRASEA.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Tam M.F., Liu L.-F.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Nucleotide sequence of class-alpha glutathione S-transferases from chicken liver."
    Liu L.-F., Wu S.-H., Tam M.F.
    Biochim. Biophys. Acta 1216:332-334(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-222.
    Tissue: Liver.

Entry informationi

Entry nameiGSTA2_CHICK
AccessioniPrimary (citable) accession number: Q08393
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 30, 2000
Last modified: September 3, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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