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Protein

Catalase-peroxidase 1

Gene

katG1

Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei94Transition state stabilizerUniRule annotation1
Active sitei98Proton acceptorUniRule annotation1
Metal bindingi266Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2662. SfrCP01_NCIMB400.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 1UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 1UniRule annotation
Alternative name(s):
Peroxidase/catalase 1UniRule annotation
Gene namesi
Name:katG1UniRule annotation
Ordered Locus Names:Sfri_1917
OrganismiShewanella frigidimarina (strain NCIMB 400)
Taxonomic identifieri318167 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000000684 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16UniRule annotationAdd BLAST16
ChainiPRO_000035491817 – 728Catalase-peroxidase 1Add BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki97 ↔ 225Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-251)UniRule annotation
Cross-linki225 ↔ 251Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ082Q2.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi318167.Sfri_1917.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q082Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKAQHTQGK CPVAHGGNTT VASDVMEWWP NALNLDILHQ HDNKTNPMDP
60 70 80 90 100
NFDYREAFKS LDLSAVKQDL RALMTDSKDW WPADWGHYGG LMIRMAWHSA
110 120 130 140 150
GTYRMADGRG GAGTGNQRFA PLNSWPDNAN LDKARRLLWP IKKKYGNKLS
160 170 180 190 200
WADLIILAGT IAYESMGLKT FGFAGGRADI WHPEKDIYWG SEKQWLAASD
210 220 230 240 250
AENSRYSGQR DLENPLAAVM MGLIYVNPEG VDGQPDPLKT AQDIRVTFER
260 270 280 290 300
MAMNDEETVA LTAGGHTVGK CHGNGRAENL EAAPEGAELE DQGLGWLNKT
310 320 330 340 350
SRGIGRDTVT SGIEGAWTTH PTQWDNGYFE LLLNYDWELK KSPAGAWQWQ
360 370 380 390 400
PINIKEEHKP VDVEDPSIRL SPIMTDADMA MKMDPEYRKI SDRFYQDPAY
410 420 430 440 450
FSEVFARAWF KLTHRDLGPK SRYLGTDVPA EELIWQDPIP QVDYSLTEQE
460 470 480 490 500
VTDIKAKILA SGLSIAQLVA TAWDSARTFR GSDFRGGANG ARIRLAPQKD
510 520 530 540 550
WQGNEPARLQ KVLAVLATIQ AGLTKSVSIA DLIVLGGTAA VEKAAHAAGV
560 570 580 590 600
HVKVPFAAGR GDSTLAQTDV ESFDVLEPLH DAFRNWQKKD YVVQPEEMML
610 620 630 640 650
DRTQLMGLTA HEMTVLVGGM RVLGANYDNS KHGVFTDNVG VLSNDFFVNL
660 670 680 690 700
TDMSYNWKPA GKNLYHIVDR STDKVKWTAT RVDLVFGSNS ILRSYAEIYA
710 720
QDDAKEKFVN DFVKTWTKVM NADRFDLM
Length:728
Mass (Da):81,314
Last modified:November 25, 2008 - v2
Checksum:i8CDEEEF3A613CB6C
GO

Sequence cautioni

The sequence ABI71763 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000447 Genomic DNA. Translation: ABI71763.1. Different initiation.
RefSeqiWP_041412930.1. NC_008345.1.

Genome annotation databases

EnsemblBacteriaiABI71763; ABI71763; Sfri_1917.
KEGGisfr:Sfri_1917.
PATRICi23497817. VBISheFri14343_1992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000447 Genomic DNA. Translation: ABI71763.1. Different initiation.
RefSeqiWP_041412930.1. NC_008345.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi318167.Sfri_1917.

Protein family/group databases

PeroxiBasei2662. SfrCP01_NCIMB400.

Proteomic databases

PRIDEiQ082Q2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI71763; ABI71763; Sfri_1917.
KEGGisfr:Sfri_1917.
PATRICi23497817. VBISheFri14343_1992.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG1_SHEFN
AccessioniPrimary (citable) accession number: Q082Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.