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Q08393

- GSTA2_CHICK

UniProt

Q08393 - GSTA2_CHICK

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Protein

Glutathione S-transferase

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91GlutathioneBy similarity
Binding sitei45 – 451GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_189537. Detoxification of Reactive Oxygen Species.
REACT_222911. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase (EC:2.5.1.18)
Alternative name(s):
Class-alpha
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 3

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Glutathione S-transferasePRO_0000185802Add
BLAST

Proteomic databases

PaxDbiQ08393.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036174.

Structurei

3D structure databases

ProteinModelPortaliQ08393.
SMRiQ08393. Positions 2-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8381GST N-terminalAdd
BLAST
Domaini85 – 208124GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 552Glutathione bindingBy similarity
Regioni67 – 682Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG266414.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiQ08393.
KOiK00799.
OMAiRYESYTE.
OrthoDBiEOG79CZ0K.
PhylomeDBiQ08393.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08393-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGKPKLHYT RGRGKMESIR WLLAAAGVEF EEEFIEKKED LEKLRNDGSL
60 70 80 90 100
LFQQVPMVEI DGMKMVQSRA ILCYIAGKYN LYGKDLKERA WIDMYVEGTT
110 120 130 140 150
DLMGMIMALP FQAADVKEKN IALITERATT RYFPVYEKAL KDHGQDYLVG
160 170 180 190 200
NKLSWADIHL LEAILMTEEL KSDILSAFPL LQAFKGRMSN VPTIKKFLQP
210 220
GSQRKPPLDE KSIANVRKIF SF
Length:222
Mass (Da):25,414
Last modified:May 30, 2000 - v2
Checksum:i7B25B823051C9B8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15387 mRNA. Translation: AAA16573.2.
PIRiS43432.
RefSeqiNP_001001776.1. NM_001001776.1.
UniGeneiGga.39241.

Genome annotation databases

EnsembliENSGALT00000026339; ENSGALP00000026289; ENSGALG00000016328.
GeneIDi414895.
KEGGigga:414895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15387 mRNA. Translation: AAA16573.2 .
PIRi S43432.
RefSeqi NP_001001776.1. NM_001001776.1.
UniGenei Gga.39241.

3D structure databases

ProteinModelPortali Q08393.
SMRi Q08393. Positions 2-220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000036174.

Proteomic databases

PaxDbi Q08393.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000026339 ; ENSGALP00000026289 ; ENSGALG00000016328 .
GeneIDi 414895.
KEGGi gga:414895.

Organism-specific databases

CTDi 111484.

Phylogenomic databases

eggNOGi NOG266414.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115734.
HOVERGENi HBG053749.
InParanoidi Q08393.
KOi K00799.
OMAi RYESYTE.
OrthoDBi EOG79CZ0K.
PhylomeDBi Q08393.
TreeFami TF105321.

Enzyme and pathway databases

Reactomei REACT_189537. Detoxification of Reactive Oxygen Species.
REACT_222911. Glutathione conjugation.

Miscellaneous databases

NextBioi 20818769.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01266. GSTRNSFRASEA.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Tam M.F., Liu L.-F.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Nucleotide sequence of class-alpha glutathione S-transferases from chicken liver."
    Liu L.-F., Wu S.-H., Tam M.F.
    Biochim. Biophys. Acta 1216:332-334(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-222.
    Tissue: Liver.

Entry informationi

Entry nameiGSTA2_CHICK
AccessioniPrimary (citable) accession number: Q08393
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 30, 2000
Last modified: November 26, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3