ID   RD22_ARATH              Reviewed;         392 AA.
AC   Q08298; Q56WL9;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   24-JAN-2024, entry version 130.
DE   RecName: Full=BURP domain protein RD22 {ECO:0000303|PubMed:9790599};
DE   AltName: Full=Dehydration-responsive protein RD22 {ECO:0000303|PubMed:8479424};
DE   Flags: Precursor;
GN   Name=RD22 {ECO:0000303|PubMed:8479424};
GN   OrderedLocusNames=At5g25610 {ECO:0000312|Araport:AT5G25610};
GN   ORFNames=T14C9.150 {ECO:0000312|EMBL:AC006601};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP   AND INDUCTION.
RC   STRAIN=cv. Columbia;
RX   PubMed=8479424; DOI=10.1007/bf00279525;
RA   Yamaguchi-Shinozaki K., Shinozaki K.;
RT   "The plant hormone abscisic acid mediates the drought-induced expression
RT   but not the seed-specific expression of rd22, a gene responsive to
RT   dehydration stress in Arabidopsis thaliana.";
RL   Mol. Gen. Genet. 238:17-25(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 285-392.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   DOMAIN.
RX   PubMed=9790599; DOI=10.1007/s004380050832;
RA   Hattori J., Boutilier K.A., van Lookeren Campagne M.M., Miki B.L.;
RT   "A conserved BURP domain defines a novel group of plant proteins with
RT   unusual primary structures.";
RL   Mol. Gen. Genet. 259:424-428(1998).
RN   [7]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19639386; DOI=10.1007/s11103-009-9526-6;
RA   Van Son L., Tiedemann J., Rutten T., Hillmer S., Hinz G., Zank T.,
RA   Manteuffel R., Baeumlein H.;
RT   "The BURP domain protein AtUSPL1 of Arabidopsis thaliana is destined to the
RT   protein storage vacuoles and overexpression of the cognate gene distorts
RT   seed development.";
RL   Plant Mol. Biol. 71:319-329(2009).
RN   [8]
RP   FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=cv. Columbia;
RX   PubMed=25333723; DOI=10.1371/journal.pone.0110065;
RA   Harshavardhan V.T., Van Son L., Seiler C., Junker A., Weigelt-Fischer K.,
RA   Klukas C., Altmann T., Sreenivasulu N., Baeumlein H., Kuhlmann M.;
RT   "AtRD22 and AtUSPL1, members of the plant-specific BURP domain family
RT   involved in Arabidopsis thaliana drought tolerance.";
RL   PLoS ONE 9:E110065-E110065(2014).
RN   [9]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=26106400; DOI=10.3389/fpls.2015.00412;
RA   Park J., Cui Y., Kang B.H.;
RT   "AtPGL3 is an Arabidopsis BURP domain protein that is localized to the cell
RT   wall and promotes cell enlargement.";
RL   Front. Plant Sci. 6:412-412(2015).
CC   -!- FUNCTION: Acts to suppress chlorophyll degradation under moisture
CC       stress. {ECO:0000269|PubMed:25333723}.
CC   -!- TISSUE SPECIFICITY: Expressed in seed (PubMed:8479424). Highest
CC       expression in leaves and guard cells (PubMed:25333723).
CC       {ECO:0000269|PubMed:8479424, ECO:0000305|PubMed:25333723}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during the early and middle stages of
CC       seed development (PubMed:8479424). Abundant throughout plant
CC       development in the aerial part of the plant (PubMed:25333723).
CC       {ECO:0000269|PubMed:8479424, ECO:0000305|PubMed:25333723}.
CC   -!- INDUCTION: Up-regulated by dehydration, salt stress and abscisic acid
CC       (ABA). Not regulated by cold. {ECO:0000269|PubMed:25333723,
CC       ECO:0000269|PubMed:8479424}.
CC   -!- DOMAIN: The BURP domain located at the C-terminus has not been
CC       identified in non-plant proteins. {ECO:0000269|PubMed:9790599}.
CC   -!- DISRUPTION PHENOTYPE: Enhanced drought tolerance.
CC       {ECO:0000269|PubMed:25333723}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD93841.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAD94687.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; D10703; BAA01546.1; -; Genomic_DNA.
DR   EMBL; AC006601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; AED93472.1; -; Genomic_DNA.
DR   EMBL; AY090244; AAL90908.1; -; mRNA.
DR   EMBL; AY060560; AAL31189.1; -; mRNA.
DR   EMBL; BT009697; AAP88331.1; -; mRNA.
DR   EMBL; AK220718; BAD93841.1; ALT_INIT; mRNA.
DR   EMBL; AK222019; BAD94687.1; ALT_INIT; mRNA.
DR   PIR; S34823; S34823.
DR   RefSeq; NP_197943.1; NM_122472.4.
DR   AlphaFoldDB; Q08298; -.
DR   BioGRID; 17911; 2.
DR   STRING; 3702.Q08298; -.
DR   SwissPalm; Q08298; -.
DR   PaxDb; 3702-AT5G25610-1; -.
DR   ProteomicsDB; 225927; -.
DR   EnsemblPlants; AT5G25610.1; AT5G25610.1; AT5G25610.
DR   GeneID; 832636; -.
DR   Gramene; AT5G25610.1; AT5G25610.1; AT5G25610.
DR   KEGG; ath:AT5G25610; -.
DR   Araport; AT5G25610; -.
DR   TAIR; AT5G25610; RD22.
DR   eggNOG; ENOG502QQHP; Eukaryota.
DR   HOGENOM; CLU_011822_1_1_1; -.
DR   InParanoid; Q08298; -.
DR   OMA; NVAPFIY; -.
DR   OrthoDB; 473418at2759; -.
DR   PhylomeDB; Q08298; -.
DR   PRO; PR:Q08298; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q08298; baseline and differential.
DR   GO; GO:0005768; C:endosome; HDA:TAIR.
DR   GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR   GO; GO:0005802; C:trans-Golgi network; HDA:TAIR.
DR   GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR   GO; GO:0009651; P:response to salt stress; IEP:TAIR.
DR   InterPro; IPR044816; BURP.
DR   InterPro; IPR004873; BURP_dom.
DR   PANTHER; PTHR31236:SF2; BURP DOMAIN PROTEIN RD22; 1.
DR   PANTHER; PTHR31236; BURP DOMAIN PROTEIN USPL1-LIKE; 1.
DR   Pfam; PF03181; BURP; 1.
DR   SMART; SM01045; BURP; 1.
DR   PROSITE; PS51277; BURP; 1.
DR   Genevisible; Q08298; AT.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Signal; Stress response.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..392
FT                   /note="BURP domain protein RD22"
FT                   /id="PRO_0000022202"
FT   REPEAT          56..58
FT                   /note="TXV 1"
FT                   /evidence="ECO:0000305"
FT   REPEAT          78..80
FT                   /note="TXV 2"
FT                   /evidence="ECO:0000305"
FT   REPEAT          100..102
FT                   /note="TXV 3"
FT                   /evidence="ECO:0000305"
FT   REPEAT          125..127
FT                   /note="TXV 4"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          176..392
FT                   /note="BURP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00604"
FT   REGION          57..164
FT                   /note="5 X approximate repeats"
FT   REGION          61..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..76
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   392 AA;  42260 MW;  511A76D8C59225B3 CRC64;
     MAIRLPLICL LGSFMVVAIA ADLTPERYWS TALPNTPIPN SLHNLLTFDF TDEKSTNVQV
     GKGGVNVNTH KGKTGSGTAV NVGKGGVRVD TGKGKPGGGT HVSVGSGKGH GGGVAVHTGK
     PGKRTDVGVG KGGVTVHTRH KGRPIYVGVK PGANPFVYNY AAKETQLHDD PNAALFFLEK
     DLVRGKEMNV RFNAEDGYGG KTAFLPRGEA ETVPFGSEKF SETLKRFSVE AGSEEAEMMK
     KTIEECEARK VSGEEKYCAT SLESMVDFSV SKLGKYHVRA VSTEVAKKNA PMQKYKIAAA
     GVKKLSDDKS VVCHKQKYPF AVFYCHKAMM TTVYAVPLEG ENGMRAKAVA VCHKNTSAWN
     PNHLAFKVLK VKPGTVPVCH FLPETHVVWF SY
//