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Protein

RNA exonuclease 4

Gene

REX4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.2 Publications

GO - Molecular functioni

  • 3'-5' exonuclease activity Source: SGD
  • nucleic acid binding Source: InterPro

GO - Biological processi

  • ribosomal large subunit assembly Source: SGD
  • rRNA processing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-33483-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA exonuclease 4 (EC:3.1.-.-)
Gene namesi
Name:REX4
Ordered Locus Names:YOL080C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL080C.
SGDiS000005440. REX4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289RNA exonuclease 4PRO_0000131702Add
BLAST

Proteomic databases

MaxQBiQ08237.

Interactioni

Protein-protein interaction databases

BioGridi34322. 38 interactions.
DIPiDIP-5458N.
IntActiQ08237. 3 interactions.
MINTiMINT-543211.

Structurei

3D structure databases

ProteinModelPortaliQ08237.
SMRiQ08237. Positions 74-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 273153ExonucleaseAdd
BLAST

Sequence similaritiesi

Belongs to the REXO4 family.Curated
Contains 1 exonuclease domain.Curated

Phylogenomic databases

GeneTreeiENSGT00520000055542.
HOGENOMiHOG000182422.
InParanoidiQ08237.
KOiK18327.
OMAiALMLSHP.
OrthoDBiEOG092C2R0D.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSSNWQAL LASESNPTSN GKNKQSNRKI RNVKKVSKTV NVSSTTQYAP
60 70 80 90 100
RKRKNGSKIM DMVYNMNKEI SKHEKDKLEG KVFEFNPNKA NTSTTIKEPV
110 120 130 140 150
KVGISEDTRI NSNKSKEIGK YIAMDCEFVG VGPEGKESAL ARISIVNYFG
160 170 180 190 200
HVVLDEFVKP REKVVEWRTW VSGIKPEHMK NAITFKEAQK KTADILEGRI
210 220 230 240 250
LVGHALKHDL EALMLSHPKS LLRDTSRHLP FRKLYAKGKT PSLKKLTREV
260 270 280
LKISIQEGEH SSVEDARATM LLYKKEKTEF EKIHRNTFN
Length:289
Mass (Da):32,895
Last modified:November 1, 1996 - v1
Checksum:iB4DC2FA3BA1B7FCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74822 Genomic DNA. Translation: CAA99090.1.
BK006948 Genomic DNA. Translation: DAA10704.1.
PIRiS66773.
RefSeqiNP_014561.1. NM_001183334.1.

Genome annotation databases

EnsemblFungiiYOL080C; YOL080C; YOL080C.
GeneIDi854075.
KEGGisce:YOL080C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74822 Genomic DNA. Translation: CAA99090.1.
BK006948 Genomic DNA. Translation: DAA10704.1.
PIRiS66773.
RefSeqiNP_014561.1. NM_001183334.1.

3D structure databases

ProteinModelPortaliQ08237.
SMRiQ08237. Positions 74-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34322. 38 interactions.
DIPiDIP-5458N.
IntActiQ08237. 3 interactions.
MINTiMINT-543211.

Proteomic databases

MaxQBiQ08237.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL080C; YOL080C; YOL080C.
GeneIDi854075.
KEGGisce:YOL080C.

Organism-specific databases

EuPathDBiFungiDB:YOL080C.
SGDiS000005440. REX4.

Phylogenomic databases

GeneTreeiENSGT00520000055542.
HOGENOMiHOG000182422.
InParanoidiQ08237.
KOiK18327.
OMAiALMLSHP.
OrthoDBiEOG092C2R0D.

Enzyme and pathway databases

BioCyciYEAST:G3O-33483-MONOMER.

Miscellaneous databases

PROiQ08237.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiREXO4_YEAST
AccessioniPrimary (citable) accession number: Q08237
Secondary accession number(s): D6W1Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4280 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.