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Protein

Probable dipeptidyl peptidase 3

Gene

YOL057W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi460Zinc; catalyticBy similarity1
Active sitei461By similarity1
Metal bindingi465Zinc; catalyticBy similarity1
Metal bindingi517Zinc; catalyticBy similarity1

GO - Molecular functioni

  • dipeptidyl-peptidase activity Source: SGD
  • metal ion binding Source: UniProtKB-KW
  • metallopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  • proteolysis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33468-MONOMER.
BRENDAi3.4.14.4. 984.

Protein family/group databases

MEROPSiM49.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl peptidase 3 (EC:3.4.14.4)
Alternative name(s):
Dipeptidyl aminopeptidase III
Dipeptidyl arylamidase III
Dipeptidyl peptidase III
Short name:
DPP III
Gene namesi
Ordered Locus Names:YOL057W
ORF Names:O1232
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL057W.
SGDiS000005418. YOL057W.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000782431 – 711Probable dipeptidyl peptidase 3Add BLAST711

Proteomic databases

MaxQBiQ08225.
PRIDEiQ08225.

Interactioni

Protein-protein interaction databases

BioGridi34344. 11 interactors.
MINTiMINT-624789.

Structurei

Secondary structure

1711
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 14Combined sources3
Turni18 – 21Combined sources4
Helixi22 – 24Combined sources3
Helixi27 – 41Combined sources15
Helixi44 – 51Combined sources8
Helixi55 – 68Combined sources14
Turni69 – 71Combined sources3
Helixi78 – 97Combined sources20
Beta strandi99 – 101Combined sources3
Turni103 – 105Combined sources3
Helixi115 – 124Combined sources10
Helixi133 – 136Combined sources4
Helixi143 – 145Combined sources3
Helixi148 – 150Combined sources3
Helixi154 – 159Combined sources6
Turni160 – 163Combined sources4
Turni167 – 170Combined sources4
Beta strandi171 – 173Combined sources3
Helixi175 – 177Combined sources3
Beta strandi184 – 187Combined sources4
Helixi191 – 200Combined sources10
Helixi202 – 205Combined sources4
Beta strandi212 – 218Combined sources7
Beta strandi221 – 227Combined sources7
Turni236 – 238Combined sources3
Beta strandi242 – 245Combined sources4
Beta strandi252 – 259Combined sources8
Helixi261 – 275Combined sources15
Helixi281 – 296Combined sources16
Helixi299 – 310Combined sources12
Beta strandi316 – 325Combined sources10
Beta strandi327 – 329Combined sources3
Beta strandi336 – 343Combined sources8
Helixi346 – 357Combined sources12
Helixi359 – 365Combined sources7
Beta strandi366 – 368Combined sources3
Helixi370 – 372Combined sources3
Beta strandi384 – 393Combined sources10
Beta strandi397 – 401Combined sources5
Helixi405 – 410Combined sources6
Beta strandi414 – 418Combined sources5
Helixi419 – 427Combined sources9
Turni439 – 441Combined sources3
Helixi442 – 466Combined sources25
Beta strandi472 – 474Combined sources3
Beta strandi477 – 480Combined sources4
Beta strandi482 – 484Combined sources3
Beta strandi491 – 493Combined sources3
Helixi504 – 508Combined sources5
Helixi509 – 511Combined sources3
Helixi512 – 527Combined sources16
Helixi531 – 536Combined sources6
Helixi542 – 562Combined sources21
Helixi563 – 566Combined sources4
Turni569 – 571Combined sources3
Helixi577 – 591Combined sources15
Beta strandi592 – 595Combined sources4
Beta strandi598 – 603Combined sources6
Beta strandi610 – 614Combined sources5
Helixi616 – 618Combined sources3
Turni619 – 621Combined sources3
Helixi622 – 639Combined sources18
Helixi643 – 653Combined sources11
Helixi658 – 661Combined sources4
Helixi664 – 669Combined sources6
Beta strandi676 – 678Combined sources3
Beta strandi681 – 684Combined sources4
Beta strandi690 – 693Combined sources4
Helixi699 – 710Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CSKX-ray1.95A1-711[»]
ProteinModelPortaliQ08225.
SMRiQ08225.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08225.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M49 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000007335.
HOGENOMiHOG000187784.
InParanoidiQ08225.
KOiK01277.
OMAiELTGHGC.
OrthoDBiEOG092C0TQ0.

Family and domain databases

InterProiIPR005317. Dipeptidyl-peptase3.
[Graphical view]
PIRSFiPIRSF007828. Dipeptidyl-peptidase_III. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHFFADHDA PLSMLSVKTE YFPQLTDKEQ KYAHFMSKAS HAGSRVVMRQ
60 70 80 90 100
VSHESEPIFD LILAIHSKLN GKYPEDDITQ KQQTGLYLEY VSQFLSNLGN
110 120 130 140 150
FKSFGDTKFI PRCEVKFFKQ LLELAKINPC SSPLTLSPVD VNHEFTSHHL
160 170 180 190 200
FSTINELIDI GIYHVEEKAA LLGFPSQGYT SAYYLGLPVT PEDMALLKEQ
210 220 230 240 250
LFAELAILPE NTRINKVGEN SFQIWVASEN VKNQITETYP SGQITLSNAV
260 270 280 290 300
TKVEFIFGDH SREMRLVASY LKEAQKFAAN DTQKAMLQEY INHFVTGSSQ
310 320 330 340 350
AHKEAQKLWV KDISPVIETN IGFIETYREP SGIIGEFESL VAIQNKERTA
360 370 380 390 400
KFSSLVNNAE EFISLLPWSK DYEKPIFNPP DFTSLEVLTF TGSGIPAGIN
410 420 430 440 450
IPNYDDVRLK IGFKNVSLGN ILSAAAKSSS KHPPSFISQE DRPIFEKYQS
460 470 480 490 500
DSFEVQVGIH ELLGHGSGKL LTEFTDGFNF DKENPPLGLD GKPVSTYYKV
510 520 530 540 550
GETWGSKFGQ LAGPFEECRA EVIAMFLLTN KKILDIFGFH DVESQDKVIY
560 570 580 590 600
AGYLQMARAG LLALEYWNPK TGKWGQPHMQ ARFSIMKTFM KHSTDKNFLK
610 620 630 640 650
LEMNSTNDDF AIKLDKSLIK TAGHECVKDY LKHLHVYKCS GDVEQGSKYF
660 670 680 690 700
IDRSTVTPDL ASLRDIVLSK RLPRRQFIQS NSYIDDNNKV TLKEYDETPQ
710
GMLQSFLDRE L
Length:711
Mass (Da):80,510
Last modified:November 1, 1996 - v1
Checksum:iC8FEBD32834FA683
GO

Sequence cautioni

The sequence CAA62529 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91067 Genomic DNA. Translation: CAA62529.1. Different initiation.
Z74798 Genomic DNA. Translation: CAA99065.1.
Z74799 Genomic DNA. Translation: CAA99066.1.
BK006948 Genomic DNA. Translation: DAA10726.1.
PIRiS66749.
RefSeqiNP_014584.1. NM_001183312.1.

Genome annotation databases

EnsemblFungiiYOL057W; YOL057W; YOL057W.
GeneIDi854097.
KEGGisce:YOL057W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91067 Genomic DNA. Translation: CAA62529.1. Different initiation.
Z74798 Genomic DNA. Translation: CAA99065.1.
Z74799 Genomic DNA. Translation: CAA99066.1.
BK006948 Genomic DNA. Translation: DAA10726.1.
PIRiS66749.
RefSeqiNP_014584.1. NM_001183312.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CSKX-ray1.95A1-711[»]
ProteinModelPortaliQ08225.
SMRiQ08225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34344. 11 interactors.
MINTiMINT-624789.

Protein family/group databases

MEROPSiM49.004.

Proteomic databases

MaxQBiQ08225.
PRIDEiQ08225.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL057W; YOL057W; YOL057W.
GeneIDi854097.
KEGGisce:YOL057W.

Organism-specific databases

EuPathDBiFungiDB:YOL057W.
SGDiS000005418. YOL057W.

Phylogenomic databases

GeneTreeiENSGT00390000007335.
HOGENOMiHOG000187784.
InParanoidiQ08225.
KOiK01277.
OMAiELTGHGC.
OrthoDBiEOG092C0TQ0.

Enzyme and pathway databases

BioCyciYEAST:G3O-33468-MONOMER.
BRENDAi3.4.14.4. 984.

Miscellaneous databases

EvolutionaryTraceiQ08225.
PROiQ08225.

Family and domain databases

InterProiIPR005317. Dipeptidyl-peptase3.
[Graphical view]
PIRSFiPIRSF007828. Dipeptidyl-peptidase_III. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPP3_YEAST
AccessioniPrimary (citable) accession number: Q08225
Secondary accession number(s): O94146, Q05663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3260 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.