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Q08334

- I10R2_HUMAN

UniProt

Q08334 - I10R2_HUMAN

Protein

Interleukin-10 receptor subunit beta

Gene

IL10RB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. receptor activity Source: ProtInc

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: GOC
    2. immune response Source: ProtInc
    3. inflammatory response Source: ProtInc
    4. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    SignaLinkiQ08334.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-10 receptor subunit beta
    Short name:
    IL-10 receptor subunit beta
    Short name:
    IL-10R subunit beta
    Short name:
    IL-10RB
    Alternative name(s):
    Cytokine receptor class-II member 4
    Cytokine receptor family 2 member 4
    Short name:
    CRF2-4
    Interleukin-10 receptor subunit 2
    Short name:
    IL-10R subunit 2
    Short name:
    IL-10R2
    CD_antigen: CDw210b
    Gene namesi
    Name:IL10RB
    Synonyms:CRFB4, D21S58, D21S66
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:5965. IL10RB.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: ProtInc
    3. interleukin-28 receptor complex Source: UniProtKB
    4. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Inflammatory bowel disease 25 (IBD25) [MIM:612567]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi610424. phenotype.
    612567. phenotype.
    Orphaneti238569. Autosomal recessive early-onset inflammatory bowel disease.
    PharmGKBiPA29780.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 325306Interleukin-10 receptor subunit betaPRO_0000011014Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi66 ↔ 741 Publication
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi188 ↔ 2091 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ08334.
    PaxDbiQ08334.
    PRIDEiQ08334.

    PTM databases

    PhosphoSiteiQ08334.

    Expressioni

    Gene expression databases

    ArrayExpressiQ08334.
    BgeeiQ08334.
    CleanExiHS_IL10RB.
    GenevestigatoriQ08334.

    Organism-specific databases

    HPAiCAB020670.
    HPA047550.

    Interactioni

    Subunit structurei

    Heterodimer with IFNLR1.1 Publication

    Protein-protein interaction databases

    BioGridi109802. 3 interactions.
    DIPiDIP-6016N.
    STRINGi9606.ENSP00000290200.

    Structurei

    Secondary structure

    1
    325
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi25 – 328
    Beta strandi35 – 417
    Beta strandi46 – 483
    Beta strandi51 – 588
    Beta strandi61 – 7515
    Beta strandi81 – 833
    Beta strandi85 – 939
    Beta strandi101 – 1055
    Helixi107 – 1104
    Beta strandi117 – 1237
    Beta strandi126 – 1327
    Beta strandi135 – 1373
    Beta strandi142 – 1443
    Helixi145 – 1484
    Beta strandi153 – 1608
    Beta strandi167 – 1693
    Beta strandi172 – 1787
    Beta strandi186 – 1949
    Turni196 – 1983
    Beta strandi208 – 2114
    Helixi215 – 2173

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LQMX-ray2.14A/B20-220[»]
    ProteinModelPortaliQ08334.
    SMRiQ08334. Positions 20-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ08334.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 220201ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini243 – 32583CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei221 – 24222HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 11189Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini114 – 216103Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the type II cytokine receptor family.Curated
    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47180.
    HOVERGENiHBG052057.
    InParanoidiQ08334.
    KOiK05135.
    OMAiSDENDVF.
    OrthoDBiEOG7JQBNP.
    PhylomeDBiQ08334.
    TreeFamiTF332537.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view]
    PfamiPF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q08334-1 [UniParc]FASTAAdd to Basket

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    MAWSLGSWLG GCLLVSALGM VPPPENVRMN SVNFKNILQW ESPAFAKGNL    50
    TFTAQYLSYR IFQDKCMNTT LTECDFSSLS KYGDHTLRVR AEFADEHSDW 100
    VNITFCPVDD TIIGPPGMQV EVLADSLHMR FLAPKIENEY ETWTMKNVYN 150
    SWTYNVQYWK NGTDEKFQIT PQYDFEVLRN LEPWTTYCVQ VRGFLPDRNK 200
    AGEWSEPVCE QTTHDETVPS WMVAVILMAS VFMVCLALLG CFALLWCVYK 250
    KTKYAFSPRN SLPQHLKEFL GHPHHNTLLF FSFPLSDEND VFDKLSVIAE 300
    DSESGKQNPG DSCSLGTPPG QGPQS 325
    Length:325
    Mass (Da):36,995
    Last modified:December 21, 2004 - v2
    Checksum:iE470726619AF54C2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1241A → D in AAA86872. (PubMed:7563119)Curated
    Sequence conflicti243 – 2431A → S in CAA78933. (PubMed:8314576)Curated
    Sequence conflicti243 – 2431A → S in AAA86872. (PubMed:7563119)Curated
    Sequence conflicti269 – 2735FLGHP → VGRME in AAA86872. (PubMed:7563119)Curated
    Sequence conflicti274 – 32552Missing in AAA86872. (PubMed:7563119)CuratedAdd
    BLAST

    Polymorphismi

    Genetic variations in IL10RB influence susceptibility to hepatitis B virus (HBV) infection [MIMi:610424].

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471K → E Associated with susceptibility to HBV infection; higher cell surface levels. 2 Publications
    Corresponds to variant rs2834167 [ dbSNP | Ensembl ].
    VAR_020666

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z17227 mRNA. Translation: CAA78933.1.
    U08988 Genomic DNA. Translation: AAA86872.1.
    BT009777 mRNA. Translation: AAP88779.1.
    AY323826 Genomic DNA. Translation: AAP72016.1.
    BC001903 mRNA. Translation: AAH01903.1.
    CCDSiCCDS13623.1.
    PIRiA47003.
    RefSeqiNP_000619.3. NM_000628.4.
    UniGeneiHs.654593.

    Genome annotation databases

    EnsembliENST00000290200; ENSP00000290200; ENSG00000243646.
    GeneIDi3588.
    KEGGihsa:3588.
    UCSCiuc002yrk.2. human.

    Polymorphism databases

    DMDMi56757647.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z17227 mRNA. Translation: CAA78933.1 .
    U08988 Genomic DNA. Translation: AAA86872.1 .
    BT009777 mRNA. Translation: AAP88779.1 .
    AY323826 Genomic DNA. Translation: AAP72016.1 .
    BC001903 mRNA. Translation: AAH01903.1 .
    CCDSi CCDS13623.1.
    PIRi A47003.
    RefSeqi NP_000619.3. NM_000628.4.
    UniGenei Hs.654593.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LQM X-ray 2.14 A/B 20-220 [» ]
    ProteinModelPortali Q08334.
    SMRi Q08334. Positions 20-220.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109802. 3 interactions.
    DIPi DIP-6016N.
    STRINGi 9606.ENSP00000290200.

    PTM databases

    PhosphoSitei Q08334.

    Polymorphism databases

    DMDMi 56757647.

    Proteomic databases

    MaxQBi Q08334.
    PaxDbi Q08334.
    PRIDEi Q08334.

    Protocols and materials databases

    DNASUi 3588.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000290200 ; ENSP00000290200 ; ENSG00000243646 .
    GeneIDi 3588.
    KEGGi hsa:3588.
    UCSCi uc002yrk.2. human.

    Organism-specific databases

    CTDi 3588.
    GeneCardsi GC21P034638.
    H-InvDB HIX0213245.
    HGNCi HGNC:5965. IL10RB.
    HPAi CAB020670.
    HPA047550.
    MIMi 123889. gene.
    610424. phenotype.
    612567. phenotype.
    neXtProti NX_Q08334.
    Orphaneti 238569. Autosomal recessive early-onset inflammatory bowel disease.
    PharmGKBi PA29780.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47180.
    HOVERGENi HBG052057.
    InParanoidi Q08334.
    KOi K05135.
    OMAi SDENDVF.
    OrthoDBi EOG7JQBNP.
    PhylomeDBi Q08334.
    TreeFami TF332537.

    Enzyme and pathway databases

    SignaLinki Q08334.

    Miscellaneous databases

    ChiTaRSi IL10RB. human.
    EvolutionaryTracei Q08334.
    GeneWikii Interleukin_10_receptor,_beta_subunit.
    GenomeRNAii 3588.
    NextBioi 14019.
    PROi Q08334.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q08334.
    Bgeei Q08334.
    CleanExi HS_IL10RB.
    Genevestigatori Q08334.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view ]
    Pfami PF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR."
      Lutfalla G., Gardiner K., Uze G.
      Genomics 16:366-373(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "Structure of the human CRFB4 gene: comparison with its IFNAR neighbor."
      Lutfalla G., McInnis M.G., Antonarakis S.E., Uze G.
      J. Mol. Evol. 41:338-344(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. SeattleSNPs variation discovery resource
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-47.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-34.
    7. "Identification and functional characterization of a second chain of the interleukin-10 receptor complex."
      Kotenko S.V., Krause C.D., Izotova L.S., Pollack B.P., Wu W., Pestka S.
      EMBO J. 16:5894-5903(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    8. "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."
      Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J., Wood W.I., Goddard A.D., Gurney A.L.
      J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    9. Cited for: FUNCTION, SUBUNIT.
    10. "The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain."
      Donnelly R.P., Sheikh F., Kotenko S.V., Dickensheets H.
      J. Leukoc. Biol. 76:314-321(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO HBV INFECTION, VARIANT GLU-47, CHARACTERIZATION OF VARIANT GLU-47.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: INVOLVEMENT IN IBD25.
    14. "Structure and mechanism of receptor sharing by the IL-10R2 common chain."
      Yoon S.I., Jones B.C., Logsdon N.J., Harris B.D., Deshpande A., Radaeva S., Halloran B.A., Gao B., Walter M.R.
      Structure 18:638-648(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.14 ANGSTROMS) OF 20-220, DISULFIDE BONDS.

    Entry informationi

    Entry nameiI10R2_HUMAN
    AccessioniPrimary (citable) accession number: Q08334
    Secondary accession number(s): Q9BUU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3