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Protein

Nucleolar protein 12

Gene

NOP12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-25S rRNA processing.1 Publication

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • RNA binding Source: SGD
  • rRNA binding Source: GO_Central

GO - Biological processi

  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD

Keywordsi

Molecular functionRNA-binding
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-33455-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 12
Gene namesi
Name:NOP12
Ordered Locus Names:YOL041C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL041C.
SGDiS000005401. NOP12.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: SGD
  • preribosome Source: SGD

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816751 – 459Nucleolar protein 12Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineCombined sources1
Modified residuei181PhosphothreonineCombined sources1
Modified residuei184PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08208.
PRIDEiQ08208.

PTM databases

iPTMnetiQ08208.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34361. 397 interactors.
DIPiDIP-6505N.
IntActiQ08208. 42 interactors.
MINTiMINT-8285440.

Structurei

3D structure databases

ProteinModelPortaliQ08208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini279 – 371RRMPROSITE-ProRule annotationAdd BLAST93

Sequence similaritiesi

Belongs to the RRM RBM34 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000011249.
HOGENOMiHOG000157415.
InParanoidiQ08208.
KOiK14837.
OMAiRVDHVAH.
OrthoDBiEOG092D3VPV.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiView protein in InterPro
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 2 hits.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q08208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAIDNLFG NIDEKKIESS VDKLFSSSCG PINKLEVKSK TRTVLPDSKK
60 70 80 90 100
RERAAEADQE EKEASKPDVS DEQTEEVALP KVKKAKKSKR NDEDEDLEAR
110 120 130 140 150
YYAKLLNEEA EAEDDKPTVT KTDETSVPLT SAAKKVDFKE DELEKAERTV
160 170 180 190 200
FIGNILSTVI TSKKVYKEFK KLFGTNPIAE TEESGNEKEE ESSKKSDNNE
210 220 230 240 250
FAIESIRFRS ISFDEALPRK VAFVQQKFHK SRDTINAYIV YKNKSAVRKI
260 270 280 290 300
CSNLNAVVFQ DHHLRVDSVA HPAPHDKKRS IFVGNLDFEE IEESLWKHFE
310 320 330 340 350
PCGDIEYVRI IRDSKTNMGK GFAYVQFKDL QSVNKALLLN EKPMKSQKQE
360 370 380 390 400
DENTKKPTKK ARKLRVSRCK NMKKGTTIGT GLDRNGLTDS QRTRAGRAKK
410 420 430 440 450
ILGKADRATL GQEITIEGLR AKKGEGSTHL KKKKQRSATG RVTKRSIAFK

KAQAEKSKK
Length:459
Mass (Da):51,942
Last modified:November 1, 1996 - v1
Checksum:i338F73B13DAE3282
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74783 Genomic DNA. Translation: CAA99043.1.
BK006948 Genomic DNA. Translation: DAA10741.1.
PIRiS66726.
RefSeqiNP_014601.1. NM_001183295.1.

Genome annotation databases

EnsemblFungiiYOL041C; YOL041C; YOL041C.
GeneIDi854116.
KEGGisce:YOL041C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74783 Genomic DNA. Translation: CAA99043.1.
BK006948 Genomic DNA. Translation: DAA10741.1.
PIRiS66726.
RefSeqiNP_014601.1. NM_001183295.1.

3D structure databases

ProteinModelPortaliQ08208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34361. 397 interactors.
DIPiDIP-6505N.
IntActiQ08208. 42 interactors.
MINTiMINT-8285440.

PTM databases

iPTMnetiQ08208.

Proteomic databases

MaxQBiQ08208.
PRIDEiQ08208.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL041C; YOL041C; YOL041C.
GeneIDi854116.
KEGGisce:YOL041C.

Organism-specific databases

EuPathDBiFungiDB:YOL041C.
SGDiS000005401. NOP12.

Phylogenomic databases

GeneTreeiENSGT00390000011249.
HOGENOMiHOG000157415.
InParanoidiQ08208.
KOiK14837.
OMAiRVDHVAH.
OrthoDBiEOG092D3VPV.

Enzyme and pathway databases

BioCyciYEAST:G3O-33455-MONOMER.

Miscellaneous databases

PROiQ08208.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiView protein in InterPro
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 2 hits.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNOP12_YEAST
AccessioniPrimary (citable) accession number: Q08208
Secondary accession number(s): D6W225
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: February 15, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5910 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.