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Q08392 (GSTA1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase

EC=2.5.1.18
Alternative name(s):
GST class-alpha
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the GST superfamily. Alpha family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutathione metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionglutathione transferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221Glutathione S-transferase
PRO_0000185801

Regions

Domain3 – 8381GST N-terminal
Domain85 – 208124GST C-terminal
Region54 – 552Glutathione binding By similarity
Region67 – 682Glutathione binding By similarity

Sites

Binding site91Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
Q08392 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A6FB936D0E998C90

FASTA22125,299
        10         20         30         40         50         60 
MSGKPVLHYA NTRGRMESVR WLLAAAGVEF EEKFLEKKED LQKLKSDGSL LFQQVPMVEI 

        70         80         90        100        110        120 
DGMKMVQTRA ILNYIAGKYN LYGKDLKERA LIDMYVEGLA DLYELIMMNV VQPADKKEEH 

       130        140        150        160        170        180 
LANALDKAAN RYFPVFEKVL KDHGHDFLVG NKLSRADVHL LETILAVEES KPDALAKFPL 

       190        200        210        220 
LQSFKARTSN IPNIKKFLQP GSQRKPRLEE KDIPRLMAIF H 

« Hide

References

[1]"Nucleotide sequence of class-alpha glutathione S-transferases from chicken liver."
Liu L.-F., Wu S.-H., Tam M.F.
Biochim. Biophys. Acta 1216:332-334(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L15386 mRNA. Translation: AAA16572.1.
PIRS43431.
RefSeqNP_001001777.1. NM_001001777.1.
UniGeneGga.2533.

3D structure databases

ProteinModelPortalQ08392.
SMRQ08392. Positions 2-213.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000030998.

Proteomic databases

PaxDbQ08392.
PRIDEQ08392.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000026336; ENSGALP00000026286; ENSGALG00000016325.
GeneID414896.
KEGGgga:414896.

Organism-specific databases

CTD2940.

Phylogenomic databases

eggNOGNOG266414.
GeneTreeENSGT00670000097856.
HOGENOMHOG000115734.
HOVERGENHBG053749.
InParanoidQ08392.
KOK00799.
OMALEIMILY.
OrthoDBEOG79CZ0K.
PhylomeDBQ08392.
TreeFamTF105321.

Enzyme and pathway databases

SABIO-RKQ08392.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11571:SF4. PTHR11571:SF4. 1 hit.
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01266. GSTRNSFRASEA.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20818770.
PROQ08392.

Entry information

Entry nameGSTA1_CHICK
AccessionPrimary (citable) accession number: Q08392
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families