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Q08331

- CALB2_MOUSE

UniProt

Q08331 - CALB2_MOUSE

Protein

Calretinin

Gene

Calb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Calretinin is a calcium-binding protein which is abundant in auditory neurons.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi29 – 40121CuratedAdd
    BLAST
    Calcium bindingi76 – 87122; possibly ancestralCuratedAdd
    BLAST
    Calcium bindingi120 – 131123CuratedAdd
    BLAST
    Calcium bindingi164 – 175124CuratedAdd
    BLAST
    Calcium bindingi208 – 219125CuratedAdd
    BLAST
    Calcium bindingi251 – 262126; possibly ancestralCuratedAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: Ensembl

    GO - Biological processi

    1. cytosolic calcium ion homeostasis Source: Ensembl

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calretinin
    Short name:
    CR
    Gene namesi
    Name:Calb2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:101914. Calb2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. gap junction Source: MGI
    3. nucleus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271CalretininPRO_0000073480Add
    BLAST

    Proteomic databases

    MaxQBiQ08331.
    PaxDbiQ08331.
    PRIDEiQ08331.

    2D gel databases

    UCD-2DPAGEQ08331.

    PTM databases

    PhosphoSiteiQ08331.

    Expressioni

    Gene expression databases

    BgeeiQ08331.
    CleanExiMM_CALB2.
    GenevestigatoriQ08331.

    Interactioni

    Protein-protein interaction databases

    IntActiQ08331. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08331.
    SMRiQ08331. Positions 10-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 5136EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini63 – 9836EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini107 – 14236EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini151 – 18636EF-hand 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini195 – 23036EF-hand 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini235 – 27036EF-hand 6PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the calbindin family.Curated
    Contains 6 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG299305.
    GeneTreeiENSGT00390000013118.
    HOGENOMiHOG000231866.
    HOVERGENiHBG000855.
    InParanoidiQ08331.
    OMAiSSTEFME.
    OrthoDBiEOG71G9VB.
    PhylomeDBiQ08331.
    TreeFamiTF325083.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13405. EF-hand_6. 1 hit.
    PF13499. EF-hand_7. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 5 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 5 hits.
    PS50222. EF_HAND_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08331-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK    50
    ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL 100
    CFRQHVGSSA EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP 150
    KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF 200
    NAIFTFYDKD GSGYIDENEL DALLKDLYEK NKKEMNIQQL TTYRKSVMSL 250
    AEAGKLYRKD LEIVLCSEPP V 271
    Length:271
    Mass (Da):31,373
    Last modified:April 27, 2001 - v3
    Checksum:iC6376AD7130DAACD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037969 Genomic DNA. Translation: BAA90701.1.
    BC017646 mRNA. Translation: AAH17646.1.
    U34818 Genomic DNA. Translation: AAA84429.1.
    X73985 mRNA. Translation: CAA52163.1.
    CCDSiCCDS22661.1.
    PIRiS41476.
    RefSeqiNP_031612.1. NM_007586.1.
    UniGeneiMm.2755.

    Genome annotation databases

    EnsembliENSMUST00000003754; ENSMUSP00000003754; ENSMUSG00000003657.
    GeneIDi12308.
    KEGGimmu:12308.
    UCSCiuc009nko.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037969 Genomic DNA. Translation: BAA90701.1 .
    BC017646 mRNA. Translation: AAH17646.1 .
    U34818 Genomic DNA. Translation: AAA84429.1 .
    X73985 mRNA. Translation: CAA52163.1 .
    CCDSi CCDS22661.1.
    PIRi S41476.
    RefSeqi NP_031612.1. NM_007586.1.
    UniGenei Mm.2755.

    3D structure databases

    ProteinModelPortali Q08331.
    SMRi Q08331. Positions 10-267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q08331. 2 interactions.

    PTM databases

    PhosphoSitei Q08331.

    2D gel databases

    UCD-2DPAGE Q08331.

    Proteomic databases

    MaxQBi Q08331.
    PaxDbi Q08331.
    PRIDEi Q08331.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003754 ; ENSMUSP00000003754 ; ENSMUSG00000003657 .
    GeneIDi 12308.
    KEGGi mmu:12308.
    UCSCi uc009nko.1. mouse.

    Organism-specific databases

    CTDi 794.
    MGIi MGI:101914. Calb2.

    Phylogenomic databases

    eggNOGi NOG299305.
    GeneTreei ENSGT00390000013118.
    HOGENOMi HOG000231866.
    HOVERGENi HBG000855.
    InParanoidi Q08331.
    OMAi SSTEFME.
    OrthoDBi EOG71G9VB.
    PhylomeDBi Q08331.
    TreeFami TF325083.

    Miscellaneous databases

    NextBioi 280848.
    PROi Q08331.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q08331.
    CleanExi MM_CALB2.
    Genevestigatori Q08331.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13405. EF-hand_6. 1 hit.
    PF13499. EF-hand_7. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 5 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 5 hits.
    PS50222. EF_HAND_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Tanaka Y., Taki K., Eguchi N., Kaneko T.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    3. "The mouse calretinin gene promoter region: structural and functional components."
      Strauss K.I., Kuznicki J., Winsky L., Kawagoe J.I., Hammer M., Jacobowitz D.M.
      Brain Res. Mol. Brain Res. 49:175-187(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-31.
      Strain: 129/Sv.
    4. Lubec G., Klug S., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 27-50; 124-133; 179-189 AND 234-244, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    5. "Design and specificity of hammerhead ribozymes against calretinin mRNA."
      Ellis J., Rogers J.
      Nucleic Acids Res. 21:5171-5178(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-271.

    Entry informationi

    Entry nameiCALB2_MOUSE
    AccessioniPrimary (citable) accession number: Q08331
    Secondary accession number(s): Q60964, Q9JM81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3