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Protein

Bypass of stop codon protein 6

Gene

BSC6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33530-MONOMER.

Protein family/group databases

TCDBi2.A.1.7.13. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Bypass of stop codon protein 6
Gene namesi
Name:BSC6
Ordered Locus Names:YOL137W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL137W.
SGDiS000005497. BSC6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7272LumenalSequence analysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST
Topological domaini94 – 14451CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence analysisAdd
BLAST
Topological domaini166 – 1672LumenalSequence analysis
Transmembranei168 – 18821HelicalSequence analysisAdd
BLAST
Topological domaini189 – 20517CytoplasmicSequence analysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST
Topological domaini227 – 2326LumenalSequence analysis
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Topological domaini254 – 30047CytoplasmicSequence analysisAdd
BLAST
Transmembranei301 – 32121HelicalSequence analysisAdd
BLAST
Topological domaini322 – 34019LumenalSequence analysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence analysisAdd
BLAST
Topological domaini362 – 37312CytoplasmicSequence analysisAdd
BLAST
Transmembranei374 – 39421HelicalSequence analysisAdd
BLAST
Topological domaini395 – 3973LumenalSequence analysis
Transmembranei398 – 41821HelicalSequence analysisAdd
BLAST
Topological domaini419 – 43921CytoplasmicSequence analysisAdd
BLAST
Transmembranei440 – 46021HelicalSequence analysisAdd
BLAST
Topological domaini461 – 4622LumenalSequence analysis
Transmembranei463 – 48321HelicalSequence analysisAdd
BLAST
Topological domaini484 – 49714CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Bypass of stop codon protein 6PRO_0000084864Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371PhosphoserineCombined sources
Modified residuei41 – 411PhosphoserineCombined sources
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ08280.

PTM databases

iPTMnetiQ08280.

Interactioni

Protein-protein interaction databases

BioGridi34239. 19 interactions.
DIPiDIP-4683N.
IntActiQ08280. 7 interactions.
MINTiMINT-481943.

Structurei

3D structure databases

ProteinModelPortaliQ08280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000095266.
InParanoidiQ08280.
OMAiWHDSART.
OrthoDBiEOG092C3Y59.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDASSVPPKV DDYGMYTTEI SHHNPIELKN LLSSSDSRRN SQDEDSLPNN
60 70 80 90 100
TNLIKEIDWQ GEKVKTYPLN YQTVPLVKLQ VIACLIMFVV FGMNDQTVGA
110 120 130 140 150
LLPTLIEYYH ISRVDVSNVF IVQLCGYVMA SLSKERLNKH FGMRGGMLLA
160 170 180 190 200
AGLCIVFLII LATAPSSFYV CMFCGLPLGL GIGILDSTGN VLMGSLLVHK
210 220 230 240 250
NELMGIMHGL YGAAAMVTPP LVSYFVEWGH WSLFFLIPLF FSIIGMIVIF
260 270 280 290 300
PAFKFETASK YDYLCSVENK ESNNDVEEAG DNSLMESTKA SPGFFELLRN
310 320 330 340 350
PAIFLYSLYL FLYLGAEITT GSWFFSYLLE TKSSNKVAMS YIAASFWTGL
360 370 380 390 400
TVGRLCLGFV TERFFENEYK ASKAYAFLTL SSYTLFVLVG LINSSSVFYF
410 420 430 440 450
VVLFFVVFCC GTFIGPLFPN ASIVALQVLP KRLHVSGVGV AVAVGGCGGA
460 470 480 490
AIPYLAGVIA HTVGIQYIPL LCWIMVALFT LEWTLYPKFI KGHEEYF
Length:497
Mass (Da):55,084
Last modified:November 1, 1996 - v1
Checksum:i2458A5A8DA6BC731
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti472 – 4721C → R in AAT92920 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95465 Genomic DNA. Translation: CAA64736.1.
Z74879 Genomic DNA. Translation: CAA99158.1.
AY692901 Genomic DNA. Translation: AAT92920.1.
BK006948 Genomic DNA. Translation: DAA10648.1.
PIRiS66834.
RefSeqiNP_014504.1. NM_001183391.1.

Genome annotation databases

EnsemblFungiiYOL137W; YOL137W; YOL137W.
GeneIDi853983.
KEGGisce:YOL137W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95465 Genomic DNA. Translation: CAA64736.1.
Z74879 Genomic DNA. Translation: CAA99158.1.
AY692901 Genomic DNA. Translation: AAT92920.1.
BK006948 Genomic DNA. Translation: DAA10648.1.
PIRiS66834.
RefSeqiNP_014504.1. NM_001183391.1.

3D structure databases

ProteinModelPortaliQ08280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34239. 19 interactions.
DIPiDIP-4683N.
IntActiQ08280. 7 interactions.
MINTiMINT-481943.

Protein family/group databases

TCDBi2.A.1.7.13. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ08280.

Proteomic databases

MaxQBiQ08280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL137W; YOL137W; YOL137W.
GeneIDi853983.
KEGGisce:YOL137W.

Organism-specific databases

EuPathDBiFungiDB:YOL137W.
SGDiS000005497. BSC6.

Phylogenomic databases

HOGENOMiHOG000095266.
InParanoidiQ08280.
OMAiWHDSART.
OrthoDBiEOG092C3Y59.

Enzyme and pathway databases

BioCyciYEAST:G3O-33530-MONOMER.

Miscellaneous databases

PROiQ08280.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBSC6_YEAST
AccessioniPrimary (citable) accession number: Q08280
Secondary accession number(s): D6W1T2, Q6B229
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 414 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.