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Protein

Adenylyl cyclase-associated protein 1

Gene

Cap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl cyclase-associated protein 1
Short name:
CAP 1
Gene namesi
Name:Cap1
Synonyms:Cap, Mch1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620309 Cap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002056992 – 474Adenylyl cyclase-associated protein 1Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei31PhosphotyrosineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei80N6-acetyllysineBy similarity1
Modified residuei286N6-methyllysineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei294PhosphoserineBy similarity1
Modified residuei300PhosphoserineBy similarity1
Modified residuei306PhosphothreonineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei309PhosphoserineBy similarity1
Cross-linki347Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ08163
PRIDEiQ08163

2D gel databases

World-2DPAGEi0004:Q08163

PTM databases

iPTMnetiQ08163
PhosphoSitePlusiQ08163
SwissPalmiQ08163

Expressioni

Tissue specificityi

In all cell and tissue types examined.

Gene expression databases

BgeeiENSRNOG00000013492
GenevisibleiQ08163 RN

Interactioni

Subunit structurei

Homodimer. Binds actin monomers (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248992, 1 interactor
DIPiDIP-225N
IntActiQ08163, 2 interactors
STRINGi10116.ENSRNOP00000018711

Structurei

3D structure databases

ProteinModelPortaliQ08163
SMRiQ08163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini312 – 452C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST141

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi217 – 255Ala/Pro/Ser-richAdd BLAST39
Compositional biasi229 – 240Poly-ProAdd BLAST12

Sequence similaritiesi

Belongs to the CAP family.Curated

Phylogenomic databases

eggNOGiKOG2675 Eukaryota
ENOG410XPXJ LUCA
GeneTreeiENSGT00390000017955
HOGENOMiHOG000206192
HOVERGENiHBG003080
InParanoidiQ08163
KOiK17261
OMAiHCGYGDS
OrthoDBiEOG091G0DLX
PhylomeDBiQ08163
TreeFamiTF313791

Family and domain databases

Gene3Di1.25.40.330, 1 hit
2.160.20.70, 1 hit
InterProiView protein in InterPro
IPR001837 Adenylate_cyclase-assoc_CAP
IPR013912 Adenylate_cyclase-assoc_CAP_C
IPR013992 Adenylate_cyclase-assoc_CAP_N
IPR017901 C-CAP_CF_C-like
IPR016098 CAP/MinC_C
IPR028415 CAP1
IPR036223 CAP_C_sf
IPR028417 CAP_CS_C
IPR018106 CAP_CS_N
IPR036222 CAP_N_sf
IPR006599 CARP_motif
PANTHERiPTHR10652 PTHR10652, 1 hit
PTHR10652:SF1 PTHR10652:SF1, 1 hit
PfamiView protein in Pfam
PF08603 CAP_C, 1 hit
PF01213 CAP_N, 1 hit
SMARTiView protein in SMART
SM00673 CARP, 2 hits
SUPFAMiSSF101278 SSF101278, 1 hit
SSF69340 SSF69340, 1 hit
PROSITEiView protein in PROSITE
PS51329 C_CAP_COFACTOR_C, 1 hit
PS01088 CAP_1, 1 hit
PS01089 CAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADMQNLVER LERAVGRLEA VSHTSDMHCG YGDSPSKGAV PYVQAFDSLL
60 70 80 90 100
ANPVAEYLKM SKEIGGDVQK HAEMVHTGLK LERALLVTAS QCQQPAGNKL
110 120 130 140 150
SDLLAPISEQ IQEVITFREK NRGSKFFNHL SAVSESIQAL GWVALAAKPG
160 170 180 190 200
PFVKEMNDAA MFYTNRVLKE YRDVDKKHVD WVRAYLSIWT ELQAYIKEFH
210 220 230 240 250
TTGLAWSKTG PVAKELSGLP SGPSVGSGPP PPPPGPPPPP VPTSSGSDDS
260 270 280 290 300
ASRSALFAQI NQGESITHAL KHVSDDMKTH KNPALKAQSG PVRSGPKPFS
310 320 330 340 350
APKPQTSPSP KPATKKEPAL LELEGKKWRV ENQENVSNLV IDDTELKQVA
360 370 380 390 400
YIYKCVNTTL QIKGKINSIT VDNCKKLGLV FDDVVGIVEI INSRDVKVQV
410 420 430 440 450
MGKVPTISIN KTDGCHAYLS KNSLDCEIVS AKSSEMNVLI PTEGGDFNEF
460 470
PVPEQFKTLW NGQKLVTTVT EIAG
Length:474
Mass (Da):51,589
Last modified:January 23, 2007 - v3
Checksum:iEB2CC635109479B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti388V → G in AAA41579 (PubMed:8514780).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11930 mRNA Translation: AAA41579.1
BC089801 mRNA Translation: AAH89801.1
PIRiA46584
RefSeqiNP_071778.2, NM_022383.2
XP_006238892.1, XM_006238830.3
XP_006238893.1, XM_006238831.3
XP_006238894.1, XM_006238832.3
UniGeneiRn.112585

Genome annotation databases

EnsembliENSRNOT00000018711; ENSRNOP00000018711; ENSRNOG00000013492
GeneIDi64185
KEGGirno:64185
UCSCiRGD:620309 rat

Similar proteinsi

Entry informationi

Entry nameiCAP1_RAT
AccessioniPrimary (citable) accession number: Q08163
Secondary accession number(s): Q5FVS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health