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Q08334

- I10R2_HUMAN

UniProt

Q08334 - I10R2_HUMAN

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Protein
Interleukin-10 receptor subunit beta
Gene
IL10RB, CRFB4, D21S58, D21S66
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. receptor activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: GOC
  2. immune response Source: ProtInc
  3. inflammatory response Source: ProtInc
  4. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

SignaLinkiQ08334.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10 receptor subunit beta
Short name:
IL-10 receptor subunit beta
Short name:
IL-10R subunit beta
Short name:
IL-10RB
Alternative name(s):
Cytokine receptor class-II member 4
Cytokine receptor family 2 member 4
Short name:
CRF2-4
Interleukin-10 receptor subunit 2
Short name:
IL-10R subunit 2
Short name:
IL-10R2
CD_antigen: CDw210b
Gene namesi
Name:IL10RB
Synonyms:CRFB4, D21S58, D21S66
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:5965. IL10RB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 220201Extracellular Reviewed prediction
Add
BLAST
Transmembranei221 – 24222Helical; Reviewed prediction
Add
BLAST
Topological domaini243 – 32583Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: ProtInc
  3. interleukin-28 receptor complex Source: UniProtKB
  4. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Inflammatory bowel disease 25 (IBD25) [MIM:612567]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi610424. phenotype.
612567. phenotype.
Orphaneti238569. Autosomal recessive early-onset inflammatory bowel disease.
PharmGKBiPA29780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 Publication
Add
BLAST
Chaini20 – 325306Interleukin-10 receptor subunit beta
PRO_0000011014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi66 ↔ 741 Publication
Glycosylationi68 – 681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi188 ↔ 2091 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ08334.
PaxDbiQ08334.
PRIDEiQ08334.

PTM databases

PhosphoSiteiQ08334.

Expressioni

Gene expression databases

ArrayExpressiQ08334.
BgeeiQ08334.
CleanExiHS_IL10RB.
GenevestigatoriQ08334.

Organism-specific databases

HPAiCAB020670.
HPA047550.

Interactioni

Subunit structurei

Heterodimer with IFNLR1.

Protein-protein interaction databases

BioGridi109802. 3 interactions.
DIPiDIP-6016N.
STRINGi9606.ENSP00000290200.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 328
Beta strandi35 – 417
Beta strandi46 – 483
Beta strandi51 – 588
Beta strandi61 – 7515
Beta strandi81 – 833
Beta strandi85 – 939
Beta strandi101 – 1055
Helixi107 – 1104
Beta strandi117 – 1237
Beta strandi126 – 1327
Beta strandi135 – 1373
Beta strandi142 – 1443
Helixi145 – 1484
Beta strandi153 – 1608
Beta strandi167 – 1693
Beta strandi172 – 1787
Beta strandi186 – 1949
Turni196 – 1983
Beta strandi208 – 2114
Helixi215 – 2173

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LQMX-ray2.14A/B20-220[»]
ProteinModelPortaliQ08334.
SMRiQ08334. Positions 20-220.

Miscellaneous databases

EvolutionaryTraceiQ08334.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 11189Fibronectin type-III 1
Add
BLAST
Domaini114 – 216103Fibronectin type-III 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47180.
HOVERGENiHBG052057.
InParanoidiQ08334.
KOiK05135.
OMAiSDENDVF.
OrthoDBiEOG7JQBNP.
PhylomeDBiQ08334.
TreeFamiTF332537.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08334-1 [UniParc]FASTAAdd to Basket

« Hide

MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL    50
TFTAQYLSYR IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW 100
VNITFCPVDD TIIGPPGMQV EVLADSLHMR FLAPKIENEY ETWTMKNVYN 150
SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN LEPWTTYCVQ VRGFLPDRNK 200
AGEWSEPVCE QTTHDETVPS WMVAVILMAS VFMVCLALLG CFALLWCVYK 250
KTKYAFSPRN SLPQHLKEFL GHPHHNTLLF FSFPLSDEND VFDKLSVIAE 300
DSESGKQNPG DSCSLGTPPG QGPQS 325
Length:325
Mass (Da):36,995
Last modified:December 21, 2004 - v2
Checksum:iE470726619AF54C2
GO

Polymorphismi

Genetic variations in IL10RB influence susceptibility to hepatitis B virus (HBV) infection [MIMi:610424].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471K → E Associated with susceptibility to HBV infection; higher cell surface levels. 2 Publications
Corresponds to variant rs2834167 [ dbSNP | Ensembl ].
VAR_020666

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241A → D in AAA86872. 1 Publication
Sequence conflicti243 – 2431A → S in CAA78933. 1 Publication
Sequence conflicti243 – 2431A → S in AAA86872. 1 Publication
Sequence conflicti269 – 2735FLGHP → VGRME in AAA86872. 1 Publication
Sequence conflicti274 – 32552Missing in AAA86872. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z17227 mRNA. Translation: CAA78933.1.
U08988 Genomic DNA. Translation: AAA86872.1.
BT009777 mRNA. Translation: AAP88779.1.
AY323826 Genomic DNA. Translation: AAP72016.1.
BC001903 mRNA. Translation: AAH01903.1.
CCDSiCCDS13623.1.
PIRiA47003.
RefSeqiNP_000619.3. NM_000628.4.
UniGeneiHs.654593.

Genome annotation databases

EnsembliENST00000290200; ENSP00000290200; ENSG00000243646.
GeneIDi3588.
KEGGihsa:3588.
UCSCiuc002yrk.2. human.

Polymorphism databases

DMDMi56757647.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z17227 mRNA. Translation: CAA78933.1 .
U08988 Genomic DNA. Translation: AAA86872.1 .
BT009777 mRNA. Translation: AAP88779.1 .
AY323826 Genomic DNA. Translation: AAP72016.1 .
BC001903 mRNA. Translation: AAH01903.1 .
CCDSi CCDS13623.1.
PIRi A47003.
RefSeqi NP_000619.3. NM_000628.4.
UniGenei Hs.654593.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3LQM X-ray 2.14 A/B 20-220 [» ]
ProteinModelPortali Q08334.
SMRi Q08334. Positions 20-220.
ModBasei Search...

Protein-protein interaction databases

BioGridi 109802. 3 interactions.
DIPi DIP-6016N.
STRINGi 9606.ENSP00000290200.

PTM databases

PhosphoSitei Q08334.

Polymorphism databases

DMDMi 56757647.

Proteomic databases

MaxQBi Q08334.
PaxDbi Q08334.
PRIDEi Q08334.

Protocols and materials databases

DNASUi 3588.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000290200 ; ENSP00000290200 ; ENSG00000243646 .
GeneIDi 3588.
KEGGi hsa:3588.
UCSCi uc002yrk.2. human.

Organism-specific databases

CTDi 3588.
GeneCardsi GC21P034638.
H-InvDB HIX0213245.
HGNCi HGNC:5965. IL10RB.
HPAi CAB020670.
HPA047550.
MIMi 123889. gene.
610424. phenotype.
612567. phenotype.
neXtProti NX_Q08334.
Orphaneti 238569. Autosomal recessive early-onset inflammatory bowel disease.
PharmGKBi PA29780.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47180.
HOVERGENi HBG052057.
InParanoidi Q08334.
KOi K05135.
OMAi SDENDVF.
OrthoDBi EOG7JQBNP.
PhylomeDBi Q08334.
TreeFami TF332537.

Enzyme and pathway databases

SignaLinki Q08334.

Miscellaneous databases

ChiTaRSi IL10RB. human.
EvolutionaryTracei Q08334.
GeneWikii Interleukin_10_receptor,_beta_subunit.
GenomeRNAii 3588.
NextBioi 14019.
PROi Q08334.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q08334.
Bgeei Q08334.
CleanExi HS_IL10RB.
Genevestigatori Q08334.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view ]
Pfami PF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR."
    Lutfalla G., Gardiner K., Uze G.
    Genomics 16:366-373(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "Structure of the human CRFB4 gene: comparison with its IFNAR neighbor."
    Lutfalla G., McInnis M.G., Antonarakis S.E., Uze G.
    J. Mol. Evol. 41:338-344(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. SeattleSNPs variation discovery resource
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-47.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-34.
  7. "Identification and functional characterization of a second chain of the interleukin-10 receptor complex."
    Kotenko S.V., Krause C.D., Izotova L.S., Pollack B.P., Wu W., Pestka S.
    EMBO J. 16:5894-5903(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  8. "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."
    Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J., Wood W.I., Goddard A.D., Gurney A.L.
    J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  9. Cited for: FUNCTION, SUBUNIT.
  10. "The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain."
    Donnelly R.P., Sheikh F., Kotenko S.V., Dickensheets H.
    J. Leukoc. Biol. 76:314-321(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO HBV INFECTION, VARIANT GLU-47, CHARACTERIZATION OF VARIANT GLU-47.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: INVOLVEMENT IN IBD25.
  14. "Structure and mechanism of receptor sharing by the IL-10R2 common chain."
    Yoon S.I., Jones B.C., Logsdon N.J., Harris B.D., Deshpande A., Radaeva S., Halloran B.A., Gao B., Walter M.R.
    Structure 18:638-648(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.14 ANGSTROMS) OF 20-220, DISULFIDE BONDS.

Entry informationi

Entry nameiI10R2_HUMAN
AccessioniPrimary (citable) accession number: Q08334
Secondary accession number(s): Q9BUU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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