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Q08379

- GOGA2_HUMAN

UniProt

Q08379 - GOGA2_HUMAN

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Protein
Golgin subfamily A member 2
Gene
GOLGA2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. mitotic cell cycle Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_1100. Golgi Cisternae Pericentriolar Stack Reorganization.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 2
Alternative name(s):
130 kDa cis-Golgi matrix protein
Short name:
GM130
GM130 autoantigen
Golgin-95
Gene namesi
Name:GOLGA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:4425. GOLGA2.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi cisterna membrane Source: UniProtKB-SubCell
  3. Golgi membrane Source: Reactome
  4. cis-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10021002Golgin subfamily A member 2
PRO_0000190054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371Phosphoserine3 Publications
Modified residuei438 – 4381Phosphoserine1 Publication
Modified residuei953 – 9531Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08379.
PaxDbiQ08379.
PRIDEiQ08379.

PTM databases

PhosphoSiteiQ08379.

Expressioni

Gene expression databases

ArrayExpressiQ08379.
BgeeiQ08379.
CleanExiHS_GOLGA2.
GenevestigatoriQ08379.

Organism-specific databases

HPAiCAB015421.
HPA021178.
HPA021230.
HPA021799.

Interactioni

Subunit structurei

Part of a larger oligomeric complex. Interacts with p115 By similarity. Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P299913EBI-618309,EBI-8826488From a different organism.
Q9WMX22EBI-618309,EBI-6863748From a different organism.
AKAP9Q999963EBI-618309,EBI-1048311
STK25O005063EBI-618309,EBI-618295
ZDHHC17Q8IUH53EBI-618309,EBI-524753

Protein-protein interaction databases

BioGridi109063. 38 interactions.
DIPiDIP-34271N.
IntActiQ08379. 59 interactions.
MINTiMINT-1343711.
STRINGi9606.ENSP00000416097.

Structurei

3D structure databases

ProteinModelPortaliQ08379.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili16 – 892877 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 516Poly-Lys
Compositional biasi449 – 4557Poly-Pro
Compositional biasi704 – 71512Poly-Glu
Add
BLAST

Domaini

Extended rod-like protein with coiled-coil domains.

Sequence similaritiesi

Belongs to the GOLGA2 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG304043.
HOGENOMiHOG000218631.
HOVERGENiHBG051752.
InParanoidiQ08379.
OMAiGERNEWQ.
OrthoDBiEOG71P29T.
PhylomeDBiQ08379.
TreeFamiTF316990.

Family and domain databases

InterProiIPR024858. Golgin_A.
[Graphical view]
PANTHERiPTHR10881. PTHR10881. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q08379-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWPQPRLPPR PAMSEETRQS KLAAAKKKLR EYQQRNSPGV PTGAKKKKKI     50
KNGSNPETTT SGGCHSPEDT PKDNAATLQP SDDTVLPGGV PSPGASLTSM 100
AASQNHDADN VPNLMDETKT FSSTESLRQL SQQLNGLVCE SATCVNGEGP 150
ASSANLKDLE SRYQQLAVAL DSSYVTNKQL NITIEKLKQQ NQEITDQLEE 200
EKKECHQKQG ALREQLQVHI QTIGILVSEK AELQTALAHT QHAARQKEGE 250
SEDLASRLQY SRRRVGELER ALSAVSTQQK KADRYNKELT KERDALRLEL 300
YKNTQSNEDL KQEKSELEEK LRVLVTEKAG MQLNLEELQK KLEMTELLLQ 350
QFSSRCEAPD ANQQLQQAME ERAQLEAHLG QVMESVRQLQ MERDKYAENL 400
KGESAMWRQR MQQMSEQVHT LREEKECSMS RVQELETSLA ELRNQMAEPP 450
PPEPPAGPSE VEQQLQAEAE HLRKELEGLA GQLQAQVQDN EGLSRLNREQ 500
EERLLELERA AELWGEQAEA RRQILETMQN DRTTISRALS QNRELKEQLA 550
ELQSGFVKLT NENMEITSAL QSEQHVKREL GKKLGELQEK LSELKETVEL 600
KSQEAQSLQQ QRDQYLGHLQ QYVAAYQQLT SEKEVLHNQL LLQTQLVDQL 650
QQQEAQGKAV AEMARQELQE TQERLEAATQ QNQQLRAQLS LMAHPGEGDG 700
LDREEEEDEE EEEEEAVAVP QPMPSIPEDL ESREAMVAFF NSAVASAEEE 750
QARLRGQLKE QRVRCRRLAH LLASAQKEPE AAAPAPGTGG DSVCGETHRA 800
LQGAMEKLQS RFMELMQEKA DLKERVEELE HRCIQLSGET DTIGEYIALY 850
QSQRAVLKER HREKEEYISR LAQDKEEMKV KLLELQELVL RLVGDRNEWH 900
GRFLAAAQNP ADEPTSGAPA PQELGAANQQ GDLCEVSLAG SVEPAQGEAR 950
EGSPRDNPTA QQIMQLLREM QNPRERPGLG SNPCIPFFYR ADENDEVKIT 1000
VI 1002
Length:1,002
Mass (Da):113,086
Last modified:April 20, 2010 - v3
Checksum:iBD067145C5092237
GO
Isoform 2 (identifier: Q08379-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.

Show »
Length:620
Mass (Da):70,473
Checksum:i54B31A0FBB42BFC8
GO

Sequence cautioni

The sequence AAP35912.1 differs from that shown. Reason: Sequence differs from that shown after position 826 due to an internal deletion.
The sequence AAH69268.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti902 – 9021R → G.
Corresponds to variant rs2240961 [ dbSNP | Ensembl ].
VAR_033974

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 382382Missing in isoform 2.
VSP_007727Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti709 – 7091Missing in AAP35912. 1 Publication
Sequence conflicti762 – 7621R → S in AAP35912. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L06147 mRNA. Translation: AAA35920.1.
AL590708 Genomic DNA. Translation: CAI13841.2.
BC014188 mRNA. Translation: AAH14188.2.
BC069268 mRNA. Translation: AAH69268.1. Different initiation.
AF248953 mRNA. Translation: AAF65550.1.
BT007248 mRNA. Translation: AAP35912.1. Sequence problems.
CCDSiCCDS6896.2. [Q08379-1]
PIRiJH0821.
RefSeqiNP_004477.3. NM_004486.4. [Q08379-1]
UniGeneiHs.155827.

Genome annotation databases

EnsembliENST00000421699; ENSP00000416097; ENSG00000167110. [Q08379-1]
ENST00000609374; ENSP00000476265; ENSG00000167110.
GeneIDi2801.
KEGGihsa:2801.
UCSCiuc011maw.2. human. [Q08379-1]

Polymorphism databases

DMDMi294862511.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L06147 mRNA. Translation: AAA35920.1 .
AL590708 Genomic DNA. Translation: CAI13841.2 .
BC014188 mRNA. Translation: AAH14188.2 .
BC069268 mRNA. Translation: AAH69268.1 . Different initiation.
AF248953 mRNA. Translation: AAF65550.1 .
BT007248 mRNA. Translation: AAP35912.1 . Sequence problems.
CCDSi CCDS6896.2. [Q08379-1 ]
PIRi JH0821.
RefSeqi NP_004477.3. NM_004486.4. [Q08379-1 ]
UniGenei Hs.155827.

3D structure databases

ProteinModelPortali Q08379.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109063. 38 interactions.
DIPi DIP-34271N.
IntActi Q08379. 59 interactions.
MINTi MINT-1343711.
STRINGi 9606.ENSP00000416097.

PTM databases

PhosphoSitei Q08379.

Polymorphism databases

DMDMi 294862511.

Proteomic databases

MaxQBi Q08379.
PaxDbi Q08379.
PRIDEi Q08379.

Protocols and materials databases

DNASUi 2801.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000421699 ; ENSP00000416097 ; ENSG00000167110 . [Q08379-1 ]
ENST00000609374 ; ENSP00000476265 ; ENSG00000167110 .
GeneIDi 2801.
KEGGi hsa:2801.
UCSCi uc011maw.2. human. [Q08379-1 ]

Organism-specific databases

CTDi 2801.
GeneCardsi GC09M131018.
H-InvDB HIX0010915.
HIX0017404.
HIX0177625.
HIX0177626.
HGNCi HGNC:4425. GOLGA2.
HPAi CAB015421.
HPA021178.
HPA021230.
HPA021799.
MIMi 602580. gene.
neXtProti NX_Q08379.
PharmGKBi PA28805.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304043.
HOGENOMi HOG000218631.
HOVERGENi HBG051752.
InParanoidi Q08379.
OMAi GERNEWQ.
OrthoDBi EOG71P29T.
PhylomeDBi Q08379.
TreeFami TF316990.

Enzyme and pathway databases

Reactomei REACT_1100. Golgi Cisternae Pericentriolar Stack Reorganization.

Miscellaneous databases

ChiTaRSi GOLGA2. human.
GeneWikii GOLGA2.
GenomeRNAii 2801.
NextBioi 11041.
PROi Q08379.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q08379.
Bgeei Q08379.
CleanExi HS_GOLGA2.
Genevestigatori Q08379.

Family and domain databases

InterProi IPR024858. Golgin_A.
[Graphical view ]
PANTHERi PTHR10881. PTHR10881. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex."
    Fritzler M.J., Hamel J.C., Ochs R.L., Chan E.K.L.
    J. Exp. Med. 178:49-62(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Liver.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Colon adenocarcinoma.
  4. "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b."
    Weide T., Bayer M., Koester M., Siebrasse J.-P., Peters R., Barnekow A.
    EMBO Rep. 2:336-341(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-1002 (ISOFORM 1), INTERACTION WITH RAB1B.
    Tissue: Placenta.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-1002 (ISOFORM 1).
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport."
    Chiu C.-F., Ghanekar Y., Frost L., Diao A., Morrison D., McKenzie E., Lowe M.
    EMBO J. 27:934-947(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZFPL1.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-953, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGOGA2_HUMAN
AccessioniPrimary (citable) accession number: Q08379
Secondary accession number(s): Q6GRM9, Q9BRB0, Q9NYF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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