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Protein

Calretinin

Gene

Calb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi29 – 40121CuratedAdd
BLAST
Calcium bindingi76 – 87122; possibly ancestralCuratedAdd
BLAST
Calcium bindingi120 – 131123CuratedAdd
BLAST
Calcium bindingi164 – 175124CuratedAdd
BLAST
Calcium bindingi208 – 219125CuratedAdd
BLAST
Calcium bindingi251 – 262126; possibly ancestralCuratedAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calretinin
Short name:
CR
Gene namesi
Name:Calb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:101914. Calb2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: GOC
  • gap junction Source: MGI
  • nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271CalretininPRO_0000073480Add
BLAST

Proteomic databases

MaxQBiQ08331.
PaxDbiQ08331.
PRIDEiQ08331.

2D gel databases

UCD-2DPAGEQ08331.

PTM databases

PhosphoSiteiQ08331.

Expressioni

Gene expression databases

BgeeiQ08331.
CleanExiMM_CALB2.
GenevisibleiQ08331. MM.

Interactioni

Protein-protein interaction databases

BioGridi198450. 1 interaction.
IntActiQ08331. 2 interactions.
STRINGi10090.ENSMUSP00000003754.

Structurei

3D structure databases

ProteinModelPortaliQ08331.
SMRiQ08331. Positions 10-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 5136EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini63 – 9836EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini107 – 14236EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 18636EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini195 – 23036EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini235 – 27036EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calbindin family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG299305.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiQ08331.
OMAiFLDIWKH.
OrthoDBiEOG71G9VB.
PhylomeDBiQ08331.
TreeFamiTF325083.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR029646. CALB2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR19972:SF4. PTHR19972:SF4. 1 hit.
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08331-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK
60 70 80 90 100
ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL
110 120 130 140 150
CFRQHVGSSA EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP
160 170 180 190 200
KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF
210 220 230 240 250
NAIFTFYDKD GSGYIDENEL DALLKDLYEK NKKEMNIQQL TTYRKSVMSL
260 270
AEAGKLYRKD LEIVLCSEPP V
Length:271
Mass (Da):31,373
Last modified:April 27, 2001 - v3
Checksum:iC6376AD7130DAACD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037969 Genomic DNA. Translation: BAA90701.1.
BC017646 mRNA. Translation: AAH17646.1.
U34818 Genomic DNA. Translation: AAA84429.1.
X73985 mRNA. Translation: CAA52163.1.
CCDSiCCDS22661.1.
PIRiS41476.
RefSeqiNP_031612.1. NM_007586.1.
UniGeneiMm.2755.

Genome annotation databases

EnsembliENSMUST00000003754; ENSMUSP00000003754; ENSMUSG00000003657.
GeneIDi12308.
KEGGimmu:12308.
UCSCiuc009nko.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037969 Genomic DNA. Translation: BAA90701.1.
BC017646 mRNA. Translation: AAH17646.1.
U34818 Genomic DNA. Translation: AAA84429.1.
X73985 mRNA. Translation: CAA52163.1.
CCDSiCCDS22661.1.
PIRiS41476.
RefSeqiNP_031612.1. NM_007586.1.
UniGeneiMm.2755.

3D structure databases

ProteinModelPortaliQ08331.
SMRiQ08331. Positions 10-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198450. 1 interaction.
IntActiQ08331. 2 interactions.
STRINGi10090.ENSMUSP00000003754.

PTM databases

PhosphoSiteiQ08331.

2D gel databases

UCD-2DPAGEQ08331.

Proteomic databases

MaxQBiQ08331.
PaxDbiQ08331.
PRIDEiQ08331.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003754; ENSMUSP00000003754; ENSMUSG00000003657.
GeneIDi12308.
KEGGimmu:12308.
UCSCiuc009nko.1. mouse.

Organism-specific databases

CTDi794.
MGIiMGI:101914. Calb2.

Phylogenomic databases

eggNOGiNOG299305.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiQ08331.
OMAiFLDIWKH.
OrthoDBiEOG71G9VB.
PhylomeDBiQ08331.
TreeFamiTF325083.

Miscellaneous databases

NextBioi280848.
PROiQ08331.
SOURCEiSearch...

Gene expression databases

BgeeiQ08331.
CleanExiMM_CALB2.
GenevisibleiQ08331. MM.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR029646. CALB2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR19972:SF4. PTHR19972:SF4. 1 hit.
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Tanaka Y., Taki K., Eguchi N., Kaneko T.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "The mouse calretinin gene promoter region: structural and functional components."
    Strauss K.I., Kuznicki J., Winsky L., Kawagoe J.I., Hammer M., Jacobowitz D.M.
    Brain Res. Mol. Brain Res. 49:175-187(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-31.
    Strain: 129/Sv.
  4. Lubec G., Klug S., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 27-50; 124-133; 179-189 AND 234-244, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. "Design and specificity of hammerhead ribozymes against calretinin mRNA."
    Ellis J., Rogers J.
    Nucleic Acids Res. 21:5171-5178(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-271.

Entry informationi

Entry nameiCALB2_MOUSE
AccessioniPrimary (citable) accession number: Q08331
Secondary accession number(s): Q60964, Q9JM81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 27, 2001
Last modified: June 24, 2015
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.