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Protein

Quinone oxidoreductase

Gene

CRYZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.2 Publications

Catalytic activityi

NADPH + 2 quinone = NADP+ + 2 semiquinone.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53NADP1 Publication1
Binding sitei181NADP; via amide nitrogen1 Publication1
Binding sitei200NADP1 Publication1
Binding sitei229NADP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi158 – 161NADP1 Publication4
Nucleotide bindingi246 – 249NADP1 Publication4
Nucleotide bindingi269 – 271NADP1 Publication3

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: UniProtKB
  • NADPH:quinone reductase activity Source: UniProtKB
  • NADPH binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • protein homotetramerization Source: UniProtKB
  • visual perception Source: ProtInc
  • xenobiotic catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP, RNA-binding

Enzyme and pathway databases

BioCyciZFISH:HS04055-MONOMER.
BRENDAi1.3.1.27. 2681.
1.6.5.5. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinone oxidoreductase (EC:1.6.5.5)
Alternative name(s):
NADPH:quinone reductase
Zeta-crystallin
Gene namesi
Name:CRYZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:2419. CRYZ.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi1429.
OpenTargetsiENSG00000116791.
PharmGKBiPA26925.

Chemistry databases

ChEMBLiCHEMBL6118.
DrugBankiDB00266. Dicoumarol.

Polymorphism and mutation databases

BioMutaiCRYZ.
DMDMi585013.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001609062 – 329Quinone oxidoreductaseAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei23N6-acetyllysineCombined sources1
Modified residuei248PhosphoserineCombined sources1
Modified residuei296N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ08257.
MaxQBiQ08257.
PaxDbiQ08257.
PeptideAtlasiQ08257.
PRIDEiQ08257.

2D gel databases

REPRODUCTION-2DPAGEIPI00000792.

PTM databases

iPTMnetiQ08257.
PhosphoSitePlusiQ08257.
SwissPalmiQ08257.

Expressioni

Tissue specificityi

Only very low amounts in the lens.

Gene expression databases

BgeeiENSG00000116791.
CleanExiHS_CRYZ.
ExpressionAtlasiQ08257. baseline and differential.
GenevisibleiQ08257. HS.

Organism-specific databases

HPAiHPA021921.
HPA023290.

Interactioni

Subunit structurei

Homotetramer.2 Publications

Protein-protein interaction databases

BioGridi107816. 25 interactors.
IntActiQ08257. 8 interactors.
MINTiMINT-5002754.
STRINGi9606.ENSP00000339399.

Structurei

Secondary structure

1329
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 15Combined sources9
Helixi19 – 21Combined sources3
Beta strandi22 – 29Combined sources8
Beta strandi37 – 46Combined sources10
Helixi49 – 55Combined sources7
Beta strandi65 – 67Combined sources3
Beta strandi73 – 80Combined sources8
Beta strandi92 – 96Combined sources5
Beta strandi102 – 110Combined sources9
Helixi111 – 113Combined sources3
Beta strandi114 – 116Combined sources3
Helixi123 – 126Combined sources4
Turni127 – 129Combined sources3
Helixi130 – 141Combined sources12
Beta strandi151 – 156Combined sources6
Helixi160 – 171Combined sources12
Beta strandi175 – 182Combined sources8
Helixi183 – 191Combined sources9
Beta strandi195 – 199Combined sources5
Helixi205 – 213Combined sources9
Beta strandi218 – 224Combined sources7
Helixi226 – 236Combined sources11
Beta strandi237 – 245Combined sources9
Beta strandi252 – 254Combined sources3
Helixi257 – 260Combined sources4
Turni261 – 263Combined sources3
Beta strandi265 – 268Combined sources4
Helixi271 – 273Combined sources3
Helixi276 – 292Combined sources17
Beta strandi299 – 304Combined sources6
Helixi305 – 307Combined sources3
Helixi308 – 317Combined sources10
Beta strandi322 – 328Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YB5X-ray1.85A/B1-329[»]
ProteinModelPortaliQ08257.
SMRiQ08257.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08257.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1197. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294672.
HOVERGENiHBG002466.
InParanoidiQ08257.
KOiK00344.
OMAiPIPKGHQ.
OrthoDBiEOG091G0DQO.
PhylomeDBiQ08257.
TreeFamiTF314255.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q08257-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATGQKLMRA VRVFEFGGPE VLKLRSDIAV PIPKDHQVLI KVHACGVNPV
60 70 80 90 100
ETYIRSGTYS RKPLLPYTPG SDVAGVIEAV GDNASAFKKG DRVFTSSTIS
110 120 130 140 150
GGYAEYALAA DHTVYKLPEK LDFKQGAAIG IPYFTAYRAL IHSACVKAGE
160 170 180 190 200
SVLVHGASGG VGLAACQIAR AYGLKILGTA GTEEGQKIVL QNGAHEVFNH
210 220 230 240 250
REVNYIDKIK KYVGEKGIDI IIEMLANVNL SKDLSLLSHG GRVIVVGSRG
260 270 280 290 300
TIEINPRDTM AKESSIIGVT LFSSTKEEFQ QYAAALQAGM EIGWLKPVIG
310 320
SQYPLEKVAE AHENIIHGSG ATGKMILLL
Length:329
Mass (Da):35,207
Last modified:October 1, 1994 - v1
Checksum:i68C1828911486D4E
GO
Isoform 2 (identifier: Q08257-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MATGQ → MHLLS
     6-142: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):20,421
Checksum:iCA6C67D141CDD8B5
GO
Isoform 3 (identifier: Q08257-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-244: Missing.

Note: No experimental confirmation available.
Show »
Length:295
Mass (Da):31,528
Checksum:i6062614A6DCB2A9E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105E → G in AK314813 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02291366P → S.1 PublicationCorresponds to variant rs11551729dbSNPEnsembl.1
Natural variantiVAR_022914176I → V.1 PublicationCorresponds to variant rs3819946dbSNPEnsembl.1
Natural variantiVAR_048200183E → K.Corresponds to variant rs17095822dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0429271 – 5MATGQ → MHLLS in isoform 2. 1 Publication5
Alternative sequenceiVSP_0429286 – 142Missing in isoform 2. 1 PublicationAdd BLAST137
Alternative sequenceiVSP_046425211 – 244Missing in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13278 mRNA. Translation: AAA36536.1.
L31526
, L31521, L31522, L31523, L31524, L31525 Genomic DNA. Translation: AAK40311.1.
AB209714 mRNA. Translation: BAD92951.1.
AK223150 mRNA. Translation: BAD96870.1.
AK223201 mRNA. Translation: BAD96921.1.
BX647883 mRNA. Translation: CAI46072.1.
AK314813 mRNA. No translation available.
AC091611 Genomic DNA. No translation available.
AC135803 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06409.1.
CH471059 Genomic DNA. Translation: EAX06410.1.
CH471059 Genomic DNA. Translation: EAX06411.1.
CH471059 Genomic DNA. Translation: EAX06412.1.
BC039578 mRNA. Translation: AAH39578.1.
BC070058 mRNA. Translation: AAH70058.1.
CCDSiCCDS44162.1. [Q08257-3]
CCDS44163.1. [Q08257-2]
CCDS665.1. [Q08257-1]
PIRiPN0448.
RefSeqiNP_001123514.1. NM_001130042.1. [Q08257-1]
NP_001123515.1. NM_001130043.1. [Q08257-3]
NP_001128231.1. NM_001134759.1. [Q08257-2]
NP_001880.2. NM_001889.3. [Q08257-1]
XP_005270548.1. XM_005270491.4. [Q08257-2]
XP_011539049.1. XM_011540747.1. [Q08257-1]
XP_016855856.1. XM_017000367.1. [Q08257-3]
XP_016855857.1. XM_017000368.1. [Q08257-2]
UniGeneiHs.83114.

Genome annotation databases

EnsembliENST00000340866; ENSP00000339399; ENSG00000116791. [Q08257-1]
ENST00000370871; ENSP00000359908; ENSG00000116791. [Q08257-3]
ENST00000370872; ENSP00000359909; ENSG00000116791. [Q08257-2]
ENST00000417775; ENSP00000399805; ENSG00000116791. [Q08257-1]
GeneIDi1429.
KEGGihsa:1429.
UCSCiuc001dgj.4. human. [Q08257-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13278 mRNA. Translation: AAA36536.1.
L31526
, L31521, L31522, L31523, L31524, L31525 Genomic DNA. Translation: AAK40311.1.
AB209714 mRNA. Translation: BAD92951.1.
AK223150 mRNA. Translation: BAD96870.1.
AK223201 mRNA. Translation: BAD96921.1.
BX647883 mRNA. Translation: CAI46072.1.
AK314813 mRNA. No translation available.
AC091611 Genomic DNA. No translation available.
AC135803 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06409.1.
CH471059 Genomic DNA. Translation: EAX06410.1.
CH471059 Genomic DNA. Translation: EAX06411.1.
CH471059 Genomic DNA. Translation: EAX06412.1.
BC039578 mRNA. Translation: AAH39578.1.
BC070058 mRNA. Translation: AAH70058.1.
CCDSiCCDS44162.1. [Q08257-3]
CCDS44163.1. [Q08257-2]
CCDS665.1. [Q08257-1]
PIRiPN0448.
RefSeqiNP_001123514.1. NM_001130042.1. [Q08257-1]
NP_001123515.1. NM_001130043.1. [Q08257-3]
NP_001128231.1. NM_001134759.1. [Q08257-2]
NP_001880.2. NM_001889.3. [Q08257-1]
XP_005270548.1. XM_005270491.4. [Q08257-2]
XP_011539049.1. XM_011540747.1. [Q08257-1]
XP_016855856.1. XM_017000367.1. [Q08257-3]
XP_016855857.1. XM_017000368.1. [Q08257-2]
UniGeneiHs.83114.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YB5X-ray1.85A/B1-329[»]
ProteinModelPortaliQ08257.
SMRiQ08257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107816. 25 interactors.
IntActiQ08257. 8 interactors.
MINTiMINT-5002754.
STRINGi9606.ENSP00000339399.

Chemistry databases

ChEMBLiCHEMBL6118.
DrugBankiDB00266. Dicoumarol.

PTM databases

iPTMnetiQ08257.
PhosphoSitePlusiQ08257.
SwissPalmiQ08257.

Polymorphism and mutation databases

BioMutaiCRYZ.
DMDMi585013.

2D gel databases

REPRODUCTION-2DPAGEIPI00000792.

Proteomic databases

EPDiQ08257.
MaxQBiQ08257.
PaxDbiQ08257.
PeptideAtlasiQ08257.
PRIDEiQ08257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340866; ENSP00000339399; ENSG00000116791. [Q08257-1]
ENST00000370871; ENSP00000359908; ENSG00000116791. [Q08257-3]
ENST00000370872; ENSP00000359909; ENSG00000116791. [Q08257-2]
ENST00000417775; ENSP00000399805; ENSG00000116791. [Q08257-1]
GeneIDi1429.
KEGGihsa:1429.
UCSCiuc001dgj.4. human. [Q08257-1]

Organism-specific databases

CTDi1429.
DisGeNETi1429.
GeneCardsiCRYZ.
HGNCiHGNC:2419. CRYZ.
HPAiHPA021921.
HPA023290.
MIMi123691. gene.
neXtProtiNX_Q08257.
OpenTargetsiENSG00000116791.
PharmGKBiPA26925.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1197. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294672.
HOVERGENiHBG002466.
InParanoidiQ08257.
KOiK00344.
OMAiPIPKGHQ.
OrthoDBiEOG091G0DQO.
PhylomeDBiQ08257.
TreeFamiTF314255.

Enzyme and pathway databases

BioCyciZFISH:HS04055-MONOMER.
BRENDAi1.3.1.27. 2681.
1.6.5.5. 2681.

Miscellaneous databases

ChiTaRSiCRYZ. human.
EvolutionaryTraceiQ08257.
GeneWikiiCRYZ.
GenomeRNAii1429.
PROiQ08257.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116791.
CleanExiHS_CRYZ.
ExpressionAtlasiQ08257. baseline and differential.
GenevisibleiQ08257. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQOR_HUMAN
AccessioniPrimary (citable) accession number: Q08257
Secondary accession number(s): A6NN60
, D3DQ76, Q53FT0, Q59EU7, Q5HYE7, Q6NSK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.