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Q08357

- S20A2_HUMAN

UniProt

Q08357 - S20A2_HUMAN

Protein

Sodium-dependent phosphate transporter 2

Gene

SLC20A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.5 Publications

    GO - Molecular functioni

    1. inorganic phosphate transmembrane transporter activity Source: InterPro
    2. receptor activity Source: ProtInc
    3. sodium:phosphate symporter activity Source: ProtInc
    4. virus receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. ion transport Source: Reactome
    2. phosphate ion transmembrane transport Source: GOC
    3. sodium ion transmembrane transport Source: GOC
    4. transmembrane transport Source: Reactome
    5. transport Source: ProtInc
    6. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Host cell receptor for virus entry, Receptor

    Keywords - Biological processi

    Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_19275. Sodium-coupled phosphate cotransporters.

    Protein family/group databases

    TCDBi2.A.20.2.3. the inorganic phosphate transporter (pit) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent phosphate transporter 2
    Alternative name(s):
    Gibbon ape leukemia virus receptor 2
    Short name:
    GLVR-2
    Phosphate transporter 2
    Short name:
    PiT-2
    Short name:
    Pit2
    Short name:
    hPit2
    Solute carrier family 20 member 2
    Gene namesi
    Name:SLC20A2
    Synonyms:GLVR2, PIT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:10947. SLC20A2.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of plasma membrane Source: ProtInc
    3. membrane Source: ProtInc
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Basal ganglia calcification, idiopathic, 1 (IBGC1) [MIM:213600]: A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421Missing in IBGC1; substantially impaired phosphate transport. 1 Publication
    VAR_067545
    Natural varianti498 – 4981G → R in IBGC1; substantially impaired phosphate transport. 1 Publication
    VAR_067546
    Natural varianti575 – 5751E → K in IBGC1; substantially impaired phosphate transport. 1 Publication
    VAR_067547
    Natural varianti595 – 5951T → M in IBGC1; substantially impaired phosphate transport. 1 Publication
    VAR_067548
    Natural varianti601 – 6011S → L in IBGC1; substantially impaired phosphate transport. 1 Publication
    VAR_067549
    Natural varianti601 – 6011S → W in IBGC1; substantially impaired phosphate transport. 1 Publication
    VAR_067550

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi28 – 281D → N: Impairs phosphate transport; no effect on retroviral receptor function. 1 Publication
    Mutagenesisi55 – 551E → D or K: Abolishes sodium-dependent phosphate transport; no effect on retroviral receptor function. 2 Publications
    Mutagenesisi55 – 551E → Q: Abolishes phosphate but not sodium uptake; when associated with Q-91 and Q-575. 2 Publications
    Mutagenesisi81 – 811N → V: Abolishes N-glycosylation. 1 Publication
    Mutagenesisi91 – 911E → Q: Abolishes phosphate but not sodium uptake; when associated with Q-55 and Q-575. 1 Publication
    Mutagenesisi506 – 5061D → N: Impairs phosphate transport; no effect on retroviral receptor function. 1 Publication
    Mutagenesisi575 – 5751E → D or K: Abolishes sodium-dependent phosphate transport; no effect on retroviral receptor function. 2 Publications
    Mutagenesisi575 – 5751E → Q: Abolishes phosphate but not sodium uptake; when associated with Q-55 and Q-91. 2 Publications

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi213600. phenotype.
    Orphaneti1980. Bilateral striopallidodentate calcinosis.
    PharmGKBiPA35834.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 652652Sodium-dependent phosphate transporter 2PRO_0000341268Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi81 – 811N-linked (GlcNAc...)1 Publication
    Modified residuei268 – 2681Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ08357.
    PaxDbiQ08357.
    PRIDEiQ08357.

    PTM databases

    PhosphoSiteiQ08357.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.

    Inductioni

    Increased by phosphate depletion in osteosarcoma cell lines.1 Publication

    Gene expression databases

    ArrayExpressiQ08357.
    BgeeiQ08357.
    CleanExiHS_SLC20A2.
    GenevestigatoriQ08357.

    Organism-specific databases

    HPAiHPA026540.

    Interactioni

    Subunit structurei

    Homodimer.2 Publications

    Protein-protein interaction databases

    BioGridi112463. 1 interaction.
    STRINGi9606.ENSP00000340465.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08357.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55ExtracellularSequence Analysis
    Topological domaini27 – 4620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini68 – 8619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini108 – 1092CytoplasmicSequence Analysis
    Topological domaini131 – 14212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini164 – 19027CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini212 – 2132ExtracellularSequence Analysis
    Topological domaini235 – 482248CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini504 – 53027ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini552 – 57120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini587 – 5937ExtracellularSequence Analysis
    Topological domaini610 – 62112CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini643 – 65210ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei483 – 50321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei531 – 55121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei572 – 58615HelicalSequence AnalysisAdd
    BLAST
    Transmembranei594 – 60916HelicalSequence AnalysisAdd
    BLAST
    Transmembranei622 – 64221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0306.
    HOGENOMiHOG000231892.
    HOVERGENiHBG053358.
    InParanoidiQ08357.
    KOiK14640.
    OMAiMYGYKVI.
    OrthoDBiEOG79KPDT.
    PhylomeDBiQ08357.
    TreeFamiTF314426.

    Family and domain databases

    InterProiIPR001204. Phos_transporter.
    [Graphical view]
    PANTHERiPTHR11101. PTHR11101. 1 hit.
    PfamiPF01384. PHO4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08357-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMDEYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL    50
    ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV 100
    WQLIASFLRL PISGTHCIVG STIGFSLVAI GTKGVQWMEL VKIVASWFIS 150
    PLLSGFMSGL LFVLIRIFIL KKEDPVPNGL RALPVFYAAT IAINVFSIMY 200
    TGAPVLGLVL PMWAIALISF GVALLFAFFV WLFVCPWMRR KITGKLQKEG 250
    ALSRVSDESL SKVQEAESPV FKELPGAKAN DDSTIPLTGA AGETLGTSEG 300
    TSAGSHPRAA YGRALSMTHG SVKSPISNGT FGFDGHTRSD GHVYHTVHKD 350
    SGLYKDLLHK IHIDRGPEEK PAQESNYRLL RRNNSYTCYT AAICGLPVHA 400
    TFRAADSSAP EDSEKLVGDT VSYSKKRLRY DSYSSYCNAV AEAEIEAEEG 450
    GVEMKLASEL ADPDQPREDP AEEEKEEKDA PEVHLLFHFL QVLTACFGSF 500
    AHGGNDVSNA IGPLVALWLI YKQGGVTQEA ATPVWLLFYG GVGICTGLWV 550
    WGRRVIQTMG KDLTPITPSS GFTIELASAF TVVIASNIGL PVSTTHCKVG 600
    SVVAVGWIRS RKAVDWRLFR NIFVAWFVTV PVAGLFSAAV MALLMYGILP 650
    YV 652
    Length:652
    Mass (Da):70,392
    Last modified:November 1, 1996 - v1
    Checksum:iA0A870C7927DE39C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421Missing in IBGC1; substantially impaired phosphate transport. 1 Publication
    VAR_067545
    Natural varianti498 – 4981G → R in IBGC1; substantially impaired phosphate transport. 1 Publication
    VAR_067546
    Natural varianti575 – 5751E → K in IBGC1; substantially impaired phosphate transport. 1 Publication
    VAR_067547
    Natural varianti595 – 5951T → M in IBGC1; substantially impaired phosphate transport. 1 Publication
    VAR_067548
    Natural varianti601 – 6011S → L in IBGC1; substantially impaired phosphate transport. 1 Publication
    VAR_067549
    Natural varianti601 – 6011S → W in IBGC1; substantially impaired phosphate transport. 1 Publication
    VAR_067550

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20852 mRNA. Translation: AAA18018.1.
    AK291202 mRNA. Translation: BAF83891.1.
    BC028600 mRNA. Translation: AAH28600.1.
    CCDSiCCDS6132.1.
    PIRiA37000.
    RefSeqiNP_001244109.1. NM_001257180.1.
    NP_001244110.1. NM_001257181.1.
    NP_006740.1. NM_006749.4.
    XP_005273670.1. XM_005273613.1.
    UniGeneiHs.653173.
    Hs.654763.

    Genome annotation databases

    EnsembliENST00000342228; ENSP00000340465; ENSG00000168575.
    ENST00000520179; ENSP00000429712; ENSG00000168575.
    ENST00000520262; ENSP00000429754; ENSG00000168575.
    GeneIDi6575.
    KEGGihsa:6575.
    UCSCiuc003xpe.4. human.

    Polymorphism databases

    DMDMi74735615.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20852 mRNA. Translation: AAA18018.1 .
    AK291202 mRNA. Translation: BAF83891.1 .
    BC028600 mRNA. Translation: AAH28600.1 .
    CCDSi CCDS6132.1.
    PIRi A37000.
    RefSeqi NP_001244109.1. NM_001257180.1.
    NP_001244110.1. NM_001257181.1.
    NP_006740.1. NM_006749.4.
    XP_005273670.1. XM_005273613.1.
    UniGenei Hs.653173.
    Hs.654763.

    3D structure databases

    ProteinModelPortali Q08357.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112463. 1 interaction.
    STRINGi 9606.ENSP00000340465.

    Protein family/group databases

    TCDBi 2.A.20.2.3. the inorganic phosphate transporter (pit) family.

    PTM databases

    PhosphoSitei Q08357.

    Polymorphism databases

    DMDMi 74735615.

    Proteomic databases

    MaxQBi Q08357.
    PaxDbi Q08357.
    PRIDEi Q08357.

    Protocols and materials databases

    DNASUi 6575.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342228 ; ENSP00000340465 ; ENSG00000168575 .
    ENST00000520179 ; ENSP00000429712 ; ENSG00000168575 .
    ENST00000520262 ; ENSP00000429754 ; ENSG00000168575 .
    GeneIDi 6575.
    KEGGi hsa:6575.
    UCSCi uc003xpe.4. human.

    Organism-specific databases

    CTDi 6575.
    GeneCardsi GC08M042291.
    GeneReviewsi SLC20A2.
    HGNCi HGNC:10947. SLC20A2.
    HPAi HPA026540.
    MIMi 158378. gene.
    213600. phenotype.
    neXtProti NX_Q08357.
    Orphaneti 1980. Bilateral striopallidodentate calcinosis.
    PharmGKBi PA35834.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0306.
    HOGENOMi HOG000231892.
    HOVERGENi HBG053358.
    InParanoidi Q08357.
    KOi K14640.
    OMAi MYGYKVI.
    OrthoDBi EOG79KPDT.
    PhylomeDBi Q08357.
    TreeFami TF314426.

    Enzyme and pathway databases

    Reactomei REACT_19275. Sodium-coupled phosphate cotransporters.

    Miscellaneous databases

    ChiTaRSi SLC20A2. human.
    GeneWikii SLC20A2.
    GenomeRNAii 6575.
    NextBioi 25583.
    PROi Q08357.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q08357.
    Bgeei Q08357.
    CleanExi HS_SLC20A2.
    Genevestigatori Q08357.

    Family and domain databases

    InterProi IPR001204. Phos_transporter.
    [Graphical view ]
    PANTHERi PTHR11101. PTHR11101. 1 hit.
    Pfami PF01384. PHO4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family."
      van Zeijl M., Johann S.V., Closs E., Cunningham J., Eddy R., Shows T.B., O'Hara B.
      Proc. Natl. Acad. Sci. U.S.A. 91:1168-1172(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION AS RETROVIRAL RECEPTOR.
      Tissue: Placenta.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Transmembrane topology of PiT-2, a phosphate transporter-retrovirus receptor."
      Salauen C., Rodrigues P., Heard J.M.
      J. Virol. 75:5584-5592(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY, GLYCOSYLATION AT ASN-81, MUTAGENESIS OF ASN-81.
    5. "The amphotropic murine leukemia virus receptor gene encodes a 71-kilodalton protein that is induced by phosphate depletion."
      Chien M.L., Foster J.L., Douglas J.L., Garcia J.V.
      J. Virol. 71:4564-4570(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY, SUBCELLULAR LOCATION, INDUCTION.
    6. "Identification of envelope determinants of feline leukemia virus subgroup B that permit infection and gene transfer to cells expressing human Pit1 or Pit2."
      Sugai J., Eiden M., Anderson M.M., Van Hoeven N., Meiering C.D., Overbaugh J.
      J. Virol. 75:6841-6849(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS RETROVIRAL RECEPTOR.
    7. "Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function."
      Boettger P., Pedersen L.
      J. Biol. Chem. 277:42741-42747(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS SODIUM-PHOSPHATE SYMPORTER, SUBUNIT, MUTAGENESIS OF GLU-55 AND GLU-575.
    8. "Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic acids critical for sodium-dependent phosphate transport function of human PiT2."
      Boettger P., Pedersen L.
      FEBS J. 272:3060-3074(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS SODIUM-PHOSPHATE SYMPORTER, SUBUNIT, MUTAGENESIS OF ASP-28 AND ASP-506.
    9. "Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2."
      Boettger P., Hede S.E., Grunnet M., Hoyer B., Klaerke D.A., Pedersen L.
      Am. J. Physiol. 291:C1377-C1387(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS SODIUM-PHOSPHATE SYMPORTER, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF GLU-55; GLU-91 AND GLU-575.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: VARIANTS IBGC1 VAL-42 DEL; ARG-498; LYS-575; MET-595; TRP-601 AND LEU-601, CHARACTERIZATION OF VARIANTS IBGC1 VAL-42 DEL; ARG-498; LYS-575; MET-595; TRP-601 AND LEU-601.

    Entry informationi

    Entry nameiS20A2_HUMAN
    AccessioniPrimary (citable) accession number: Q08357
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3