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Q08380

- LG3BP_HUMAN

UniProt

Q08380 - LG3BP_HUMAN

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Protein

Galectin-3-binding protein

Gene
LGALS3BP, M2BP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.3 Publications

GO - Molecular functioni

  1. scavenger receptor activity Source: ProtInc

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cellular defense response Source: ProtInc
  3. receptor-mediated endocytosis Source: GOC
  4. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-3-binding protein
Alternative name(s):
Basement membrane autoantigen p105
Lectin galactoside-binding soluble 3-binding protein
Mac-2-binding protein
Short name:
MAC2BP
Short name:
Mac-2 BP
Tumor-associated antigen 90K
Gene namesi
Synonyms:M2BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6564. LGALS3BP.

Subcellular locationi

Secreted. Secretedextracellular spaceextracellular matrix 2 Publications

GO - Cellular componenti

  1. blood microparticle Source: UniProt
  2. extracellular space Source: UniProt
  3. extracellular vesicular exosome Source: UniProtKB
  4. membrane Source: InterPro
  5. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30341.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18183 PublicationsAdd
BLAST
Chaini19 – 585567Galectin-3-binding proteinPRO_0000033230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 113
Disulfide bondi62 ↔ 123
Glycosylationi69 – 691N-linked (GlcNAc...) (complex)6 Publications
Disulfide bondi93 ↔ 103
Glycosylationi125 – 1251N-linked (GlcNAc...)2 Publications
Glycosylationi192 – 1921N-linked (GlcNAc...)2 Publications
Glycosylationi362 – 3621N-linked (GlcNAc...)
Glycosylationi398 – 3981N-linked (GlcNAc...) (complex)4 Publications
Glycosylationi551 – 5511N-linked (GlcNAc...) (complex)5 Publications
Glycosylationi580 – 5801N-linked (GlcNAc...) (complex)3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ08380.
PaxDbiQ08380.
PeptideAtlasiQ08380.
PRIDEiQ08380.

PTM databases

PhosphoSiteiQ08380.

Miscellaneous databases

PMAP-CutDBQ08380.

Expressioni

Tissue specificityi

Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.3 Publications

Gene expression databases

ArrayExpressiQ08380.
BgeeiQ08380.
CleanExiHS_LGALS3BP.
GenevestigatoriQ08380.

Organism-specific databases

HPAiCAB002158.
HPA000554.

Interactioni

Subunit structurei

Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID.1 Publication

Protein-protein interaction databases

BioGridi110150. 39 interactions.
IntActiQ08380. 27 interactions.
MINTiMINT-1153112.
STRINGi9606.ENSP00000262776.

Structurei

Secondary structure

1
585
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 285
Beta strandi34 – 418
Beta strandi44 – 496
Helixi55 – 6410
Beta strandi70 – 745
Turni76 – 794
Beta strandi86 – 883
Helixi100 – 1023
Helixi115 – 1173
Beta strandi120 – 1234

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BY2X-ray2.00A19-133[»]
ProteinModelPortaliQ08380.
SMRiQ08380. Positions 18-127.

Miscellaneous databases

EvolutionaryTraceiQ08380.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 124101SRCRAdd
BLAST
Domaini153 – 22169BTBAdd
BLAST
Domaini260 – 360101BACKAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.
Contains 1 SRCR domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41083.
HOGENOMiHOG000113318.
HOVERGENiHBG052323.
InParanoidiQ08380.
KOiK17300.
OMAiQHPSFLF.
OrthoDBiEOG7JDQXP.
PhylomeDBiQ08380.
TreeFamiTF331368.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00875. BACK. 1 hit.
SM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08380-1 [UniParc]FASTAAdd to Basket

« Hide

MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD    50
NLWDLTDASV VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL 100
ADCKSLGWLK SNCRHERDAG VVCTNETRST HTLDLSRELS EALGQIFDSQ 150
RGCDLSISVN VQGEDALGFC GHTVILTANL EAQALWKEPG SNVTMSVDAE 200
CVPMVRDLLR YFYSRRIDIT LSSVKCFHKL ASAYGARQLQ GYCASLFAIL 250
LPQDPSFQMP LDLYAYAVAT GDALLEKLCL QFLAWNFEAL TQAEAWPSVP 300
TDLLQLLLPR SDLAVPSELA LLKAVDTWSW GERASHEEVE GLVEKIRFPM 350
MLPEELFELQ FNLSLYWSHE ALFQKKTLQA LEFHTVPFQL LARYKGLNLT 400
EDTYKPRIYT SPTWSAFVTD SSWSARKSQL VYQSRRGPLV KYSSDYFQAP 450
SDYRYYPYQS FQTPQHPSFL FQDKRVSWSL VYLPTIQSCW NYGFSCSSDE 500
LPVLGLTKSG GSDRTIAYEN KALMLCEGLF VADVTDFEGW KAAIPSALDT 550
NSSKSTSSFP CPAGHFNGFR TVIRPFYLTN SSGVD 585
Length:585
Mass (Da):65,331
Last modified:November 1, 1996 - v1
Checksum:iC488C2E99D77435B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191V → S AA sequence 1 Publication
Sequence conflicti25 – 251R → C AA sequence 1 Publication
Sequence conflicti25 – 251R → P AA sequence 1 Publication
Sequence conflicti26 – 261L → M AA sequence 1 Publication
Sequence conflicti30 – 312GA → ED AA sequence 1 Publication
Sequence conflicti36 – 361R → H AA sequence 1 Publication
Sequence conflicti36 – 361R → L AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13210 mRNA. Translation: AAA36193.1.
X79089 mRNA. Translation: CAA55699.1.
BC002403 mRNA. Translation: AAH02403.1.
BC002998 mRNA. Translation: AAH02998.1.
BC015761 mRNA. Translation: AAH15761.1.
CCDSiCCDS11759.1.
PIRiA47161.
A55899.
RefSeqiNP_005558.1. NM_005567.3.
UniGeneiHs.514535.

Genome annotation databases

EnsembliENST00000262776; ENSP00000262776; ENSG00000108679.
GeneIDi3959.
KEGGihsa:3959.
UCSCiuc002jwh.3. human.

Polymorphism databases

DMDMi47115668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13210 mRNA. Translation: AAA36193.1 .
X79089 mRNA. Translation: CAA55699.1 .
BC002403 mRNA. Translation: AAH02403.1 .
BC002998 mRNA. Translation: AAH02998.1 .
BC015761 mRNA. Translation: AAH15761.1 .
CCDSi CCDS11759.1.
PIRi A47161.
A55899.
RefSeqi NP_005558.1. NM_005567.3.
UniGenei Hs.514535.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BY2 X-ray 2.00 A 19-133 [» ]
ProteinModelPortali Q08380.
SMRi Q08380. Positions 18-127.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110150. 39 interactions.
IntActi Q08380. 27 interactions.
MINTi MINT-1153112.
STRINGi 9606.ENSP00000262776.

PTM databases

PhosphoSitei Q08380.

Polymorphism databases

DMDMi 47115668.

Proteomic databases

MaxQBi Q08380.
PaxDbi Q08380.
PeptideAtlasi Q08380.
PRIDEi Q08380.

Protocols and materials databases

DNASUi 3959.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262776 ; ENSP00000262776 ; ENSG00000108679 .
GeneIDi 3959.
KEGGi hsa:3959.
UCSCi uc002jwh.3. human.

Organism-specific databases

CTDi 3959.
GeneCardsi GC17M076970.
HGNCi HGNC:6564. LGALS3BP.
HPAi CAB002158.
HPA000554.
MIMi 600626. gene.
neXtProti NX_Q08380.
PharmGKBi PA30341.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41083.
HOGENOMi HOG000113318.
HOVERGENi HBG052323.
InParanoidi Q08380.
KOi K17300.
OMAi QHPSFLF.
OrthoDBi EOG7JDQXP.
PhylomeDBi Q08380.
TreeFami TF331368.

Miscellaneous databases

EvolutionaryTracei Q08380.
GeneWikii LGALS3BP.
GenomeRNAii 3959.
NextBioi 15536.
PMAP-CutDB Q08380.
PROi Q08380.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q08380.
Bgeei Q08380.
CleanExi HS_LGALS3BP.
Genevestigatori Q08380.

Family and domain databases

Gene3Di 3.10.250.10. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view ]
Pfami PF07707. BACK. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view ]
PRINTSi PR00258. SPERACTRCPTR.
SMARTi SM00875. BACK. 1 hit.
SM00202. SR. 1 hit.
[Graphical view ]
SUPFAMi SSF56487. SSF56487. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain."
    Koths K., Taylor E., Halenbeck R., Casipit C., Wang A.
    J. Biol. Chem. 268:14245-14249(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-34; 188-191; 193-200; 202-207; 230-242; 244-259; 261-267; 324-328 AND 437-440, INTERACTION WITH LGALS3, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The secreted tumor-associated antigen 90K is a potent immune stimulator."
    Ullrich A., Sures I., D'Egido M., Jallal B., Powell T.J., Herbst R., Dreps A., Azam M., Rubinstein M., Natoli C.
    J. Biol. Chem. 269:18401-18407(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, GLYCOSYLATION, TISSUE SPECIFICITY.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Lung.
  4. "Purification and characterization of a 90 kDa protein released from human tumors and tumor cell lines."
    Iacobelli S., Bucci I., D'Egidio M., Giuliani C., Natoli C., Tinari N., Rubistein M., Schlessinger J.
    FEBS Lett. 319:59-65(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-40.
    Tissue: Ascites and Serum.
  5. "The 105-kDa basement membrane autoantigen p105 is N-terminally homologous to a tumor-associated antigen."
    Chan L.S., Woodley D.T.
    J. Invest. Dermatol. 107:209-214(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-38, TISSUE SPECIFICITY.
    Tissue: Fibroblast.
  6. "Functional studies on recombinant domains of Mac-2-binding protein."
    Hellstern S., Sasaki T., Fauser C., Lustig A., Timpl R., Engel J.
    J. Biol. Chem. 277:15690-15696(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 442-446, GLYCOSYLATION, INTERACTION WITH LGALS3, SUBUNIT STRUCTURE.
  7. "Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation."
    Tinari N., Kuwabara I., Huflejt M.E., Shen P.F., Iacobelli S., Liu F.-T.
    Int. J. Cancer 91:167-172(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH LGALS1 AND LGALS3.
  8. Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69.
    Tissue: Bile.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69; ASN-125; ASN-192; ASN-398; ASN-551 AND ASN-580.
    Tissue: Plasma.
  10. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69; ASN-398; ASN-551 AND ASN-580.
    Tissue: Saliva.
  11. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
    Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
    Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69 AND ASN-551.
    Tissue: Milk.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69; ASN-125; ASN-192; ASN-398 AND ASN-551.
    Tissue: Liver.
  13. Cited for: GLYCOSYLATION AT ASN-69; ASN-398; ASN-551 AND ASN-580.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin."
    Sasaki T., Brakebusch C., Engel J., Timpl R.
    EMBO J. 17:1606-1613(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 18-133, FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, INTERACTION WITH ITGB1; COL4A1; COL5A1; COL6A1; LGALS3; FN1 AND NID.

Entry informationi

Entry nameiLG3BP_HUMAN
AccessioniPrimary (citable) accession number: Q08380
Secondary accession number(s): Q7M4S0
, Q9UCH8, Q9UCH9, Q9UCI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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