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Protein

Guanine nucleotide exchange factor MSS4

Gene

Rabif

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23ZincPROSITE-ProRule annotation1
Metal bindingi26ZincPROSITE-ProRule annotation1
Metal bindingi94ZincPROSITE-ProRule annotation1
Metal bindingi97ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor MSS4
Alternative name(s):
Rab-interacting factor
Gene namesi
Name:Rabif
Synonyms:Mss4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 13, Chromosome 2

Organism-specific databases

RGDi1359331 Rabif

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001741761 – 123Guanine nucleotide exchange factor MSS4Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ08326
PRIDEiQ08326

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSRNOG00000004424
ExpressionAtlasiQ08326 baseline and differential
GenevisibleiQ08326 RN

Interactioni

Subunit structurei

Interacts with RAB8A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi257986, 1 interactor
STRINGi10116.ENSRNOP00000066145

Structurei

Secondary structure

1123
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 19Combined sources5
Beta strandi21 – 23Combined sources3
Turni24 – 26Combined sources3
Beta strandi29 – 31Combined sources3
Beta strandi35 – 39Combined sources5
Beta strandi43 – 46Combined sources4
Beta strandi62 – 65Combined sources4
Beta strandi68 – 72Combined sources5
Helixi74 – 76Combined sources3
Beta strandi89 – 93Combined sources5
Turni95 – 97Combined sources3
Beta strandi102 – 106Combined sources5
Beta strandi113 – 116Combined sources4
Helixi117 – 119Combined sources3
Beta strandi120 – 122Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HXRX-ray1.65A/B9-123[»]
ProteinModelPortaliQ08326
SMRiQ08326
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08326

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 123MSS4PROSITE-ProRule annotationAdd BLAST115

Sequence similaritiesi

Belongs to the DSS4/MSS4 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4113 Eukaryota
ENOG4111UFA LUCA
GeneTreeiENSGT00390000016889
HOGENOMiHOG000007903
HOVERGENiHBG006402
InParanoidiQ08326
KOiK19952
OMAiGPIGWHD
OrthoDBiEOG091G0XXM
PhylomeDBiQ08326
TreeFamiTF314029

Family and domain databases

CDDicd00246 RabGEF, 1 hit
Gene3Di2.170.150.10, 1 hit
InterProiView protein in InterPro
IPR007515 Mss4
IPR011057 Mss4-like_sf
IPR011323 Mss4/transl-control_tumor
PANTHERiPTHR13276 PTHR13276, 1 hit
PfamiView protein in Pfam
PF04421 Mss4, 1 hit
SUPFAMiSSF51316 SSF51316, 1 hit
PROSITEiView protein in PROSITE
PS51796 MSS4, 1 hit

Sequencei

Sequence statusi: Complete.

Q08326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPCELQNEL VSAEGRNRKA VLCQRCGSRV LQPGTALFSR RQLFLPSMRK
60 70 80 90 100
KPDLVDGSNP DGDVLEEHWL VNDMFIFENV GFTKDVGNVK FLVCADCEIG
110 120
PIGWHCLDDK NSFYVALERV SHE
Length:123
Mass (Da):13,928
Last modified:February 1, 1995 - v1
Checksum:iACB7D07E2735811C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70496 mRNA Translation: CAA49904.1
PIRiS29714
RefSeqiNP_001007679.1, NM_001007678.2
XP_003749349.1, XM_003749301.4
UniGeneiRn.204985

Genome annotation databases

EnsembliENSRNOT00000005845; ENSRNOP00000005845; ENSRNOG00000004424
ENSRNOT00000073716; ENSRNOP00000066145; ENSRNOG00000045814
GeneIDi304807
499636
KEGGirno:304807
rno:499636
UCSCiRGD:1359331 rat

Similar proteinsi

Entry informationi

Entry nameiMSS4_RAT
AccessioniPrimary (citable) accession number: Q08326
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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