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Q08357

- S20A2_HUMAN

UniProt

Q08357 - S20A2_HUMAN

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Protein

Sodium-dependent phosphate transporter 2

Gene
SLC20A2, GLVR2, PIT2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.5 Publications

GO - Molecular functioni

  1. inorganic phosphate transmembrane transporter activity Source: InterPro
  2. receptor activity Source: ProtInc
  3. sodium:phosphate symporter activity Source: ProtInc
  4. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. ion transport Source: Reactome
  2. phosphate ion transmembrane transport Source: GOC
  3. sodium ion transmembrane transport Source: GOC
  4. transmembrane transport Source: Reactome
  5. transport Source: ProtInc
  6. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_19275. Sodium-coupled phosphate cotransporters.

Protein family/group databases

TCDBi2.A.20.2.3. the inorganic phosphate transporter (pit) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Gibbon ape leukemia virus receptor 2
Short name:
GLVR-2
Phosphate transporter 2
Short name:
PiT-2
Short name:
Pit2
Short name:
hPit2
Solute carrier family 20 member 2
Gene namesi
Name:SLC20A2
Synonyms:GLVR2, PIT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:10947. SLC20A2.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55Extracellular Reviewed prediction
Transmembranei6 – 2621Helical; Reviewed predictionAdd
BLAST
Topological domaini27 – 4620Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei47 – 6721Helical; Reviewed predictionAdd
BLAST
Topological domaini68 – 8619Extracellular Reviewed predictionAdd
BLAST
Transmembranei87 – 10721Helical; Reviewed predictionAdd
BLAST
Topological domaini108 – 1092Cytoplasmic Reviewed prediction
Transmembranei110 – 13021Helical; Reviewed predictionAdd
BLAST
Topological domaini131 – 14212Extracellular Reviewed predictionAdd
BLAST
Transmembranei143 – 16321Helical; Reviewed predictionAdd
BLAST
Topological domaini164 – 19027Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei191 – 21121Helical; Reviewed predictionAdd
BLAST
Topological domaini212 – 2132Extracellular Reviewed prediction
Transmembranei214 – 23421Helical; Reviewed predictionAdd
BLAST
Topological domaini235 – 482248Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei483 – 50321Helical; Reviewed predictionAdd
BLAST
Topological domaini504 – 53027Extracellular Reviewed predictionAdd
BLAST
Transmembranei531 – 55121Helical; Reviewed predictionAdd
BLAST
Topological domaini552 – 57120Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei572 – 58615Helical; Reviewed predictionAdd
BLAST
Topological domaini587 – 5937Extracellular Reviewed prediction
Transmembranei594 – 60916Helical; Reviewed predictionAdd
BLAST
Topological domaini610 – 62112Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei622 – 64221Helical; Reviewed predictionAdd
BLAST
Topological domaini643 – 65210Extracellular Reviewed prediction

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: ProtInc
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Basal ganglia calcification, idiopathic, 1 (IBGC1) [MIM:213600]: A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421Missing in IBGC1; substantially impaired phosphate transport. 1 Publication
VAR_067545
Natural varianti498 – 4981G → R in IBGC1; substantially impaired phosphate transport. 1 Publication
VAR_067546
Natural varianti575 – 5751E → K in IBGC1; substantially impaired phosphate transport. 1 Publication
VAR_067547
Natural varianti595 – 5951T → M in IBGC1; substantially impaired phosphate transport. 1 Publication
VAR_067548
Natural varianti601 – 6011S → L in IBGC1; substantially impaired phosphate transport. 1 Publication
VAR_067549
Natural varianti601 – 6011S → W in IBGC1; substantially impaired phosphate transport. 1 Publication
VAR_067550

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi28 – 281D → N: Impairs phosphate transport; no effect on retroviral receptor function. 1 Publication
Mutagenesisi55 – 551E → D or K: Abolishes sodium-dependent phosphate transport; no effect on retroviral receptor function. 2 Publications
Mutagenesisi55 – 551E → Q: Abolishes phosphate but not sodium uptake; when associated with Q-91 and Q-575. 2 Publications
Mutagenesisi81 – 811N → V: Abolishes N-glycosylation. 1 Publication
Mutagenesisi91 – 911E → Q: Abolishes phosphate but not sodium uptake; when associated with Q-55 and Q-575. 1 Publication
Mutagenesisi506 – 5061D → N: Impairs phosphate transport; no effect on retroviral receptor function. 1 Publication
Mutagenesisi575 – 5751E → D or K: Abolishes sodium-dependent phosphate transport; no effect on retroviral receptor function. 2 Publications
Mutagenesisi575 – 5751E → Q: Abolishes phosphate but not sodium uptake; when associated with Q-55 and Q-91. 2 Publications

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi213600. phenotype.
Orphaneti1980. Bilateral striopallidodentate calcinosis.
PharmGKBiPA35834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 652652Sodium-dependent phosphate transporter 2PRO_0000341268Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)1 Publication
Modified residuei268 – 2681Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ08357.
PaxDbiQ08357.
PRIDEiQ08357.

PTM databases

PhosphoSiteiQ08357.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Inductioni

Increased by phosphate depletion in osteosarcoma cell lines.1 Publication

Gene expression databases

ArrayExpressiQ08357.
BgeeiQ08357.
CleanExiHS_SLC20A2.
GenevestigatoriQ08357.

Organism-specific databases

HPAiHPA026540.

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

BioGridi112463. 1 interaction.
STRINGi9606.ENSP00000340465.

Structurei

3D structure databases

ProteinModelPortaliQ08357.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0306.
HOGENOMiHOG000231892.
HOVERGENiHBG053358.
InParanoidiQ08357.
KOiK14640.
OMAiMYGYKVI.
OrthoDBiEOG79KPDT.
PhylomeDBiQ08357.
TreeFamiTF314426.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08357-1 [UniParc]FASTAAdd to Basket

« Hide

MAMDEYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL    50
ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV 100
WQLIASFLRL PISGTHCIVG STIGFSLVAI GTKGVQWMEL VKIVASWFIS 150
PLLSGFMSGL LFVLIRIFIL KKEDPVPNGL RALPVFYAAT IAINVFSIMY 200
TGAPVLGLVL PMWAIALISF GVALLFAFFV WLFVCPWMRR KITGKLQKEG 250
ALSRVSDESL SKVQEAESPV FKELPGAKAN DDSTIPLTGA AGETLGTSEG 300
TSAGSHPRAA YGRALSMTHG SVKSPISNGT FGFDGHTRSD GHVYHTVHKD 350
SGLYKDLLHK IHIDRGPEEK PAQESNYRLL RRNNSYTCYT AAICGLPVHA 400
TFRAADSSAP EDSEKLVGDT VSYSKKRLRY DSYSSYCNAV AEAEIEAEEG 450
GVEMKLASEL ADPDQPREDP AEEEKEEKDA PEVHLLFHFL QVLTACFGSF 500
AHGGNDVSNA IGPLVALWLI YKQGGVTQEA ATPVWLLFYG GVGICTGLWV 550
WGRRVIQTMG KDLTPITPSS GFTIELASAF TVVIASNIGL PVSTTHCKVG 600
SVVAVGWIRS RKAVDWRLFR NIFVAWFVTV PVAGLFSAAV MALLMYGILP 650
YV 652
Length:652
Mass (Da):70,392
Last modified:November 1, 1996 - v1
Checksum:iA0A870C7927DE39C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421Missing in IBGC1; substantially impaired phosphate transport. 1 Publication
VAR_067545
Natural varianti498 – 4981G → R in IBGC1; substantially impaired phosphate transport. 1 Publication
VAR_067546
Natural varianti575 – 5751E → K in IBGC1; substantially impaired phosphate transport. 1 Publication
VAR_067547
Natural varianti595 – 5951T → M in IBGC1; substantially impaired phosphate transport. 1 Publication
VAR_067548
Natural varianti601 – 6011S → L in IBGC1; substantially impaired phosphate transport. 1 Publication
VAR_067549
Natural varianti601 – 6011S → W in IBGC1; substantially impaired phosphate transport. 1 Publication
VAR_067550

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20852 mRNA. Translation: AAA18018.1.
AK291202 mRNA. Translation: BAF83891.1.
BC028600 mRNA. Translation: AAH28600.1.
CCDSiCCDS6132.1.
PIRiA37000.
RefSeqiNP_001244109.1. NM_001257180.1.
NP_001244110.1. NM_001257181.1.
NP_006740.1. NM_006749.4.
XP_005273670.1. XM_005273613.1.
UniGeneiHs.653173.
Hs.654763.

Genome annotation databases

EnsembliENST00000342228; ENSP00000340465; ENSG00000168575.
ENST00000520179; ENSP00000429712; ENSG00000168575.
ENST00000520262; ENSP00000429754; ENSG00000168575.
GeneIDi6575.
KEGGihsa:6575.
UCSCiuc003xpe.4. human.

Polymorphism databases

DMDMi74735615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20852 mRNA. Translation: AAA18018.1 .
AK291202 mRNA. Translation: BAF83891.1 .
BC028600 mRNA. Translation: AAH28600.1 .
CCDSi CCDS6132.1.
PIRi A37000.
RefSeqi NP_001244109.1. NM_001257180.1.
NP_001244110.1. NM_001257181.1.
NP_006740.1. NM_006749.4.
XP_005273670.1. XM_005273613.1.
UniGenei Hs.653173.
Hs.654763.

3D structure databases

ProteinModelPortali Q08357.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112463. 1 interaction.
STRINGi 9606.ENSP00000340465.

Protein family/group databases

TCDBi 2.A.20.2.3. the inorganic phosphate transporter (pit) family.

PTM databases

PhosphoSitei Q08357.

Polymorphism databases

DMDMi 74735615.

Proteomic databases

MaxQBi Q08357.
PaxDbi Q08357.
PRIDEi Q08357.

Protocols and materials databases

DNASUi 6575.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342228 ; ENSP00000340465 ; ENSG00000168575 .
ENST00000520179 ; ENSP00000429712 ; ENSG00000168575 .
ENST00000520262 ; ENSP00000429754 ; ENSG00000168575 .
GeneIDi 6575.
KEGGi hsa:6575.
UCSCi uc003xpe.4. human.

Organism-specific databases

CTDi 6575.
GeneCardsi GC08M042291.
GeneReviewsi SLC20A2.
HGNCi HGNC:10947. SLC20A2.
HPAi HPA026540.
MIMi 158378. gene.
213600. phenotype.
neXtProti NX_Q08357.
Orphaneti 1980. Bilateral striopallidodentate calcinosis.
PharmGKBi PA35834.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0306.
HOGENOMi HOG000231892.
HOVERGENi HBG053358.
InParanoidi Q08357.
KOi K14640.
OMAi MYGYKVI.
OrthoDBi EOG79KPDT.
PhylomeDBi Q08357.
TreeFami TF314426.

Enzyme and pathway databases

Reactomei REACT_19275. Sodium-coupled phosphate cotransporters.

Miscellaneous databases

ChiTaRSi SLC20A2. human.
GeneWikii SLC20A2.
GenomeRNAii 6575.
NextBioi 25583.
PROi Q08357.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q08357.
Bgeei Q08357.
CleanExi HS_SLC20A2.
Genevestigatori Q08357.

Family and domain databases

InterProi IPR001204. Phos_transporter.
[Graphical view ]
PANTHERi PTHR11101. PTHR11101. 1 hit.
Pfami PF01384. PHO4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family."
    van Zeijl M., Johann S.V., Closs E., Cunningham J., Eddy R., Shows T.B., O'Hara B.
    Proc. Natl. Acad. Sci. U.S.A. 91:1168-1172(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION AS RETROVIRAL RECEPTOR.
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Transmembrane topology of PiT-2, a phosphate transporter-retrovirus receptor."
    Salauen C., Rodrigues P., Heard J.M.
    J. Virol. 75:5584-5592(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY, GLYCOSYLATION AT ASN-81, MUTAGENESIS OF ASN-81.
  5. "The amphotropic murine leukemia virus receptor gene encodes a 71-kilodalton protein that is induced by phosphate depletion."
    Chien M.L., Foster J.L., Douglas J.L., Garcia J.V.
    J. Virol. 71:4564-4570(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY, SUBCELLULAR LOCATION, INDUCTION.
  6. "Identification of envelope determinants of feline leukemia virus subgroup B that permit infection and gene transfer to cells expressing human Pit1 or Pit2."
    Sugai J., Eiden M., Anderson M.M., Van Hoeven N., Meiering C.D., Overbaugh J.
    J. Virol. 75:6841-6849(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS RETROVIRAL RECEPTOR.
  7. "Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function."
    Boettger P., Pedersen L.
    J. Biol. Chem. 277:42741-42747(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS SODIUM-PHOSPHATE SYMPORTER, SUBUNIT, MUTAGENESIS OF GLU-55 AND GLU-575.
  8. "Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic acids critical for sodium-dependent phosphate transport function of human PiT2."
    Boettger P., Pedersen L.
    FEBS J. 272:3060-3074(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS SODIUM-PHOSPHATE SYMPORTER, SUBUNIT, MUTAGENESIS OF ASP-28 AND ASP-506.
  9. "Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2."
    Boettger P., Hede S.E., Grunnet M., Hoyer B., Klaerke D.A., Pedersen L.
    Am. J. Physiol. 291:C1377-C1387(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS SODIUM-PHOSPHATE SYMPORTER, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF GLU-55; GLU-91 AND GLU-575.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: VARIANTS IBGC1 VAL-42 DEL; ARG-498; LYS-575; MET-595; TRP-601 AND LEU-601, CHARACTERIZATION OF VARIANTS IBGC1 VAL-42 DEL; ARG-498; LYS-575; MET-595; TRP-601 AND LEU-601.

Entry informationi

Entry nameiS20A2_HUMAN
AccessioniPrimary (citable) accession number: Q08357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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