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Q08379

- GOGA2_HUMAN

UniProt

Q08379 - GOGA2_HUMAN

Protein

Golgin subfamily A member 2

Gene

GOLGA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 3 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. mitotic cell cycle Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_1100. Golgi Cisternae Pericentriolar Stack Reorganization.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgin subfamily A member 2
    Alternative name(s):
    130 kDa cis-Golgi matrix protein
    Short name:
    GM130
    GM130 autoantigen
    Golgin-95
    Gene namesi
    Name:GOLGA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:4425. GOLGA2.

    Subcellular locationi

    GO - Cellular componenti

    1. cis-Golgi network Source: MGI
    2. Golgi apparatus Source: UniProtKB
    3. Golgi cisterna membrane Source: UniProtKB-SubCell
    4. Golgi membrane Source: Reactome

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28805.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10021002Golgin subfamily A member 2PRO_0000190054Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371Phosphoserine3 Publications
    Modified residuei438 – 4381Phosphoserine1 Publication
    Modified residuei953 – 9531Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ08379.
    PaxDbiQ08379.
    PRIDEiQ08379.

    PTM databases

    PhosphoSiteiQ08379.

    Expressioni

    Gene expression databases

    ArrayExpressiQ08379.
    BgeeiQ08379.
    CleanExiHS_GOLGA2.
    GenevestigatoriQ08379.

    Organism-specific databases

    HPAiCAB015421.
    HPA021178.
    HPA021230.
    HPA021799.

    Interactioni

    Subunit structurei

    Part of a larger oligomeric complex. Interacts with p115 By similarity. Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    P299913EBI-618309,EBI-8826488From a different organism.
    Q9WMX22EBI-618309,EBI-6863748From a different organism.
    AKAP9Q999963EBI-618309,EBI-1048311
    STK25O005063EBI-618309,EBI-618295
    ZDHHC17Q8IUH53EBI-618309,EBI-524753

    Protein-protein interaction databases

    BioGridi109063. 38 interactions.
    DIPiDIP-34271N.
    IntActiQ08379. 61 interactions.
    MINTiMINT-1343711.
    STRINGi9606.ENSP00000416097.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08379.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili16 – 892877Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi46 – 516Poly-Lys
    Compositional biasi449 – 4557Poly-Pro
    Compositional biasi704 – 71512Poly-GluAdd
    BLAST

    Domaini

    Extended rod-like protein with coiled-coil domains.

    Sequence similaritiesi

    Belongs to the GOLGA2 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG304043.
    HOGENOMiHOG000218631.
    HOVERGENiHBG051752.
    InParanoidiQ08379.
    OMAiGERNEWQ.
    OrthoDBiEOG71P29T.
    PhylomeDBiQ08379.
    TreeFamiTF316990.

    Family and domain databases

    InterProiIPR024858. Golgin_A.
    [Graphical view]
    PANTHERiPTHR10881. PTHR10881. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q08379-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWPQPRLPPR PAMSEETRQS KLAAAKKKLR EYQQRNSPGV PTGAKKKKKI     50
    KNGSNPETTT SGGCHSPEDT PKDNAATLQP SDDTVLPGGV PSPGASLTSM 100
    AASQNHDADN VPNLMDETKT FSSTESLRQL SQQLNGLVCE SATCVNGEGP 150
    ASSANLKDLE SRYQQLAVAL DSSYVTNKQL NITIEKLKQQ NQEITDQLEE 200
    EKKECHQKQG ALREQLQVHI QTIGILVSEK AELQTALAHT QHAARQKEGE 250
    SEDLASRLQY SRRRVGELER ALSAVSTQQK KADRYNKELT KERDALRLEL 300
    YKNTQSNEDL KQEKSELEEK LRVLVTEKAG MQLNLEELQK KLEMTELLLQ 350
    QFSSRCEAPD ANQQLQQAME ERAQLEAHLG QVMESVRQLQ MERDKYAENL 400
    KGESAMWRQR MQQMSEQVHT LREEKECSMS RVQELETSLA ELRNQMAEPP 450
    PPEPPAGPSE VEQQLQAEAE HLRKELEGLA GQLQAQVQDN EGLSRLNREQ 500
    EERLLELERA AELWGEQAEA RRQILETMQN DRTTISRALS QNRELKEQLA 550
    ELQSGFVKLT NENMEITSAL QSEQHVKREL GKKLGELQEK LSELKETVEL 600
    KSQEAQSLQQ QRDQYLGHLQ QYVAAYQQLT SEKEVLHNQL LLQTQLVDQL 650
    QQQEAQGKAV AEMARQELQE TQERLEAATQ QNQQLRAQLS LMAHPGEGDG 700
    LDREEEEDEE EEEEEAVAVP QPMPSIPEDL ESREAMVAFF NSAVASAEEE 750
    QARLRGQLKE QRVRCRRLAH LLASAQKEPE AAAPAPGTGG DSVCGETHRA 800
    LQGAMEKLQS RFMELMQEKA DLKERVEELE HRCIQLSGET DTIGEYIALY 850
    QSQRAVLKER HREKEEYISR LAQDKEEMKV KLLELQELVL RLVGDRNEWH 900
    GRFLAAAQNP ADEPTSGAPA PQELGAANQQ GDLCEVSLAG SVEPAQGEAR 950
    EGSPRDNPTA QQIMQLLREM QNPRERPGLG SNPCIPFFYR ADENDEVKIT 1000
    VI 1002
    Length:1,002
    Mass (Da):113,086
    Last modified:April 20, 2010 - v3
    Checksum:iBD067145C5092237
    GO
    Isoform 2 (identifier: Q08379-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-382: Missing.

    Show »
    Length:620
    Mass (Da):70,473
    Checksum:i54B31A0FBB42BFC8
    GO

    Sequence cautioni

    The sequence AAP35912.1 differs from that shown. Reason: Sequence differs from that shown after position 826 due to an internal deletion.
    The sequence AAH69268.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti709 – 7091Missing in AAP35912. 1 PublicationCurated
    Sequence conflicti762 – 7621R → S in AAP35912. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti902 – 9021R → G.
    Corresponds to variant rs2240961 [ dbSNP | Ensembl ].
    VAR_033974

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 382382Missing in isoform 2. 1 PublicationVSP_007727Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L06147 mRNA. Translation: AAA35920.1.
    AL590708 Genomic DNA. Translation: CAI13841.2.
    BC014188 mRNA. Translation: AAH14188.2.
    BC069268 mRNA. Translation: AAH69268.1. Different initiation.
    AF248953 mRNA. Translation: AAF65550.1.
    BT007248 mRNA. Translation: AAP35912.1. Sequence problems.
    CCDSiCCDS6896.2. [Q08379-1]
    PIRiJH0821.
    RefSeqiNP_004477.3. NM_004486.4. [Q08379-1]
    UniGeneiHs.155827.

    Genome annotation databases

    EnsembliENST00000421699; ENSP00000416097; ENSG00000167110. [Q08379-1]
    ENST00000609374; ENSP00000476265; ENSG00000167110.
    GeneIDi2801.
    KEGGihsa:2801.
    UCSCiuc011maw.2. human. [Q08379-1]

    Polymorphism databases

    DMDMi294862511.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L06147 mRNA. Translation: AAA35920.1 .
    AL590708 Genomic DNA. Translation: CAI13841.2 .
    BC014188 mRNA. Translation: AAH14188.2 .
    BC069268 mRNA. Translation: AAH69268.1 . Different initiation.
    AF248953 mRNA. Translation: AAF65550.1 .
    BT007248 mRNA. Translation: AAP35912.1 . Sequence problems.
    CCDSi CCDS6896.2. [Q08379-1 ]
    PIRi JH0821.
    RefSeqi NP_004477.3. NM_004486.4. [Q08379-1 ]
    UniGenei Hs.155827.

    3D structure databases

    ProteinModelPortali Q08379.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109063. 38 interactions.
    DIPi DIP-34271N.
    IntActi Q08379. 61 interactions.
    MINTi MINT-1343711.
    STRINGi 9606.ENSP00000416097.

    PTM databases

    PhosphoSitei Q08379.

    Polymorphism databases

    DMDMi 294862511.

    Proteomic databases

    MaxQBi Q08379.
    PaxDbi Q08379.
    PRIDEi Q08379.

    Protocols and materials databases

    DNASUi 2801.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000421699 ; ENSP00000416097 ; ENSG00000167110 . [Q08379-1 ]
    ENST00000609374 ; ENSP00000476265 ; ENSG00000167110 .
    GeneIDi 2801.
    KEGGi hsa:2801.
    UCSCi uc011maw.2. human. [Q08379-1 ]

    Organism-specific databases

    CTDi 2801.
    GeneCardsi GC09M131018.
    H-InvDB HIX0010915.
    HIX0017404.
    HIX0177625.
    HIX0177626.
    HGNCi HGNC:4425. GOLGA2.
    HPAi CAB015421.
    HPA021178.
    HPA021230.
    HPA021799.
    MIMi 602580. gene.
    neXtProti NX_Q08379.
    PharmGKBi PA28805.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304043.
    HOGENOMi HOG000218631.
    HOVERGENi HBG051752.
    InParanoidi Q08379.
    OMAi GERNEWQ.
    OrthoDBi EOG71P29T.
    PhylomeDBi Q08379.
    TreeFami TF316990.

    Enzyme and pathway databases

    Reactomei REACT_1100. Golgi Cisternae Pericentriolar Stack Reorganization.

    Miscellaneous databases

    ChiTaRSi GOLGA2. human.
    GeneWikii GOLGA2.
    GenomeRNAii 2801.
    NextBioi 11041.
    PROi Q08379.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q08379.
    Bgeei Q08379.
    CleanExi HS_GOLGA2.
    Genevestigatori Q08379.

    Family and domain databases

    InterProi IPR024858. Golgin_A.
    [Graphical view ]
    PANTHERi PTHR10881. PTHR10881. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex."
      Fritzler M.J., Hamel J.C., Ochs R.L., Chan E.K.L.
      J. Exp. Med. 178:49-62(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Liver.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Colon adenocarcinoma.
    4. "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b."
      Weide T., Bayer M., Koester M., Siebrasse J.-P., Peters R., Barnekow A.
      EMBO Rep. 2:336-341(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-1002 (ISOFORM 1), INTERACTION WITH RAB1B.
      Tissue: Placenta.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-1002 (ISOFORM 1).
    6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport."
      Chiu C.-F., Ghanekar Y., Frost L., Diao A., Morrison D., McKenzie E., Lowe M.
      EMBO J. 27:934-947(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZFPL1.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-953, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGOGA2_HUMAN
    AccessioniPrimary (citable) accession number: Q08379
    Secondary accession number(s): Q6GRM9, Q9BRB0, Q9NYF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 136 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3