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Protein

Interleukin-10 receptor subunit beta

Gene

IL10RB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.2 Publications

GO - Molecular functioni

  • receptor activity Source: ProtInc

GO - Biological processi

  • cytokine-mediated signaling pathway Source: GO_Central
  • defense response to virus Source: UniProtKB-KW
  • immune response Source: ProtInc
  • inflammatory response Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

SignaLinkiQ08334.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10 receptor subunit beta
Short name:
IL-10 receptor subunit beta
Short name:
IL-10R subunit beta
Short name:
IL-10RB
Alternative name(s):
Cytokine receptor class-II member 4
Cytokine receptor family 2 member 4
Short name:
CRF2-4
Interleukin-10 receptor subunit 2
Short name:
IL-10R subunit 2
Short name:
IL-10R2
CD_antigen: CDw210b
Gene namesi
Name:IL10RB
Synonyms:CRFB4, D21S58, D21S66
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:5965. IL10RB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 220201ExtracellularSequence AnalysisAdd
BLAST
Transmembranei221 – 24222HelicalSequence AnalysisAdd
BLAST
Topological domaini243 – 32583CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: ProtInc
  • interleukin-28 receptor complex Source: UniProtKB
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Inflammatory bowel disease 25 (IBD25)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

See also OMIM:612567

Organism-specific databases

MIMi610424. phenotype.
612567. phenotype.
Orphaneti238569. Autosomal recessive early-onset inflammatory bowel disease.
PharmGKBiPA29780.

Polymorphism and mutation databases

BioMutaiIL10RB.
DMDMi56757647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 325306Interleukin-10 receptor subunit betaPRO_0000011014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi66 ↔ 741 Publication
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi188 ↔ 2091 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ08334.
PaxDbiQ08334.
PRIDEiQ08334.

PTM databases

PhosphoSiteiQ08334.

Expressioni

Gene expression databases

BgeeiQ08334.
CleanExiHS_IL10RB.
ExpressionAtlasiQ08334. baseline and differential.
GenevisibleiQ08334. HS.

Organism-specific databases

HPAiCAB020670.
HPA047550.

Interactioni

Subunit structurei

Heterodimer with IFNLR1.1 Publication

Protein-protein interaction databases

BioGridi109802. 3 interactions.
DIPiDIP-6016N.
STRINGi9606.ENSP00000290200.

Structurei

Secondary structure

1
325
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 328Combined sources
Beta strandi35 – 417Combined sources
Beta strandi46 – 483Combined sources
Beta strandi51 – 588Combined sources
Beta strandi61 – 7515Combined sources
Beta strandi81 – 833Combined sources
Beta strandi85 – 939Combined sources
Beta strandi101 – 1055Combined sources
Helixi107 – 1104Combined sources
Beta strandi117 – 1237Combined sources
Beta strandi126 – 1327Combined sources
Beta strandi135 – 1373Combined sources
Beta strandi142 – 1443Combined sources
Helixi145 – 1484Combined sources
Beta strandi153 – 1608Combined sources
Beta strandi167 – 1693Combined sources
Beta strandi172 – 1787Combined sources
Beta strandi186 – 1949Combined sources
Turni196 – 1983Combined sources
Beta strandi208 – 2114Combined sources
Helixi215 – 2173Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LQMX-ray2.14A/B20-220[»]
ProteinModelPortaliQ08334.
SMRiQ08334. Positions 20-220.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08334.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 11189Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini114 – 216103Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47180.
GeneTreeiENSGT00530000063449.
HOVERGENiHBG052057.
InParanoidiQ08334.
KOiK05135.
OMAiDETVPSW.
OrthoDBiEOG7JQBNP.
PhylomeDBiQ08334.
TreeFamiTF332537.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL
60 70 80 90 100
TFTAQYLSYR IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW
110 120 130 140 150
VNITFCPVDD TIIGPPGMQV EVLADSLHMR FLAPKIENEY ETWTMKNVYN
160 170 180 190 200
SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN LEPWTTYCVQ VRGFLPDRNK
210 220 230 240 250
AGEWSEPVCE QTTHDETVPS WMVAVILMAS VFMVCLALLG CFALLWCVYK
260 270 280 290 300
KTKYAFSPRN SLPQHLKEFL GHPHHNTLLF FSFPLSDEND VFDKLSVIAE
310 320
DSESGKQNPG DSCSLGTPPG QGPQS
Length:325
Mass (Da):36,995
Last modified:December 21, 2004 - v2
Checksum:iE470726619AF54C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241A → D in AAA86872 (PubMed:7563119).Curated
Sequence conflicti243 – 2431A → S in CAA78933 (PubMed:8314576).Curated
Sequence conflicti243 – 2431A → S in AAA86872 (PubMed:7563119).Curated
Sequence conflicti269 – 2735FLGHP → VGRME in AAA86872 (PubMed:7563119).Curated
Sequence conflicti274 – 32552Missing in AAA86872 (PubMed:7563119).CuratedAdd
BLAST

Polymorphismi

Genetic variations in IL10RB influence susceptibility to hepatitis B virus (HBV) infection [MIMi:610424].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471K → E Associated with susceptibility to HBV infection; higher cell surface levels. 2 Publications
Corresponds to variant rs2834167 [ dbSNP | Ensembl ].
VAR_020666

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17227 mRNA. Translation: CAA78933.1.
U08988 Genomic DNA. Translation: AAA86872.1.
BT009777 mRNA. Translation: AAP88779.1.
AY323826 Genomic DNA. Translation: AAP72016.1.
BC001903 mRNA. Translation: AAH01903.1.
CCDSiCCDS13623.1.
PIRiA47003.
RefSeqiNP_000619.3. NM_000628.4.
UniGeneiHs.654593.

Genome annotation databases

EnsembliENST00000290200; ENSP00000290200; ENSG00000243646.
GeneIDi3588.
KEGGihsa:3588.
UCSCiuc002yrk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17227 mRNA. Translation: CAA78933.1.
U08988 Genomic DNA. Translation: AAA86872.1.
BT009777 mRNA. Translation: AAP88779.1.
AY323826 Genomic DNA. Translation: AAP72016.1.
BC001903 mRNA. Translation: AAH01903.1.
CCDSiCCDS13623.1.
PIRiA47003.
RefSeqiNP_000619.3. NM_000628.4.
UniGeneiHs.654593.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LQMX-ray2.14A/B20-220[»]
ProteinModelPortaliQ08334.
SMRiQ08334. Positions 20-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109802. 3 interactions.
DIPiDIP-6016N.
STRINGi9606.ENSP00000290200.

PTM databases

PhosphoSiteiQ08334.

Polymorphism and mutation databases

BioMutaiIL10RB.
DMDMi56757647.

Proteomic databases

MaxQBiQ08334.
PaxDbiQ08334.
PRIDEiQ08334.

Protocols and materials databases

DNASUi3588.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290200; ENSP00000290200; ENSG00000243646.
GeneIDi3588.
KEGGihsa:3588.
UCSCiuc002yrk.2. human.

Organism-specific databases

CTDi3588.
GeneCardsiGC21P034638.
H-InvDBHIX0213245.
HGNCiHGNC:5965. IL10RB.
HPAiCAB020670.
HPA047550.
MIMi123889. gene.
610424. phenotype.
612567. phenotype.
neXtProtiNX_Q08334.
Orphaneti238569. Autosomal recessive early-onset inflammatory bowel disease.
PharmGKBiPA29780.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47180.
GeneTreeiENSGT00530000063449.
HOVERGENiHBG052057.
InParanoidiQ08334.
KOiK05135.
OMAiDETVPSW.
OrthoDBiEOG7JQBNP.
PhylomeDBiQ08334.
TreeFamiTF332537.

Enzyme and pathway databases

SignaLinkiQ08334.

Miscellaneous databases

ChiTaRSiIL10RB. human.
EvolutionaryTraceiQ08334.
GeneWikiiInterleukin_10_receptor,_beta_subunit.
GenomeRNAii3588.
NextBioi14019.
PROiQ08334.
SOURCEiSearch...

Gene expression databases

BgeeiQ08334.
CleanExiHS_IL10RB.
ExpressionAtlasiQ08334. baseline and differential.
GenevisibleiQ08334. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR."
    Lutfalla G., Gardiner K., Uze G.
    Genomics 16:366-373(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "Structure of the human CRFB4 gene: comparison with its IFNAR neighbor."
    Lutfalla G., McInnis M.G., Antonarakis S.E., Uze G.
    J. Mol. Evol. 41:338-344(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. SeattleSNPs variation discovery resource
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-47.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-34.
  7. "Identification and functional characterization of a second chain of the interleukin-10 receptor complex."
    Kotenko S.V., Krause C.D., Izotova L.S., Pollack B.P., Wu W., Pestka S.
    EMBO J. 16:5894-5903(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  8. "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."
    Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J., Wood W.I., Goddard A.D., Gurney A.L.
    J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  9. Cited for: FUNCTION, SUBUNIT.
  10. "The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain."
    Donnelly R.P., Sheikh F., Kotenko S.V., Dickensheets H.
    J. Leukoc. Biol. 76:314-321(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO HBV INFECTION, VARIANT GLU-47, CHARACTERIZATION OF VARIANT GLU-47.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: INVOLVEMENT IN IBD25.
  14. "Structure and mechanism of receptor sharing by the IL-10R2 common chain."
    Yoon S.I., Jones B.C., Logsdon N.J., Harris B.D., Deshpande A., Radaeva S., Halloran B.A., Gao B., Walter M.R.
    Structure 18:638-648(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.14 ANGSTROMS) OF 20-220, DISULFIDE BONDS.

Entry informationi

Entry nameiI10R2_HUMAN
AccessioniPrimary (citable) accession number: Q08334
Secondary accession number(s): Q9BUU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 21, 2004
Last modified: June 24, 2015
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.