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Protein

Bypass of stop codon protein 6

Gene

BSC6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33530-MONOMER.

Protein family/group databases

TCDBi2.A.1.7.13. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Bypass of stop codon protein 6
Gene namesi
Name:BSC6
Ordered Locus Names:YOL137W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL137W.
SGDiS000005497. BSC6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 72LumenalSequence analysisAdd BLAST72
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 144CytoplasmicSequence analysisAdd BLAST51
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 167LumenalSequence analysis2
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 205CytoplasmicSequence analysisAdd BLAST17
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 232LumenalSequence analysis6
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 300CytoplasmicSequence analysisAdd BLAST47
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 340LumenalSequence analysisAdd BLAST19
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 373CytoplasmicSequence analysisAdd BLAST12
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 397LumenalSequence analysis3
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 439CytoplasmicSequence analysisAdd BLAST21
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 462LumenalSequence analysis2
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21
Topological domaini484 – 497CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848641 – 497Bypass of stop codon protein 6Add BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineCombined sources1
Modified residuei41PhosphoserineCombined sources1
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ08280.
PRIDEiQ08280.

PTM databases

iPTMnetiQ08280.

Interactioni

Protein-protein interaction databases

BioGridi34239. 19 interactors.
DIPiDIP-4683N.
IntActiQ08280. 7 interactors.
MINTiMINT-481943.

Structurei

3D structure databases

ProteinModelPortaliQ08280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000095266.
InParanoidiQ08280.
OMAiWHDSART.
OrthoDBiEOG092C3Y59.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDASSVPPKV DDYGMYTTEI SHHNPIELKN LLSSSDSRRN SQDEDSLPNN
60 70 80 90 100
TNLIKEIDWQ GEKVKTYPLN YQTVPLVKLQ VIACLIMFVV FGMNDQTVGA
110 120 130 140 150
LLPTLIEYYH ISRVDVSNVF IVQLCGYVMA SLSKERLNKH FGMRGGMLLA
160 170 180 190 200
AGLCIVFLII LATAPSSFYV CMFCGLPLGL GIGILDSTGN VLMGSLLVHK
210 220 230 240 250
NELMGIMHGL YGAAAMVTPP LVSYFVEWGH WSLFFLIPLF FSIIGMIVIF
260 270 280 290 300
PAFKFETASK YDYLCSVENK ESNNDVEEAG DNSLMESTKA SPGFFELLRN
310 320 330 340 350
PAIFLYSLYL FLYLGAEITT GSWFFSYLLE TKSSNKVAMS YIAASFWTGL
360 370 380 390 400
TVGRLCLGFV TERFFENEYK ASKAYAFLTL SSYTLFVLVG LINSSSVFYF
410 420 430 440 450
VVLFFVVFCC GTFIGPLFPN ASIVALQVLP KRLHVSGVGV AVAVGGCGGA
460 470 480 490
AIPYLAGVIA HTVGIQYIPL LCWIMVALFT LEWTLYPKFI KGHEEYF
Length:497
Mass (Da):55,084
Last modified:November 1, 1996 - v1
Checksum:i2458A5A8DA6BC731
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti472C → R in AAT92920 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95465 Genomic DNA. Translation: CAA64736.1.
Z74879 Genomic DNA. Translation: CAA99158.1.
AY692901 Genomic DNA. Translation: AAT92920.1.
BK006948 Genomic DNA. Translation: DAA10648.1.
PIRiS66834.
RefSeqiNP_014504.1. NM_001183391.1.

Genome annotation databases

EnsemblFungiiYOL137W; YOL137W; YOL137W.
GeneIDi853983.
KEGGisce:YOL137W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95465 Genomic DNA. Translation: CAA64736.1.
Z74879 Genomic DNA. Translation: CAA99158.1.
AY692901 Genomic DNA. Translation: AAT92920.1.
BK006948 Genomic DNA. Translation: DAA10648.1.
PIRiS66834.
RefSeqiNP_014504.1. NM_001183391.1.

3D structure databases

ProteinModelPortaliQ08280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34239. 19 interactors.
DIPiDIP-4683N.
IntActiQ08280. 7 interactors.
MINTiMINT-481943.

Protein family/group databases

TCDBi2.A.1.7.13. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ08280.

Proteomic databases

MaxQBiQ08280.
PRIDEiQ08280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL137W; YOL137W; YOL137W.
GeneIDi853983.
KEGGisce:YOL137W.

Organism-specific databases

EuPathDBiFungiDB:YOL137W.
SGDiS000005497. BSC6.

Phylogenomic databases

HOGENOMiHOG000095266.
InParanoidiQ08280.
OMAiWHDSART.
OrthoDBiEOG092C3Y59.

Enzyme and pathway databases

BioCyciYEAST:G3O-33530-MONOMER.

Miscellaneous databases

PROiQ08280.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBSC6_YEAST
AccessioniPrimary (citable) accession number: Q08280
Secondary accession number(s): D6W1T2, Q6B229
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 414 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.