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Q08279

- IGF2_CAVPO

UniProt

Q08279 - IGF2_CAVPO

Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
    Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 By similarity.By similarity

    GO - Biological processi

    1. glucose metabolic process Source: UniProtKB-KW
    2. ossification Source: UniProtKB-KW
    3. positive regulation of cell division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Growth factor, Hormone, Mitogen

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor II
    Short name:
    IGF-II
    Alternative name(s):
    Somatomedin-A
    Cleaved into the following 2 chains:
    Gene namesi
    Name:IGF2
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 9167Insulin-like growth factor IIPRO_0000015713Add
    BLAST
    Propeptidei92 – ›128›37E peptidePRO_0000015714Add
    BLAST
    Peptidei93 – 12634PreptinPRO_0000370374Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 71By similarity
    Disulfide bondi45 ↔ 84By similarity
    Disulfide bondi70 ↔ 75By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiQ08279.

    Expressioni

    Developmental stagei

    Expressed predominantly in fetal tissues and at lower levels in adult.

    Interactioni

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000020235.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08279.
    SMRiQ08279. Positions 25-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 5228BAdd
    BLAST
    Regioni53 – 6412CAdd
    BLAST
    Regioni65 – 8521AAdd
    BLAST
    Regioni86 – 916D

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44017.
    GeneTreeiENSGT00530000063856.
    HOGENOMiHOG000233362.
    HOVERGENiHBG006137.
    InParanoidiQ08279.
    OrthoDBiEOG7TF7CG.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view]
    PRINTSiPR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomiPD005188. IGF2_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q08279-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGISMGKSML VLLTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF    50
    YFSRPASRVS RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSASLAV 100
    LPDNFPRYPV GKFFQYDTWR QSTQRLRR 128
    Length:128
    Mass (Da):14,420
    Last modified:February 1, 1995 - v1
    Checksum:iBC65A1D81A4CE056
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei128 – 1281

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S59899 mRNA. Translation: AAB26479.1.
    PIRiI57671.

    Genome annotation databases

    EnsembliENSCPOT00000028062; ENSCPOP00000020895; ENSCPOG00000024765.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S59899 mRNA. Translation: AAB26479.1 .
    PIRi I57671.

    3D structure databases

    ProteinModelPortali Q08279.
    SMRi Q08279. Positions 25-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000020235.

    Proteomic databases

    PRIDEi Q08279.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCPOT00000028062 ; ENSCPOP00000020895 ; ENSCPOG00000024765 .

    Phylogenomic databases

    eggNOGi NOG44017.
    GeneTreei ENSGT00530000063856.
    HOGENOMi HOG000233362.
    HOVERGENi HBG006137.
    InParanoidi Q08279.
    OrthoDBi EOG7TF7CG.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view ]
    PRINTSi PR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomi PD005188. IGF2_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of an insulin-like growth factor II cDNA from guinea pig liver: expression and developmental regulation."
      Levinovitz A., Norstedt G., van den Berg S., Robinson I.C.A.F., Ekstroem T.J.
      Mol. Cell. Endocrinol. 89:105-110(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Hartley.
      Tissue: Liver.

    Entry informationi

    Entry nameiIGF2_CAVPO
    AccessioniPrimary (citable) accession number: Q08279
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3