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Protein

Adenylyl cyclase-associated protein 1

Gene

Cap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl cyclase-associated protein 1
Short name:
CAP 1
Gene namesi
Name:Cap1
Synonyms:Cap, Mch1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620309. Cap1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 474473Adenylyl cyclase-associated protein 1PRO_0000205699Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei31 – 311PhosphotyrosineBy similarity
Modified residuei34 – 341PhosphoserineBy similarity
Modified residuei80 – 801N6-acetyllysineBy similarity
Modified residuei289 – 2891PhosphoserineBy similarity
Modified residuei294 – 2941PhosphoserineBy similarity
Modified residuei300 – 3001PhosphoserineBy similarity
Modified residuei306 – 3061PhosphothreonineBy similarity
Modified residuei307 – 3071PhosphoserineBy similarity
Modified residuei309 – 3091PhosphoserineBy similarity
Cross-linki347 – 347Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ08163.
PRIDEiQ08163.

2D gel databases

World-2DPAGE0004:Q08163.

PTM databases

iPTMnetiQ08163.
PhosphoSiteiQ08163.
SwissPalmiQ08163.

Expressioni

Tissue specificityi

In all cell and tissue types examined.

Gene expression databases

GenevisibleiQ08163. RN.

Interactioni

Subunit structurei

Homodimer. Binds actin monomers (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248992. 1 interaction.
DIPiDIP-225N.
IntActiQ08163. 2 interactions.
MINTiMINT-4577870.
STRINGi10116.ENSRNOP00000018711.

Structurei

3D structure databases

ProteinModelPortaliQ08163.
SMRiQ08163. Positions 318-474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini312 – 452141C-CAP/cofactor C-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi217 – 25539Ala/Pro/Ser-richAdd
BLAST
Compositional biasi229 – 24012Poly-ProAdd
BLAST

Sequence similaritiesi

Belongs to the CAP family.Curated
Contains 1 C-CAP/cofactor C-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2675. Eukaryota.
ENOG410XPXJ. LUCA.
GeneTreeiENSGT00390000017955.
HOGENOMiHOG000206192.
HOVERGENiHBG003080.
InParanoidiQ08163.
KOiK17261.
OMAiCHTYLSK.
OrthoDBiEOG7DNNTH.
PhylomeDBiQ08163.
TreeFamiTF313791.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
InterProiIPR001837. Adenylate_cyclase-assoc_CAP.
IPR013912. Adenylate_cyclase-assoc_CAP_C.
IPR013992. Adenylate_cyclase-assoc_CAP_N.
IPR017901. C-CAP_CF_C-like.
IPR016098. CAP/MinC_C.
IPR028415. CAP1.
IPR028417. CAP_CS_C.
IPR018106. CAP_CS_N.
IPR006599. CARP_motif.
[Graphical view]
PANTHERiPTHR10652. PTHR10652. 1 hit.
PTHR10652:SF1. PTHR10652:SF1. 1 hit.
PfamiPF08603. CAP_C. 1 hit.
PF01213. CAP_N. 1 hit.
[Graphical view]
SMARTiSM00673. CARP. 2 hits.
[Graphical view]
SUPFAMiSSF101278. SSF101278. 1 hit.
SSF69340. SSF69340. 1 hit.
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
PS01088. CAP_1. 1 hit.
PS01089. CAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADMQNLVER LERAVGRLEA VSHTSDMHCG YGDSPSKGAV PYVQAFDSLL
60 70 80 90 100
ANPVAEYLKM SKEIGGDVQK HAEMVHTGLK LERALLVTAS QCQQPAGNKL
110 120 130 140 150
SDLLAPISEQ IQEVITFREK NRGSKFFNHL SAVSESIQAL GWVALAAKPG
160 170 180 190 200
PFVKEMNDAA MFYTNRVLKE YRDVDKKHVD WVRAYLSIWT ELQAYIKEFH
210 220 230 240 250
TTGLAWSKTG PVAKELSGLP SGPSVGSGPP PPPPGPPPPP VPTSSGSDDS
260 270 280 290 300
ASRSALFAQI NQGESITHAL KHVSDDMKTH KNPALKAQSG PVRSGPKPFS
310 320 330 340 350
APKPQTSPSP KPATKKEPAL LELEGKKWRV ENQENVSNLV IDDTELKQVA
360 370 380 390 400
YIYKCVNTTL QIKGKINSIT VDNCKKLGLV FDDVVGIVEI INSRDVKVQV
410 420 430 440 450
MGKVPTISIN KTDGCHAYLS KNSLDCEIVS AKSSEMNVLI PTEGGDFNEF
460 470
PVPEQFKTLW NGQKLVTTVT EIAG
Length:474
Mass (Da):51,589
Last modified:January 23, 2007 - v3
Checksum:iEB2CC635109479B3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti388 – 3881V → G in AAA41579 (PubMed:8514780).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11930 mRNA. Translation: AAA41579.1.
BC089801 mRNA. Translation: AAH89801.1.
PIRiA46584.
RefSeqiNP_071778.2. NM_022383.2.
XP_006238892.1. XM_006238830.2.
XP_006238893.1. XM_006238831.2.
XP_006238894.1. XM_006238832.2.
UniGeneiRn.112585.

Genome annotation databases

EnsembliENSRNOT00000018711; ENSRNOP00000018711; ENSRNOG00000013492.
GeneIDi64185.
KEGGirno:64185.
UCSCiRGD:620309. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11930 mRNA. Translation: AAA41579.1.
BC089801 mRNA. Translation: AAH89801.1.
PIRiA46584.
RefSeqiNP_071778.2. NM_022383.2.
XP_006238892.1. XM_006238830.2.
XP_006238893.1. XM_006238831.2.
XP_006238894.1. XM_006238832.2.
UniGeneiRn.112585.

3D structure databases

ProteinModelPortaliQ08163.
SMRiQ08163. Positions 318-474.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248992. 1 interaction.
DIPiDIP-225N.
IntActiQ08163. 2 interactions.
MINTiMINT-4577870.
STRINGi10116.ENSRNOP00000018711.

PTM databases

iPTMnetiQ08163.
PhosphoSiteiQ08163.
SwissPalmiQ08163.

2D gel databases

World-2DPAGE0004:Q08163.

Proteomic databases

PaxDbiQ08163.
PRIDEiQ08163.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018711; ENSRNOP00000018711; ENSRNOG00000013492.
GeneIDi64185.
KEGGirno:64185.
UCSCiRGD:620309. rat.

Organism-specific databases

CTDi10487.
RGDi620309. Cap1.

Phylogenomic databases

eggNOGiKOG2675. Eukaryota.
ENOG410XPXJ. LUCA.
GeneTreeiENSGT00390000017955.
HOGENOMiHOG000206192.
HOVERGENiHBG003080.
InParanoidiQ08163.
KOiK17261.
OMAiCHTYLSK.
OrthoDBiEOG7DNNTH.
PhylomeDBiQ08163.
TreeFamiTF313791.

Miscellaneous databases

PROiQ08163.

Gene expression databases

GenevisibleiQ08163. RN.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
InterProiIPR001837. Adenylate_cyclase-assoc_CAP.
IPR013912. Adenylate_cyclase-assoc_CAP_C.
IPR013992. Adenylate_cyclase-assoc_CAP_N.
IPR017901. C-CAP_CF_C-like.
IPR016098. CAP/MinC_C.
IPR028415. CAP1.
IPR028417. CAP_CS_C.
IPR018106. CAP_CS_N.
IPR006599. CARP_motif.
[Graphical view]
PANTHERiPTHR10652. PTHR10652. 1 hit.
PTHR10652:SF1. PTHR10652:SF1. 1 hit.
PfamiPF08603. CAP_C. 1 hit.
PF01213. CAP_N. 1 hit.
[Graphical view]
SMARTiSM00673. CARP. 2 hits.
[Graphical view]
SUPFAMiSSF101278. SSF101278. 1 hit.
SSF69340. SSF69340. 1 hit.
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
PS01088. CAP_1. 1 hit.
PS01089. CAP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a rat homolog of CAP, the adenylyl cyclase-associated protein from Saccharomyces cerevisiae."
    Zelicof A., Gatica J., Gerst J.E.
    J. Biol. Chem. 268:13448-13453(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  3. Lubec G., Afjehi-Sadat L., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 100-118; 254-272 AND 377-394, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus and Spinal cord.

Entry informationi

Entry nameiCAP1_RAT
AccessioniPrimary (citable) accession number: Q08163
Secondary accession number(s): Q5FVS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.