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Reviewed, UniProtKB/Swiss-Prot Q08393 (GSTA2_CHICK)

Last modified June 16, 2009. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glutathione S-transferase
    EC=2.5.1.18
Alternative name(s):
    Class-alpha
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the GST superfamily. Alpha family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
Gene Ontology (GO)
   Biological processmetabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglutathione transferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 222222Glutathione S-transferase
PRO_0000185802

Regions

Domain3 – 8381GST N-terminal
Domain85 – 208124GST C-terminal

Sequences

Sequence LengthMass (Da)Tools
Q08393-1 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 7B25B823051C9B8A

FASTA22225,414
        10         20         30         40         50         60 
MAGKPKLHYT RGRGKMESIR WLLAAAGVEF EEEFIEKKED LEKLRNDGSL LFQQVPMVEI 

        70         80         90        100        110        120 
DGMKMVQSRA ILCYIAGKYN LYGKDLKERA WIDMYVEGTT DLMGMIMALP FQAADVKEKN 

       130        140        150        160        170        180 
IALITERATT RYFPVYEKAL KDHGQDYLVG NKLSWADIHL LEAILMTEEL KSDILSAFPL 

       190        200        210        220 
LQAFKGRMSN VPTIKKFLQP GSQRKPPLDE KSIANVRKIF SF 

« Hide

References

[1]Tam M.F., Liu L.-F.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Nucleotide sequence of class-alpha glutathione S-transferases from chicken liver."
Liu L.-F., Wu S.-H., Tam M.F.
Biochim. Biophys. Acta 1216:332-334(1993) [PubMed: 8241281] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-222.
Tissue: Liver.

Cross-references

Sequence databases

L15387 mRNA. Translation: AAA16573.2.
IPIIPI00587274.
PIRS43432.
RefSeqNP_001001776.1.
UniGeneGga.39241

3D structure databases

HSSPHSSP built from PDB template 1K3O based on UniProtKB P08263.
SMRQ08393. Positions 3-220.
ModBaseSearch...

Genome annotation databases

EnsemblENSGALG00000016328. Gallus gallus. [Contig view]
GeneID414895.
KEGGgga:414895.

Phylogenomic databases

HOGENOMQ08393.
HOVERGENQ08393.
OMAQ08393. DMYADGT.

Enzyme and pathway databases

BRENDA2.5.1.18. 4.

Family and domain databases

InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017933. Glutathione_S_Trfase/Cl_chnl_C.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:1.20.1050.10. GST_C_like. 1 hit.
G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHERPTHR11571:SF4. GST_alpha. 1 hit.
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01266. GSTRNSFRASEA.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTA2_CHICK
AccessionPrimary (citable) accession number: Q08393
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 30, 2000
Last modified: June 16, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents