Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Restriction of telomere capping protein 1

Gene

RTC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. May be involved in a process influencing telomere capping.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1293 – 1335RING-type; degeneratePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

  • positive regulation of TORC1 signaling Source: SGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33531-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Restriction of telomere capping protein 1
Alternative name(s):
SEH-associated protein 2
Gene namesi
Name:RTC1
Synonyms:SEA2
Ordered Locus Names:YOL138C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL138C.
SGDiS000005498. RTC1.

Subcellular locationi

GO - Cellular componenti

  • extrinsic component of fungal-type vacuolar membrane Source: SGD
  • Seh1-associated complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

Pathology & Biotechi

Disruption phenotypei

Leads to short telomeres.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002235281 – 1341Restriction of telomere capping protein 1Add BLAST1341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1036PhosphoserineCombined sources1
Modified residuei1080PhosphoserineCombined sources1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1089PhosphoserineCombined sources1
Modified residuei1123PhosphoserineCombined sources1
Modified residuei1133PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08281.
PRIDEiQ08281.

PTM databases

iPTMnetiQ08281.

Interactioni

Subunit structurei

Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1. Interacts with ribosomes.2 Publications

Protein-protein interaction databases

BioGridi34238. 19 interactors.
IntActiQ08281. 42 interactors.
MINTiMINT-4502222.

Structurei

3D structure databases

ProteinModelPortaliQ08281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati207 – 248WD 1Add BLAST42
Repeati256 – 296WD 2Add BLAST41
Repeati305 – 342WD 3Add BLAST38
Repeati367 – 406WD 4Add BLAST40
Repeati439 – 486WD 5Add BLAST48
Repeati489 – 527WD 6Add BLAST39
Repeati843 – 883WD 7Add BLAST41
Repeati1129 – 1169WD 8Add BLAST41
Repeati1216 – 1255WD 9Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi753 – 765Poly-AspAdd BLAST13

Sequence similaritiesi

Belongs to the WD repeat RTC1 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 9 WD repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1293 – 1335RING-type; degeneratePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00850000132419.
InParanoidiQ08281.
KOiK20408.
OMAiGGRDGKC.
OrthoDBiEOG092C0ZNN.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08281-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSPHVENA SIPKGSTPIP KNRNVSSIGK GEFLGSSSSN NSSFRMNHYS
60 70 80 90 100
NSGQPSVLDS IRRPNLTPTF SYSNGVYMPE SHRTSSFNDS YLPYDKNPYA
110 120 130 140 150
KTTGSMSNKS NMKIKTKKNA INTNTRKSSG LIYTTKVDKE LSSIDKVNDP
160 170 180 190 200
NINGLVCAGK THLGLYKFSP SDRSIKCVHD FITPNSNTST RGTTSLLPKL
210 220 230 240 250
SKRTRQNKFS TIADVKTGFN NYKNCIAVCN NSTAISIYDL NKSSSIDNPL
260 270 280 290 300
ITSLCEHTRS INSFDFNMVE SNLIISGGQD SCVKIWDLRS NKSKSSNRSD
310 320 330 340 350
ISINTASDSI RDVKWMPGYN FASKNDQGSS TYGNLKSGYK FASIHDSGYL
360 370 380 390 400
LKFDLRQPAQ YEKKLNAHTG PGLCLNWHPN QEYIATGGRD GKCCLWFVGD
410 420 430 440 450
NANAAENTVL NYGNSPSLHA PNTSLNNSGS LAFPKLTINT GYPVTKLKFK
460 470 480 490 500
PAYSSNIYNS LLGISSMGDE AEVRIYSLAR KYIPKHVLLS ETPSLGLVWW
510 520 530 540 550
DENLIFNIDK GTRINGWDIN KEPTVLENLS KNTTTWRDLD GNGLLSVDQE
560 570 580 590 600
IGSYEVVEPE LQPTSSTTCK KHPGTIKNPK NGNPENQGII GGIKKGFSHT
610 620 630 640 650
GLTSFTPERP PTLKAGPTFS TKSLTLASGA SSFNSSSASL TSLTPQTENR
660 670 680 690 700
EEIAIEPPCI ITLDIPQIFN NIRLTKIAHS RKKNVISESS SMKNSPVEKF
710 720 730 740 750
KYLARQLKFS YIREHNVSDS ADTAYKNDIE NIDVVKNATE THGDNTTTTN
760 770 780 790 800
NNDDGDDDDD DDDDDKIIES HLLKKYNFPE NNTWATLMNE KVNNKKSKRN
810 820 830 840 850
SSSSREFDEK DVRSSISSIS ASRQSHDRAR KIDKNVEAEL QEKIQTLVDL
860 870 880 890 900
ISIATHNASV YLSIDDLTNF KIWILIRDSL LWDLKWMTSS QISSDNASNM
910 920 930 940 950
DANESSDFEA GENLKTGKEF PEEDGAGTSG AESLVEERPQ AFRANSDEPS
960 970 980 990 1000
DAEKKPVSKL KEQLKNTEII PYAQPNEDSD EVLTKLKELQ NQRLESRTKM
1010 1020 1030 1040 1050
GETVSDDVII EEDEHEHQEE EQPHDSPTKS AQFHASPIAK SIPILQKREH
1060 1070 1080 1090 1100
RKSFIDTFML HSPNGYNGDT DIGNEDDNIS PRFTYNSVSP RSKVSSLQSY
1110 1120 1130 1140 1150
ATTTSQLETF KKLSSHTAPI IGSPRHAPSR PDSIGREQLS SSLTKKLAKC
1160 1170 1180 1190 1200
KKIIADPPWD TKKLIKQLYN QATETGNVVL TVNILFLFQT IYQITEIDIA
1210 1220 1230 1240 1250
KDAIAHFLLL LHRYELFGIA ADVLKYCPFE DIMGSEGDQS SIRLFCERCG
1260 1270 1280 1290 1300
ELITNESSKE KLRAEAQQTG NKKIMDKFGY WYCDSCKKKN TSCVLCERPL
1310 1320 1330 1340
KKLTMVILPC GHEGHFQCIQ EWFLDENEQE CPGGCPGVAF I
Length:1,341
Mass (Da):149,344
Last modified:September 21, 2011 - v2
Checksum:i45B62E3D341397AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti393C → S in CAA64732 (PubMed:8896270).Curated1
Sequence conflicti393C → S in CAA99159 (PubMed:9169874).Curated1
Sequence conflicti548D → G in CAA64732 (PubMed:8896270).Curated1
Sequence conflicti548D → G in CAA99159 (PubMed:9169874).Curated1
Sequence conflicti1222D → DV in CAA64732 (PubMed:8896270).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95465 Genomic DNA. Translation: CAA64732.1.
Z74880 Genomic DNA. Translation: CAA99159.1.
BK006948 Genomic DNA. Translation: DAA10647.2.
PIRiS66835.
RefSeqiNP_014503.2. NM_001183392.2.

Genome annotation databases

EnsemblFungiiYOL138C; YOL138C; YOL138C.
GeneIDi853982.
KEGGisce:YOL138C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95465 Genomic DNA. Translation: CAA64732.1.
Z74880 Genomic DNA. Translation: CAA99159.1.
BK006948 Genomic DNA. Translation: DAA10647.2.
PIRiS66835.
RefSeqiNP_014503.2. NM_001183392.2.

3D structure databases

ProteinModelPortaliQ08281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34238. 19 interactors.
IntActiQ08281. 42 interactors.
MINTiMINT-4502222.

PTM databases

iPTMnetiQ08281.

Proteomic databases

MaxQBiQ08281.
PRIDEiQ08281.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL138C; YOL138C; YOL138C.
GeneIDi853982.
KEGGisce:YOL138C.

Organism-specific databases

EuPathDBiFungiDB:YOL138C.
SGDiS000005498. RTC1.

Phylogenomic databases

GeneTreeiENSGT00850000132419.
InParanoidiQ08281.
KOiK20408.
OMAiGGRDGKC.
OrthoDBiEOG092C0ZNN.

Enzyme and pathway databases

BioCyciYEAST:G3O-33531-MONOMER.

Miscellaneous databases

PROiQ08281.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRTC1_YEAST
AccessioniPrimary (citable) accession number: Q08281
Secondary accession number(s): D6W1T1, Q92271
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: September 21, 2011
Last modified: November 2, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 606 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.