Q08331 (CALB2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calretinin
Short name=CR

Gene names

Name:

Calb2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Calretinin is a calcium-binding protein which is abundant in auditory neurons.
Sequence similarities	Belongs to the calbindin family. Contains 6 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Metal-binding
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara gap junction Inferred from direct assay PubMed 12868005. Source: MGI
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Calretinin		PRO_0000073480
Regions
	Domain	16 – 51	36	EF-hand 1
	Domain	63 – 98	36	EF-hand 2
	Domain	107 – 142	36	EF-hand 3
	Domain	151 – 186	36	EF-hand 4
	Domain	195 – 230	36	EF-hand 5
	Domain	235 – 270	36	EF-hand 6
	Calcium binding	29 – 40	12	1 Probable
	Calcium binding	76 – 87	12	2; possibly ancestral Probable
	Calcium binding	120 – 131	12	3 Probable
	Calcium binding	164 – 175	12	4 Probable
	Calcium binding	208 – 219	12	5 Probable
	Calcium binding	251 – 262	12	6; possibly ancestral Probable

Sequences

	Sequence		Length	Mass (Da)
	Q08331 [UniParc]. Last modified April 27, 2001. Version 3. Checksum: C6376AD7130DAACD	FASTA	271	31,373
	10 20 30 40 50 60 MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK 70 80 90 100 110 120 SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSSA EFMEAWRKYD 130 140 150 160 170 180 TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL 190 200 210 220 230 240 PVQENFLLKF QGMKLTSEEF NAIFTFYDKD GSGYIDENEL DALLKDLYEK NKKEMNIQQL 250 260 270 TTYRKSVMSL AEAGKLYRKD LEIVLCSEPP V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Tanaka Y., Taki K., Eguchi N., Kaneko T. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[3]	"The mouse calretinin gene promoter region: structural and functional components." Strauss K.I., Kuznicki J., Winsky L., Kawagoe J.I., Hammer M., Jacobowitz D.M. Brain Res. Mol. Brain Res. 49:175-187(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 1-31. Strain: 129/Sv.
[4]	Lubec G., Klug S., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 27-50; 124-133; 179-189 AND 234-244, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
[5]	"Design and specificity of hammerhead ribozymes against calretinin mRNA." Ellis J., Rogers J. Nucleic Acids Res. 21:5171-5178(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-271.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB037969 Genomic DNA. Translation: BAA90701.1. BC017646 mRNA. Translation: AAH17646.1. U34818 Genomic DNA. Translation: AAA84429.1. X73985 mRNA. Translation: CAA52163.1.
IPI	IPI00119346.
PIR	S41476.
RefSeq	NP_031612.1. NM_007586.1.
UniGene	Mm.2755.
3D structure databases
ProteinModelPortal	Q08331.
SMR	Q08331. Positions 10-267.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q08331. 2 interactions.
PTM databases
PhosphoSite	Q08331.
2D gel databases
UCD-2DPAGE	Q08331.
Proteomic databases
PaxDb	Q08331.
PRIDE	Q08331.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000003754; ENSMUSP00000003754; ENSMUSG00000003657.
GeneID	12308.
KEGG	mmu:12308.
UCSC	uc009nko.1. mouse.
Organism-specific databases
CTD	794.
MGI	MGI:101914. Calb2.
Phylogenomic databases
eggNOG	NOG299305.
GeneTree	ENSGT00390000013118.
HOGENOM	HOG000231866.
HOVERGEN	HBG000855.
InParanoid	Q08331.
OMA	SSTEFME.
OrthoDB	EOG48SGTQ.
Gene expression databases
Bgee	Q08331.
CleanEx	MM_CALB2.
Genevestigator	Q08331.
GermOnline	ENSMUSG00000003657. Mus musculus.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. [Graphical view]
Pfam	PF13405. EF_hand_4. 1 hit. PF13499. EF_hand_5. 2 hits. [Graphical view]
SMART	SM00054. EFh. 5 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 5 hits. PS50222. EF_HAND_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	280848.
SOURCE	Search...

Entry information

Entry name

CALB2_MOUSE

Accession

Primary (citable) accession number: Q08331
Secondary accession number(s): Q60964, Q9JM81

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	April 27, 2001
Last modified:	May 1, 2013
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program