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Protein

Galectin-3-binding protein

Gene

LGALS3BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.3 Publications

GO - Molecular functioni

  • scavenger receptor activity Source: ProtInc

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cellular defense response Source: ProtInc
  • platelet degranulation Source: Reactome
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-3-binding protein
Alternative name(s):
Basement membrane autoantigen p105
Lectin galactoside-binding soluble 3-binding protein
Mac-2-binding protein
Short name:
MAC2BP
Short name:
Mac-2 BP
Tumor-associated antigen 90K
Gene namesi
Name:LGALS3BP
Synonyms:M2BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6564. LGALS3BP.

Subcellular locationi

  • Secreted 1 Publication
  • Secretedextracellular spaceextracellular matrix 1 Publication

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • membrane Source: InterPro
  • platelet dense granule lumen Source: Reactome
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30341.

Polymorphism and mutation databases

BioMutaiLGALS3BP.
DMDMi47115668.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18183 PublicationsAdd
BLAST
Chaini19 – 585567Galectin-3-binding proteinPRO_0000033230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 113Combined sources1 Publication
Disulfide bondi62 ↔ 123Combined sources1 Publication
Glycosylationi69 – 691N-linked (GlcNAc...) (complex)7 Publications
Disulfide bondi93 ↔ 103Combined sources1 Publication
Glycosylationi125 – 1251N-linked (GlcNAc...)2 Publications
Glycosylationi192 – 1921N-linked (GlcNAc...)2 Publications
Glycosylationi362 – 3621N-linked (GlcNAc...)
Glycosylationi398 – 3981N-linked (GlcNAc...) (complex)4 Publications
Glycosylationi551 – 5511N-linked (GlcNAc...) (complex)5 Publications
Glycosylationi580 – 5801N-linked (GlcNAc...) (complex)3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ08380.
MaxQBiQ08380.
PaxDbiQ08380.
PeptideAtlasiQ08380.
PRIDEiQ08380.

PTM databases

iPTMnetiQ08380.
PhosphoSiteiQ08380.
SwissPalmiQ08380.

Miscellaneous databases

PMAP-CutDBQ08380.

Expressioni

Tissue specificityi

Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.3 Publications

Gene expression databases

BgeeiENSG00000108679.
CleanExiHS_LGALS3BP.
ExpressionAtlasiQ08380. baseline and differential.
GenevisibleiQ08380. HS.

Organism-specific databases

HPAiCAB002158.
HPA000554.

Interactioni

Subunit structurei

Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID.1 Publication

Protein-protein interaction databases

BioGridi110150. 169 interactions.
IntActiQ08380. 71 interactions.
MINTiMINT-1153112.
STRINGi9606.ENSP00000262776.

Structurei

Secondary structure

1
585
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 285Combined sources
Beta strandi34 – 418Combined sources
Beta strandi44 – 496Combined sources
Helixi55 – 6410Combined sources
Beta strandi70 – 745Combined sources
Turni76 – 794Combined sources
Beta strandi86 – 883Combined sources
Helixi100 – 1023Combined sources
Helixi115 – 1173Combined sources
Beta strandi120 – 1234Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BY2X-ray2.00A19-133[»]
ProteinModelPortaliQ08380.
SMRiQ08380. Positions 18-127.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08380.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 124101SRCRPROSITE-ProRule annotationAdd
BLAST
Domaini153 – 22169BTBPROSITE-ProRule annotationAdd
BLAST
Domaini260 – 360101BACKAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 1 SRCR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY2Y. Eukaryota.
ENOG410YBYF. LUCA.
GeneTreeiENSGT00530000063814.
HOGENOMiHOG000113318.
HOVERGENiHBG052323.
InParanoidiQ08380.
KOiK17300.
OMAiQHPSFLF.
OrthoDBiEOG091G0MFZ.
PhylomeDBiQ08380.
TreeFamiTF331368.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00875. BACK. 1 hit.
SM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD
60 70 80 90 100
NLWDLTDASV VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL
110 120 130 140 150
ADCKSLGWLK SNCRHERDAG VVCTNETRST HTLDLSRELS EALGQIFDSQ
160 170 180 190 200
RGCDLSISVN VQGEDALGFC GHTVILTANL EAQALWKEPG SNVTMSVDAE
210 220 230 240 250
CVPMVRDLLR YFYSRRIDIT LSSVKCFHKL ASAYGARQLQ GYCASLFAIL
260 270 280 290 300
LPQDPSFQMP LDLYAYAVAT GDALLEKLCL QFLAWNFEAL TQAEAWPSVP
310 320 330 340 350
TDLLQLLLPR SDLAVPSELA LLKAVDTWSW GERASHEEVE GLVEKIRFPM
360 370 380 390 400
MLPEELFELQ FNLSLYWSHE ALFQKKTLQA LEFHTVPFQL LARYKGLNLT
410 420 430 440 450
EDTYKPRIYT SPTWSAFVTD SSWSARKSQL VYQSRRGPLV KYSSDYFQAP
460 470 480 490 500
SDYRYYPYQS FQTPQHPSFL FQDKRVSWSL VYLPTIQSCW NYGFSCSSDE
510 520 530 540 550
LPVLGLTKSG GSDRTIAYEN KALMLCEGLF VADVTDFEGW KAAIPSALDT
560 570 580
NSSKSTSSFP CPAGHFNGFR TVIRPFYLTN SSGVD
Length:585
Mass (Da):65,331
Last modified:November 1, 1996 - v1
Checksum:iC488C2E99D77435B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191V → S AA sequence (PubMed:8757764).Curated
Sequence conflicti25 – 251R → C AA sequence (PubMed:8454062).Curated
Sequence conflicti25 – 251R → P AA sequence (PubMed:8454062).Curated
Sequence conflicti26 – 261L → M AA sequence (PubMed:8757764).Curated
Sequence conflicti30 – 312GA → ED AA sequence (PubMed:8757764).Curated
Sequence conflicti36 – 361R → H AA sequence (PubMed:8757764).Curated
Sequence conflicti36 – 361R → L AA sequence (PubMed:8454062).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13210 mRNA. Translation: AAA36193.1.
X79089 mRNA. Translation: CAA55699.1.
BC002403 mRNA. Translation: AAH02403.1.
BC002998 mRNA. Translation: AAH02998.1.
BC015761 mRNA. Translation: AAH15761.1.
CCDSiCCDS11759.1.
PIRiA47161.
A55899.
RefSeqiNP_005558.1. NM_005567.3.
UniGeneiHs.514535.

Genome annotation databases

EnsembliENST00000262776; ENSP00000262776; ENSG00000108679.
GeneIDi3959.
KEGGihsa:3959.
UCSCiuc002jwh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13210 mRNA. Translation: AAA36193.1.
X79089 mRNA. Translation: CAA55699.1.
BC002403 mRNA. Translation: AAH02403.1.
BC002998 mRNA. Translation: AAH02998.1.
BC015761 mRNA. Translation: AAH15761.1.
CCDSiCCDS11759.1.
PIRiA47161.
A55899.
RefSeqiNP_005558.1. NM_005567.3.
UniGeneiHs.514535.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BY2X-ray2.00A19-133[»]
ProteinModelPortaliQ08380.
SMRiQ08380. Positions 18-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110150. 169 interactions.
IntActiQ08380. 71 interactions.
MINTiMINT-1153112.
STRINGi9606.ENSP00000262776.

PTM databases

iPTMnetiQ08380.
PhosphoSiteiQ08380.
SwissPalmiQ08380.

Polymorphism and mutation databases

BioMutaiLGALS3BP.
DMDMi47115668.

Proteomic databases

EPDiQ08380.
MaxQBiQ08380.
PaxDbiQ08380.
PeptideAtlasiQ08380.
PRIDEiQ08380.

Protocols and materials databases

DNASUi3959.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262776; ENSP00000262776; ENSG00000108679.
GeneIDi3959.
KEGGihsa:3959.
UCSCiuc002jwh.4. human.

Organism-specific databases

CTDi3959.
GeneCardsiLGALS3BP.
HGNCiHGNC:6564. LGALS3BP.
HPAiCAB002158.
HPA000554.
MIMi600626. gene.
neXtProtiNX_Q08380.
PharmGKBiPA30341.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY2Y. Eukaryota.
ENOG410YBYF. LUCA.
GeneTreeiENSGT00530000063814.
HOGENOMiHOG000113318.
HOVERGENiHBG052323.
InParanoidiQ08380.
KOiK17300.
OMAiQHPSFLF.
OrthoDBiEOG091G0MFZ.
PhylomeDBiQ08380.
TreeFamiTF331368.

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiLGALS3BP. human.
EvolutionaryTraceiQ08380.
GeneWikiiLGALS3BP.
GenomeRNAii3959.
PMAP-CutDBQ08380.
PROiQ08380.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108679.
CleanExiHS_LGALS3BP.
ExpressionAtlasiQ08380. baseline and differential.
GenevisibleiQ08380. HS.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00875. BACK. 1 hit.
SM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLG3BP_HUMAN
AccessioniPrimary (citable) accession number: Q08380
Secondary accession number(s): Q7M4S0
, Q9UCH8, Q9UCH9, Q9UCI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.