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Q08334 (I10R2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-10 receptor subunit beta

Short name=IL-10 receptor subunit beta
Short name=IL-10R subunit beta
Short name=IL-10RB
Alternative name(s):
Cytokine receptor class-II member 4
Cytokine receptor family 2 member 4
Short name=CRF2-4
Interleukin-10 receptor subunit 2
Short name=IL-10R subunit 2
Short name=IL-10R2
CD_antigen=CDw210b
Gene names
Name:IL10RB
Synonyms:CRFB4, D21S58, D21S66
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. Ref.9

Subcellular location

Membrane; Single-pass type I membrane protein.

Polymorphism

Genetic variations in IL10RB influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].

Involvement in disease

Inflammatory bowel disease 25 (IBD25) [MIM:612567]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12

Sequence similarities

Belongs to the type II cytokine receptor family.

Contains 2 fibronectin type-III domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.6
Chain20 – 325306Interleukin-10 receptor subunit beta
PRO_0000011014

Regions

Topological domain20 – 220201Extracellular Potential
Transmembrane221 – 24222Helical; Potential
Topological domain243 – 32583Cytoplasmic Potential
Domain23 – 11189Fibronectin type-III 1
Domain114 – 216103Fibronectin type-III 2

Amino acid modifications

Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation681N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Disulfide bond66 ↔ 74 Ref.13
Disulfide bond188 ↔ 209 Ref.13

Natural variations

Natural variant471K → E Associated with susceptibility to HBV infection; higher cell surface levels. Ref.4 Ref.10
Corresponds to variant rs2834167 [ dbSNP | Ensembl ].
VAR_020666

Experimental info

Sequence conflict1241A → D in AAA86872. Ref.2
Sequence conflict2431A → S in CAA78933. Ref.1
Sequence conflict2431A → S in AAA86872. Ref.2
Sequence conflict269 – 2735FLGHP → VGRME in AAA86872. Ref.2
Sequence conflict274 – 32552Missing in AAA86872. Ref.2

Secondary structure

.......................................... 325
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q08334 [UniParc].

Last modified December 21, 2004. Version 2.
Checksum: E470726619AF54C2

FASTA32536,995
        10         20         30         40         50         60 
MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL TFTAQYLSYR 

        70         80         90        100        110        120 
IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW VNITFCPVDD TIIGPPGMQV 

       130        140        150        160        170        180 
EVLADSLHMR FLAPKIENEY ETWTMKNVYN SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN 

       190        200        210        220        230        240 
LEPWTTYCVQ VRGFLPDRNK AGEWSEPVCE QTTHDETVPS WMVAVILMAS VFMVCLALLG 

       250        260        270        280        290        300 
CFALLWCVYK KTKYAFSPRN SLPQHLKEFL GHPHHNTLLF FSFPLSDEND VFDKLSVIAE 

       310        320 
DSESGKQNPG DSCSLGTPPG QGPQS 

« Hide

References

« Hide 'large scale' references
[1]"A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR."
Lutfalla G., Gardiner K., Uze G.
Genomics 16:366-373(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal brain.
[2]"Structure of the human CRFB4 gene: comparison with its IFNAR neighbor."
Lutfalla G., McInnis M.G., Antonarakis S.E., Uze G.
J. Mol. Evol. 41:338-344(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]SeattleSNPs variation discovery resource
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-47.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-34.
[7]"Identification and functional characterization of a second chain of the interleukin-10 receptor complex."
Kotenko S.V., Krause C.D., Izotova L.S., Pollack B.P., Wu W., Pestka S.
EMBO J. 16:5894-5903(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[8]"Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."
Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J., Wood W.I., Goddard A.D., Gurney A.L.
J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[9]"The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain."
Donnelly R.P., Sheikh F., Kotenko S.V., Dickensheets H.
J. Leukoc. Biol. 76:314-321(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[10]"Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence."
Frodsham A.J., Zhang L., Dumpis U., Taib N.A.M., Best S., Durham A., Hennig B.J.W., Hellier S., Knapp S., Wright M., Chiaramonte M., Bell J.I., Graves M., Whittle H.C., Thomas H.C., Thursz M.R., Hill A.V.S.
Proc. Natl. Acad. Sci. U.S.A. 103:9148-9153(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO HBV INFECTION, VARIANT GLU-47, CHARACTERIZATION OF VARIANT GLU-47.
[11]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Inflammatory bowel disease and mutations affecting the interleukin-10 receptor."
Glocker E.O., Kotlarz D., Boztug K., Gertz E.M., Schaffer A.A., Noyan F., Perro M., Diestelhorst J., Allroth A., Murugan D., Hatscher N., Pfeifer D., Sykora K.W., Sauer M., Kreipe H., Lacher M., Nustede R., Woellner C. expand/collapse author list , Baumann U., Salzer U., Koletzko S., Shah N., Segal A.W., Sauerbrey A., Buderus S., Snapper S.B., Grimbacher B., Klein C.
N. Engl. J. Med. 361:2033-2045(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN IBD25.
[13]"Structure and mechanism of receptor sharing by the IL-10R2 common chain."
Yoon S.I., Jones B.C., Logsdon N.J., Harris B.D., Deshpande A., Radaeva S., Halloran B.A., Gao B., Walter M.R.
Structure 18:638-648(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.14 ANGSTROMS) OF 20-220, DISULFIDE BONDS.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z17227 mRNA. Translation: CAA78933.1.
U08988 Genomic DNA. Translation: AAA86872.1.
BT009777 mRNA. Translation: AAP88779.1.
AY323826 Genomic DNA. Translation: AAP72016.1.
BC001903 mRNA. Translation: AAH01903.1.
PIRA47003.
RefSeqNP_000619.3. NM_000628.4.
UniGeneHs.654593.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3LQMX-ray2.14A/B20-220[»]
ProteinModelPortalQ08334.
SMRQ08334. Positions 20-220.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109802. 3 interactions.
DIPDIP-6016N.
STRING9606.ENSP00000290200.

PTM databases

PhosphoSiteQ08334.

Polymorphism databases

DMDM56757647.

Proteomic databases

PaxDbQ08334.
PRIDEQ08334.

Protocols and materials databases

DNASU3588.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000290200; ENSP00000290200; ENSG00000243646.
GeneID3588.
KEGGhsa:3588.
UCSCuc002yrk.2. human.

Organism-specific databases

CTD3588.
GeneCardsGC21P034638.
H-InvDBHIX0213245.
HGNCHGNC:5965. IL10RB.
HPACAB020670.
HPA047550.
MIM123889. gene.
610424. phenotype.
612567. phenotype.
neXtProtNX_Q08334.
Orphanet238569. Autosomal recessive early-onset inflammatory bowel disease.
PharmGKBPA29780.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47180.
HOVERGENHBG052057.
InParanoidQ08334.
KOK05135.
OMASDENDVF.
OrthoDBEOG7JQBNP.
PhylomeDBQ08334.
TreeFamTF332537.

Enzyme and pathway databases

SignaLinkQ08334.

Gene expression databases

ArrayExpressQ08334.
BgeeQ08334.
CleanExHS_IL10RB.
GenevestigatorQ08334.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PfamPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIL10RB. human.
EvolutionaryTraceQ08334.
GeneWikiInterleukin_10_receptor,_beta_subunit.
GenomeRNAi3588.
NextBio14019.
PROQ08334.
SOURCESearch...

Entry information

Entry nameI10R2_HUMAN
AccessionPrimary (citable) accession number: Q08334
Secondary accession number(s): Q9BUU4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries