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Protein

Golgin subfamily A member 2

Gene

GOLGA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • syntaxin binding Source: UniProtKB

GO - Biological processi

  • mitotic cell cycle Source: Reactome
  • negative regulation of protein binding Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_1100. Golgi Cisternae Pericentriolar Stack Reorganization.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 2
Alternative name(s):
130 kDa cis-Golgi matrix protein
Short name:
GM130
GM130 autoantigen
Golgin-95
Gene namesi
Name:GOLGA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:4425. GOLGA2.

Subcellular locationi

GO - Cellular componenti

  • cis-Golgi network Source: AgBase
  • ER to Golgi transport vesicle Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • Golgi cis cisterna Source: CACAO
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • Golgi membrane Source: Reactome
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28805.

Polymorphism and mutation databases

BioMutaiGOLGA2.
DMDMi294862511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10021002Golgin subfamily A member 2PRO_0000190054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371Phosphoserine3 Publications
Modified residuei273 – 2731Phosphoserine1 Publication
Modified residuei438 – 4381Phosphoserine1 Publication
Modified residuei690 – 6901Phosphoserine1 Publication
Modified residuei937 – 9371Phosphoserine1 Publication
Modified residuei953 – 9531Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08379.
PaxDbiQ08379.
PRIDEiQ08379.

PTM databases

PhosphoSiteiQ08379.

Expressioni

Gene expression databases

BgeeiQ08379.
CleanExiHS_GOLGA2.
ExpressionAtlasiQ08379. baseline and differential.
GenevisibleiQ08379. HS.

Organism-specific databases

HPAiCAB015421.
HPA021178.
HPA021230.
HPA021799.

Interactioni

Subunit structurei

Part of a larger oligomeric complex. Interacts with p115 (By similarity). Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
A8K2R33EBI-618309,EBI-9977437
P299913EBI-618309,EBI-8826488From a different organism.
Q9WMX22EBI-618309,EBI-6863748From a different organism.
ADAP1O756893EBI-618309,EBI-714732
AESQ081173EBI-618309,EBI-717810
AFF4Q9UHB73EBI-618309,EBI-395282
AFF4Q9UHB7-23EBI-618309,EBI-10261324
AKAP9Q999963EBI-618309,EBI-1048311
ALKBH3Q96Q833EBI-618309,EBI-6658697
ALS2CR11Q53TS83EBI-618309,EBI-739879
AMOTL2Q9Y2J4-43EBI-618309,EBI-10187270
ANKRD36BP1Q96IX93EBI-618309,EBI-744859
ARID5AC9J1Q03EBI-618309,EBI-10176351
ARL16Q0P5N63EBI-618309,EBI-10186132
ARL4AP406173EBI-618309,EBI-2875746
ARPC3O151453EBI-618309,EBI-351829
ATP6V1C2Q8NEY4-23EBI-618309,EBI-10270867
ATP6V1DQ6PJ053EBI-618309,EBI-10253919
ATP6V1DQ8N5Z93EBI-618309,EBI-10266952
ATP6V1G1O753483EBI-618309,EBI-711802
BAHD1Q8TBE03EBI-618309,EBI-742750
BARD1A0AVN23EBI-618309,EBI-9977322
BARD1Q997283EBI-618309,EBI-473181
BCAS2O759343EBI-618309,EBI-1050106
BCL6BA8KA133EBI-618309,EBI-10174813
BYSLQ138955EBI-618309,EBI-358049
C12orf50Q8NA573EBI-618309,EBI-10268935
C14orf105Q17R993EBI-618309,EBI-10238351
C1orf109Q9NX043EBI-618309,EBI-8643161
C20orf195Q9BVV23EBI-618309,EBI-744935
CBX8Q9HC523EBI-618309,EBI-712912
CCAR1Q8IX123EBI-618309,EBI-356265
CCDC146Q8IYE0-23EBI-618309,EBI-10247802
CCDC150Q8NCX03EBI-618309,EBI-10269342
CCDC17Q96LX73EBI-618309,EBI-719840
CCDC53Q9Y3C03EBI-618309,EBI-712969
CCDC67E9PJR53EBI-618309,EBI-10177066
CCDC67Q05D603EBI-618309,EBI-748597
CCDC70Q6NSX13EBI-618309,EBI-6873045
CCDC87Q9NVE43EBI-618309,EBI-749261
CCDC94Q9BW853EBI-618309,EBI-10300345
CCHCR1Q8TD31-33EBI-618309,EBI-10175300
CCNCP248633EBI-618309,EBI-395261
CCNHP519465EBI-618309,EBI-741406
CDC20BQ86Y333EBI-618309,EBI-10260504
CDC5LQ994593EBI-618309,EBI-374880
CDC73Q6P1J95EBI-618309,EBI-930143
CDK18Q070023EBI-618309,EBI-746238
CDKL3Q8IVW43EBI-618309,EBI-3919850
CENPPQ6IPU03EBI-618309,EBI-10250303
CEP57L1Q8IYX83EBI-618309,EBI-1104570
CEP57L1Q8IYX8-23EBI-618309,EBI-10181988
CHCHD2Q9Y6H13EBI-618309,EBI-2321769
CHCHD3Q9NX633EBI-618309,EBI-743375
CINPQ9BW663EBI-618309,EBI-739784
CORO1AP311463EBI-618309,EBI-1046676
CSPP1Q1MSJ5-13EBI-618309,EBI-10239122
CUL5Q930343EBI-618309,EBI-1057139
CYB5R2Q6BCY43EBI-618309,EBI-744761
DAXXQ9UER73EBI-618309,EBI-77321
DCTN4Q9UJW04EBI-618309,EBI-2134033
DCXO436024EBI-618309,EBI-8646694
DDX6P261963EBI-618309,EBI-351257
DLGAP5Q153983EBI-618309,EBI-748280
DMTNQ084953EBI-618309,EBI-715275
DTX2Q86UW93EBI-618309,EBI-740376
EIF3GO758213EBI-618309,EBI-366632
EXOSC5Q9NQT43EBI-618309,EBI-371876
FAM110AQ9BQ893EBI-618309,EBI-1752811
FAM124BQ9H5Z63EBI-618309,EBI-741626
FAM126BQ8IXS83EBI-618309,EBI-8787606
FAM184AQ6P9G83EBI-618309,EBI-10253239
FAM193BQ96PV7-23EBI-618309,EBI-10292648
FAM207AQ9NSI23EBI-618309,EBI-5457304
FAM214AQ32MH53EBI-618309,EBI-2866142
FAM50BQ9Y2473EBI-618309,EBI-742802
FAM90A1Q86YD73EBI-618309,EBI-6658203
FBF1Q8TES7-63EBI-618309,EBI-10244131
FBXL18Q96D163EBI-618309,EBI-744419
FBXO28Q9NVF74EBI-618309,EBI-740282
FIP1L1Q6UN153EBI-618309,EBI-1021914
FLJ34048A4D1I33EBI-618309,EBI-10173415
GATA2P237693EBI-618309,EBI-2806671
GATAD2BQ8WXI93EBI-618309,EBI-923440
GCC1Q96CN93EBI-618309,EBI-746252
GEMP550403EBI-618309,EBI-744104
GFAPP141363EBI-618309,EBI-744302
GLYCTKQ8IVS83EBI-618309,EBI-748515
GNG5P632183EBI-618309,EBI-10220734
GORASP2Q9H8Y84EBI-618309,EBI-739467
GPANK1O958723EBI-618309,EBI-751540
GPKOWQ929173EBI-618309,EBI-746309
GSE1Q146873EBI-618309,EBI-372619
GTPBP10A4D1E93EBI-618309,EBI-5453796
HAUS1Q96CS23EBI-618309,EBI-2514791
HCTP4Q643R03EBI-618309,EBI-10248808
HDAC4P565243EBI-618309,EBI-308629
HOXB9P174823EBI-618309,EBI-745290
HRASLS5Q96KN8-33EBI-618309,EBI-10290304
HYLS1Q96M113EBI-618309,EBI-720016
IFT20Q8IY313EBI-618309,EBI-744203
IFT27Q9BW833EBI-618309,EBI-747093
INPP5JQ157353EBI-618309,EBI-10236940
ISCUQ9H1K13EBI-618309,EBI-1047335
ITPKBP279874EBI-618309,EBI-751388
KANK2Q63ZY34EBI-618309,EBI-2556193
KANSL1I3L4J33EBI-618309,EBI-10178305
KAT5Q929933EBI-618309,EBI-399080
KIAA1217Q5T5P2-63EBI-618309,EBI-10188326
KIFC3Q9BVG83EBI-618309,EBI-2125614
KRT18P057833EBI-618309,EBI-297888
KRT6AP025383EBI-618309,EBI-702198
KRT6BP042593EBI-618309,EBI-740907
KRT6CP486683EBI-618309,EBI-2564105
LASP1Q148473EBI-618309,EBI-742828
LATS1Q6PJG33EBI-618309,EBI-10253976
LCORQ96JN03EBI-618309,EBI-8833163
LCP2Q130943EBI-618309,EBI-346946
LENG1Q96BZ83EBI-618309,EBI-726510
LGALS3P179313EBI-618309,EBI-1170392
LGALS3Q6NVH93EBI-618309,EBI-10187804
LIMS2Q7Z4I7-53EBI-618309,EBI-10257651
LIN7AO149103EBI-618309,EBI-2513988
LINGO1Q96FE53EBI-618309,EBI-719955
LMO1P258003EBI-618309,EBI-8639312
LMO2P257913EBI-618309,EBI-739696
LMO4P619683EBI-618309,EBI-2798728
LYPLA1Q6IAQ13EBI-618309,EBI-10249913
LYSMD1Q96S903EBI-618309,EBI-10293291
MAB21L2Q9Y5863EBI-618309,EBI-6659161
MAGOHP613263EBI-618309,EBI-299134
MAGOHBQ96A723EBI-618309,EBI-746778
MBD3O959833EBI-618309,EBI-1783068
MCM10Q7L590-23EBI-618309,EBI-10233517
MCM7P339933EBI-618309,EBI-355924
MFAP1P550813EBI-618309,EBI-1048159
MID2Q9UJV3-23EBI-618309,EBI-10172526
MMTAG2Q9BU764EBI-618309,EBI-742459
MORF4L1Q9UBU83EBI-618309,EBI-399246
MORF4L2Q150143EBI-618309,EBI-399257
MORN3Q6PF183EBI-618309,EBI-9675802
MOSP005403EBI-618309,EBI-1757866
MSRB3Q8IXL73EBI-618309,EBI-8634060
MST4Q499L93EBI-618309,EBI-6137569
MTFR2Q6P4443EBI-618309,EBI-10252703
MYEF2Q9P2K5-23EBI-618309,EBI-10318831
NCF2P198783EBI-618309,EBI-489611
NDEL1Q9GZM83EBI-618309,EBI-928842
NEBLO760413EBI-618309,EBI-2880203
NME7Q9Y5B83EBI-618309,EBI-744782
NOS3P294743EBI-618309,EBI-1391623
NUDT21O438093EBI-618309,EBI-355720
NXT2Q9NPJ83EBI-618309,EBI-752122
ORC1LQ96F823EBI-618309,EBI-10285558
PARD6BQ9BYG53EBI-618309,EBI-295391
PATL1Q86TB93EBI-618309,EBI-2562092
PIAS2O759283EBI-618309,EBI-348555
PID1Q7Z2X43EBI-618309,EBI-10256685
PIK3R2O004593EBI-618309,EBI-346930
PIN1Q135263EBI-618309,EBI-714158
PKN1Q165123EBI-618309,EBI-602382
PKP4Q995693EBI-618309,EBI-726447
POLDIP3Q8WUT13EBI-618309,EBI-10276663
PPP1R16BQ96T493EBI-618309,EBI-10293968
PPP1R18Q6NYC83EBI-618309,EBI-2557469
PQBP1O608283EBI-618309,EBI-713867
PRKAA1Q131313EBI-618309,EBI-1181405
PRKAB2O437413EBI-618309,EBI-1053424
PRPF31F1T0A53EBI-618309,EBI-10177194
PSMA1P257863EBI-618309,EBI-359352
PSMA4P257893EBI-618309,EBI-359310
PSMA4Q7Z4743EBI-618309,EBI-10257551
RAB2AP610194EBI-618309,EBI-752037
RAB2BQ8WUD13EBI-618309,EBI-5542466
RAB39AQ149643EBI-618309,EBI-3048577
RAB39BQ96DA23EBI-618309,EBI-9089467
RBM17Q96I254EBI-618309,EBI-740272
RBM39Q14498-33EBI-618309,EBI-6654703
RBM41Q96IZ53EBI-618309,EBI-740773
RCOR3Q9P2K33EBI-618309,EBI-743428
RGS8P577713EBI-618309,EBI-10216117
RHNO1Q9BSD33EBI-618309,EBI-9658624
RIBC1Q8N4433EBI-618309,EBI-10265323
RITA1Q96K304EBI-618309,EBI-2836148
RNF135Q8IUD63EBI-618309,EBI-9916363
RNF213Q63HN8-63EBI-618309,EBI-10248548
RSPH14Q9UHP63EBI-618309,EBI-748350
RSRC2Q7L4I2-23EBI-618309,EBI-10256202
RTP5Q14D333EBI-618309,EBI-10217913
SAMD4AQ9UPU93EBI-618309,EBI-1047497
SAP30BPQ9UHR53EBI-618309,EBI-751683
SCAF8Q9UPN63EBI-618309,EBI-7954236
SCELO951714EBI-618309,EBI-7543896
SCNM1Q9BWG63EBI-618309,EBI-748391
SECISBP2Q96T213EBI-618309,EBI-954116
SELVP597973EBI-618309,EBI-10216195
SFRS2Q6NXQ03EBI-618309,EBI-10251550
SH2D4AQ9H7883EBI-618309,EBI-747035
SH2D4AQ9H788-23EBI-618309,EBI-10308083
SH3RF2Q08AM83EBI-618309,EBI-10225873
SHC3Q925293EBI-618309,EBI-79084
SLU7O953913EBI-618309,EBI-750559
SMARCE1Q969G33EBI-618309,EBI-455078
SMCPP499013EBI-618309,EBI-750494
SNAP47Q5SQN13EBI-618309,EBI-10244848
SNF8Q96H203EBI-618309,EBI-747719
SNRPBP14678-23EBI-618309,EBI-372475
SNRPB2P085793EBI-618309,EBI-1053651
SNRPCQ5TAL43EBI-618309,EBI-10246938
SNW1Q135733EBI-618309,EBI-632715
SPATA2Q9UM823EBI-618309,EBI-744066
SPATA22Q8NHS93EBI-618309,EBI-7067260
STAMBPL1Q96FJ03EBI-618309,EBI-745021
STK25O005066EBI-618309,EBI-618295
SYT6Q5T7P8-23EBI-618309,EBI-10246152
TBPQ32MN63EBI-618309,EBI-10239991
TCEA2Q155603EBI-618309,EBI-710310
TCEANCQ8N8B73EBI-618309,EBI-954696
TCF19D2IYK53EBI-618309,EBI-10176552
TCL1AP562793EBI-618309,EBI-749995
TEAD4D3DUQ63EBI-618309,EBI-10176734
TFAP4Q016643EBI-618309,EBI-2514218
THAP7Q9BT493EBI-618309,EBI-741350
TPM1P094933EBI-618309,EBI-351158
TPM1P09493-53EBI-618309,EBI-10196387
TRIM29Q141345EBI-618309,EBI-702370
TRIM42A1L4B63EBI-618309,EBI-10172216
TSC22D4Q8IV543EBI-618309,EBI-10261521
TSSC4Q9Y5U23EBI-618309,EBI-717229
TSSK3Q96PN83EBI-618309,EBI-3918381
TTC23Q5W5X93EBI-618309,EBI-6447954
TTC25Q96NG33EBI-618309,EBI-1046387
TTC9CQ8N5M43EBI-618309,EBI-2851213
TXLNAP402223EBI-618309,EBI-359793
UBE2IP632793EBI-618309,EBI-80168
UBE2UQ5VVX94EBI-618309,EBI-2130181
UBE3CQ153863EBI-618309,EBI-1058871
USP2O756043EBI-618309,EBI-743272
UTP14CQ08E773EBI-618309,EBI-10225961
VPS28Q548N13EBI-618309,EBI-10243107
VPS37CA5D8V63EBI-618309,EBI-2559305
WDYHV1Q96HA83EBI-618309,EBI-741158
ZBTB16Q055163EBI-618309,EBI-711925
ZDHHC17Q8IUH53EBI-618309,EBI-524753
ZFC3H1G3V1X13EBI-618309,EBI-6448783
ZFP2Q6ZN573EBI-618309,EBI-7236323
ZFYVE26Q96H433EBI-618309,EBI-10286915
ZGPATQ8N5A53EBI-618309,EBI-3439227
ZGPATQ8N5A5-23EBI-618309,EBI-10183064
ZMAT2Q96NC03EBI-618309,EBI-2682299
ZNF124Q159733EBI-618309,EBI-2555767
ZNF250P15622-33EBI-618309,EBI-10177272
ZNF410Q86VK43EBI-618309,EBI-720304
ZNF414Q96IQ93EBI-618309,EBI-744257
ZNF417Q8TAU33EBI-618309,EBI-740727
ZNF488Q96MN93EBI-618309,EBI-948288
ZNF572A1L4E93EBI-618309,EBI-10172590
ZNF572Q7Z3I73EBI-618309,EBI-10257016
ZNF581Q9P0T43EBI-618309,EBI-745520
ZNF587Q96SQ53EBI-618309,EBI-6427977
ZNF774Q6NX453EBI-618309,EBI-10251462

Protein-protein interaction databases

BioGridi109063. 297 interactions.
DIPiDIP-34271N.
IntActiQ08379. 296 interactions.
MINTiMINT-1343711.
STRINGi9606.ENSP00000416097.

Structurei

3D structure databases

ProteinModelPortaliQ08379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili16 – 892877Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 516Poly-Lys
Compositional biasi449 – 4557Poly-Pro
Compositional biasi704 – 71512Poly-GluAdd
BLAST

Domaini

Extended rod-like protein with coiled-coil domains.

Sequence similaritiesi

Belongs to the GOLGA2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG304043.
GeneTreeiENSGT00530000062932.
HOGENOMiHOG000218631.
HOVERGENiHBG051752.
InParanoidiQ08379.
OMAiDNESLSH.
OrthoDBiEOG71P29T.
PhylomeDBiQ08379.
TreeFamiTF316990.

Family and domain databases

InterProiIPR024858. Golgin_A.
[Graphical view]
PANTHERiPTHR10881. PTHR10881. 1 hit.
PfamiPF15070. GOLGA2L5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q08379-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPQPRLPPR PAMSEETRQS KLAAAKKKLR EYQQRNSPGV PTGAKKKKKI
60 70 80 90 100
KNGSNPETTT SGGCHSPEDT PKDNAATLQP SDDTVLPGGV PSPGASLTSM
110 120 130 140 150
AASQNHDADN VPNLMDETKT FSSTESLRQL SQQLNGLVCE SATCVNGEGP
160 170 180 190 200
ASSANLKDLE SRYQQLAVAL DSSYVTNKQL NITIEKLKQQ NQEITDQLEE
210 220 230 240 250
EKKECHQKQG ALREQLQVHI QTIGILVSEK AELQTALAHT QHAARQKEGE
260 270 280 290 300
SEDLASRLQY SRRRVGELER ALSAVSTQQK KADRYNKELT KERDALRLEL
310 320 330 340 350
YKNTQSNEDL KQEKSELEEK LRVLVTEKAG MQLNLEELQK KLEMTELLLQ
360 370 380 390 400
QFSSRCEAPD ANQQLQQAME ERAQLEAHLG QVMESVRQLQ MERDKYAENL
410 420 430 440 450
KGESAMWRQR MQQMSEQVHT LREEKECSMS RVQELETSLA ELRNQMAEPP
460 470 480 490 500
PPEPPAGPSE VEQQLQAEAE HLRKELEGLA GQLQAQVQDN EGLSRLNREQ
510 520 530 540 550
EERLLELERA AELWGEQAEA RRQILETMQN DRTTISRALS QNRELKEQLA
560 570 580 590 600
ELQSGFVKLT NENMEITSAL QSEQHVKREL GKKLGELQEK LSELKETVEL
610 620 630 640 650
KSQEAQSLQQ QRDQYLGHLQ QYVAAYQQLT SEKEVLHNQL LLQTQLVDQL
660 670 680 690 700
QQQEAQGKAV AEMARQELQE TQERLEAATQ QNQQLRAQLS LMAHPGEGDG
710 720 730 740 750
LDREEEEDEE EEEEEAVAVP QPMPSIPEDL ESREAMVAFF NSAVASAEEE
760 770 780 790 800
QARLRGQLKE QRVRCRRLAH LLASAQKEPE AAAPAPGTGG DSVCGETHRA
810 820 830 840 850
LQGAMEKLQS RFMELMQEKA DLKERVEELE HRCIQLSGET DTIGEYIALY
860 870 880 890 900
QSQRAVLKER HREKEEYISR LAQDKEEMKV KLLELQELVL RLVGDRNEWH
910 920 930 940 950
GRFLAAAQNP ADEPTSGAPA PQELGAANQQ GDLCEVSLAG SVEPAQGEAR
960 970 980 990 1000
EGSPRDNPTA QQIMQLLREM QNPRERPGLG SNPCIPFFYR ADENDEVKIT

VI
Length:1,002
Mass (Da):113,086
Last modified:April 20, 2010 - v3
Checksum:iBD067145C5092237
GO
Isoform 2 (identifier: Q08379-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.

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Length:620
Mass (Da):70,473
Checksum:i54B31A0FBB42BFC8
GO

Sequence cautioni

The sequence AAH69268.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAP35912.1 differs from that shown.Sequence differs from that shown after position 826 due to an internal deletion.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti709 – 7091Missing in AAP35912 (Ref. 5) Curated
Sequence conflicti762 – 7621R → S in AAP35912 (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti902 – 9021R → G.
Corresponds to variant rs2240961 [ dbSNP | Ensembl ].
VAR_033974

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 382382Missing in isoform 2. 1 PublicationVSP_007727Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06147 mRNA. Translation: AAA35920.1.
AL590708 Genomic DNA. Translation: CAI13841.2.
BC014188 mRNA. Translation: AAH14188.2.
BC069268 mRNA. Translation: AAH69268.1. Different initiation.
AF248953 mRNA. Translation: AAF65550.1.
BT007248 mRNA. Translation: AAP35912.1. Sequence problems.
CCDSiCCDS6896.2. [Q08379-1]
PIRiJH0821.
RefSeqiNP_004477.3. NM_004486.4. [Q08379-1]
UniGeneiHs.155827.

Genome annotation databases

EnsembliENST00000421699; ENSP00000416097; ENSG00000167110.
ENST00000611957; ENSP00000478799; ENSG00000167110.
GeneIDi2801.
KEGGihsa:2801.
UCSCiuc011maw.2. human. [Q08379-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06147 mRNA. Translation: AAA35920.1.
AL590708 Genomic DNA. Translation: CAI13841.2.
BC014188 mRNA. Translation: AAH14188.2.
BC069268 mRNA. Translation: AAH69268.1. Different initiation.
AF248953 mRNA. Translation: AAF65550.1.
BT007248 mRNA. Translation: AAP35912.1. Sequence problems.
CCDSiCCDS6896.2. [Q08379-1]
PIRiJH0821.
RefSeqiNP_004477.3. NM_004486.4. [Q08379-1]
UniGeneiHs.155827.

3D structure databases

ProteinModelPortaliQ08379.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109063. 297 interactions.
DIPiDIP-34271N.
IntActiQ08379. 296 interactions.
MINTiMINT-1343711.
STRINGi9606.ENSP00000416097.

PTM databases

PhosphoSiteiQ08379.

Polymorphism and mutation databases

BioMutaiGOLGA2.
DMDMi294862511.

Proteomic databases

MaxQBiQ08379.
PaxDbiQ08379.
PRIDEiQ08379.

Protocols and materials databases

DNASUi2801.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421699; ENSP00000416097; ENSG00000167110.
ENST00000611957; ENSP00000478799; ENSG00000167110.
GeneIDi2801.
KEGGihsa:2801.
UCSCiuc011maw.2. human. [Q08379-1]

Organism-specific databases

CTDi2801.
GeneCardsiGC09M131018.
H-InvDBHIX0010915.
HIX0017404.
HIX0177625.
HIX0177626.
HGNCiHGNC:4425. GOLGA2.
HPAiCAB015421.
HPA021178.
HPA021230.
HPA021799.
MIMi602580. gene.
neXtProtiNX_Q08379.
PharmGKBiPA28805.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG304043.
GeneTreeiENSGT00530000062932.
HOGENOMiHOG000218631.
HOVERGENiHBG051752.
InParanoidiQ08379.
OMAiDNESLSH.
OrthoDBiEOG71P29T.
PhylomeDBiQ08379.
TreeFamiTF316990.

Enzyme and pathway databases

ReactomeiREACT_1100. Golgi Cisternae Pericentriolar Stack Reorganization.

Miscellaneous databases

ChiTaRSiGOLGA2. human.
GeneWikiiGOLGA2.
GenomeRNAii2801.
NextBioi11041.
PROiQ08379.
SOURCEiSearch...

Gene expression databases

BgeeiQ08379.
CleanExiHS_GOLGA2.
ExpressionAtlasiQ08379. baseline and differential.
GenevisibleiQ08379. HS.

Family and domain databases

InterProiIPR024858. Golgin_A.
[Graphical view]
PANTHERiPTHR10881. PTHR10881. 1 hit.
PfamiPF15070. GOLGA2L5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex."
    Fritzler M.J., Hamel J.C., Ochs R.L., Chan E.K.L.
    J. Exp. Med. 178:49-62(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Liver.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Colon adenocarcinoma.
  4. "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b."
    Weide T., Bayer M., Koester M., Siebrasse J.-P., Peters R., Barnekow A.
    EMBO Rep. 2:336-341(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-1002 (ISOFORM 1), INTERACTION WITH RAB1B.
    Tissue: Placenta.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-1002 (ISOFORM 1).
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport."
    Chiu C.-F., Ghanekar Y., Frost L., Diao A., Morrison D., McKenzie E., Lowe M.
    EMBO J. 27:934-947(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZFPL1.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-953, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; SER-690 AND SER-937, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGOGA2_HUMAN
AccessioniPrimary (citable) accession number: Q08379
Secondary accession number(s): Q6GRM9, Q9BRB0, Q9NYF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 20, 2010
Last modified: July 22, 2015
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.