Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q08392

- GSTA1_CHICK

UniProt

Q08392 - GSTA1_CHICK

Protein

Glutathione S-transferase

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei9 – 91GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB

    GO - Biological processi

    1. glutathione metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    ReactomeiREACT_222911. Glutathione conjugation.
    SABIO-RKQ08392.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase (EC:2.5.1.18)
    Alternative name(s):
    GST class-alpha
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 3

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221Glutathione S-transferasePRO_0000185801Add
    BLAST

    Proteomic databases

    PaxDbiQ08392.
    PRIDEiQ08392.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000030998.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08392.
    SMRiQ08392. Positions 2-213.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 8381GST N-terminalAdd
    BLAST
    Domaini85 – 208124GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni54 – 552Glutathione bindingBy similarity
    Regioni67 – 682Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Alpha family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG266414.
    GeneTreeiENSGT00670000097856.
    HOGENOMiHOG000115734.
    HOVERGENiHBG053749.
    InParanoidiQ08392.
    KOiK00799.
    OMAiKDIPRLM.
    OrthoDBiEOG79CZ0K.
    PhylomeDBiQ08392.
    TreeFamiTF105321.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR003080. GST_alpha.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01266. GSTRNSFRASEA.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08392-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGKPVLHYA NTRGRMESVR WLLAAAGVEF EEKFLEKKED LQKLKSDGSL    50
    LFQQVPMVEI DGMKMVQTRA ILNYIAGKYN LYGKDLKERA LIDMYVEGLA 100
    DLYELIMMNV VQPADKKEEH LANALDKAAN RYFPVFEKVL KDHGHDFLVG 150
    NKLSRADVHL LETILAVEES KPDALAKFPL LQSFKARTSN IPNIKKFLQP 200
    GSQRKPRLEE KDIPRLMAIF H 221
    Length:221
    Mass (Da):25,299
    Last modified:November 1, 1995 - v1
    Checksum:iA6FB936D0E998C90
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15386 mRNA. Translation: AAA16572.1.
    PIRiS43431.
    RefSeqiNP_001001777.1. NM_001001777.1.
    UniGeneiGga.2533.

    Genome annotation databases

    EnsembliENSGALT00000026336; ENSGALP00000026286; ENSGALG00000016325.
    GeneIDi414896.
    KEGGigga:414896.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15386 mRNA. Translation: AAA16572.1 .
    PIRi S43431.
    RefSeqi NP_001001777.1. NM_001001777.1.
    UniGenei Gga.2533.

    3D structure databases

    ProteinModelPortali Q08392.
    SMRi Q08392. Positions 2-213.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000030998.

    Proteomic databases

    PaxDbi Q08392.
    PRIDEi Q08392.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000026336 ; ENSGALP00000026286 ; ENSGALG00000016325 .
    GeneIDi 414896.
    KEGGi gga:414896.

    Organism-specific databases

    CTDi 2940.

    Phylogenomic databases

    eggNOGi NOG266414.
    GeneTreei ENSGT00670000097856.
    HOGENOMi HOG000115734.
    HOVERGENi HBG053749.
    InParanoidi Q08392.
    KOi K00799.
    OMAi KDIPRLM.
    OrthoDBi EOG79CZ0K.
    PhylomeDBi Q08392.
    TreeFami TF105321.

    Enzyme and pathway databases

    Reactomei REACT_222911. Glutathione conjugation.
    SABIO-RK Q08392.

    Miscellaneous databases

    NextBioi 20818770.
    PROi Q08392.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR003080. GST_alpha.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01266. GSTRNSFRASEA.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of class-alpha glutathione S-transferases from chicken liver."
      Liu L.-F., Wu S.-H., Tam M.F.
      Biochim. Biophys. Acta 1216:332-334(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiGSTA1_CHICK
    AccessioniPrimary (citable) accession number: Q08392
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3