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Protein

Sodium-dependent phosphate transporter 2

Gene

SLC20A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.5 Publications

GO - Molecular functioni

GO - Biological processi

  • ion transport Source: Reactome
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168575-MONOMER.
ReactomeiR-HSA-427652. Sodium-coupled phosphate cotransporters.

Protein family/group databases

TCDBi2.A.20.2.3. the inorganic phosphate transporter (pit) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Gibbon ape leukemia virus receptor 2
Short name:
GLVR-2
Phosphate transporter 2
Short name:
PiT-2
Short name:
Pit2
Short name:
hPit2
Solute carrier family 20 member 2
Gene namesi
Name:SLC20A2
Synonyms:GLVR2, PIT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:10947. SLC20A2.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5ExtracellularSequence analysis5
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Topological domaini27 – 46CytoplasmicSequence analysisAdd BLAST20
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 86ExtracellularSequence analysisAdd BLAST19
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 109CytoplasmicSequence analysis2
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 142ExtracellularSequence analysisAdd BLAST12
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 190CytoplasmicSequence analysisAdd BLAST27
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 213ExtracellularSequence analysis2
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 482CytoplasmicSequence analysisAdd BLAST248
Transmembranei483 – 503HelicalSequence analysisAdd BLAST21
Topological domaini504 – 530ExtracellularSequence analysisAdd BLAST27
Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
Topological domaini552 – 571CytoplasmicSequence analysisAdd BLAST20
Transmembranei572 – 586HelicalSequence analysisAdd BLAST15
Topological domaini587 – 593ExtracellularSequence analysis7
Transmembranei594 – 609HelicalSequence analysisAdd BLAST16
Topological domaini610 – 621CytoplasmicSequence analysisAdd BLAST12
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 652ExtracellularSequence analysis10

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Basal ganglia calcification, idiopathic, 1 (IBGC1)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.
See also OMIM:213600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07225511I → L in IBGC1. 1 PublicationCorresponds to variant rs201836672dbSNPEnsembl.1
Natural variantiVAR_07225628D → N in IBGC1; Impairs phosphate transport; no effect on retroviral receptor function. 3 Publications1
Natural variantiVAR_06754542Missing in IBGC1; substantially impaired phosphate transport. 1 Publication1
Natural variantiVAR_07225751A → V in IBGC1. 1 Publication1
Natural variantiVAR_07225862L → P in IBGC1. 1 Publication1
Natural variantiVAR_07225971R → H in IBGC1. 1 Publication1
Natural variantiVAR_072260115T → M in IBGC1. 1 PublicationCorresponds to variant rs775911275dbSNPEnsembl.1
Natural variantiVAR_075396184P → L in IBGC1; unknown pathological significance. 1 Publication1
Natural variantiVAR_075397194N → S in IBGC1; unknown pathological significance. 1 PublicationCorresponds to variant rs748252183dbSNPEnsembl.1
Natural variantiVAR_072261382R → Q in IBGC1. 1 PublicationCorresponds to variant rs200010919dbSNPEnsembl.1
Natural variantiVAR_072262434S → W in IBGC1. 1 Publication1
Natural variantiVAR_067546498G → R in IBGC1; substantially impaired phosphate transport. 1 Publication1
Natural variantiVAR_072263502H → Q in IBGC1. 1 Publication1
Natural variantiVAR_072264568P → L in IBGC1. 1 PublicationCorresponds to variant rs763252801dbSNPEnsembl.1
Natural variantiVAR_075398571G → S in IBGC1. 1 Publication1
Natural variantiVAR_067547575E → K in IBGC1; substantially impaired phosphate transport. 1 PublicationCorresponds to variant rs387906653dbSNPEnsembl.1
Natural variantiVAR_067548595T → M in IBGC1; substantially impaired phosphate transport. 2 PublicationsCorresponds to variant rs387906654dbSNPEnsembl.1
Natural variantiVAR_067549601S → L in IBGC1; substantially impaired phosphate transport. 2 PublicationsCorresponds to variant rs387906652dbSNPEnsembl.1
Natural variantiVAR_067550601S → W in IBGC1; substantially impaired phosphate transport. 1 PublicationCorresponds to variant rs387906652dbSNPEnsembl.1
Natural variantiVAR_072265637S → R in IBGC1. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi55E → D or K: Abolishes sodium-dependent phosphate transport; no effect on retroviral receptor function. 2 Publications1
Mutagenesisi55E → Q: Abolishes phosphate but not sodium uptake; when associated with Q-91 and Q-575. 2 Publications1
Mutagenesisi81N → V: Abolishes N-glycosylation. 1 Publication1
Mutagenesisi91E → Q: Abolishes phosphate but not sodium uptake; when associated with Q-55 and Q-575. 1 Publication1
Mutagenesisi506D → N: Impairs phosphate transport; no effect on retroviral receptor function. 1 Publication1
Mutagenesisi575E → D or K: Abolishes sodium-dependent phosphate transport; no effect on retroviral receptor function. 2 Publications1
Mutagenesisi575E → Q: Abolishes phosphate but not sodium uptake; when associated with Q-55 and Q-91. 2 Publications1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6575.
MalaCardsiSLC20A2.
MIMi213600. phenotype.
OpenTargetsiENSG00000168575.
Orphaneti1980. Bilateral striopallidodentate calcinosis.
PharmGKBiPA35834.

Polymorphism and mutation databases

BioMutaiSLC20A2.
DMDMi74735615.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003412681 – 652Sodium-dependent phosphate transporter 2Add BLAST652

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)1 Publication1
Modified residuei253PhosphoserineBy similarity1
Modified residuei256PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei268PhosphoserineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ08357.
MaxQBiQ08357.
PaxDbiQ08357.
PeptideAtlasiQ08357.
PRIDEiQ08357.

PTM databases

iPTMnetiQ08357.
PhosphoSitePlusiQ08357.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Inductioni

Increased by phosphate depletion in osteosarcoma cell lines.1 Publication

Gene expression databases

BgeeiENSG00000168575.
CleanExiHS_SLC20A2.
ExpressionAtlasiQ08357. baseline and differential.
GenevisibleiQ08357. HS.

Organism-specific databases

HPAiHPA026540.

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

BioGridi112463. 13 interactors.
IntActiQ08357. 2 interactors.
STRINGi9606.ENSP00000340465.

Structurei

3D structure databases

ProteinModelPortaliQ08357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2493. Eukaryota.
COG0306. LUCA.
GeneTreeiENSGT00390000014879.
HOGENOMiHOG000231892.
HOVERGENiHBG053358.
InParanoidiQ08357.
KOiK14640.
OMAiPAQESNY.
OrthoDBiEOG091G07J5.
PhylomeDBiQ08357.
TreeFamiTF314426.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMDEYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL
60 70 80 90 100
ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV
110 120 130 140 150
WQLIASFLRL PISGTHCIVG STIGFSLVAI GTKGVQWMEL VKIVASWFIS
160 170 180 190 200
PLLSGFMSGL LFVLIRIFIL KKEDPVPNGL RALPVFYAAT IAINVFSIMY
210 220 230 240 250
TGAPVLGLVL PMWAIALISF GVALLFAFFV WLFVCPWMRR KITGKLQKEG
260 270 280 290 300
ALSRVSDESL SKVQEAESPV FKELPGAKAN DDSTIPLTGA AGETLGTSEG
310 320 330 340 350
TSAGSHPRAA YGRALSMTHG SVKSPISNGT FGFDGHTRSD GHVYHTVHKD
360 370 380 390 400
SGLYKDLLHK IHIDRGPEEK PAQESNYRLL RRNNSYTCYT AAICGLPVHA
410 420 430 440 450
TFRAADSSAP EDSEKLVGDT VSYSKKRLRY DSYSSYCNAV AEAEIEAEEG
460 470 480 490 500
GVEMKLASEL ADPDQPREDP AEEEKEEKDA PEVHLLFHFL QVLTACFGSF
510 520 530 540 550
AHGGNDVSNA IGPLVALWLI YKQGGVTQEA ATPVWLLFYG GVGICTGLWV
560 570 580 590 600
WGRRVIQTMG KDLTPITPSS GFTIELASAF TVVIASNIGL PVSTTHCKVG
610 620 630 640 650
SVVAVGWIRS RKAVDWRLFR NIFVAWFVTV PVAGLFSAAV MALLMYGILP

YV
Length:652
Mass (Da):70,392
Last modified:November 1, 1996 - v1
Checksum:iA0A870C7927DE39C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07225511I → L in IBGC1. 1 PublicationCorresponds to variant rs201836672dbSNPEnsembl.1
Natural variantiVAR_07225628D → N in IBGC1; Impairs phosphate transport; no effect on retroviral receptor function. 3 Publications1
Natural variantiVAR_06754542Missing in IBGC1; substantially impaired phosphate transport. 1 Publication1
Natural variantiVAR_07225751A → V in IBGC1. 1 Publication1
Natural variantiVAR_07225862L → P in IBGC1. 1 Publication1
Natural variantiVAR_07225971R → H in IBGC1. 1 Publication1
Natural variantiVAR_072260115T → M in IBGC1. 1 PublicationCorresponds to variant rs775911275dbSNPEnsembl.1
Natural variantiVAR_075396184P → L in IBGC1; unknown pathological significance. 1 Publication1
Natural variantiVAR_075397194N → S in IBGC1; unknown pathological significance. 1 PublicationCorresponds to variant rs748252183dbSNPEnsembl.1
Natural variantiVAR_072261382R → Q in IBGC1. 1 PublicationCorresponds to variant rs200010919dbSNPEnsembl.1
Natural variantiVAR_072262434S → W in IBGC1. 1 Publication1
Natural variantiVAR_067546498G → R in IBGC1; substantially impaired phosphate transport. 1 Publication1
Natural variantiVAR_072263502H → Q in IBGC1. 1 Publication1
Natural variantiVAR_072264568P → L in IBGC1. 1 PublicationCorresponds to variant rs763252801dbSNPEnsembl.1
Natural variantiVAR_075398571G → S in IBGC1. 1 Publication1
Natural variantiVAR_067547575E → K in IBGC1; substantially impaired phosphate transport. 1 PublicationCorresponds to variant rs387906653dbSNPEnsembl.1
Natural variantiVAR_067548595T → M in IBGC1; substantially impaired phosphate transport. 2 PublicationsCorresponds to variant rs387906654dbSNPEnsembl.1
Natural variantiVAR_067549601S → L in IBGC1; substantially impaired phosphate transport. 2 PublicationsCorresponds to variant rs387906652dbSNPEnsembl.1
Natural variantiVAR_067550601S → W in IBGC1; substantially impaired phosphate transport. 1 PublicationCorresponds to variant rs387906652dbSNPEnsembl.1
Natural variantiVAR_072265637S → R in IBGC1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20852 mRNA. Translation: AAA18018.1.
AK291202 mRNA. Translation: BAF83891.1.
BC028600 mRNA. Translation: AAH28600.1.
CCDSiCCDS6132.1.
PIRiA37000.
RefSeqiNP_001244109.1. NM_001257180.1.
NP_001244110.1. NM_001257181.1.
NP_006740.1. NM_006749.4.
XP_005273670.1. XM_005273613.3.
XP_016869237.1. XM_017013748.1.
UniGeneiHs.653173.
Hs.654763.

Genome annotation databases

EnsembliENST00000342228; ENSP00000340465; ENSG00000168575.
ENST00000520179; ENSP00000429712; ENSG00000168575.
ENST00000520262; ENSP00000429754; ENSG00000168575.
GeneIDi6575.
KEGGihsa:6575.
UCSCiuc003xpe.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20852 mRNA. Translation: AAA18018.1.
AK291202 mRNA. Translation: BAF83891.1.
BC028600 mRNA. Translation: AAH28600.1.
CCDSiCCDS6132.1.
PIRiA37000.
RefSeqiNP_001244109.1. NM_001257180.1.
NP_001244110.1. NM_001257181.1.
NP_006740.1. NM_006749.4.
XP_005273670.1. XM_005273613.3.
XP_016869237.1. XM_017013748.1.
UniGeneiHs.653173.
Hs.654763.

3D structure databases

ProteinModelPortaliQ08357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112463. 13 interactors.
IntActiQ08357. 2 interactors.
STRINGi9606.ENSP00000340465.

Protein family/group databases

TCDBi2.A.20.2.3. the inorganic phosphate transporter (pit) family.

PTM databases

iPTMnetiQ08357.
PhosphoSitePlusiQ08357.

Polymorphism and mutation databases

BioMutaiSLC20A2.
DMDMi74735615.

Proteomic databases

EPDiQ08357.
MaxQBiQ08357.
PaxDbiQ08357.
PeptideAtlasiQ08357.
PRIDEiQ08357.

Protocols and materials databases

DNASUi6575.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342228; ENSP00000340465; ENSG00000168575.
ENST00000520179; ENSP00000429712; ENSG00000168575.
ENST00000520262; ENSP00000429754; ENSG00000168575.
GeneIDi6575.
KEGGihsa:6575.
UCSCiuc003xpe.5. human.

Organism-specific databases

CTDi6575.
DisGeNETi6575.
GeneCardsiSLC20A2.
GeneReviewsiSLC20A2.
HGNCiHGNC:10947. SLC20A2.
HPAiHPA026540.
MalaCardsiSLC20A2.
MIMi158378. gene.
213600. phenotype.
neXtProtiNX_Q08357.
OpenTargetsiENSG00000168575.
Orphaneti1980. Bilateral striopallidodentate calcinosis.
PharmGKBiPA35834.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2493. Eukaryota.
COG0306. LUCA.
GeneTreeiENSGT00390000014879.
HOGENOMiHOG000231892.
HOVERGENiHBG053358.
InParanoidiQ08357.
KOiK14640.
OMAiPAQESNY.
OrthoDBiEOG091G07J5.
PhylomeDBiQ08357.
TreeFamiTF314426.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168575-MONOMER.
ReactomeiR-HSA-427652. Sodium-coupled phosphate cotransporters.

Miscellaneous databases

ChiTaRSiSLC20A2. human.
GeneWikiiSLC20A2.
GenomeRNAii6575.
PROiQ08357.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168575.
CleanExiHS_SLC20A2.
ExpressionAtlasiQ08357. baseline and differential.
GenevisibleiQ08357. HS.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS20A2_HUMAN
AccessioniPrimary (citable) accession number: Q08357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.