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Q08393

- GSTA2_CHICK

UniProt

Q08393 - GSTA2_CHICK

Protein

Glutathione S-transferase

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei9 – 91GlutathioneBy similarity
    Binding sitei45 – 451GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB

    GO - Biological processi

    1. glutathione metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    ReactomeiREACT_222911. Glutathione conjugation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase (EC:2.5.1.18)
    Alternative name(s):
    Class-alpha
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 3

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222Glutathione S-transferasePRO_0000185802Add
    BLAST

    Proteomic databases

    PaxDbiQ08393.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000036174.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08393.
    SMRiQ08393. Positions 2-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 8381GST N-terminalAdd
    BLAST
    Domaini85 – 208124GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni54 – 552Glutathione bindingBy similarity
    Regioni67 – 682Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Alpha family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG266414.
    GeneTreeiENSGT00670000097856.
    HOGENOMiHOG000115734.
    HOVERGENiHBG053749.
    InParanoidiQ08393.
    KOiK00799.
    OMAiRYESYTE.
    OrthoDBiEOG79CZ0K.
    PhylomeDBiQ08393.
    TreeFamiTF105321.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR003080. GST_alpha.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01266. GSTRNSFRASEA.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08393-1 [UniParc]FASTAAdd to Basket

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    MAGKPKLHYT RGRGKMESIR WLLAAAGVEF EEEFIEKKED LEKLRNDGSL    50
    LFQQVPMVEI DGMKMVQSRA ILCYIAGKYN LYGKDLKERA WIDMYVEGTT 100
    DLMGMIMALP FQAADVKEKN IALITERATT RYFPVYEKAL KDHGQDYLVG 150
    NKLSWADIHL LEAILMTEEL KSDILSAFPL LQAFKGRMSN VPTIKKFLQP 200
    GSQRKPPLDE KSIANVRKIF SF 222
    Length:222
    Mass (Da):25,414
    Last modified:May 30, 2000 - v2
    Checksum:i7B25B823051C9B8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15387 mRNA. Translation: AAA16573.2.
    PIRiS43432.
    RefSeqiNP_001001776.1. NM_001001776.1.
    UniGeneiGga.39241.

    Genome annotation databases

    EnsembliENSGALT00000026339; ENSGALP00000026289; ENSGALG00000016328.
    GeneIDi414895.
    KEGGigga:414895.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15387 mRNA. Translation: AAA16573.2 .
    PIRi S43432.
    RefSeqi NP_001001776.1. NM_001001776.1.
    UniGenei Gga.39241.

    3D structure databases

    ProteinModelPortali Q08393.
    SMRi Q08393. Positions 2-220.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000036174.

    Proteomic databases

    PaxDbi Q08393.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000026339 ; ENSGALP00000026289 ; ENSGALG00000016328 .
    GeneIDi 414895.
    KEGGi gga:414895.

    Organism-specific databases

    CTDi 111484.

    Phylogenomic databases

    eggNOGi NOG266414.
    GeneTreei ENSGT00670000097856.
    HOGENOMi HOG000115734.
    HOVERGENi HBG053749.
    InParanoidi Q08393.
    KOi K00799.
    OMAi RYESYTE.
    OrthoDBi EOG79CZ0K.
    PhylomeDBi Q08393.
    TreeFami TF105321.

    Enzyme and pathway databases

    Reactomei REACT_222911. Glutathione conjugation.

    Miscellaneous databases

    NextBioi 20818769.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR003080. GST_alpha.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01266. GSTRNSFRASEA.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Tam M.F., Liu L.-F.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Nucleotide sequence of class-alpha glutathione S-transferases from chicken liver."
      Liu L.-F., Wu S.-H., Tam M.F.
      Biochim. Biophys. Acta 1216:332-334(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-222.
      Tissue: Liver.

    Entry informationi

    Entry nameiGSTA2_CHICK
    AccessioniPrimary (citable) accession number: Q08393
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3