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Q08392

- GSTA1_CHICK

UniProt

Q08392 - GSTA1_CHICK

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Protein

Glutathione S-transferase

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_222911. Glutathione conjugation.
SABIO-RKQ08392.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase (EC:2.5.1.18)
Alternative name(s):
GST class-alpha
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Glutathione S-transferasePRO_0000185801Add
BLAST

Proteomic databases

PaxDbiQ08392.
PRIDEiQ08392.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000030998.

Structurei

3D structure databases

ProteinModelPortaliQ08392.
SMRiQ08392. Positions 2-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8381GST N-terminalAdd
BLAST
Domaini85 – 208124GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 552Glutathione bindingBy similarity
Regioni67 – 682Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG266414.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiQ08392.
KOiK00799.
OMAiKDIPRLM.
OrthoDBiEOG79CZ0K.
PhylomeDBiQ08392.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08392-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGKPVLHYA NTRGRMESVR WLLAAAGVEF EEKFLEKKED LQKLKSDGSL
60 70 80 90 100
LFQQVPMVEI DGMKMVQTRA ILNYIAGKYN LYGKDLKERA LIDMYVEGLA
110 120 130 140 150
DLYELIMMNV VQPADKKEEH LANALDKAAN RYFPVFEKVL KDHGHDFLVG
160 170 180 190 200
NKLSRADVHL LETILAVEES KPDALAKFPL LQSFKARTSN IPNIKKFLQP
210 220
GSQRKPRLEE KDIPRLMAIF H
Length:221
Mass (Da):25,299
Last modified:November 1, 1995 - v1
Checksum:iA6FB936D0E998C90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15386 mRNA. Translation: AAA16572.1.
PIRiS43431.
RefSeqiNP_001001777.1. NM_001001777.1.
UniGeneiGga.2533.

Genome annotation databases

EnsembliENSGALT00000026336; ENSGALP00000026286; ENSGALG00000016325.
GeneIDi414896.
KEGGigga:414896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15386 mRNA. Translation: AAA16572.1 .
PIRi S43431.
RefSeqi NP_001001777.1. NM_001001777.1.
UniGenei Gga.2533.

3D structure databases

ProteinModelPortali Q08392.
SMRi Q08392. Positions 2-213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000030998.

Proteomic databases

PaxDbi Q08392.
PRIDEi Q08392.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000026336 ; ENSGALP00000026286 ; ENSGALG00000016325 .
GeneIDi 414896.
KEGGi gga:414896.

Organism-specific databases

CTDi 2940.

Phylogenomic databases

eggNOGi NOG266414.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115734.
HOVERGENi HBG053749.
InParanoidi Q08392.
KOi K00799.
OMAi KDIPRLM.
OrthoDBi EOG79CZ0K.
PhylomeDBi Q08392.
TreeFami TF105321.

Enzyme and pathway databases

Reactomei REACT_222911. Glutathione conjugation.
SABIO-RK Q08392.

Miscellaneous databases

NextBioi 20818770.
PROi Q08392.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01266. GSTRNSFRASEA.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of class-alpha glutathione S-transferases from chicken liver."
    Liu L.-F., Wu S.-H., Tam M.F.
    Biochim. Biophys. Acta 1216:332-334(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiGSTA1_CHICK
AccessioniPrimary (citable) accession number: Q08392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3