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Protein

Galectin-3-binding protein

Gene

LGALS3BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.3 Publications

GO - Molecular functioni

  • scavenger receptor activity Source: ProtInc

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cellular defense response Source: ProtInc
  • platelet degranulation Source: Reactome
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108679-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-3-binding protein
Alternative name(s):
Basement membrane autoantigen p105
Lectin galactoside-binding soluble 3-binding protein
Mac-2-binding protein
Short name:
MAC2BP
Short name:
Mac-2 BP
Tumor-associated antigen 90K
Gene namesi
Name:LGALS3BP
Synonyms:M2BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6564. LGALS3BP.

Subcellular locationi

  • Secreted 1 Publication
  • Secretedextracellular spaceextracellular matrix 1 Publication

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • membrane Source: InterPro
  • platelet dense granule lumen Source: Reactome
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3959.
OpenTargetsiENSG00000108679.
PharmGKBiPA30341.

Polymorphism and mutation databases

BioMutaiLGALS3BP.
DMDMi47115668.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 183 PublicationsAdd BLAST18
ChainiPRO_000003323019 – 585Galectin-3-binding proteinAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 113Combined sources1 Publication
Disulfide bondi62 ↔ 123Combined sources1 Publication
Glycosylationi69N-linked (GlcNAc...) (complex)7 Publications1
Disulfide bondi93 ↔ 103Combined sources1 Publication
Glycosylationi125N-linked (GlcNAc...)2 Publications1
Glycosylationi192N-linked (GlcNAc...)2 Publications1
Glycosylationi362N-linked (GlcNAc...)1
Glycosylationi398N-linked (GlcNAc...) (complex)4 Publications1
Glycosylationi551N-linked (GlcNAc...) (complex)5 Publications1
Glycosylationi580N-linked (GlcNAc...) (complex)3 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ08380.
MaxQBiQ08380.
PaxDbiQ08380.
PeptideAtlasiQ08380.
PRIDEiQ08380.

PTM databases

iPTMnetiQ08380.
PhosphoSitePlusiQ08380.
SwissPalmiQ08380.

Miscellaneous databases

PMAP-CutDBQ08380.

Expressioni

Tissue specificityi

Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.3 Publications

Gene expression databases

BgeeiENSG00000108679.
CleanExiHS_LGALS3BP.
ExpressionAtlasiQ08380. baseline and differential.
GenevisibleiQ08380. HS.

Organism-specific databases

HPAiCAB002158.
HPA000554.

Interactioni

Subunit structurei

Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID.1 Publication

Protein-protein interaction databases

BioGridi110150. 169 interactors.
IntActiQ08380. 71 interactors.
MINTiMINT-1153112.
STRINGi9606.ENSP00000262776.

Structurei

Secondary structure

1585
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 28Combined sources5
Beta strandi34 – 41Combined sources8
Beta strandi44 – 49Combined sources6
Helixi55 – 64Combined sources10
Beta strandi70 – 74Combined sources5
Turni76 – 79Combined sources4
Beta strandi86 – 88Combined sources3
Helixi100 – 102Combined sources3
Helixi115 – 117Combined sources3
Beta strandi120 – 123Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BY2X-ray2.00A19-133[»]
ProteinModelPortaliQ08380.
SMRiQ08380.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08380.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 124SRCRPROSITE-ProRule annotationAdd BLAST101
Domaini153 – 221BTBPROSITE-ProRule annotationAdd BLAST69
Domaini260 – 360BACKAdd BLAST101

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 1 SRCR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY2Y. Eukaryota.
ENOG410YBYF. LUCA.
GeneTreeiENSGT00530000063814.
HOGENOMiHOG000113318.
HOVERGENiHBG052323.
InParanoidiQ08380.
KOiK17300.
OMAiQHPSFLF.
OrthoDBiEOG091G0MFZ.
PhylomeDBiQ08380.
TreeFamiTF331368.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00875. BACK. 1 hit.
SM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD
60 70 80 90 100
NLWDLTDASV VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL
110 120 130 140 150
ADCKSLGWLK SNCRHERDAG VVCTNETRST HTLDLSRELS EALGQIFDSQ
160 170 180 190 200
RGCDLSISVN VQGEDALGFC GHTVILTANL EAQALWKEPG SNVTMSVDAE
210 220 230 240 250
CVPMVRDLLR YFYSRRIDIT LSSVKCFHKL ASAYGARQLQ GYCASLFAIL
260 270 280 290 300
LPQDPSFQMP LDLYAYAVAT GDALLEKLCL QFLAWNFEAL TQAEAWPSVP
310 320 330 340 350
TDLLQLLLPR SDLAVPSELA LLKAVDTWSW GERASHEEVE GLVEKIRFPM
360 370 380 390 400
MLPEELFELQ FNLSLYWSHE ALFQKKTLQA LEFHTVPFQL LARYKGLNLT
410 420 430 440 450
EDTYKPRIYT SPTWSAFVTD SSWSARKSQL VYQSRRGPLV KYSSDYFQAP
460 470 480 490 500
SDYRYYPYQS FQTPQHPSFL FQDKRVSWSL VYLPTIQSCW NYGFSCSSDE
510 520 530 540 550
LPVLGLTKSG GSDRTIAYEN KALMLCEGLF VADVTDFEGW KAAIPSALDT
560 570 580
NSSKSTSSFP CPAGHFNGFR TVIRPFYLTN SSGVD
Length:585
Mass (Da):65,331
Last modified:November 1, 1996 - v1
Checksum:iC488C2E99D77435B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19V → S AA sequence (PubMed:8757764).Curated1
Sequence conflicti25R → C AA sequence (PubMed:8454062).Curated1
Sequence conflicti25R → P AA sequence (PubMed:8454062).Curated1
Sequence conflicti26L → M AA sequence (PubMed:8757764).Curated1
Sequence conflicti30 – 31GA → ED AA sequence (PubMed:8757764).Curated2
Sequence conflicti36R → H AA sequence (PubMed:8757764).Curated1
Sequence conflicti36R → L AA sequence (PubMed:8454062).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13210 mRNA. Translation: AAA36193.1.
X79089 mRNA. Translation: CAA55699.1.
BC002403 mRNA. Translation: AAH02403.1.
BC002998 mRNA. Translation: AAH02998.1.
BC015761 mRNA. Translation: AAH15761.1.
CCDSiCCDS11759.1.
PIRiA47161.
A55899.
RefSeqiNP_005558.1. NM_005567.3.
UniGeneiHs.514535.

Genome annotation databases

EnsembliENST00000262776; ENSP00000262776; ENSG00000108679.
GeneIDi3959.
KEGGihsa:3959.
UCSCiuc002jwh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13210 mRNA. Translation: AAA36193.1.
X79089 mRNA. Translation: CAA55699.1.
BC002403 mRNA. Translation: AAH02403.1.
BC002998 mRNA. Translation: AAH02998.1.
BC015761 mRNA. Translation: AAH15761.1.
CCDSiCCDS11759.1.
PIRiA47161.
A55899.
RefSeqiNP_005558.1. NM_005567.3.
UniGeneiHs.514535.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BY2X-ray2.00A19-133[»]
ProteinModelPortaliQ08380.
SMRiQ08380.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110150. 169 interactors.
IntActiQ08380. 71 interactors.
MINTiMINT-1153112.
STRINGi9606.ENSP00000262776.

PTM databases

iPTMnetiQ08380.
PhosphoSitePlusiQ08380.
SwissPalmiQ08380.

Polymorphism and mutation databases

BioMutaiLGALS3BP.
DMDMi47115668.

Proteomic databases

EPDiQ08380.
MaxQBiQ08380.
PaxDbiQ08380.
PeptideAtlasiQ08380.
PRIDEiQ08380.

Protocols and materials databases

DNASUi3959.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262776; ENSP00000262776; ENSG00000108679.
GeneIDi3959.
KEGGihsa:3959.
UCSCiuc002jwh.4. human.

Organism-specific databases

CTDi3959.
DisGeNETi3959.
GeneCardsiLGALS3BP.
HGNCiHGNC:6564. LGALS3BP.
HPAiCAB002158.
HPA000554.
MIMi600626. gene.
neXtProtiNX_Q08380.
OpenTargetsiENSG00000108679.
PharmGKBiPA30341.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY2Y. Eukaryota.
ENOG410YBYF. LUCA.
GeneTreeiENSGT00530000063814.
HOGENOMiHOG000113318.
HOVERGENiHBG052323.
InParanoidiQ08380.
KOiK17300.
OMAiQHPSFLF.
OrthoDBiEOG091G0MFZ.
PhylomeDBiQ08380.
TreeFamiTF331368.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108679-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiLGALS3BP. human.
EvolutionaryTraceiQ08380.
GeneWikiiLGALS3BP.
GenomeRNAii3959.
PMAP-CutDBQ08380.
PROiQ08380.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108679.
CleanExiHS_LGALS3BP.
ExpressionAtlasiQ08380. baseline and differential.
GenevisibleiQ08380. HS.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00875. BACK. 1 hit.
SM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLG3BP_HUMAN
AccessioniPrimary (citable) accession number: Q08380
Secondary accession number(s): Q7M4S0
, Q9UCH8, Q9UCH9, Q9UCI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.