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Protein

Golgin subfamily A member 2

Gene

GOLGA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401).By similarity6 Publications

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • importin-alpha family protein binding Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • syntaxin binding Source: UniProtKB

GO - Biological processi

  • asymmetric cell division Source: UniProtKB
  • centrosome cycle Source: UniProtKB
  • COPII vesicle coating Source: Reactome
  • ER to Golgi vesicle-mediated transport Source: UniProtKB
  • Golgi disassembly Source: UniProtKB
  • Golgi ribbon formation Source: UniProtKB
  • microtubule nucleation Source: UniProtKB
  • mitotic spindle assembly Source: UniProtKB
  • negative regulation of autophagy Source: ParkinsonsUK-UCL
  • negative regulation of protein binding Source: UniProtKB
  • positive regulation of protein glycosylation Source: ParkinsonsUK-UCL
  • positive regulation of ubiquitin protein ligase activity Source: Reactome
  • protein glycosylation Source: UniProtKB
  • protein homotetramerization Source: UniProtKB
  • spindle assembly Source: UniProtKB
  • spindle assembly involved in meiosis Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-162658. Golgi Cisternae Pericentriolar Stack Reorganization.
R-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-8862803. Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.
SIGNORiQ08379.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 2
Alternative name(s):
130 kDa cis-Golgi matrix protein1 Publication
Short name:
GM1301 Publication
GM130 autoantigen1 Publication
Golgin-951 Publication
Gene namesi
Name:GOLGA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000167110.16.
HGNCiHGNC:4425. GOLGA2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi18R → K: Impaired methylation; when associated with R-30 and R-35. 1 Publication1
Mutagenesisi26 – 49KKKLR…KKKKK → AAALAEYQQANSPGVPTGAA AAAA: Abolishes interaction with importin-alpha. 1 PublicationAdd BLAST24
Mutagenesisi30R → K: Impaired methylation; when associated with R-18 and R-35. 1 Publication1
Mutagenesisi35R → K: Impaired methylation; when associated with R-18 and R-35. 1 Publication1
Mutagenesisi37S → D: Phosphomimetic mutant. Does not affect interaction with importin-alpha. 1 Publication1

Organism-specific databases

DisGeNETi2801.
OpenTargetsiENSG00000167110.
PharmGKBiPA28805.

Polymorphism and mutation databases

BioMutaiGOLGA2.
DMDMi294862511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900541 – 1002Golgin subfamily A member 2Add BLAST1002

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Omega-N-methylated arginine1 Publication1
Modified residuei30Dimethylated arginine1 Publication1
Modified residuei35Dimethylated arginine1 Publication1
Modified residuei37PhosphoserineCombined sources1 Publication1
Modified residuei66PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei690PhosphoserineCombined sources1
Modified residuei937PhosphoserineCombined sources1
Modified residuei953PhosphoserineCombined sources1
Modified residuei981PhosphoserineCombined sources1

Post-translational modificationi

Cleaved by caspases at the onset of apoptosis.1 Publication
Methylation by PRMT5 is required for Golgi ribbon formation. While dimethylation at Arg-30 and Arg-35 are confirmed in vivo, it is unclear whether Arg-18 is methylated in vivo.1 Publication
Phosphorylated at Ser-37 by CDK1 at the onset of mitosis, inhibiting the interaction with p115/USO1 and triggering Golgi disassembly (PubMed:20421892, PubMed:26165940). Phosphorylated at Ser-37 in prophase as the Golgi complex starts to break down, and remains phosphorylated during further breakdown and partitioning of the Golgi fragments in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble (By similarity).By similarity2 Publications

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ08379.
MaxQBiQ08379.
PaxDbiQ08379.
PeptideAtlasiQ08379.
PRIDEiQ08379.

PTM databases

iPTMnetiQ08379.
PhosphoSitePlusiQ08379.

Expressioni

Gene expression databases

BgeeiENSG00000167110.
CleanExiHS_GOLGA2.
ExpressionAtlasiQ08379. baseline and differential.
GenevisibleiQ08379. HS.

Organism-specific databases

HPAiCAB015421.
HPA021178.
HPA021230.
HPA021799.

Interactioni

Subunit structurei

Part of a larger oligomeric complex (By similarity). Interacts with p115/USO1 (By similarity). Interacts with RAB1B that has been activated by GTP-binding (PubMed:11306556). Interacts with GORASP1/GRASP65 (PubMed:16489344, PubMed:18045989). Interacts with ZFPL1 (PubMed:18323775). Interacts with AKAP450/AKAP9; leading to recruit AKAP450/AKAP9 to the cis-Golgi (PubMed:19242490).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
A8K2R33EBI-618309,EBI-9977437
P299913EBI-618309,EBI-8826488From Dengue virus type 2 (strain 16681-PDK53).
Q9WMX22EBI-618309,EBI-6863748From Hepatitis C virus genotype 1b (isolate Con1).
ADAP1O756893EBI-618309,EBI-714732
AESQ081173EBI-618309,EBI-717810
AESQ08117-25EBI-618309,EBI-11741437
AFF4Q9UHB73EBI-618309,EBI-395282
AFF4Q9UHB7-23EBI-618309,EBI-10261324
AKAP9Q999963EBI-618309,EBI-1048311
ALKBH3Q96Q833EBI-618309,EBI-6658697
AMOTL2Q9Y2J4-43EBI-618309,EBI-10187270
ANKRD36BP1Q96IX95EBI-618309,EBI-744859
ARL16Q0P5N65EBI-618309,EBI-10186132
ARL4AP406175EBI-618309,EBI-2875746
ARPC3O151455EBI-618309,EBI-351829
ATP6V1C2Q8NEY4-25EBI-618309,EBI-10270867
ATP6V1DQ6PJ053EBI-618309,EBI-10253919
ATP6V1DQ8N5Z93EBI-618309,EBI-10266952
ATP6V1G1O753483EBI-618309,EBI-711802
BAHD1Q8TBE03EBI-618309,EBI-742750
BARD1A0AVN23EBI-618309,EBI-9977322
BARD1Q997285EBI-618309,EBI-473181
BAZ2BA0A0A0MR974EBI-618309,EBI-11985607
BCAS2O759347EBI-618309,EBI-1050106
BCL6P411824EBI-618309,EBI-765407
BCL6BA8KA133EBI-618309,EBI-10174813
BYSLQ138957EBI-618309,EBI-358049
C12orf50Q8NA575EBI-618309,EBI-10268935
C14orf105Q9NVL85EBI-618309,EBI-10238351
C1orf109Q9NX043EBI-618309,EBI-8643161
C2CD6Q53TS85EBI-618309,EBI-739879
CBX8Q9HC525EBI-618309,EBI-712912
CCAR1Q8IX125EBI-618309,EBI-356265
CCDC146Q8IYE0-23EBI-618309,EBI-10247802
CCDC150Q8NCX03EBI-618309,EBI-10269342
CCDC17Q96LX73EBI-618309,EBI-719840
CCDC70Q6NSX13EBI-618309,EBI-6873045
CCDC87Q9NVE45EBI-618309,EBI-749261
CCDC94Q9BW857EBI-618309,EBI-10300345
CCHCR1Q8TD31-37EBI-618309,EBI-10175300
CCNCP248633EBI-618309,EBI-395261
CCNHP519465EBI-618309,EBI-741406
CDC20BQ86Y333EBI-618309,EBI-10260504
CDC5LQ994595EBI-618309,EBI-374880
CDC73Q6P1J910EBI-618309,EBI-930143
CDK18Q070023EBI-618309,EBI-746238
CDKL3Q8IVW43EBI-618309,EBI-3919850
CENPPQ6IPU03EBI-618309,EBI-10250303
CEP57L1Q8IYX87EBI-618309,EBI-1104570
CEP57L1Q8IYX8-23EBI-618309,EBI-10181988
CHCHD2Q9Y6H15EBI-618309,EBI-2321769
CHCHD3Q9NX633EBI-618309,EBI-743375
CINPQ9BW667EBI-618309,EBI-739784
CORO1AP311463EBI-618309,EBI-1046676
CSPP1Q1MSJ5-13EBI-618309,EBI-10239122
CUL5Q930343EBI-618309,EBI-1057139
CYB5R2Q6BCY43EBI-618309,EBI-744761
DAXXQ9UER77EBI-618309,EBI-77321
DCTN4Q9UJW04EBI-618309,EBI-2134033
DCXO436024EBI-618309,EBI-8646694
DDX6P261965EBI-618309,EBI-351257
DEUP1Q05D606EBI-618309,EBI-748597
DLGAP5Q153983EBI-618309,EBI-748280
DMTNQ084953EBI-618309,EBI-715275
DTX2Q86UW93EBI-618309,EBI-740376
EFHC1Q5JVL43EBI-618309,EBI-743105
EIF3GO758213EBI-618309,EBI-366632
ENPP7Q6UWV64EBI-618309,EBI-12047821
EXOSC5Q9NQT43EBI-618309,EBI-371876
FAM110AQ9BQ895EBI-618309,EBI-1752811
FAM124BQ9H5Z63EBI-618309,EBI-741626
FAM126BQ8IXS83EBI-618309,EBI-8787606
FAM161AQ3B8204EBI-618309,EBI-719941
FAM161BQ96MY74EBI-618309,EBI-7225287
FAM184AQ6P9G83EBI-618309,EBI-10253239
FAM193BQ96PV7-23EBI-618309,EBI-10292648
FAM207AQ9NSI23EBI-618309,EBI-5457304
FAM214AQ32MH53EBI-618309,EBI-2866142
FAM50BQ9Y2473EBI-618309,EBI-742802
FAM90A1Q86YD77EBI-618309,EBI-6658203
FBF1Q8TES7-63EBI-618309,EBI-10244131
FBXL18Q96D163EBI-618309,EBI-744419
FBXO28Q9NVF78EBI-618309,EBI-740282
FIP1L1Q6UN153EBI-618309,EBI-1021914
FLJ34048A4D1I33EBI-618309,EBI-10173415
FNDC11Q9BVV23EBI-618309,EBI-744935
GATA2P237693EBI-618309,EBI-2806671
GATAD2BQ8WXI93EBI-618309,EBI-923440
GCC1Q96CN95EBI-618309,EBI-746252
GEMP550405EBI-618309,EBI-744104
GFAPP141368EBI-618309,EBI-744302
GGNQ86UU54EBI-618309,EBI-10259069
GLYCTKQ8IVS85EBI-618309,EBI-748515
GNG5P632183EBI-618309,EBI-10220734
GORASP2Q9H8Y84EBI-618309,EBI-739467
GPANK1O958723EBI-618309,EBI-751540
GPKOWQ929175EBI-618309,EBI-746309
GSE1Q146875EBI-618309,EBI-372619
GTPBP10A4D1E93EBI-618309,EBI-5453796
HAUS1Q96CS23EBI-618309,EBI-2514791
HCTP4Q643R03EBI-618309,EBI-10248808
HDAC4P565243EBI-618309,EBI-308629
HOXB9P174823EBI-618309,EBI-745290
HRASLS5Q96KN8-35EBI-618309,EBI-10290304
HYLS1Q96M113EBI-618309,EBI-720016
IFT20Q8IY313EBI-618309,EBI-744203
IFT27Q9BW833EBI-618309,EBI-747093
INPP5JQ157357EBI-618309,EBI-10236940
ISCUQ9H1K13EBI-618309,EBI-1047335
ITPKBP279874EBI-618309,EBI-751388
KANK2Q63ZY36EBI-618309,EBI-2556193
KANSL1Q7Z3B34EBI-618309,EBI-740244
KAT5Q929933EBI-618309,EBI-399080
KIAA1217Q5T5P2-65EBI-618309,EBI-10188326
KIFC3Q9BVG83EBI-618309,EBI-2125614
KRT1P042645EBI-618309,EBI-298429
KRT18P057836EBI-618309,EBI-297888
KRT6AP025386EBI-618309,EBI-702198
KRT6BP042593EBI-618309,EBI-740907
KRT6CP486683EBI-618309,EBI-2564105
LASP1Q148473EBI-618309,EBI-742828
LATS1Q6PJG33EBI-618309,EBI-10253976
LCORQ96JN03EBI-618309,EBI-746045
LCP2Q130945EBI-618309,EBI-346946
LENG1Q96BZ87EBI-618309,EBI-726510
LGALS3P179313EBI-618309,EBI-1170392
LGALS3Q6NVH93EBI-618309,EBI-10187804
LIMS2Q7Z4I7-53EBI-618309,EBI-10257651
LIN7AO149103EBI-618309,EBI-2513988
LINGO1Q96FE53EBI-618309,EBI-719955
LMO1P258005EBI-618309,EBI-8639312
LMO2P257913EBI-618309,EBI-739696
LMO3Q8TAP4-44EBI-618309,EBI-11742507
LMO4P619685EBI-618309,EBI-2798728
LYPLA1Q6IAQ13EBI-618309,EBI-10249913
LYSMD1Q96S903EBI-618309,EBI-10293291
MAB21L2Q9Y5863EBI-618309,EBI-6659161
MAGOHP613265EBI-618309,EBI-299134
MAGOHBQ96A727EBI-618309,EBI-746778
MBD3O959833EBI-618309,EBI-1783068
MCM10Q7L590-23EBI-618309,EBI-10233517
MCM7P339933EBI-618309,EBI-355924
MFAP1P550815EBI-618309,EBI-1048159
MID2Q9UJV3-23EBI-618309,EBI-10172526
MMTAG2Q9BU764EBI-618309,EBI-742459
MORF4L1Q9UBU83EBI-618309,EBI-399246
MORF4L2Q150143EBI-618309,EBI-399257
MORN3Q6PF185EBI-618309,EBI-9675802
MOSP005405EBI-618309,EBI-1757866
MSRB3Q8IXL73EBI-618309,EBI-8634060
MST4Q499L93EBI-618309,EBI-6137569
MTFR2Q6P4443EBI-618309,EBI-10252703
MYEF2Q9P2K5-25EBI-618309,EBI-10318831
NCF2P198786EBI-618309,EBI-489611
NDEL1Q9GZM83EBI-618309,EBI-928842
NEBLO760413EBI-618309,EBI-2880203
NME7Q9Y5B85EBI-618309,EBI-744782
NOS3P294745EBI-618309,EBI-1391623
NUDT21O438097EBI-618309,EBI-355720
NXT2Q9NPJ83EBI-618309,EBI-752122
ORC1LQ96F823EBI-618309,EBI-10285558
PARD6BQ9BYG53EBI-618309,EBI-295391
PATL1Q86TB95EBI-618309,EBI-2562092
PIAS2O759283EBI-618309,EBI-348555
PID1Q7Z2X43EBI-618309,EBI-10256685
PIK3R2O004593EBI-618309,EBI-346930
PIN1Q135267EBI-618309,EBI-714158
PITX1P783373EBI-618309,EBI-748265
PKN1Q165125EBI-618309,EBI-602382
PKP4Q995693EBI-618309,EBI-726447
POLDIP3Q8WUT13EBI-618309,EBI-10276663
POU4F3Q153194EBI-618309,EBI-12033574
PPP1R16BQ96T495EBI-618309,EBI-10293968
PPP1R18Q6NYC85EBI-618309,EBI-2557469
PPP1R32Q7Z5V6-24EBI-618309,EBI-12000762
PQBP1O608283EBI-618309,EBI-713867
PRKAA1Q131313EBI-618309,EBI-1181405
PRKAB2O437417EBI-618309,EBI-1053424
PRPF31Q8WWY310EBI-618309,EBI-1567797
PSMA1P257865EBI-618309,EBI-359352
PSMA4P257893EBI-618309,EBI-359310
RAB2AP610196EBI-618309,EBI-752037
RAB2BQ8WUD15EBI-618309,EBI-5542466
RAB39AQ149645EBI-618309,EBI-3048577
RAB39BQ96DA23EBI-618309,EBI-9089467
RBM17Q96I256EBI-618309,EBI-740272
RBM39Q14498-33EBI-618309,EBI-6654703
RBM41Q96IZ55EBI-618309,EBI-740773
RCOR3Q9P2K33EBI-618309,EBI-743428
RGS8P577713EBI-618309,EBI-10216117
RHNO1Q9BSD33EBI-618309,EBI-9658624
RIBC1Q8N4433EBI-618309,EBI-10265323
RITA1Q96K304EBI-618309,EBI-2836148
RNF135Q8IUD65EBI-618309,EBI-9916363
RNF213Q63HN8-63EBI-618309,EBI-10248548
RSPH14Q9UHP65EBI-618309,EBI-748350
RSRC2Q7L4I2-23EBI-618309,EBI-10256202
RTP5Q14D333EBI-618309,EBI-10217913
SAMD4AQ9UPU93EBI-618309,EBI-1047497
SAP30BPQ9UHR53EBI-618309,EBI-751683
SCAF8Q9UPN63EBI-618309,EBI-7954236
SCELO951714EBI-618309,EBI-7543896
SCNM1Q9BWG65EBI-618309,EBI-748391
SECISBP2Q96T213EBI-618309,EBI-954116
SELENOVP597973EBI-618309,EBI-10216195
SFRS2Q6NXQ07EBI-618309,EBI-10251550
SH2D4AQ9H7885EBI-618309,EBI-747035
SH2D4AQ9H788-23EBI-618309,EBI-10308083
SH3RF2Q08AM83EBI-618309,EBI-10225873
SHC3Q925293EBI-618309,EBI-79084
SLU7O953915EBI-618309,EBI-750559
SMARCE1Q969G35EBI-618309,EBI-455078
SMCPP499013EBI-618309,EBI-750494
SNAP47Q5SQN13EBI-618309,EBI-10244848
SNF8Q96H203EBI-618309,EBI-747719
SNRPBP14678-23EBI-618309,EBI-372475
SNRPB2P085793EBI-618309,EBI-1053651
SNRPCQ5TAL43EBI-618309,EBI-10246938
SNW1Q135735EBI-618309,EBI-632715
SPATA2Q9UM823EBI-618309,EBI-744066
SPATA22Q8NHS93EBI-618309,EBI-7067260
SPG21Q9NZD84EBI-618309,EBI-742688
STAMBPL1Q96FJ03EBI-618309,EBI-745021
STK25O0050610EBI-618309,EBI-618295
STK26Q9P2894EBI-618309,EBI-618239
SYT6Q5T7P8-25EBI-618309,EBI-10246152
TBC1D22BQ9NU194EBI-618309,EBI-8787464
TBPQ32MN65EBI-618309,EBI-10239991
TCEA2Q155605EBI-618309,EBI-710310
TCEANCQ8N8B73EBI-618309,EBI-954696
TCF19D2IYK53EBI-618309,EBI-10176552
TCF19Q9Y2423EBI-618309,EBI-7413767
TCL1AP562797EBI-618309,EBI-749995
TEAD4D3DUQ63EBI-618309,EBI-10176734
TFAP4Q016645EBI-618309,EBI-2514218
THAP7Q9BT493EBI-618309,EBI-741350
TPM1P094933EBI-618309,EBI-351158
TPM1P09493-103EBI-618309,EBI-12123928
TPM1P09493-53EBI-618309,EBI-10196387
TRAF4Q9BUZ44EBI-618309,EBI-3650647
TRIM29Q141345EBI-618309,EBI-702370
TRIM42Q8IWZ53EBI-618309,EBI-5235829
TSC22D4Q8IV543EBI-618309,EBI-10261521
TSSC4Q9Y5U23EBI-618309,EBI-717229
TSSK3Q96PN85EBI-618309,EBI-3918381
TTC23Q5W5X93EBI-618309,EBI-6447954
TTC25Q96NG33EBI-618309,EBI-1046387
TTC9CQ8N5M43EBI-618309,EBI-2851213
TXLNAP402223EBI-618309,EBI-359793
UBE2IP632793EBI-618309,EBI-80168
UBE2UQ5VVX94EBI-618309,EBI-2130181
UBE3CQ153863EBI-618309,EBI-1058871
USP2O756045EBI-618309,EBI-743272
UTP14CQ08E773EBI-618309,EBI-10225961
UTP14CQ5TAP64EBI-618309,EBI-11737646
VPS28Q548N13EBI-618309,EBI-10243107
VPS37CA5D8V63EBI-618309,EBI-2559305
WASHC3Q9Y3C05EBI-618309,EBI-712969
WDYHV1Q96HA87EBI-618309,EBI-741158
ZBTB16Q055167EBI-618309,EBI-711925
ZBTB42B2RXF54EBI-618309,EBI-12287587
ZDHHC17Q8IUH53EBI-618309,EBI-524753
ZFC3H1G3V1X13EBI-618309,EBI-6448783
ZFP2Q6ZN573EBI-618309,EBI-7236323
ZFYVE26Q68DK2-53EBI-618309,EBI-8656416
ZGPATQ8N5A53EBI-618309,EBI-3439227
ZGPATQ8N5A5-25EBI-618309,EBI-10183064
ZMAT2Q96NC05EBI-618309,EBI-2682299
ZNF124Q159733EBI-618309,EBI-2555767
ZNF250P15622-37EBI-618309,EBI-10177272
ZNF410Q86VK43EBI-618309,EBI-720304
ZNF414Q96IQ95EBI-618309,EBI-744257
ZNF417Q8TAU33EBI-618309,EBI-740727
ZNF488Q96MN93EBI-618309,EBI-948288
ZNF572Q7Z3I76EBI-618309,EBI-10172590
ZNF581Q9P0T43EBI-618309,EBI-745520
ZNF587Q96SQ53EBI-618309,EBI-6427977
ZNF774Q6NX455EBI-618309,EBI-10251462

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • importin-alpha family protein binding Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • syntaxin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109063. 332 interactors.
CORUMiQ08379.
DIPiDIP-34271N.
IntActiQ08379. 466 interactors.
MINTiMINT-1343711.
STRINGi9606.ENSP00000416097.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4REYX-ray1.96B980-1002[»]
ProteinModelPortaliQ08379.
SMRiQ08379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 84Interaction with p115/USO1By similarityAdd BLAST84
Regioni992 – 1002Interaction with GORASP1/GRASP65By similarityAdd BLAST11

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili16 – 892Sequence analysisAdd BLAST877

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi26 – 49Nuclear localization signal1 PublicationAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 51Poly-Lys6
Compositional biasi449 – 455Poly-Pro7
Compositional biasi704 – 715Poly-GluAdd BLAST12

Domaini

The nuclear localization signal (cNLS) mediates interaction with importin-alpha, recruiting importin-alpha to the Golgi membrane and liberating TPX2.1 Publication

Sequence similaritiesi

Belongs to the GOLGA2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410INYK. Eukaryota.
ENOG4111MFD. LUCA.
GeneTreeiENSGT00530000062932.
HOGENOMiHOG000218631.
HOVERGENiHBG051752.
InParanoidiQ08379.
KOiK20358.
OMAiRRMLKQR.
OrthoDBiEOG091G0DDT.
PhylomeDBiQ08379.
TreeFamiTF316990.

Family and domain databases

InterProiView protein in InterPro
IPR024858. Golgin_A.
PfamiView protein in Pfam
PF15070. GOLGA2L5. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q08379-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPQPRLPPR PAMSEETRQS KLAAAKKKLR EYQQRNSPGV PTGAKKKKKI
60 70 80 90 100
KNGSNPETTT SGGCHSPEDT PKDNAATLQP SDDTVLPGGV PSPGASLTSM
110 120 130 140 150
AASQNHDADN VPNLMDETKT FSSTESLRQL SQQLNGLVCE SATCVNGEGP
160 170 180 190 200
ASSANLKDLE SRYQQLAVAL DSSYVTNKQL NITIEKLKQQ NQEITDQLEE
210 220 230 240 250
EKKECHQKQG ALREQLQVHI QTIGILVSEK AELQTALAHT QHAARQKEGE
260 270 280 290 300
SEDLASRLQY SRRRVGELER ALSAVSTQQK KADRYNKELT KERDALRLEL
310 320 330 340 350
YKNTQSNEDL KQEKSELEEK LRVLVTEKAG MQLNLEELQK KLEMTELLLQ
360 370 380 390 400
QFSSRCEAPD ANQQLQQAME ERAQLEAHLG QVMESVRQLQ MERDKYAENL
410 420 430 440 450
KGESAMWRQR MQQMSEQVHT LREEKECSMS RVQELETSLA ELRNQMAEPP
460 470 480 490 500
PPEPPAGPSE VEQQLQAEAE HLRKELEGLA GQLQAQVQDN EGLSRLNREQ
510 520 530 540 550
EERLLELERA AELWGEQAEA RRQILETMQN DRTTISRALS QNRELKEQLA
560 570 580 590 600
ELQSGFVKLT NENMEITSAL QSEQHVKREL GKKLGELQEK LSELKETVEL
610 620 630 640 650
KSQEAQSLQQ QRDQYLGHLQ QYVAAYQQLT SEKEVLHNQL LLQTQLVDQL
660 670 680 690 700
QQQEAQGKAV AEMARQELQE TQERLEAATQ QNQQLRAQLS LMAHPGEGDG
710 720 730 740 750
LDREEEEDEE EEEEEAVAVP QPMPSIPEDL ESREAMVAFF NSAVASAEEE
760 770 780 790 800
QARLRGQLKE QRVRCRRLAH LLASAQKEPE AAAPAPGTGG DSVCGETHRA
810 820 830 840 850
LQGAMEKLQS RFMELMQEKA DLKERVEELE HRCIQLSGET DTIGEYIALY
860 870 880 890 900
QSQRAVLKER HREKEEYISR LAQDKEEMKV KLLELQELVL RLVGDRNEWH
910 920 930 940 950
GRFLAAAQNP ADEPTSGAPA PQELGAANQQ GDLCEVSLAG SVEPAQGEAR
960 970 980 990 1000
EGSPRDNPTA QQIMQLLREM QNPRERPGLG SNPCIPFFYR ADENDEVKIT

VI
Length:1,002
Mass (Da):113,086
Last modified:April 20, 2010 - v3
Checksum:iBD067145C5092237
GO
Isoform 2 (identifier: Q08379-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.

Show »
Length:620
Mass (Da):70,473
Checksum:i54B31A0FBB42BFC8
GO

Sequence cautioni

Q08379: The sequence AAH69268 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Q08379: The sequence AAP35912 differs from that shown. Sequence differs from that shown after position 826 due to an internal deletion.Curated
Q08379: The sequence EAW87762 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti709Missing in AAP35912 (Ref. 6) Curated1
Sequence conflicti762R → S in AAP35912 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033974902R → G. Corresponds to variant dbSNP:rs2240961Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0077271 – 382Missing in isoform 2. 1 PublicationAdd BLAST382

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06147 mRNA. Translation: AAA35920.1.
AL590708 Genomic DNA. Translation: CAI13841.2.
CH471090 Genomic DNA. Translation: EAW87762.1. Sequence problems.
BC014188 mRNA. Translation: AAH14188.2.
BC069268 mRNA. Translation: AAH69268.1. Different initiation.
AF248953 mRNA. Translation: AAF65550.1.
BT007248 mRNA. Translation: AAP35912.1. Sequence problems.
CCDSiCCDS6896.2. [Q08379-1]
PIRiJH0821.
RefSeqiNP_004477.3. NM_004486.4. [Q08379-1]
UniGeneiHs.155827.

Genome annotation databases

EnsembliENST00000421699; ENSP00000416097; ENSG00000167110. [Q08379-1]
ENST00000611957; ENSP00000478799; ENSG00000167110. [Q08379-1]
GeneIDi2801.
KEGGihsa:2801.
UCSCiuc011maw.2. human. [Q08379-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGOGA2_HUMAN
AccessioniPrimary (citable) accession number: Q08379
Secondary accession number(s): A0A0C4DGS5
, Q6GRM9, Q9BRB0, Q9NYF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 20, 2010
Last modified: October 25, 2017
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families