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Protein

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP54

Gene

INP54

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the phosphatidylinositol (4,5)-diphosphate levels on the cytoplasmic surface of the endoplasmic reticulum and thereby regulates secretion. Does not utilize phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 4-phosphate (PtdIns4P).2 Publications

Miscellaneous

Present with 1200 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.

GO - Molecular functioni

  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: SGD

GO - Biological processi

  • phosphatidylinositol dephosphorylation Source: SGD
  • protein transport Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:YOL065C-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP54 (EC:3.1.3.36)
Gene namesi
Name:INP54
Ordered Locus Names:YOL065C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL065C
SGDiS000005426 INP54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686821 – 384Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP54Add BLAST384

Proteomic databases

MaxQBiQ08227
PaxDbiQ08227
PRIDEiQ08227
TopDownProteomicsiQ08227

PTM databases

iPTMnetiQ08227

Interactioni

Protein-protein interaction databases

BioGridi34336, 70 interactors
DIPiDIP-2768N
IntActiQ08227, 13 interactors
MINTiQ08227
STRINGi4932.YOL065C

Structurei

3D structure databases

ProteinModelPortaliQ08227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000113076
InParanoidiQ08227
KOiK01106
OMAiYTTSDHK
OrthoDBiEOG092C2RQC

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000300 IPPc
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit

Sequencei

Sequence statusi: Complete.

Q08227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKTNWKVSV TTFNCGKEFP VENSKAIVKQ LLFPYDDGIS QLELQDLYVL
60 70 80 90 100
GFQEVVPIWQ GSFPAVNRDL IDRITTTAVN CLNEKVSATQ GDEQYSCLGV
110 120 130 140 150
NSLGAITIIV LYNNNALKVK DDILKRNGKC GWFGTHLKGG TLISFQMTRN
160 170 180 190 200
GEENWERFSY ICAHLNANEG VNNRNQRIDD YKRIMSEVCD SEVAKSDHFF
210 220 230 240 250
FLGDLNFRVT STYDPTTNYS STTTLRRLLE NHEELNLLRK GEDEPLCKGF
260 270 280 290 300
QELKITFPPT YKFKLFEKET YNTKRIPSWC DRILYKSYAV PTFAQEGTYH
310 320 330 340 350
SVPRSNALLF SDHQPVNLTV RLPRSTGTPV PLSLHIEKYP LSWSSGLIGQ
360 370 380
IGDAVIGYCG WLVTKNVHYW ILGSLLLYLL LKIL
Length:384
Mass (Da):43,799
Last modified:November 1, 1996 - v1
Checksum:iC77711D57C64B365
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74807 Genomic DNA Translation: CAA99075.1
BK006948 Genomic DNA Translation: DAA10718.1
PIRiS66758
RefSeqiNP_014576.1, NM_001183320.1

Genome annotation databases

EnsemblFungiiYOL065C; YOL065C; YOL065C
GeneIDi854089
KEGGisce:YOL065C

Similar proteinsi

Entry informationi

Entry nameiINP54_YEAST
AccessioniPrimary (citable) accession number: Q08227
Secondary accession number(s): D6W202
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health