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Protein

Zinc finger and BTB domain-containing protein 14

Gene

Zbtb14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene (By similarity). Transcriptional repressor of MYC and thymidine kinase promoters.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri305 – 332C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri333 – 360C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri361 – 388C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri389 – 417C2H2-type 5PROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

  • cardiac septum development Source: MGI
  • coronary vasculature development Source: MGI
  • heart valve development Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 14
Alternative name(s):
Zinc finger protein 161
Short name:
Zfp-161
Zinc finger protein 5
Short name:
ZF5
Gene namesi
Name:Zbtb14
Synonyms:Zfp-5, Zfp161, Zfp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1195345. Zbtb14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473181 – 449Zinc finger and BTB domain-containing protein 14Add BLAST449

Proteomic databases

EPDiQ08376.
PaxDbiQ08376.
PeptideAtlasiQ08376.
PRIDEiQ08376.

PTM databases

iPTMnetiQ08376.
PhosphoSitePlusiQ08376.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000049672.
CleanExiMM_ZFP161.
ExpressionAtlasiQ08376. baseline and differential.
GenevisibleiQ08376. MM.

Interactioni

Subunit structurei

Interacts with ZBTB21.By similarity

Protein-protein interaction databases

BioGridi204642. 1 interactor.
STRINGi10090.ENSMUSP00000054897.

Structurei

3D structure databases

ProteinModelPortaliQ08376.
SMRiQ08376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 102BTBPROSITE-ProRule annotationAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 66Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 179Asp/Glu-rich (acidic)Add BLAST26

Domaini

The BTB/POZ domain seems to direct the protein to discrete regions in the nucleus.By similarity

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri305 – 332C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri333 – 360C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri361 – 388C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri389 – 417C2H2-type 5PROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125416.
HOGENOMiHOG000136853.
HOVERGENiHBG054222.
InParanoidiQ08376.
OMAiKKHEVDS.
OrthoDBiEOG091G06U1.
PhylomeDBiQ08376.
TreeFamiTF333100.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFFISMSET IKYNDDDHKT LFLKTLNEQR LEGEFCDIAI VVEDVKFRAH
60 70 80 90 100
RCVLAACSTY FKKLFKKLEV DSSSVIEIDF LRSDIFEEVL NYMYTAKISV
110 120 130 140 150
KKEDVNLMMS SGQILGIRFL DKLCSQKRDV SSPDESNGQS KSKYCLKLNR
160 170 180 190 200
PIGDAADAQD DDVEEIGDQD DSPSDDTVEG TPPSQEDGKS PTTTLRVQEA
210 220 230 240 250
ILKELGSEEV RKVNCYGQEV ESMETPESKD LGSQTPQALT FNDGMSEVKD
260 270 280 290 300
EQTPGWTTAA SDMKFEYLLY GHHREQIACQ ACGKTFSDEG RLRKHEKLHT
310 320 330 340 350
ADRPFVCEMC TKGFTTQAHL KEHLKIHTGY KPYSCEVCGK SFIRAPDLKK
360 370 380 390 400
HERVHSNERP FACHMCDKAF KHKSHLKDHE RRHRGEKPFV CGSCTKAFAK
410 420 430 440
ASDLKRHENN MHSERKQVTP SAIQSETEQL QAAAMAAEAE QQLETIACS
Length:449
Mass (Da):50,899
Last modified:November 1, 1996 - v1
Checksum:i288E76CB689948D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15325 mRNA. Translation: AAA02940.1.
BC052017 mRNA. Translation: AAH52017.1.
CCDSiCCDS37682.1.
PIRiS41647.
RefSeqiNP_033573.1. NM_009547.2.
XP_006524275.1. XM_006524212.2.
XP_011244726.1. XM_011246424.2.
UniGeneiMm.29434.

Genome annotation databases

EnsembliENSMUST00000062369; ENSMUSP00000054897; ENSMUSG00000049672.
ENSMUST00000112674; ENSMUSP00000108294; ENSMUSG00000049672.
ENSMUST00000112676; ENSMUSP00000108296; ENSMUSG00000049672.
GeneIDi22666.
KEGGimmu:22666.
UCSCiuc008dkt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15325 mRNA. Translation: AAA02940.1.
BC052017 mRNA. Translation: AAH52017.1.
CCDSiCCDS37682.1.
PIRiS41647.
RefSeqiNP_033573.1. NM_009547.2.
XP_006524275.1. XM_006524212.2.
XP_011244726.1. XM_011246424.2.
UniGeneiMm.29434.

3D structure databases

ProteinModelPortaliQ08376.
SMRiQ08376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204642. 1 interactor.
STRINGi10090.ENSMUSP00000054897.

PTM databases

iPTMnetiQ08376.
PhosphoSitePlusiQ08376.

Proteomic databases

EPDiQ08376.
PaxDbiQ08376.
PeptideAtlasiQ08376.
PRIDEiQ08376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062369; ENSMUSP00000054897; ENSMUSG00000049672.
ENSMUST00000112674; ENSMUSP00000108294; ENSMUSG00000049672.
ENSMUST00000112676; ENSMUSP00000108296; ENSMUSG00000049672.
GeneIDi22666.
KEGGimmu:22666.
UCSCiuc008dkt.1. mouse.

Organism-specific databases

CTDi7541.
MGIiMGI:1195345. Zbtb14.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125416.
HOGENOMiHOG000136853.
HOVERGENiHBG054222.
InParanoidiQ08376.
OMAiKKHEVDS.
OrthoDBiEOG091G06U1.
PhylomeDBiQ08376.
TreeFamiTF333100.

Miscellaneous databases

PROiQ08376.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049672.
CleanExiMM_ZFP161.
ExpressionAtlasiQ08376. baseline and differential.
GenevisibleiQ08376. MM.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT14_MOUSE
AccessioniPrimary (citable) accession number: Q08376
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.