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Protein

Golgin subfamily A member 3

Gene

GOLGA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Golgi auto-antigen; probably involved in maintaining Golgi structure.

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • transporter activity Source: UniProtKB

GO - Biological processi

  • intra-Golgi vesicle-mediated transport Source: UniProtKB
  • spermatogenesis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 3
Alternative name(s):
Golgi complex-associated protein of 170 kDa
Short name:
GCP170
Golgin-160
Gene namesi
Name:GOLGA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:4426. GOLGA3.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytosol Source: UniProtKB
  • extrinsic component of Golgi membrane Source: UniProtKB
  • Golgi apparatus Source: HPA
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • Golgi membrane Source: ProtInc
  • Golgi transport complex Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi59D → A: Abolishes cleavage by caspase-2. 1 Publication1
Mutagenesisi121L → A: Loss of interaction with GOPC; when associated with A-128 and A-135. 1 Publication1
Mutagenesisi128L → A: Loss of interaction with GOPC; when associated with A-121 and A-135. 1 Publication1
Mutagenesisi135L → A: Loss of interaction with GOPC; when associated with A-121 and A-128. 1 Publication1
Mutagenesisi139D → A: Abolishes cleavage by caspase-3. 1 Publication1
Mutagenesisi311D → A: Abolishes cleavage by caspase-7. 1 Publication1

Organism-specific databases

DisGeNETi2802.
OpenTargetsiENSG00000090615.
ENSG00000283396.
PharmGKBiPA28807.

Polymorphism and mutation databases

BioMutaiGOLGA3.
DMDMi32470610.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900571 – 1498Golgin subfamily A member 3Add BLAST1498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei18PhosphoserineCombined sources1
Modified residuei57PhosphoserineBy similarity1
Modified residuei272PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei983PhosphoserineCombined sources1
Modified residuei1392PhosphoserineCombined sources1

Post-translational modificationi

Cleaved by caspases in apoptotic cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59 – 60Cleavage; by caspase-22
Sitei139 – 140Cleavage; by caspase-32
Sitei311 – 312Cleavage; by caspase-72

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ08378.
MaxQBiQ08378.
PaxDbiQ08378.
PeptideAtlasiQ08378.
PRIDEiQ08378.

PTM databases

iPTMnetiQ08378.
PhosphoSitePlusiQ08378.

Miscellaneous databases

PMAP-CutDBQ08378.

Expressioni

Tissue specificityi

Expressed in all tissues tested. Expressed in liver, testis, lung, heart, salivary gland and kidney.1 Publication

Gene expression databases

BgeeiENSG00000090615.
CleanExiHS_GOLGA3.
ExpressionAtlasiQ08378. baseline and differential.
GenevisibleiQ08378. HS.

Organism-specific databases

HPAiHPA039809.
HPA040044.

Interactioni

Subunit structurei

Homodimer. Interacts with GOLGA7. Isoform 1 interacts with GOPC while isoform 3 does not.2 Publications

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi109064. 40 interactors.
IntActiQ08378. 17 interactors.
MINTiMINT-1157195.
STRINGi9606.ENSP00000204726.

Structurei

3D structure databases

ProteinModelPortaliQ08378.
SMRiQ08378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni121 – 141Interaction with GOPC1 PublicationAdd BLAST21
Regioni172 – 257Golgi-targeting domainAdd BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili394 – 1459Sequence analysisAdd BLAST1066

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 95Pro-richAdd BLAST76
Compositional biasi538 – 744Gln-richAdd BLAST207
Compositional biasi1231 – 1369Gln-richAdd BLAST139

Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFW4. Eukaryota.
ENOG410YGSW. LUCA.
GeneTreeiENSGT00730000111197.
HOVERGENiHBG051753.
InParanoidiQ08378.
OMAiKQKMRRL.
OrthoDBiEOG091G0D2X.
PhylomeDBiQ08378.
TreeFamiTF332014.

Family and domain databases

InterProiIPR033288. Golga3.
[Graphical view]
PANTHERiPTHR18902:SF26. PTHR18902:SF26. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q08378-1) [UniParc]FASTAAdd to basket
Also known as: Golgin-160B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGASAEQDG LQEDRSHSGP SSLPEAPLKP PGPLVPPDQQ DKVQCAEVNR
60 70 80 90 100
ASTEGESPDG PGQGGLCQNG PTPPFPDPPS SLDPTTSPVG PDASPGVAGF
110 120 130 140 150
HDNLRKSQGT SAEGSVRKEA LQSLRLSLPM QETQLCSTDS PLPLEKEEQV
160 170 180 190 200
RLQARKWLEE QLKQYRVKRQ QERSSQPATK TRLFSTLDPE LMLNPENLPR
210 220 230 240 250
ASTLAMTKEY SFLRTSVPRG PKVGSLGLPA HPREKKTSKS SKIRSLADYR
260 270 280 290 300
TEDSNAGNSG GNVPAPDSTK GSLKQNRSSA ASVVSEISLS PDTDDRLENT
310 320 330 340 350
SLAGDSVSEV DGNDSDSSSY SSASTRGTYG ILSKTVGTQD TPYMVNGQEI
360 370 380 390 400
PADTLGQFPS IKDVLQAAAA EHQDQGQEVN GEVRSRRDSI CSSVSLESSA
410 420 430 440 450
AETQEEMLQV LKEKMRLEGQ LEALSLEASQ ALKEKAELQA QLAALSTKLQ
460 470 480 490 500
AQVECSHSSQ QRQDSLSSEV DTLKQSCWDL ERAMTDLQNM LEAKNASLAS
510 520 530 540 550
SNNDLQVAEE QYQRLMAKVE DMQRSMLSKD NTVHDLRQQM TALQSQLQQV
560 570 580 590 600
QLERTTLTSK LKASQAEISS LQSVRQWYQQ QLALAQEARV RLQGEMAHIQ
610 620 630 640 650
VGQMTQAGLL EHLKLENVSL SQQLTETQHR SMKEKGRIAA QLQGIEADML
660 670 680 690 700
DQEAAFMQIQ EAKTMVEEDL QRRLEEFEGE RERLQRMADS AASLEQQLEQ
710 720 730 740 750
VKLTLLQRDQ QLEALQQEHL DLMKQLTLTQ EALQSREQSL DALQTHYDEL
760 770 780 790 800
QARLGELQGE AASREDTICL LQNEKIILEA ALQAAKSGKE ELDRGARRLE
810 820 830 840 850
EGTEETSETL EKLREELAIK SGQVEHLQQE TAALKKQMQK IKEQFLQQKV
860 870 880 890 900
MVEAYRRDAT SKDQLISELK ATRKRLDSEL KELRQELMQV HGEKRTAEAE
910 920 930 940 950
LSRLHREVAQ VRQHMADLEG HLQSAQKERD EMETHLQSLQ FDKEQMVAVT
960 970 980 990 1000
EANEALKKQI EELQQEARKA ITEQKQKMRR LGSDLTSAQK EMKTKHKAYE
1010 1020 1030 1040 1050
NAVGILSRRL QEALAAKEAA DAELGQLRAQ GGSSDSSLAL HERIQALEAE
1060 1070 1080 1090 1100
LQAVSHSKTL LEKELQEVIA LTSQELEESR EKVLELEDEL QESRGFRKKI
1110 1120 1130 1140 1150
KRLEESNKKL ALELEHEKGK LTGLGQSNAA LREHNSILET ALAKREADLV
1160 1170 1180 1190 1200
QLNLQVQAVL QRKEEEDRQM KHLVQALQAS LEKEKEKVNS LKEQVAAAKV
1210 1220 1230 1240 1250
EAGHNRRHFK AASLELSEVK KELQAKEHLV QKLQAEADDL QIREGKHSQE
1260 1270 1280 1290 1300
IAQFQAELAE ARAQLQLLQK QLDEQLSKQP VGNQEMENLK WEVDQKEREI
1310 1320 1330 1340 1350
QSLKQQLDLT EQQGRKELEG LQQLLQNVKS ELEMAQEDLS MTQKDKFMLQ
1360 1370 1380 1390 1400
AKVSELKNNM KTLLQQNQQL KLDLRRGAAK TRKEPKGEAS SSNPATPIKI
1410 1420 1430 1440 1450
PDCPVPASLL EELLRPPPAV SKEPLKNLNS CLQQLKQEMD SLQRQMEEHA
1460 1470 1480 1490
LTVHESLSSW TPLEPATASP VPPGGHAGPR GDPQRHSQSR ASKEGPGE
Length:1,498
Mass (Da):167,355
Last modified:July 3, 2003 - v2
Checksum:i4B95CDCFD3D64667
GO
Isoform 2 (identifier: Q08378-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1382-1390: RKEPKGEAS → VLRPASLPG
     1391-1498: Missing.

Note: No experimental confirmation available. May be due to an intron retention.
Show »
Length:1,390
Mass (Da):155,683
Checksum:iA7A2BA5DD87ACE30
GO
Isoform 3 (identifier: Q08378-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1134: LQESRGFRKK...GQSNAALREH → VRPGHLLWRQ...SVATFGVATF
     1135-1498: Missing.

Note: No experimental confirmation available.
Show »
Length:1,134
Mass (Da):126,129
Checksum:i29EB52DCDD5B21D1
GO

Sequence cautioni

The sequence AAA35921 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH60826 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA23661 differs from that shown. Reason: Frameshift at position 1378.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159E → K in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti609L → I in BAA23661 (PubMed:9295333).Curated1
Sequence conflicti746H → R in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti785A → V in AAA35921 (PubMed:15489334).Curated1
Sequence conflicti932M → V in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti1017K → R in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti1281V → A in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti1315R → W in AAL93149 (PubMed:10791974).Curated1
Sequence conflicti1443Q → R in AAL93149 (PubMed:10791974).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02015370G → E.Corresponds to variant rs2291256dbSNPEnsembl.1
Natural variantiVAR_021901264P → L.Corresponds to variant rs3741486dbSNPEnsembl.1
Natural variantiVAR_0201541185K → R.Corresponds to variant rs2291260dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0380001090 – 1134LQESR…ALREH → VRPGHLLWRQRGAGHVSPGH AATRETRRTKLHRVPSVATF GVATF in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_0380011135 – 1498Missing in isoform 3. 1 PublicationAdd BLAST364
Alternative sequenceiVSP_0077281382 – 1390RKEPKGEAS → VLRPASLPG in isoform 2. 1 Publication9
Alternative sequenceiVSP_0077291391 – 1498Missing in isoform 2. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63997 mRNA. Translation: BAA23661.1. Frameshift.
AF485338 mRNA. Translation: AAL93149.1.
AB027133 mRNA. Translation: BAB71953.1.
BC060826 mRNA. Translation: AAH60826.1. Sequence problems.
BC142658 mRNA. Translation: AAI42659.1.
BC146675 mRNA. Translation: AAI46676.1.
L06148 mRNA. Translation: AAA35921.1. Different initiation.
CCDSiCCDS53846.1. [Q08378-4]
CCDS9281.1. [Q08378-1]
PIRiJH0820.
RefSeqiNP_001166028.1. NM_001172557.1. [Q08378-4]
NP_005886.2. NM_005895.3. [Q08378-1]
XP_006719799.1. XM_006719736.3. [Q08378-1]
XP_006719800.1. XM_006719737.3. [Q08378-1]
UniGeneiHs.507333.

Genome annotation databases

EnsembliENST00000204726; ENSP00000204726; ENSG00000090615. [Q08378-1]
ENST00000450791; ENSP00000410378; ENSG00000090615. [Q08378-1]
ENST00000456883; ENSP00000409303; ENSG00000090615. [Q08378-2]
GeneIDi2802.
KEGGihsa:2802.
UCSCiuc001ukz.1. human. [Q08378-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63997 mRNA. Translation: BAA23661.1. Frameshift.
AF485338 mRNA. Translation: AAL93149.1.
AB027133 mRNA. Translation: BAB71953.1.
BC060826 mRNA. Translation: AAH60826.1. Sequence problems.
BC142658 mRNA. Translation: AAI42659.1.
BC146675 mRNA. Translation: AAI46676.1.
L06148 mRNA. Translation: AAA35921.1. Different initiation.
CCDSiCCDS53846.1. [Q08378-4]
CCDS9281.1. [Q08378-1]
PIRiJH0820.
RefSeqiNP_001166028.1. NM_001172557.1. [Q08378-4]
NP_005886.2. NM_005895.3. [Q08378-1]
XP_006719799.1. XM_006719736.3. [Q08378-1]
XP_006719800.1. XM_006719737.3. [Q08378-1]
UniGeneiHs.507333.

3D structure databases

ProteinModelPortaliQ08378.
SMRiQ08378.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109064. 40 interactors.
IntActiQ08378. 17 interactors.
MINTiMINT-1157195.
STRINGi9606.ENSP00000204726.

PTM databases

iPTMnetiQ08378.
PhosphoSitePlusiQ08378.

Polymorphism and mutation databases

BioMutaiGOLGA3.
DMDMi32470610.

Proteomic databases

EPDiQ08378.
MaxQBiQ08378.
PaxDbiQ08378.
PeptideAtlasiQ08378.
PRIDEiQ08378.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000204726; ENSP00000204726; ENSG00000090615. [Q08378-1]
ENST00000450791; ENSP00000410378; ENSG00000090615. [Q08378-1]
ENST00000456883; ENSP00000409303; ENSG00000090615. [Q08378-2]
GeneIDi2802.
KEGGihsa:2802.
UCSCiuc001ukz.1. human. [Q08378-1]

Organism-specific databases

CTDi2802.
DisGeNETi2802.
GeneCardsiGOLGA3.
HGNCiHGNC:4426. GOLGA3.
HPAiHPA039809.
HPA040044.
MIMi602581. gene.
neXtProtiNX_Q08378.
OpenTargetsiENSG00000090615.
ENSG00000283396.
PharmGKBiPA28807.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFW4. Eukaryota.
ENOG410YGSW. LUCA.
GeneTreeiENSGT00730000111197.
HOVERGENiHBG051753.
InParanoidiQ08378.
OMAiKQKMRRL.
OrthoDBiEOG091G0D2X.
PhylomeDBiQ08378.
TreeFamiTF332014.

Miscellaneous databases

ChiTaRSiGOLGA3. human.
GeneWikiiGOLGA3.
GenomeRNAii2802.
PMAP-CutDBQ08378.
PROiQ08378.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090615.
CleanExiHS_GOLGA3.
ExpressionAtlasiQ08378. baseline and differential.
GenevisibleiQ08378. HS.

Family and domain databases

InterProiIPR033288. Golga3.
[Graphical view]
PANTHERiPTHR18902:SF26. PTHR18902:SF26. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGOGA3_HUMAN
AccessioniPrimary (citable) accession number: Q08378
Secondary accession number(s): A5PKX6
, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 3, 2003
Last modified: November 2, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.