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Protein

Interleukin-10 receptor subunit beta

Gene

IL10RB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.2 Publications

GO - Molecular functioni

  • receptor activity Source: ProtInc

GO - Biological processi

  • cytokine-mediated signaling pathway Source: GOC
  • defense response to virus Source: UniProtKB-KW
  • immune response Source: ProtInc
  • inflammatory response Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

BioCyciZFISH:G66-30686-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
R-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ08334.
SIGNORiQ08334.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10 receptor subunit beta
Short name:
IL-10 receptor subunit beta
Short name:
IL-10R subunit beta
Short name:
IL-10RB
Alternative name(s):
Cytokine receptor class-II member 4
Cytokine receptor family 2 member 4
Short name:
CRF2-4
Interleukin-10 receptor subunit 2
Short name:
IL-10R subunit 2
Short name:
IL-10R2
CD_antigen: CDw210b
Gene namesi
Name:IL10RB
Synonyms:CRFB4, D21S58, D21S66
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:5965. IL10RB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 220ExtracellularSequence analysisAdd BLAST201
Transmembranei221 – 242HelicalSequence analysisAdd BLAST22
Topological domaini243 – 325CytoplasmicSequence analysisAdd BLAST83

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: ProtInc
  • interleukin-28 receptor complex Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Inflammatory bowel disease 25 (IBD25)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
See also OMIM:612567

Organism-specific databases

DisGeNETi3588.
MalaCardsiIL10RB.
MIMi610424. phenotype.
612567. phenotype.
OpenTargetsiENSG00000243646.
Orphaneti238569. Autosomal recessive early-onset inflammatory bowel disease.
PharmGKBiPA29780.

Polymorphism and mutation databases

BioMutaiIL10RB.
DMDMi56757647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001101420 – 325Interleukin-10 receptor subunit betaAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi66 ↔ 741 Publication
Glycosylationi68N-linked (GlcNAc...)Sequence analysis1
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi188 ↔ 2091 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ08334.
MaxQBiQ08334.
PaxDbiQ08334.
PeptideAtlasiQ08334.
PRIDEiQ08334.

PTM databases

iPTMnetiQ08334.
PhosphoSitePlusiQ08334.
SwissPalmiQ08334.

Expressioni

Gene expression databases

BgeeiENSG00000243646.
CleanExiHS_IL10RB.
ExpressionAtlasiQ08334. baseline and differential.
GenevisibleiQ08334. HS.

Organism-specific databases

HPAiCAB020670.
HPA047550.

Interactioni

Subunit structurei

Heterodimer with IFNLR1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IL22RA1Q8N6P75EBI-11175900,EBI-3940749

Protein-protein interaction databases

BioGridi109802. 2 interactors.
DIPiDIP-6016N.
IntActiQ08334. 4 interactors.
STRINGi9606.ENSP00000290200.

Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 32Combined sources8
Beta strandi35 – 41Combined sources7
Beta strandi46 – 48Combined sources3
Beta strandi51 – 58Combined sources8
Beta strandi61 – 75Combined sources15
Beta strandi81 – 83Combined sources3
Beta strandi85 – 93Combined sources9
Beta strandi101 – 105Combined sources5
Helixi107 – 110Combined sources4
Beta strandi117 – 123Combined sources7
Beta strandi126 – 132Combined sources7
Beta strandi135 – 137Combined sources3
Beta strandi142 – 144Combined sources3
Helixi145 – 148Combined sources4
Beta strandi153 – 160Combined sources8
Beta strandi167 – 169Combined sources3
Beta strandi172 – 178Combined sources7
Beta strandi186 – 194Combined sources9
Turni196 – 198Combined sources3
Beta strandi208 – 211Combined sources4
Helixi215 – 217Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LQMX-ray2.14A/B20-220[»]
ProteinModelPortaliQ08334.
SMRiQ08334.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08334.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 111Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST89
Domaini114 – 216Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST103

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IER7. Eukaryota.
ENOG410YTBJ. LUCA.
GeneTreeiENSGT00530000063449.
HOVERGENiHBG052057.
InParanoidiQ08334.
KOiK05135.
OMAiDETVPSW.
OrthoDBiEOG091G0C7P.
PhylomeDBiQ08334.
TreeFamiTF332537.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL
60 70 80 90 100
TFTAQYLSYR IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW
110 120 130 140 150
VNITFCPVDD TIIGPPGMQV EVLADSLHMR FLAPKIENEY ETWTMKNVYN
160 170 180 190 200
SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN LEPWTTYCVQ VRGFLPDRNK
210 220 230 240 250
AGEWSEPVCE QTTHDETVPS WMVAVILMAS VFMVCLALLG CFALLWCVYK
260 270 280 290 300
KTKYAFSPRN SLPQHLKEFL GHPHHNTLLF FSFPLSDEND VFDKLSVIAE
310 320
DSESGKQNPG DSCSLGTPPG QGPQS
Length:325
Mass (Da):36,995
Last modified:December 21, 2004 - v2
Checksum:iE470726619AF54C2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124A → D in AAA86872 (PubMed:7563119).Curated1
Sequence conflicti243A → S in CAA78933 (PubMed:8314576).Curated1
Sequence conflicti243A → S in AAA86872 (PubMed:7563119).Curated1
Sequence conflicti269 – 273FLGHP → VGRME in AAA86872 (PubMed:7563119).Curated5
Sequence conflicti274 – 325Missing in AAA86872 (PubMed:7563119).CuratedAdd BLAST52

Polymorphismi

Genetic variations in IL10RB influence susceptibility to hepatitis B virus (HBV) infection [MIMi:610424].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02066647K → E Associated with susceptibility to HBV infection; higher cell surface levels. 2 PublicationsCorresponds to variant rs2834167dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17227 mRNA. Translation: CAA78933.1.
U08988 Genomic DNA. Translation: AAA86872.1.
BT009777 mRNA. Translation: AAP88779.1.
AY323826 Genomic DNA. Translation: AAP72016.1.
BC001903 mRNA. Translation: AAH01903.1.
CCDSiCCDS13623.1.
PIRiA47003.
RefSeqiNP_000619.3. NM_000628.4.
UniGeneiHs.654593.

Genome annotation databases

EnsembliENST00000290200; ENSP00000290200; ENSG00000243646.
GeneIDi3588.
KEGGihsa:3588.
UCSCiuc002yrk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17227 mRNA. Translation: CAA78933.1.
U08988 Genomic DNA. Translation: AAA86872.1.
BT009777 mRNA. Translation: AAP88779.1.
AY323826 Genomic DNA. Translation: AAP72016.1.
BC001903 mRNA. Translation: AAH01903.1.
CCDSiCCDS13623.1.
PIRiA47003.
RefSeqiNP_000619.3. NM_000628.4.
UniGeneiHs.654593.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LQMX-ray2.14A/B20-220[»]
ProteinModelPortaliQ08334.
SMRiQ08334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109802. 2 interactors.
DIPiDIP-6016N.
IntActiQ08334. 4 interactors.
STRINGi9606.ENSP00000290200.

PTM databases

iPTMnetiQ08334.
PhosphoSitePlusiQ08334.
SwissPalmiQ08334.

Polymorphism and mutation databases

BioMutaiIL10RB.
DMDMi56757647.

Proteomic databases

EPDiQ08334.
MaxQBiQ08334.
PaxDbiQ08334.
PeptideAtlasiQ08334.
PRIDEiQ08334.

Protocols and materials databases

DNASUi3588.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290200; ENSP00000290200; ENSG00000243646.
GeneIDi3588.
KEGGihsa:3588.
UCSCiuc002yrk.3. human.

Organism-specific databases

CTDi3588.
DisGeNETi3588.
GeneCardsiIL10RB.
H-InvDBHIX0213245.
HGNCiHGNC:5965. IL10RB.
HPAiCAB020670.
HPA047550.
MalaCardsiIL10RB.
MIMi123889. gene.
610424. phenotype.
612567. phenotype.
neXtProtiNX_Q08334.
OpenTargetsiENSG00000243646.
Orphaneti238569. Autosomal recessive early-onset inflammatory bowel disease.
PharmGKBiPA29780.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IER7. Eukaryota.
ENOG410YTBJ. LUCA.
GeneTreeiENSGT00530000063449.
HOVERGENiHBG052057.
InParanoidiQ08334.
KOiK05135.
OMAiDETVPSW.
OrthoDBiEOG091G0C7P.
PhylomeDBiQ08334.
TreeFamiTF332537.

Enzyme and pathway databases

BioCyciZFISH:G66-30686-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
R-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ08334.
SIGNORiQ08334.

Miscellaneous databases

ChiTaRSiIL10RB. human.
EvolutionaryTraceiQ08334.
GeneWikiiInterleukin_10_receptor,_beta_subunit.
GenomeRNAii3588.
PROiQ08334.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243646.
CleanExiHS_IL10RB.
ExpressionAtlasiQ08334. baseline and differential.
GenevisibleiQ08334. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI10R2_HUMAN
AccessioniPrimary (citable) accession number: Q08334
Secondary accession number(s): Q9BUU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.