Q08347 (BDS1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkyl/aryl-sulfatase BDS1
EC=3.1.6.-

Alternative name(s):
Bacterially-derived sulfatase 1

Gene names

Name:	BDS1
Ordered Locus Names:	YOL164W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	646 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Alkyl/aryl-sulfatase. Enables the use of SDS and 4-nitrocatechol as sulfur source. Ref.4
Induction	Expression is increased in sulfur-limited chemostat cultures. Ref.3
Miscellaneous	The presence of this bacterial-like protein in Saccharomyces cerevisiae results probably from a recent horizontal gene transfer event.
Sequence similarities	Belongs to the class-B beta-lactamase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dodecyl sulfate metabolic process Inferred from mutant phenotype Ref.4. Source: SGD
Molecular_function	alkyl sulfatase activity Inferred from mutant phenotype Ref.4. Source: SGD arylsulfatase activity Inferred from direct assay Ref.4. Source: SGD sterol binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 646	646	Alkyl/aryl-sulfatase BDS1		PRO_0000227682

Sequences

	Sequence		Length	Mass (Da)
	Q08347 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 153BA6F9831F4642	FASTA	646	72,646
	10 20 30 40 50 60 MIGAFKRNRG SSQSFAKECQ PSTLKANLEV AKELPFSDRR DFEDATQGYI GSLSDEQIIG 70 80 90 100 110 120 PDGGVVWCMK SYGFLEPETP ANTVNPSLWR QAQLNAIHGL FKITDNVYQV RGLDISNMTI 130 140 150 160 170 180 IEGNTSLIII DTLFTTETAQ ESLKLYYRHR PQKPVRTVIY THSHSDHYGG VKGIVKEADV 190 200 210 220 230 240 KSGEVQIIAP VGFMESVVAE NILAGNAMHR RSQYQFGMLL SPSVKGHVDC GIGKAASHGT 250 260 270 280 290 300 VTLIAPTIII EEPVEERTID GVDFVFQLAP GSEAPSEMLI YMPQQRVLNM AEDVTHHMHN 310 320 330 340 350 360 LYALRGVEVR DGNQWAKYID AARVAFGSKT DVLIAQHHWP TTGQMRINEL LKKQRDMYKF 370 380 390 400 410 420 IHDQTLRLLN QGYTSRDIAE TLRMPSSLEQ EWSTRGYYGT LSHNVKAVYQ KYLGWYDANP 430 440 450 460 470 480 ANLNPLPPVA YAKKAVEYMG GADAVLARAY KDFQKGEFRW VASVVNQLVF ADPNNHQARE 490 500 510 520 530 540 LCADALEQLG YQAEASTWRN AYLVGAMELR QGVPKRRSTG KRNNIAVLNN EMFFDFLAVR 550 560 570 580 590 600 LNATKAEGKI IVSNWCFINS NERFVITLEN CALTYIQGWQ TDADATITLK RTTFEALLAN 610 620 630 640 EITMVDFLRS KEVEIEGNRL RIEELLKLFD DFDQSFPVVE PMGGST

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur." Boer V.M., de Winde J.H., Pronk J.T., Piper M.D.W. J. Biol. Chem. 278:3265-3274(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[4]	"Contribution of horizontal gene transfer to the evolution of Saccharomyces cerevisiae." Hall C.R., Brachat S., Dietrich F.S. Eukaryot. Cell 4:1102-1115(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z74906 Genomic DNA. Translation: CAA99186.1. BK006948 Genomic DNA. Translation: DAA10622.1.
PIR	S66863.
RefSeq	NP_014478.1. NM_001183417.1.
3D structure databases
ProteinModelPortal	Q08347.
SMR	Q08347. Positions 16-640.
ModBase	Search...
Protein-protein interaction databases
STRING	4932.YOL164W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YOL164W; YOL164W; YOL164W.
GeneID	854000.
KEGG	sce:YOL164W.
Organism-specific databases
CYGD	YOL164w.
SGD	S000005524. BDS1.
Phylogenomic databases
eggNOG	COG2015.
GeneTree	ENSGT00390000013976.
HOGENOM	HOG000050609.
OMA	KGQRDMY.
OrthoDB	EOG48D43K.
Enzyme and pathway databases
BioCyc	YEAST:G3O-33551-MONOMER.
Gene expression databases
Genevestigator	Q08347.
GermOnline	YOL164W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	3.60.15.10. 2 hits.
InterPro	IPR001279. Beta-lactamas-like. IPR003033. SCP2_sterol-bd_dom. [Graphical view]
Pfam	PF00753. Lactamase_B. 1 hit. [Graphical view]
SMART	SM00849. Lactamase_B. 1 hit. [Graphical view]
SUPFAM	SSF55718. SCP2. 1 hit.
PROSITE	PS00743. BETA_LACTAMASE_B_1. False negative. PS00744. BETA_LACTAMASE_B_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	975497.

Entry information

Entry name

BDS1_YEAST

Accession

Primary (citable) accession number: Q08347
Secondary accession number(s): D6W1Q6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program