Reviewed, UniProtKB/Swiss-Prot Q08393 (GSTA2_CHICK)

Names and origin

Protein names	Recommended name:     Glutathione S-transferase     EC=2.5.1.18 Alternative name(s):     Class-alpha
Organism	Gallus gallus (Chicken)
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GST superfamily. Alpha family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Glutathione S-transferase		PRO_0000185802
Regions
	Domain	3 – 83	81	GST N-terminal
	Domain	85 – 208	124	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	Q08393-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 7B25B823051C9B8A	FASTA	222	25,414
	10 20 30 40 50 60 MAGKPKLHYT RGRGKMESIR WLLAAAGVEF EEEFIEKKED LEKLRNDGSL LFQQVPMVEI 70 80 90 100 110 120 DGMKMVQSRA ILCYIAGKYN LYGKDLKERA WIDMYVEGTT DLMGMIMALP FQAADVKEKN 130 140 150 160 170 180 IALITERATT RYFPVYEKAL KDHGQDYLVG NKLSWADIHL LEAILMTEEL KSDILSAFPL 190 200 210 220 LQAFKGRMSN VPTIKKFLQP GSQRKPPLDE KSIANVRKIF SF

References

[1]	Tam M.F., Liu L.-F. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Nucleotide sequence of class-alpha glutathione S-transferases from chicken liver." Liu L.-F., Wu S.-H., Tam M.F. Biochim. Biophys. Acta 1216:332-334(1993) [PubMed: 8241281] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-222. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L15387 mRNA. Translation: AAA16573.2.
IPI	IPI00587274.
PIR	S43432.
RefSeq	NP_001001776.1.
UniGene	Gga.39241
3D structure databases
HSSP	HSSP built from PDB template 1K3O based on UniProtKB P08263.
SMR	Q08393. Positions 3-220.
ModBase	Search...
Genome annotation databases
Ensembl	ENSGALG00000016328. Gallus gallus. [Contig view]
GeneID	414895.
KEGG	gga:414895.
Phylogenomic databases
HOGENOM	Q08393.
HOVERGEN	Q08393.
OMA	Q08393. DMYADGT.
Enzyme and pathway databases
BRENDA	2.5.1.18. 4.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR003080. GST_alpha. IPR004046. GST_C. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11571:SF4. GST_alpha. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01266. GSTRNSFRASEA.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTA2_CHICK

Accession

Primary (citable) accession number: Q08393

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	May 30, 2000
Last modified:	June 16, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)