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Protein

Galectin-3-binding protein

Gene

LGALS3BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.3 Publications

GO - Molecular functioni

  • scavenger receptor activity Source: ProtInc

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cellular defense response Source: ProtInc
  • platelet degranulation Source: Reactome
  • signal transduction Source: ProtInc

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
SIGNORiQ08380

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-3-binding protein
Alternative name(s):
Basement membrane autoantigen p105
Lectin galactoside-binding soluble 3-binding protein
Mac-2-binding protein
Short name:
MAC2BP
Short name:
Mac-2 BP
Tumor-associated antigen 90K
Gene namesi
Name:LGALS3BP
Synonyms:M2BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108679.12
HGNCiHGNC:6564 LGALS3BP
MIMi600626 gene
neXtProtiNX_Q08380

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3959
OpenTargetsiENSG00000108679
PharmGKBiPA30341

Polymorphism and mutation databases

BioMutaiLGALS3BP
DMDMi47115668

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 183 PublicationsAdd BLAST18
ChainiPRO_000003323019 – 585Galectin-3-binding proteinAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 113Combined sources1 Publication
Disulfide bondi62 ↔ 123Combined sources1 Publication
Glycosylationi69N-linked (GlcNAc...) (complex) asparagine7 Publications1
Disulfide bondi93 ↔ 103Combined sources1 Publication
Glycosylationi125N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi192N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi362N-linked (GlcNAc...) asparagine1
Glycosylationi398N-linked (GlcNAc...) (complex) asparagine4 Publications1
Glycosylationi551N-linked (GlcNAc...) (complex) asparagine5 Publications1
Glycosylationi580N-linked (GlcNAc...) (complex) asparagine3 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ08380
MaxQBiQ08380
PaxDbiQ08380
PeptideAtlasiQ08380
PRIDEiQ08380

PTM databases

iPTMnetiQ08380
PhosphoSitePlusiQ08380
SwissPalmiQ08380

Miscellaneous databases

PMAP-CutDBiQ08380

Expressioni

Tissue specificityi

Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.3 Publications

Gene expression databases

BgeeiENSG00000108679
CleanExiHS_LGALS3BP
ExpressionAtlasiQ08380 baseline and differential
GenevisibleiQ08380 HS

Organism-specific databases

HPAiCAB002158
HPA000554

Interactioni

Subunit structurei

Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID. Interacts with the gamma-tubulin ring complex (gamma-TuRC), composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 (PubMed:29162697). The unglycosylated form interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction may connect a pericentrosomal complex, made of AKAP9, CDK5RAP2, EB1/MAPRE1 and PDE4DIP, to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (PubMed:29162697).2 Publications

Protein-protein interaction databases

BioGridi110150176 interactors.
IntActiQ08380 80 interactors.
MINTiQ08380
STRINGi9606.ENSP00000262776

Structurei

Secondary structure

1585
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 28Combined sources5
Beta strandi34 – 41Combined sources8
Beta strandi44 – 49Combined sources6
Helixi55 – 64Combined sources10
Beta strandi70 – 74Combined sources5
Turni76 – 79Combined sources4
Beta strandi86 – 88Combined sources3
Helixi100 – 102Combined sources3
Helixi115 – 117Combined sources3
Beta strandi120 – 123Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BY2X-ray2.00A19-133[»]
ProteinModelPortaliQ08380
SMRiQ08380
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08380

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 124SRCRPROSITE-ProRule annotationAdd BLAST101
Domaini153 – 221BTBPROSITE-ProRule annotationAdd BLAST69
Domaini260 – 360BACKAdd BLAST101

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY2Y Eukaryota
ENOG410YBYF LUCA
GeneTreeiENSGT00530000063814
HOGENOMiHOG000113318
HOVERGENiHBG052323
InParanoidiQ08380
KOiK17300
OMAiQHPSFLF
OrthoDBiEOG091G0MFZ
PhylomeDBiQ08380
TreeFamiTF331368

Family and domain databases

Gene3Di3.10.250.101 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00530 SRCR, 1 hit
PRINTSiPR00258 SPERACTRCPTR
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00202 SR, 1 hit
SUPFAMiSSF56487 SSF56487, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00420 SRCR_1, 1 hit
PS50287 SRCR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD
60 70 80 90 100
NLWDLTDASV VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL
110 120 130 140 150
ADCKSLGWLK SNCRHERDAG VVCTNETRST HTLDLSRELS EALGQIFDSQ
160 170 180 190 200
RGCDLSISVN VQGEDALGFC GHTVILTANL EAQALWKEPG SNVTMSVDAE
210 220 230 240 250
CVPMVRDLLR YFYSRRIDIT LSSVKCFHKL ASAYGARQLQ GYCASLFAIL
260 270 280 290 300
LPQDPSFQMP LDLYAYAVAT GDALLEKLCL QFLAWNFEAL TQAEAWPSVP
310 320 330 340 350
TDLLQLLLPR SDLAVPSELA LLKAVDTWSW GERASHEEVE GLVEKIRFPM
360 370 380 390 400
MLPEELFELQ FNLSLYWSHE ALFQKKTLQA LEFHTVPFQL LARYKGLNLT
410 420 430 440 450
EDTYKPRIYT SPTWSAFVTD SSWSARKSQL VYQSRRGPLV KYSSDYFQAP
460 470 480 490 500
SDYRYYPYQS FQTPQHPSFL FQDKRVSWSL VYLPTIQSCW NYGFSCSSDE
510 520 530 540 550
LPVLGLTKSG GSDRTIAYEN KALMLCEGLF VADVTDFEGW KAAIPSALDT
560 570 580
NSSKSTSSFP CPAGHFNGFR TVIRPFYLTN SSGVD
Length:585
Mass (Da):65,331
Last modified:November 1, 1996 - v1
Checksum:iC488C2E99D77435B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19V → S AA sequence (PubMed:8757764).Curated1
Sequence conflicti25R → C AA sequence (PubMed:8454062).Curated1
Sequence conflicti25R → P AA sequence (PubMed:8454062).Curated1
Sequence conflicti26L → M AA sequence (PubMed:8757764).Curated1
Sequence conflicti30 – 31GA → ED AA sequence (PubMed:8757764).Curated2
Sequence conflicti36R → H AA sequence (PubMed:8757764).Curated1
Sequence conflicti36R → L AA sequence (PubMed:8454062).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13210 mRNA Translation: AAA36193.1
X79089 mRNA Translation: CAA55699.1
BC002403 mRNA Translation: AAH02403.1
BC002998 mRNA Translation: AAH02998.1
BC015761 mRNA Translation: AAH15761.1
CCDSiCCDS11759.1
PIRiA47161
A55899
RefSeqiNP_005558.1, NM_005567.3
UniGeneiHs.514535

Genome annotation databases

EnsembliENST00000262776; ENSP00000262776; ENSG00000108679
GeneIDi3959
KEGGihsa:3959
UCSCiuc002jwh.4 human

Similar proteinsi

Entry informationi

Entry nameiLG3BP_HUMAN
AccessioniPrimary (citable) accession number: Q08380
Secondary accession number(s): Q7M4S0
, Q9UCH8, Q9UCH9, Q9UCI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome