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Protein

Calretinin

Gene

Calb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi29 – 401CuratedAdd BLAST12
Calcium bindingi76 – 872; possibly ancestralCuratedAdd BLAST12
Calcium bindingi120 – 1313CuratedAdd BLAST12
Calcium bindingi164 – 1754CuratedAdd BLAST12
Calcium bindingi208 – 2195CuratedAdd BLAST12
Calcium bindingi251 – 2626; possibly ancestralCuratedAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calretinin
Short name:
CR
Gene namesi
Name:Calb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:101914. Calb2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: GO_Central
  • gap junction Source: MGI
  • neuron projection Source: GO_Central
  • nucleus Source: GO_Central
  • synapse Source: GO_Central
  • terminal bouton Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000734801 – 271CalretininAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei214PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08331.
PaxDbiQ08331.
PeptideAtlasiQ08331.
PRIDEiQ08331.

2D gel databases

UCD-2DPAGEQ08331.

PTM databases

iPTMnetiQ08331.
PhosphoSitePlusiQ08331.

Expressioni

Gene expression databases

BgeeiENSMUSG00000003657.
CleanExiMM_CALB2.
GenevisibleiQ08331. MM.

Interactioni

Protein-protein interaction databases

BioGridi198450. 1 interactor.
IntActiQ08331. 2 interactors.
STRINGi10090.ENSMUSP00000003754.

Structurei

3D structure databases

ProteinModelPortaliQ08331.
SMRiQ08331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 51EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini63 – 98EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini107 – 142EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini151 – 186EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini195 – 230EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini235 – 270EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the calbindin family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiQ08331.
OMAiTYRKSVM.
OrthoDBiEOG091G0GNH.
PhylomeDBiQ08331.
TreeFamiTF325083.

Family and domain databases

CDDicd00051. EFh. 3 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR029646. CALB2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR19972:SF4. PTHR19972:SF4. 1 hit.
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08331-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK
60 70 80 90 100
ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL
110 120 130 140 150
CFRQHVGSSA EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP
160 170 180 190 200
KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF
210 220 230 240 250
NAIFTFYDKD GSGYIDENEL DALLKDLYEK NKKEMNIQQL TTYRKSVMSL
260 270
AEAGKLYRKD LEIVLCSEPP V
Length:271
Mass (Da):31,373
Last modified:April 27, 2001 - v3
Checksum:iC6376AD7130DAACD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037969 Genomic DNA. Translation: BAA90701.1.
BC017646 mRNA. Translation: AAH17646.1.
U34818 Genomic DNA. Translation: AAA84429.1.
X73985 mRNA. Translation: CAA52163.1.
CCDSiCCDS22661.1.
PIRiS41476.
RefSeqiNP_031612.1. NM_007586.1.
UniGeneiMm.2755.

Genome annotation databases

EnsembliENSMUST00000003754; ENSMUSP00000003754; ENSMUSG00000003657.
GeneIDi12308.
KEGGimmu:12308.
UCSCiuc009nko.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037969 Genomic DNA. Translation: BAA90701.1.
BC017646 mRNA. Translation: AAH17646.1.
U34818 Genomic DNA. Translation: AAA84429.1.
X73985 mRNA. Translation: CAA52163.1.
CCDSiCCDS22661.1.
PIRiS41476.
RefSeqiNP_031612.1. NM_007586.1.
UniGeneiMm.2755.

3D structure databases

ProteinModelPortaliQ08331.
SMRiQ08331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198450. 1 interactor.
IntActiQ08331. 2 interactors.
STRINGi10090.ENSMUSP00000003754.

PTM databases

iPTMnetiQ08331.
PhosphoSitePlusiQ08331.

2D gel databases

UCD-2DPAGEQ08331.

Proteomic databases

MaxQBiQ08331.
PaxDbiQ08331.
PeptideAtlasiQ08331.
PRIDEiQ08331.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003754; ENSMUSP00000003754; ENSMUSG00000003657.
GeneIDi12308.
KEGGimmu:12308.
UCSCiuc009nko.1. mouse.

Organism-specific databases

CTDi794.
MGIiMGI:101914. Calb2.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiQ08331.
OMAiTYRKSVM.
OrthoDBiEOG091G0GNH.
PhylomeDBiQ08331.
TreeFamiTF325083.

Miscellaneous databases

PROiQ08331.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003657.
CleanExiMM_CALB2.
GenevisibleiQ08331. MM.

Family and domain databases

CDDicd00051. EFh. 3 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR029646. CALB2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR19972:SF4. PTHR19972:SF4. 1 hit.
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALB2_MOUSE
AccessioniPrimary (citable) accession number: Q08331
Secondary accession number(s): Q60964, Q9JM81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 27, 2001
Last modified: November 30, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.