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Protein

Siderophore iron transporter ENB1

Gene

ENB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of siderophore enterobactin and so has a role in iron homeostasis.1 Publication

GO - Molecular functioni

  • ferric-enterobactin transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular iron ion homeostasis Source: GO_Central
  • ferric-enterobactin transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciYEAST:G3O-33546-MONOMER.

Protein family/group databases

TCDBi2.A.1.16.2. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Siderophore iron transporter ENB1
Alternative name(s):
Enterobactin permease
Siderophore iron transporter ARN4
Gene namesi
Name:ENB1
Synonyms:ARN4
Ordered Locus Names:YOL158C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL158C.
SGDiS000005518. ENB1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 140CytoplasmicSequence analysisAdd BLAST140
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 187LumenalSequence analysisAdd BLAST26
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 224CytoplasmicSequence analysisAdd BLAST16
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 279LumenalSequence analysisAdd BLAST34
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Topological domaini301 – 310CytoplasmicSequence analysis10
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 337LumenalSequence analysis6
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Topological domaini359 – 360CytoplasmicSequence analysis2
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Topological domaini382 – 390LumenalSequence analysis9
Transmembranei391 – 410HelicalSequence analysisAdd BLAST20
Topological domaini411 – 414CytoplasmicSequence analysis4
Transmembranei415 – 432HelicalSequence analysisAdd BLAST18
Topological domaini433 – 435LumenalSequence analysis3
Transmembranei436 – 456HelicalSequence analysisAdd BLAST21
Topological domaini457 – 480CytoplasmicSequence analysisAdd BLAST24
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Topological domaini502 – 550LumenalSequence analysisAdd BLAST49
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Topological domaini572 – 606CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

  • cellular bud membrane Source: SGD
  • endosome Source: GO_Central
  • endosome membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
  • vacuolar membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848651 – 606Siderophore iron transporter ENB1Add BLAST606

Proteomic databases

MaxQBiQ08299.
PRIDEiQ08299.

PTM databases

iPTMnetiQ08299.

Interactioni

Protein-protein interaction databases

BioGridi34260. 9 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ08299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002930.
InParanoidiQ08299.
KOiK08197.
OMAiSSTNWQF.
OrthoDBiEOG092C2P9I.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLETDHSRND NLDDKSTVCY SEKTDSNVEK STTSGLRRID AVNKVLSDYS
60 70 80 90 100
SFTAFGVTFS SLKTALLVAL FLQGYCTGLG GQISQSIQTY AANSFGKHSQ
110 120 130 140 150
VGSINTVKSI VASVVAVPYA RISDRFGRIE CWIFALVLYT IGEIISAATP
160 170 180 190 200
TFSGLFAGIV IQQFGYSGFR LLATALTGDL SGLRDRTFAM NIFLIPVIIN
210 220 230 240 250
TWVSGNIVSS VAGNVAPYKW RWGYGIFCII VPISTLILVL PYVYAQYISW
260 270 280 290 300
RSGKLPPLKL KEKGQTLRQT LWKFADDINL IGVILFTAFL VLVLLPLTIA
310 320 330 340 350
GGATSKWREG HIIAMIVVGG CLGFIFLIWE LKFAKNPFIP RVYLGDPTIY
360 370 380 390 400
VALLMEFVWR LGLQIELEYL VTVLMVAFGE STLSAQRIAQ LYNFLQSCTN
410 420 430 440 450
IVVGIMLHFY PHPKVFVVAG SLLGVIGMGL LYKYRVVYDG ISGLIGAEIV
460 470 480 490 500
VGIAGGMIRF PMWTLVHAST THNEMATVTG LLMSVYQIGD AVGASIAGAI
510 520 530 540 550
WTQRLAKELI QRLGSSLGMA IYKSPLNYLK KYPIGSEVRV QMIESYSKIQ
560 570 580 590 600
RLLIIVSISF AAFNAVLCFF LRGFTVNKKQ SLSAEEREKE KLKIKQQSWL

RRVIGY
Length:606
Mass (Da):66,970
Last modified:November 1, 1996 - v1
Checksum:i4ED81A2A6A43815D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74900 Genomic DNA. Translation: CAA99180.1.
BK006948 Genomic DNA. Translation: DAA10628.1.
PIRiS66857.
RefSeqiNP_014484.1. NM_001183411.1.

Genome annotation databases

EnsemblFungiiYOL158C; YOL158C; YOL158C.
GeneIDi854007.
KEGGisce:YOL158C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74900 Genomic DNA. Translation: CAA99180.1.
BK006948 Genomic DNA. Translation: DAA10628.1.
PIRiS66857.
RefSeqiNP_014484.1. NM_001183411.1.

3D structure databases

ProteinModelPortaliQ08299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34260. 9 interactors.

Protein family/group databases

TCDBi2.A.1.16.2. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ08299.

Proteomic databases

MaxQBiQ08299.
PRIDEiQ08299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL158C; YOL158C; YOL158C.
GeneIDi854007.
KEGGisce:YOL158C.

Organism-specific databases

EuPathDBiFungiDB:YOL158C.
SGDiS000005518. ENB1.

Phylogenomic databases

GeneTreeiENSGT00390000002930.
InParanoidiQ08299.
KOiK08197.
OMAiSSTNWQF.
OrthoDBiEOG092C2P9I.

Enzyme and pathway databases

BioCyciYEAST:G3O-33546-MONOMER.

Miscellaneous databases

PROiQ08299.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENB1_YEAST
AccessioniPrimary (citable) accession number: Q08299
Secondary accession number(s): D6W1R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.