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Protein

Nucleolar protein 12

Gene

NOP12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-25S rRNA processing.1 Publication

Miscellaneous

Present with 5910 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • RNA binding Source: SGD
  • rRNA binding Source: GO_Central

GO - Biological processi

  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD

Keywordsi

Molecular functionRNA-binding
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-33455-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 12
Gene namesi
Name:NOP12
Ordered Locus Names:YOL041C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL041C
SGDiS000005401 NOP12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816751 – 459Nucleolar protein 12Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineCombined sources1
Modified residuei181PhosphothreonineCombined sources1
Modified residuei184PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08208
PaxDbiQ08208
PRIDEiQ08208

PTM databases

iPTMnetiQ08208

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34361, 404 interactors
DIPiDIP-6505N
IntActiQ08208, 63 interactors
MINTiQ08208
STRINGi4932.YOL041C

Structurei

3D structure databases

ProteinModelPortaliQ08208
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini279 – 371RRMPROSITE-ProRule annotationAdd BLAST93

Sequence similaritiesi

Belongs to the RRM RBM34 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000011249
HOGENOMiHOG000157415
InParanoidiQ08208
KOiK14837
OMAiEEHFLDC
OrthoDBiEOG092C3SCB

Family and domain databases

CDDicd12669 RRM1_Nop12p_like, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034777 Nop12_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q08208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAIDNLFG NIDEKKIESS VDKLFSSSCG PINKLEVKSK TRTVLPDSKK
60 70 80 90 100
RERAAEADQE EKEASKPDVS DEQTEEVALP KVKKAKKSKR NDEDEDLEAR
110 120 130 140 150
YYAKLLNEEA EAEDDKPTVT KTDETSVPLT SAAKKVDFKE DELEKAERTV
160 170 180 190 200
FIGNILSTVI TSKKVYKEFK KLFGTNPIAE TEESGNEKEE ESSKKSDNNE
210 220 230 240 250
FAIESIRFRS ISFDEALPRK VAFVQQKFHK SRDTINAYIV YKNKSAVRKI
260 270 280 290 300
CSNLNAVVFQ DHHLRVDSVA HPAPHDKKRS IFVGNLDFEE IEESLWKHFE
310 320 330 340 350
PCGDIEYVRI IRDSKTNMGK GFAYVQFKDL QSVNKALLLN EKPMKSQKQE
360 370 380 390 400
DENTKKPTKK ARKLRVSRCK NMKKGTTIGT GLDRNGLTDS QRTRAGRAKK
410 420 430 440 450
ILGKADRATL GQEITIEGLR AKKGEGSTHL KKKKQRSATG RVTKRSIAFK

KAQAEKSKK
Length:459
Mass (Da):51,942
Last modified:November 1, 1996 - v1
Checksum:i338F73B13DAE3282
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74783 Genomic DNA Translation: CAA99043.1
BK006948 Genomic DNA Translation: DAA10741.1
PIRiS66726
RefSeqiNP_014601.1, NM_001183295.1

Genome annotation databases

EnsemblFungiiYOL041C; YOL041C; YOL041C
GeneIDi854116
KEGGisce:YOL041C

Similar proteinsi

Entry informationi

Entry nameiNOP12_YEAST
AccessioniPrimary (citable) accession number: Q08208
Secondary accession number(s): D6W225
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health