ID   I10R2_HUMAN             Reviewed;         325 AA.
AC   Q08334; Q9BUU4;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 2.
DT   24-JAN-2024, entry version 203.
DE   RecName: Full=Interleukin-10 receptor subunit beta;
DE            Short=IL-10 receptor subunit beta;
DE            Short=IL-10R subunit beta;
DE            Short=IL-10RB;
DE   AltName: Full=Cytokine receptor class-II member 4;
DE   AltName: Full=Cytokine receptor family 2 member 4;
DE            Short=CRF2-4;
DE   AltName: Full=Interleukin-10 receptor subunit 2;
DE            Short=IL-10R subunit 2;
DE            Short=IL-10R2;
DE   AltName: CD_antigen=CDw210b;
DE   Flags: Precursor;
GN   Name=IL10RB; Synonyms=CRFB4, D21S58, D21S66;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fetal brain;
RX   PubMed=8314576; DOI=10.1006/geno.1993.1199;
RA   Lutfalla G., Gardiner K., Uze G.;
RT   "A new member of the cytokine receptor gene family maps on chromosome 21 at
RT   less than 35 kb from IFNAR.";
RL   Genomics 16:366-373(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7563119; DOI=10.1007/bf00186545;
RA   Lutfalla G., McInnis M.G., Antonarakis S.E., Uze G.;
RT   "Structure of the human CRFB4 gene: comparison with its IFNAR neighbor.";
RL   J. Mol. Evol. 41:338-344(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLU-47.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PROTEIN SEQUENCE OF 20-34.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally verified
RT   cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
RN   [7]
RP   CHARACTERIZATION.
RX   PubMed=9312047; DOI=10.1093/emboj/16.19.5894;
RA   Kotenko S.V., Krause C.D., Izotova L.S., Pollack B.P., Wu W., Pestka S.;
RT   "Identification and functional characterization of a second chain of the
RT   interleukin-10 receptor complex.";
RL   EMBO J. 16:5894-5903(1997).
RN   [8]
RP   CHARACTERIZATION.
RX   PubMed=10875937; DOI=10.1074/jbc.m005304200;
RA   Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J.,
RA   Wood W.I., Goddard A.D., Gurney A.L.;
RT   "Interleukin (IL)-22, a novel human cytokine that signals through the
RT   interferon receptor-related proteins CRF2-4 and IL-22R.";
RL   J. Biol. Chem. 275:31335-31339(2000).
RN   [9]
RP   FUNCTION, AND SUBUNIT.
RX   PubMed=12469119; DOI=10.1038/ni873;
RA   Sheppard P., Kindsvogel W., Xu W., Henderson K., Schlutsmeyer S.,
RA   Whitmore T.E., Kuestner R., Garrigues U., Birks C., Roraback J.,
RA   Ostrander C., Dong D., Shin J., Presnell S., Fox B., Haldeman B.,
RA   Cooper E., Taft D., Gilbert T., Grant F.J., Tackett M., Krivan W.,
RA   McKnight G., Clegg C., Foster D., Klucher K.M.;
RT   "IL-28, IL-29 and their class II cytokine receptor IL-28R.";
RL   Nat. Immunol. 4:63-68(2003).
RN   [10]
RP   FUNCTION.
RX   PubMed=15123776; DOI=10.1189/jlb.0204117;
RA   Donnelly R.P., Sheikh F., Kotenko S.V., Dickensheets H.;
RT   "The expanded family of class II cytokines that share the IL-10 receptor-2
RT   (IL-10R2) chain.";
RL   J. Leukoc. Biol. 76:314-321(2004).
RN   [11]
RP   INVOLVEMENT IN SUSCEPTIBILITY TO HBV INFECTION, VARIANT GLU-47, AND
RP   CHARACTERIZATION OF VARIANT GLU-47.
RX   PubMed=16757563; DOI=10.1073/pnas.0602800103;
RA   Frodsham A.J., Zhang L., Dumpis U., Taib N.A.M., Best S., Durham A.,
RA   Hennig B.J.W., Hellier S., Knapp S., Wright M., Chiaramonte M., Bell J.I.,
RA   Graves M., Whittle H.C., Thomas H.C., Thursz M.R., Hill A.V.S.;
RT   "Class II cytokine receptor gene cluster is a major locus for hepatitis B
RT   persistence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:9148-9153(2006).
RN   [12]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT   refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [13]
RP   INVOLVEMENT IN IBD25.
RX   PubMed=19890111; DOI=10.1056/nejmoa0907206;
RA   Glocker E.O., Kotlarz D., Boztug K., Gertz E.M., Schaffer A.A., Noyan F.,
RA   Perro M., Diestelhorst J., Allroth A., Murugan D., Hatscher N., Pfeifer D.,
RA   Sykora K.W., Sauer M., Kreipe H., Lacher M., Nustede R., Woellner C.,
RA   Baumann U., Salzer U., Koletzko S., Shah N., Segal A.W., Sauerbrey A.,
RA   Buderus S., Snapper S.B., Grimbacher B., Klein C.;
RT   "Inflammatory bowel disease and mutations affecting the interleukin-10
RT   receptor.";
RL   N. Engl. J. Med. 361:2033-2045(2009).
RN   [14]
RP   X-RAY CRYSTALLOGRAPHY (2.14 ANGSTROMS) OF 20-220, AND DISULFIDE BONDS.
RX   PubMed=20462497; DOI=10.1016/j.str.2010.02.009;
RA   Yoon S.I., Jones B.C., Logsdon N.J., Harris B.D., Deshpande A., Radaeva S.,
RA   Halloran B.A., Gao B., Walter M.R.;
RT   "Structure and mechanism of receptor sharing by the IL-10R2 common chain.";
RL   Structure 18:638-648(2010).
CC   -!- FUNCTION: Shared cell surface receptor required for the activation of
CC       five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The
CC       IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and
CC       IFNL3 and mediates their antiviral activity. The ligand/receptor
CC       complex stimulate the activation of the JAK/STAT signaling pathway
CC       leading to the expression of IFN-stimulated genes (ISG), which
CC       contribute to the antiviral state. {ECO:0000269|PubMed:12469119,
CC       ECO:0000269|PubMed:15123776}.
CC   -!- SUBUNIT: Heterodimer with IFNLR1. {ECO:0000269|PubMed:12469119}.
CC   -!- INTERACTION:
CC       Q08334; P22301: IL10; NbExp=2; IntAct=EBI-11175900, EBI-1031632;
CC       Q08334; Q9GZX6: IL22; NbExp=2; IntAct=EBI-11175900, EBI-8040250;
CC       Q08334; Q8N6P7: IL22RA1; NbExp=5; IntAct=EBI-11175900, EBI-3940749;
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   -!- POLYMORPHISM: Genetic variations in IL10RB influence susceptibility to
CC       hepatitis B virus (HBV) infection [MIM:610424].
CC   -!- DISEASE: Inflammatory bowel disease 25, autosomal recessive (IBD25)
CC       [MIM:612567]: A chronic, relapsing inflammation of the gastrointestinal
CC       tract with a complex etiology. It is subdivided into Crohn disease and
CC       ulcerative colitis phenotypes. Crohn disease may affect any part of the
CC       gastrointestinal tract from the mouth to the anus, but most frequently
CC       it involves the terminal ileum and colon. Bowel inflammation is
CC       transmural and discontinuous; it may contain granulomas or be
CC       associated with intestinal or perianal fistulas. In contrast, in
CC       ulcerative colitis, the inflammation is continuous and limited to
CC       rectal and colonic mucosal layers; fistulas and granulomas are not
CC       observed. Both diseases include extraintestinal inflammation of the
CC       skin, eyes, or joints. {ECO:0000269|PubMed:19890111}. Note=The disease
CC       is caused by variants affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il10rb/";
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DR   EMBL; Z17227; CAA78933.1; -; mRNA.
DR   EMBL; U08988; AAA86872.1; -; Genomic_DNA.
DR   EMBL; BT009777; AAP88779.1; -; mRNA.
DR   EMBL; AY323826; AAP72016.1; -; Genomic_DNA.
DR   EMBL; BC001903; AAH01903.1; -; mRNA.
DR   CCDS; CCDS13623.1; -.
DR   PIR; A47003; A47003.
DR   RefSeq; NP_000619.3; NM_000628.4.
DR   PDB; 3LQM; X-ray; 2.14 A; A/B=20-220.
DR   PDB; 5T5W; X-ray; 2.85 A; A=19-220.
DR   PDB; 6X93; EM; 3.50 A; C/F=20-220.
DR   PDBsum; 3LQM; -.
DR   PDBsum; 5T5W; -.
DR   PDBsum; 6X93; -.
DR   AlphaFoldDB; Q08334; -.
DR   EMDB; EMD-22098; -.
DR   SMR; Q08334; -.
DR   BioGRID; 109802; 11.
DR   ComplexPortal; CPX-6011; Interferon lambda receptor-ligand complex, IFNL1 variant.
DR   ComplexPortal; CPX-6012; Interferon lambda receptor-ligand complex, IFNL2 variant.
DR   ComplexPortal; CPX-6013; Interferon lambda receptor-ligand complex, IFNL3 variant.
DR   ComplexPortal; CPX-6014; Interferon lambda receptor-ligand complex, IFNL4 variant.
DR   CORUM; Q08334; -.
DR   DIP; DIP-6016N; -.
DR   IntAct; Q08334; 8.
DR   STRING; 9606.ENSP00000290200; -.
DR   ChEMBL; CHEMBL3831284; -.
DR   ChEMBL; CHEMBL4804251; -.
DR   ChEMBL; CHEMBL4804254; -.
DR   GuidetoPHARMACOLOGY; 1728; -.
DR   TCDB; 8.A.132.1.13; the interferon/interleukin receptor (iir) family.
DR   GlyCosmos; Q08334; 4 sites, No reported glycans.
DR   GlyGen; Q08334; 5 sites.
DR   iPTMnet; Q08334; -.
DR   PhosphoSitePlus; Q08334; -.
DR   SwissPalm; Q08334; -.
DR   BioMuta; IL10RB; -.
DR   DMDM; 56757647; -.
DR   EPD; Q08334; -.
DR   jPOST; Q08334; -.
DR   MassIVE; Q08334; -.
DR   MaxQB; Q08334; -.
DR   PaxDb; 9606-ENSP00000290200; -.
DR   PeptideAtlas; Q08334; -.
DR   ProteomicsDB; 58594; -.
DR   Pumba; Q08334; -.
DR   Antibodypedia; 34939; 397 antibodies from 30 providers.
DR   DNASU; 3588; -.
DR   Ensembl; ENST00000290200.7; ENSP00000290200.2; ENSG00000243646.11.
DR   GeneID; 3588; -.
DR   KEGG; hsa:3588; -.
DR   MANE-Select; ENST00000290200.7; ENSP00000290200.2; NM_000628.5; NP_000619.3.
DR   UCSC; uc002yrk.3; human.
DR   AGR; HGNC:5965; -.
DR   CTD; 3588; -.
DR   DisGeNET; 3588; -.
DR   GeneCards; IL10RB; -.
DR   HGNC; HGNC:5965; IL10RB.
DR   HPA; ENSG00000243646; Low tissue specificity.
DR   MalaCards; IL10RB; -.
DR   MIM; 123889; gene.
DR   MIM; 610424; phenotype.
DR   MIM; 612567; phenotype.
DR   neXtProt; NX_Q08334; -.
DR   OpenTargets; ENSG00000243646; -.
DR   Orphanet; 238569; Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome.
DR   PharmGKB; PA29780; -.
DR   VEuPathDB; HostDB:ENSG00000243646; -.
DR   eggNOG; ENOG502S2QA; Eukaryota.
DR   GeneTree; ENSGT00940000158231; -.
DR   HOGENOM; CLU_057526_1_0_1; -.
DR   InParanoid; Q08334; -.
DR   OMA; ASTECDF; -.
DR   OrthoDB; 4004685at2759; -.
DR   PhylomeDB; Q08334; -.
DR   TreeFam; TF332537; -.
DR   PathwayCommons; Q08334; -.
DR   Reactome; R-HSA-449836; Other interleukin signaling.
DR   Reactome; R-HSA-6783783; Interleukin-10 signaling.
DR   Reactome; R-HSA-8854691; Interleukin-20 family signaling.
DR   SignaLink; Q08334; -.
DR   SIGNOR; Q08334; -.
DR   BioGRID-ORCS; 3588; 11 hits in 1160 CRISPR screens.
DR   ChiTaRS; IL10RB; human.
DR   EvolutionaryTrace; Q08334; -.
DR   GeneWiki; Interleukin_10_receptor,_beta_subunit; -.
DR   GenomeRNAi; 3588; -.
DR   Pharos; Q08334; Tbio.
DR   PRO; PR:Q08334; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; Q08334; Protein.
DR   Bgee; ENSG00000243646; Expressed in placenta and 99 other cell types or tissues.
DR   ExpressionAtlas; Q08334; baseline and differential.
DR   GO; GO:0032002; C:interleukin-28 receptor complex; NAS:UniProtKB.
DR   GO; GO:0016020; C:membrane; TAS:ProtInc.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004920; F:interleukin-10 receptor activity; IBA:GO_Central.
DR   GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc.
DR   GO; GO:0098586; P:cellular response to virus; NAS:ComplexPortal.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; TAS:ProtInc.
DR   GO; GO:0006954; P:inflammatory response; TAS:ProtInc.
DR   GO; GO:1901857; P:positive regulation of cellular respiration; IMP:ARUK-UCL.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IDA:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR   GO; GO:0038196; P:type III interferon-mediated signaling pathway; NAS:ComplexPortal.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR   PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR   PANTHER; PTHR20859:SF50; INTERLEUKIN-10 RECEPTOR SUBUNIT BETA; 1.
DR   Pfam; PF09294; Interfer-bind; 1.
DR   Pfam; PF01108; Tissue_fac; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
DR   PROSITE; PS50853; FN3; 2.
DR   Genevisible; Q08334; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Antiviral defense; Direct protein sequencing; Disulfide bond;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:15340161"
FT   CHAIN           20..325
FT                   /note="Interleukin-10 receptor subunit beta"
FT                   /id="PRO_0000011014"
FT   TOPO_DOM        20..220
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        243..325
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          23..111
FT                   /note="Fibronectin type-III 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          114..216
FT                   /note="Fibronectin type-III 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   REGION          301..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        49
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        68
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        161
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        66..74
FT                   /evidence="ECO:0000269|PubMed:20462497"
FT   DISULFID        188..209
FT                   /evidence="ECO:0000269|PubMed:20462497"
FT   VARIANT         47
FT                   /note="K -> E (risk factor for HBV infection; higher cell
FT                   surface levels; dbSNP:rs2834167)"
FT                   /evidence="ECO:0000269|PubMed:16757563, ECO:0000269|Ref.4"
FT                   /id="VAR_020666"
FT   CONFLICT        124
FT                   /note="A -> D (in Ref. 2; AAA86872)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        243
FT                   /note="A -> S (in Ref. 1; CAA78933 and 2; AAA86872)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        269..273
FT                   /note="FLGHP -> VGRME (in Ref. 2; AAA86872)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        274..325
FT                   /note="Missing (in Ref. 2; AAA86872)"
FT                   /evidence="ECO:0000305"
FT   STRAND          25..32
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          35..41
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          46..48
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          51..58
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          61..75
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          81..83
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          85..93
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          101..105
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   HELIX           107..110
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          117..123
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          126..132
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          135..137
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          139..141
FT                   /evidence="ECO:0007829|PDB:6X93"
FT   STRAND          142..144
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   HELIX           145..148
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          153..160
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   TURN            161..163
FT                   /evidence="ECO:0007829|PDB:5T5W"
FT   STRAND          167..169
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          172..178
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          186..194
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   TURN            196..198
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   STRAND          208..211
FT                   /evidence="ECO:0007829|PDB:3LQM"
FT   HELIX           215..217
FT                   /evidence="ECO:0007829|PDB:3LQM"
SQ   SEQUENCE   325 AA;  36995 MW;  E470726619AF54C2 CRC64;
     MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL TFTAQYLSYR
     IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW VNITFCPVDD TIIGPPGMQV
     EVLADSLHMR FLAPKIENEY ETWTMKNVYN SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN
     LEPWTTYCVQ VRGFLPDRNK AGEWSEPVCE QTTHDETVPS WMVAVILMAS VFMVCLALLG
     CFALLWCVYK KTKYAFSPRN SLPQHLKEFL GHPHHNTLLF FSFPLSDEND VFDKLSVIAE
     DSESGKQNPG DSCSLGTPPG QGPQS
//