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Reviewed, UniProtKB/Swiss-Prot Q08235 (BRX1_YEAST)

Last modified November 24, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ribosome biogenesis protein BRX1
Gene names
Name: BRX1
Ordered Locus Names: YOL077C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Required for biogenesis of the 60S ribosomal subunit. Ref.3

Subunit structure

Part of a complex that includes BRX1, RPF1, RPF2 and SSF1 or SSF2.

Subcellular location

Nucleus › nucleolus.

Miscellaneous

Present with 13200 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Belongs to the BXDC2/BRX1 family.

Contains 1 Brix domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291Ribosome biogenesis protein BRX1
PRO_0000120235

Regions

Domain31 – 232202Brix

Amino acid modifications

Modified residue2851Phosphoserine Ref.5

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Sequences

Sequence LengthMass (Da)Tools
Q08235-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 34526B87E9CE7301

FASTA29133,577
        10         20         30         40         50         60 
MSSIYKALAG KSKDNKSEKK QGNVKQFMNK QRTLLISSRG VNYRHRHLIQ DLSGLLPHSR 

        70         80         90        100        110        120 
KEPKLDTKKD LQQLNEIAEL YNCNNVLFFE ARKHQDLYLW LSKPPNGPTI KFYIQNLHTM 

       130        140        150        160        170        180 
DELNFTGNCL KGSRPVLSFD QRFESSPHYQ LIKELLVHNF CVPPNARKSK PFIDHVMSFS 

       190        200        210        220        230        240 
IVDDKIWVRT YEISHSTKNK EEYEDGEEDI SLVEIGPRFV MTVILILEGS FGGPKIYENK 

       250        260        270        280        290 
QYVSPNVVRA QIKQQAAEEA KSRAEAAVER KIKRRENVLA ADPLSNDALF K

« Hide

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References

« Hide 'large scale' references
[1]"Sequence analysis of a 33.2 kb segment from the left arm of yeast chromosome XV reveals eight known genes and ten new open reading frames including homologues of ABC transporters, inositol phosphatases and human expressed sequence tags."
Tzermia M., Katsoulou C., Alexandraki D.
Yeast 13:583-589(1997) [PubMed: 9178509] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed: 9169874] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"Brix from Xenopus laevis and brx1p from yeast define a new family of proteins involved in the biogenesis of large ribosomal subunits."
Kaser A., Bogengruber E., Hallegger M., Doppler E., Lepperdinger G., Jantsch M., Breitenbach M., Kreil G.
Biol. Chem. 382:1637-1647(2001) [PubMed: 11843177] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z74819 Genomic DNA. Translation: CAA99087.1.
PIRS66770.
RefSeqNP_014565.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:6317N.
IntActQ08235. 97 interactions.
STRINGQ08235.

Proteomic databases

PeptideAtlasQ08235.
PRIDEQ08235.

Genome annotation databases

EnsemblYOL077C; YOL077C; YOL077C; Saccharomyces cerevisiae. [Genome view]
GeneID854078.
KEGGsce:YOL077C.
NMPDRfig|4932.3.peg.5657.

Organism-specific databases

CYGDYOL077c.
SGDS000005437. BRX1.

Phylogenomic databases

HOGENOMQ08235.
OMAGPKIYEN
OrthoDBEOG9QNPCD

Gene expression databases

ArrayExpressQ08235.
GenevestigatorQ08235.
GermOnlineYOL077C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR007109. Brix.
[Graphical view]
PfamPF04427. Brix. 1 hit.
[Graphical view]
SMARTSM00879. Brix. 1 hit.
[Graphical view]
PROSITEPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio975707.

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Entry information

Entry nameBRX1_YEAST
AccessionPrimary (citable) accession number: Q08235
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: November 1, 1996
Last modified: November 24, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents