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Protein

Alkyl/aryl-sulfatase BDS1

Gene

BDS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Alkyl/aryl-sulfatase. Enables the use of SDS and 4-nitrocatechol as sulfur source.1 Publication

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi162Zinc; via tele nitrogenBy similarity1
Metal bindingi164Zinc; via pros nitrogenBy similarity1
Metal bindingi166ZincBy similarity1

GO - Molecular functioni

  • alkyl sulfatase activity Source: SGD
  • arylsulfatase activity Source: SGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • dodecyl sulfate metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33551-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkyl/aryl-sulfatase BDS11 Publication (EC:3.1.6.-)
Alternative name(s):
Bacterially-derived sulfatase 11 Publication
Gene namesi
Name:BDS1
Ordered Locus Names:YOL164W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL164W.
SGDiS000005524. BDS1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002276821 – 646Alkyl/aryl-sulfatase BDS1Add BLAST646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ08347.

Expressioni

Inductioni

Expression is increased in sulfur-limited chemostat cultures.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi34254. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ08347.
SMRiQ08347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-beta-lactamase superfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013976.
HOGENOMiHOG000050609.
InParanoidiQ08347.
OMAiLHDQTLH.
OrthoDBiEOG092C0XNX.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
3.60.15.10. 2 hits.
InterProiIPR029229. Alkyl_sulf_C.
IPR029228. Alkyl_sulf_dimr.
IPR001279. Metallo-B-lactamas.
IPR003033. SCP2_sterol-bd_dom.
[Graphical view]
PfamiPF14864. Alkyl_sulf_C. 1 hit.
PF14863. Alkyl_sulf_dimr. 1 hit.
PF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF55718. SSF55718. 1 hit.
SSF56281. SSF56281. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGAFKRNRG SSQSFAKECQ PSTLKANLEV AKELPFSDRR DFEDATQGYI
60 70 80 90 100
GSLSDEQIIG PDGGVVWCMK SYGFLEPETP ANTVNPSLWR QAQLNAIHGL
110 120 130 140 150
FKITDNVYQV RGLDISNMTI IEGNTSLIII DTLFTTETAQ ESLKLYYRHR
160 170 180 190 200
PQKPVRTVIY THSHSDHYGG VKGIVKEADV KSGEVQIIAP VGFMESVVAE
210 220 230 240 250
NILAGNAMHR RSQYQFGMLL SPSVKGHVDC GIGKAASHGT VTLIAPTIII
260 270 280 290 300
EEPVEERTID GVDFVFQLAP GSEAPSEMLI YMPQQRVLNM AEDVTHHMHN
310 320 330 340 350
LYALRGVEVR DGNQWAKYID AARVAFGSKT DVLIAQHHWP TTGQMRINEL
360 370 380 390 400
LKKQRDMYKF IHDQTLRLLN QGYTSRDIAE TLRMPSSLEQ EWSTRGYYGT
410 420 430 440 450
LSHNVKAVYQ KYLGWYDANP ANLNPLPPVA YAKKAVEYMG GADAVLARAY
460 470 480 490 500
KDFQKGEFRW VASVVNQLVF ADPNNHQARE LCADALEQLG YQAEASTWRN
510 520 530 540 550
AYLVGAMELR QGVPKRRSTG KRNNIAVLNN EMFFDFLAVR LNATKAEGKI
560 570 580 590 600
IVSNWCFINS NERFVITLEN CALTYIQGWQ TDADATITLK RTTFEALLAN
610 620 630 640
EITMVDFLRS KEVEIEGNRL RIEELLKLFD DFDQSFPVVE PMGGST
Length:646
Mass (Da):72,646
Last modified:November 1, 1996 - v1
Checksum:i153BA6F9831F4642
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74906 Genomic DNA. Translation: CAA99186.1.
BK006948 Genomic DNA. Translation: DAA10622.1.
PIRiS66863.
RefSeqiNP_014478.1. NM_001183417.1.

Genome annotation databases

EnsemblFungiiYOL164W; YOL164W; YOL164W.
GeneIDi854000.
KEGGisce:YOL164W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74906 Genomic DNA. Translation: CAA99186.1.
BK006948 Genomic DNA. Translation: DAA10622.1.
PIRiS66863.
RefSeqiNP_014478.1. NM_001183417.1.

3D structure databases

ProteinModelPortaliQ08347.
SMRiQ08347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34254. 3 interactors.

Proteomic databases

PRIDEiQ08347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL164W; YOL164W; YOL164W.
GeneIDi854000.
KEGGisce:YOL164W.

Organism-specific databases

EuPathDBiFungiDB:YOL164W.
SGDiS000005524. BDS1.

Phylogenomic databases

GeneTreeiENSGT00390000013976.
HOGENOMiHOG000050609.
InParanoidiQ08347.
OMAiLHDQTLH.
OrthoDBiEOG092C0XNX.

Enzyme and pathway databases

BioCyciYEAST:G3O-33551-MONOMER.

Miscellaneous databases

PROiQ08347.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
3.60.15.10. 2 hits.
InterProiIPR029229. Alkyl_sulf_C.
IPR029228. Alkyl_sulf_dimr.
IPR001279. Metallo-B-lactamas.
IPR003033. SCP2_sterol-bd_dom.
[Graphical view]
PfamiPF14864. Alkyl_sulf_C. 1 hit.
PF14863. Alkyl_sulf_dimr. 1 hit.
PF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF55718. SSF55718. 1 hit.
SSF56281. SSF56281. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBDS1_YEAST
AccessioniPrimary (citable) accession number: Q08347
Secondary accession number(s): D6W1Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

The presence of this bacterial-like protein in Saccharomyces cerevisiae results probably from a recent horizontal gene transfer event.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.