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Protein

Calponin-1

Gene

Cnn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

GO - Molecular functioni

  • actin binding Source: RGD
  • calmodulin binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calponin-1
Alternative name(s):
Basic calponin
Calponin H1, smooth muscle
Gene namesi
Name:Cnn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621883 Cnn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047701 – 297Calponin-1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48PhosphoserineCombined sources1
Modified residuei170Phosphothreonine; by ROCK2By similarity1
Modified residuei175Phosphoserine; by ROCK2By similarity1
Modified residuei180Phosphothreonine; by ROCK2By similarity1
Modified residuei184Phosphothreonine; by ROCK2By similarity1
Modified residuei259Phosphothreonine; by ROCK2By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ08290
PRIDEiQ08290

PTM databases

iPTMnetiQ08290
PhosphoSitePlusiQ08290

Expressioni

Tissue specificityi

Smooth muscle, and tissues containing significant amounts of smooth muscle.

Gene expression databases

BgeeiENSRNOG00000027736
GenevisibleiQ08290 RN

Interactioni

Subunit structurei

Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1.By similarity

GO - Molecular functioni

  • actin binding Source: RGD
  • calmodulin binding Source: UniProtKB-KW

Protein-protein interaction databases

BioGridi249316, 3 interactors
IntActiQ08290, 1 interactor
MINTiQ08290
STRINGi10116.ENSRNOP00000029782

Structurei

3D structure databases

ProteinModelPortaliQ08290
SMRiQ08290
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 131Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST104
Repeati164 – 189Calponin-like 1Add BLAST26
Repeati204 – 229Calponin-like 2Add BLAST26
Repeati243 – 268Calponin-like 3Add BLAST26

Sequence similaritiesi

Belongs to the calponin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
HOVERGENiHBG005186
InParanoidiQ08290
OMAiAGMAKSK
OrthoDBiEOG091G0LY2
PhylomeDBiQ08290

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001997 Calponin/LIMCH1
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003096 SM22_calponin
PfamiView protein in Pfam
PF00402 Calponin, 3 hits
PF00307 CH, 1 hit
PRINTSiPR00889 CALPONIN
PR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 3 hits
PS51122 CALPONIN_2, 3 hits
PS50021 CH, 1 hit

Sequencei

Sequence statusi: Complete.

Q08290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGSNF
60 70 80 90 100
MDGLKDGIIL CEFINKLQPG SVKKVNESTQ NWHQLENIGN FIKAITKYGV
110 120 130 140 150
KPHDIFEAND LFENTNHTQV QSTLLALASM AKTKGNKVNV GVKYAEKQER
160 170 180 190 200
RFEPEKLREG RNIIGLQMGT NKFASQQGMT AYGTRRHLYD PKLGTDQPLD
210 220 230 240 250
QATISLQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT LNVSLQMGSN
260 270 280 290
KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LDEPTHNHHP HNYYNSA
Length:297
Mass (Da):33,344
Last modified:October 1, 1994 - v1
Checksum:i80483631899BE025
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97K → E in BAA03320 (PubMed:8359698).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71071 mRNA Translation: CAA50397.1
D14437 mRNA Translation: BAA03320.1
BC061809 mRNA Translation: AAH61809.1
PIRiS37640 JN0773
RefSeqiNP_113935.1, NM_031747.1
UniGeneiRn.31788

Genome annotation databases

EnsembliENSRNOT00000029577; ENSRNOP00000029782; ENSRNOG00000027736
GeneIDi65204
KEGGirno:65204
UCSCiRGD:621883 rat

Similar proteinsi

Entry informationi

Entry nameiCNN1_RAT
AccessioniPrimary (citable) accession number: Q08290
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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