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Q08331

- CALB2_MOUSE

UniProt

Q08331 - CALB2_MOUSE

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Protein

Calretinin

Gene
Calb2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi29 – 40121 InferredAdd
BLAST
Calcium bindingi76 – 87122; possibly ancestral InferredAdd
BLAST
Calcium bindingi120 – 131123 InferredAdd
BLAST
Calcium bindingi164 – 175124 InferredAdd
BLAST
Calcium bindingi208 – 219125 InferredAdd
BLAST
Calcium bindingi251 – 262126; possibly ancestral InferredAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl

GO - Biological processi

  1. cytosolic calcium ion homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calretinin
Short name:
CR
Gene namesi
Name:Calb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:101914. Calb2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. gap junction Source: MGI
  3. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271CalretininPRO_0000073480Add
BLAST

Proteomic databases

MaxQBiQ08331.
PaxDbiQ08331.
PRIDEiQ08331.

2D gel databases

UCD-2DPAGEQ08331.

PTM databases

PhosphoSiteiQ08331.

Expressioni

Gene expression databases

BgeeiQ08331.
CleanExiMM_CALB2.
GenevestigatoriQ08331.

Interactioni

Protein-protein interaction databases

IntActiQ08331. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ08331.
SMRiQ08331. Positions 10-267.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 5136EF-hand 1Add
BLAST
Domaini63 – 9836EF-hand 2Add
BLAST
Domaini107 – 14236EF-hand 3Add
BLAST
Domaini151 – 18636EF-hand 4Add
BLAST
Domaini195 – 23036EF-hand 5Add
BLAST
Domaini235 – 27036EF-hand 6Add
BLAST

Sequence similaritiesi

Belongs to the calbindin family.
Contains 6 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG299305.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiQ08331.
OMAiSSTEFME.
OrthoDBiEOG71G9VB.
PhylomeDBiQ08331.
TreeFamiTF325083.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08331-1 [UniParc]FASTAAdd to Basket

« Hide

MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK    50
ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL 100
CFRQHVGSSA EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP 150
KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF 200
NAIFTFYDKD GSGYIDENEL DALLKDLYEK NKKEMNIQQL TTYRKSVMSL 250
AEAGKLYRKD LEIVLCSEPP V 271
Length:271
Mass (Da):31,373
Last modified:April 27, 2001 - v3
Checksum:iC6376AD7130DAACD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037969 Genomic DNA. Translation: BAA90701.1.
BC017646 mRNA. Translation: AAH17646.1.
U34818 Genomic DNA. Translation: AAA84429.1.
X73985 mRNA. Translation: CAA52163.1.
CCDSiCCDS22661.1.
PIRiS41476.
RefSeqiNP_031612.1. NM_007586.1.
UniGeneiMm.2755.

Genome annotation databases

EnsembliENSMUST00000003754; ENSMUSP00000003754; ENSMUSG00000003657.
GeneIDi12308.
KEGGimmu:12308.
UCSCiuc009nko.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037969 Genomic DNA. Translation: BAA90701.1 .
BC017646 mRNA. Translation: AAH17646.1 .
U34818 Genomic DNA. Translation: AAA84429.1 .
X73985 mRNA. Translation: CAA52163.1 .
CCDSi CCDS22661.1.
PIRi S41476.
RefSeqi NP_031612.1. NM_007586.1.
UniGenei Mm.2755.

3D structure databases

ProteinModelPortali Q08331.
SMRi Q08331. Positions 10-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q08331. 2 interactions.

PTM databases

PhosphoSitei Q08331.

2D gel databases

UCD-2DPAGE Q08331.

Proteomic databases

MaxQBi Q08331.
PaxDbi Q08331.
PRIDEi Q08331.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003754 ; ENSMUSP00000003754 ; ENSMUSG00000003657 .
GeneIDi 12308.
KEGGi mmu:12308.
UCSCi uc009nko.1. mouse.

Organism-specific databases

CTDi 794.
MGIi MGI:101914. Calb2.

Phylogenomic databases

eggNOGi NOG299305.
GeneTreei ENSGT00390000013118.
HOGENOMi HOG000231866.
HOVERGENi HBG000855.
InParanoidi Q08331.
OMAi SSTEFME.
OrthoDBi EOG71G9VB.
PhylomeDBi Q08331.
TreeFami TF325083.

Miscellaneous databases

NextBioi 280848.
PROi Q08331.
SOURCEi Search...

Gene expression databases

Bgeei Q08331.
CleanExi MM_CALB2.
Genevestigatori Q08331.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 5 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Tanaka Y., Taki K., Eguchi N., Kaneko T.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "The mouse calretinin gene promoter region: structural and functional components."
    Strauss K.I., Kuznicki J., Winsky L., Kawagoe J.I., Hammer M., Jacobowitz D.M.
    Brain Res. Mol. Brain Res. 49:175-187(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-31.
    Strain: 129/Sv.
  4. Lubec G., Klug S., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 27-50; 124-133; 179-189 AND 234-244, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. "Design and specificity of hammerhead ribozymes against calretinin mRNA."
    Ellis J., Rogers J.
    Nucleic Acids Res. 21:5171-5178(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-271.

Entry informationi

Entry nameiCALB2_MOUSE
AccessioniPrimary (citable) accession number: Q08331
Secondary accession number(s): Q60964, Q9JM81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 27, 2001
Last modified: July 9, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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