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Protein

Cell growth-regulating nucleolar protein

Gene

Lyar

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Zinc 11
Metal bindingi9Zinc 11
Metal bindingi21Zinc 11
Metal bindingi25Zinc 11
Metal bindingi33Zinc 21
Metal bindingi36Zinc 21
Metal bindingi48Zinc 21
Metal bindingi51Zinc 21

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 26C2HC LYAR-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri28 – 52C2HC LYAR-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cell growth-regulating nucleolar protein
Alternative name(s):
Protein expressed in male leptotene and zygotene spermatocytes 264
Short name:
MLZ-264
Gene namesi
Name:Lyar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107470. Lyar.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000845291 – 388Cell growth-regulating nucleolar proteinAdd BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki204Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ08288.
MaxQBiQ08288.
PaxDbiQ08288.
PeptideAtlasiQ08288.
PRIDEiQ08288.

PTM databases

iPTMnetiQ08288.
PhosphoSitePlusiQ08288.

Expressioni

Tissue specificityi

Very high levels in immature spermatocytes in testis. Expressed in ovary.1 Publication

Developmental stagei

Expressed in testis and ovary at E15.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000067367.
CleanExiMM_LYAR.
ExpressionAtlasiQ08288. baseline and differential.
GenevisibleiQ08288. MM.

Interactioni

Protein-protein interaction databases

BioGridi201254. 1 interactor.
IntActiQ08288. 3 interactors.
MINTiMINT-4127850.
STRINGi10090.ENSMUSP00000084791.

Structurei

Secondary structure

1388
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 9Combined sources7
Beta strandi12 – 14Combined sources3
Helixi17 – 24Combined sources8
Beta strandi30 – 33Combined sources4
Turni34 – 37Combined sources4
Beta strandi38 – 41Combined sources4
Helixi42 – 44Combined sources3
Turni45 – 47Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJVNMR-A1-66[»]
ProteinModelPortaliQ08288.
SMRiQ08288.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08288.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili174 – 216Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi182 – 344Lys-richAdd BLAST163

Sequence similaritiesi

Contains 2 C2HC LYAR-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 26C2HC LYAR-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri28 – 52C2HC LYAR-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2186. Eukaryota.
ENOG411081U. LUCA.
GeneTreeiENSGT00390000003477.
HOGENOMiHOG000006633.
HOVERGENiHBG006298.
InParanoidiQ08288.
KOiK15263.
OMAiQYYAVTN.
OrthoDBiEOG091G0L4Z.
PhylomeDBiQ08288.
TreeFamiTF314925.

Family and domain databases

InterProiIPR014898. Znf_C2H2_LYAR.
[Graphical view]
PfamiPF08790. zf-LYAR. 1 hit.
[Graphical view]
PROSITEiPS51804. ZF_C2HC_LYAR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFFTCNACG ESVKKIQVEK HVSNCRNCEC LSCIDCGKDF WGDDYKSHVK
60 70 80 90 100
CISEGQKYGG KGYEAKTHKG DAKQQAWIQK INELIKKPNV SPKVRELLQQ
110 120 130 140 150
ISAFDNVPRK KAKFQNWMKN SLKVHSDSVL EQVWDIFSEA SSSEQDQQQP
160 170 180 190 200
PSHTAKPHAE MPITKVPSAK TNGTTEEQTE AKKNKRERKE ERQKNRKKEK
210 220 230 240 250
KELKLENHQE NLRGQKPKKR KKNQEAGHEA AGEEAAEASG PPEKKKAQGG
260 270 280 290 300
QASEEGADRN GGPGEDAAEG QTKTAAGKRK RPKHSGAESG YKKKKMKLPE
310 320 330 340 350
QPEEGEAKDH EAPSKGKFNW KGTIKAVLKQ APDNEISVKK LKKKVIAQYH
360 370 380
AVMNDHHTSE EELLAIFNRK ISRNPTFKVL KDRVKLLK
Length:388
Mass (Da):43,736
Last modified:July 19, 2005 - v2
Checksum:iD39A0CDC2257BE8C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21H → Q in AAB26644 (PubMed:8491376).Curated1
Sequence conflicti109R → I in AAB26644 (PubMed:8491376).Curated1
Sequence conflicti234 – 238EAAEA → DGADG in AAB26644 (PubMed:8491376).Curated5
Sequence conflicti267A → R in AAB26644 (PubMed:8491376).Curated1
Sequence conflicti354N → K in BAB24554 (PubMed:16141072).Curated1
Sequence conflicti356 – 359HHTS → TSHH in AAB26644 (PubMed:8491376).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S60885 mRNA. Translation: AAB26644.1.
AK006373 mRNA. Translation: BAB24554.1.
CCDSiCCDS19253.1.
PIRiA40683.
RefSeqiNP_079557.2. NM_025281.3.
XP_006503822.1. XM_006503759.1.
XP_006503823.1. XM_006503760.1.
XP_006503824.1. XM_006503761.1.
XP_006503825.1. XM_006503762.1.
XP_006503826.1. XM_006503763.1.
XP_006503827.1. XM_006503764.1.
UniGeneiMm.28560.

Genome annotation databases

EnsembliENSMUST00000087514; ENSMUSP00000084791; ENSMUSG00000067367.
ENSMUST00000114106; ENSMUSP00000109741; ENSMUSG00000067367.
GeneIDi17089.
KEGGimmu:17089.
UCSCiuc008xgh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S60885 mRNA. Translation: AAB26644.1.
AK006373 mRNA. Translation: BAB24554.1.
CCDSiCCDS19253.1.
PIRiA40683.
RefSeqiNP_079557.2. NM_025281.3.
XP_006503822.1. XM_006503759.1.
XP_006503823.1. XM_006503760.1.
XP_006503824.1. XM_006503761.1.
XP_006503825.1. XM_006503762.1.
XP_006503826.1. XM_006503763.1.
XP_006503827.1. XM_006503764.1.
UniGeneiMm.28560.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJVNMR-A1-66[»]
ProteinModelPortaliQ08288.
SMRiQ08288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201254. 1 interactor.
IntActiQ08288. 3 interactors.
MINTiMINT-4127850.
STRINGi10090.ENSMUSP00000084791.

PTM databases

iPTMnetiQ08288.
PhosphoSitePlusiQ08288.

Proteomic databases

EPDiQ08288.
MaxQBiQ08288.
PaxDbiQ08288.
PeptideAtlasiQ08288.
PRIDEiQ08288.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087514; ENSMUSP00000084791; ENSMUSG00000067367.
ENSMUST00000114106; ENSMUSP00000109741; ENSMUSG00000067367.
GeneIDi17089.
KEGGimmu:17089.
UCSCiuc008xgh.2. mouse.

Organism-specific databases

CTDi55646.
MGIiMGI:107470. Lyar.

Phylogenomic databases

eggNOGiKOG2186. Eukaryota.
ENOG411081U. LUCA.
GeneTreeiENSGT00390000003477.
HOGENOMiHOG000006633.
HOVERGENiHBG006298.
InParanoidiQ08288.
KOiK15263.
OMAiQYYAVTN.
OrthoDBiEOG091G0L4Z.
PhylomeDBiQ08288.
TreeFamiTF314925.

Miscellaneous databases

ChiTaRSiLyar. mouse.
EvolutionaryTraceiQ08288.
PROiQ08288.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067367.
CleanExiMM_LYAR.
ExpressionAtlasiQ08288. baseline and differential.
GenevisibleiQ08288. MM.

Family and domain databases

InterProiIPR014898. Znf_C2H2_LYAR.
[Graphical view]
PfamiPF08790. zf-LYAR. 1 hit.
[Graphical view]
PROSITEiPS51804. ZF_C2HC_LYAR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYAR_MOUSE
AccessioniPrimary (citable) accession number: Q08288
Secondary accession number(s): Q9D9X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.