Reviewed, UniProtKB/Swiss-Prot Q08392 (GSTA1_CHICK)

Names and origin

Protein names	Recommended name:     Glutathione S-transferase     EC=2.5.1.18 Alternative name(s):     GST class-alpha
Organism	Gallus gallus (Chicken)
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the GST superfamily. Alpha family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Glutathione S-transferase		PRO_0000185801
Regions
	Domain	3 – 83	81	GST N-terminal
	Domain	85 – 208	124	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	Q08392-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: A6FB936D0E998C90	FASTA	221	25,299
	10 20 30 40 50 60 MSGKPVLHYA NTRGRMESVR WLLAAAGVEF EEKFLEKKED LQKLKSDGSL LFQQVPMVEI 70 80 90 100 110 120 DGMKMVQTRA ILNYIAGKYN LYGKDLKERA LIDMYVEGLA DLYELIMMNV VQPADKKEEH 130 140 150 160 170 180 LANALDKAAN RYFPVFEKVL KDHGHDFLVG NKLSRADVHL LETILAVEES KPDALAKFPL 190 200 210 220 LQSFKARTSN IPNIKKFLQP GSQRKPRLEE KDIPRLMAIF H

References

[1]	"Nucleotide sequence of class-alpha glutathione S-transferases from chicken liver." Liu L.-F., Wu S.-H., Tam M.F. Biochim. Biophys. Acta 1216:332-334(1993) [PubMed: 8241281] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L15386 mRNA. Translation: AAA16572.1.
IPI	IPI00574866.
PIR	S43431.
RefSeq	NP_001001777.1.
UniGene	Gga.2533
3D structure databases
HSSP	HSSP built from PDB template 1K3O based on UniProtKB P08263.
ModBase	Search...
Protein-protein interaction databases
STRING	Q08392.
Proteomic databases
PRIDE	Q08392.
Genome annotation databases
Ensembl	ENSGALT00000026336; ENSGALP00000026286; ENSGALG00000016325; Gallus gallus. [Genome view] ENSGALT00000031634; ENSGALP00000030998; ENSGALG00000016325; Gallus gallus. [Genome view]
GeneID	414896.
KEGG	gga:414896.
Organism-specific databases
CTD	414896.
Phylogenomic databases
HOGENOM	Q08392.
HOVERGEN	Q08392.
OMA	DANWPET.
Enzyme and pathway databases
BRENDA	2.5.1.18. 4.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR003080. GST_alpha. IPR004046. GST_C. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11571:SF4. GST_alpha. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01266. GSTRNSFRASEA.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTA1_CHICK

Accession

Primary (citable) accession number: Q08392

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)